Strychnine-like action of the convulsant barbiturate, CHEB.

abstract：:P2Y1 receptors mediate nerve mediated purinergic inhibitory junction potentials (IJP) and relaxations in the gastrointestinal (GI) tract in a wide range of species including rodents and humans. A new P2Y1 antagonist, with a non-nucleotide structure, BPTU, has recently been described using X-ray crystallography as the ...

journal_title：Neuropharmacology

authors： Mañé N,Jiménez-Sábado V,Jiménez M

更新日期：2016-11-01 00:00:00

abstract：:Receptor-mediated signal transduction is thought to play an important role in neuronal differentiation and the modification of synaptic connections during brain development. The intracellular signalling molecule phospholipase C-beta1 (PLC-beta1), which is activated via specific neurotransmitter receptors, has recently...

journal_title：Neuropharmacology

authors： Hannan AJ,Kind PC,Blakemore C

更新日期：1998-04-01 00:00:00

abstract：:Although there is evidence from in vitro studies to suggest that NO synthesis may be involved in the induction of hippocampal LTP, other in vitro studies and experiments conducted in vivo have provided conflicting results. In agreement with previous work conducted in this laboratory using an i.p. route of administrati...

journal_title：Neuropharmacology

authors： Bannerman DM,Butcher SP,Morris RG

更新日期：1994-11-01 00:00:00

abstract：:The so-called generalized polarization (GP) of the fluorescent probe Laurdan and the steady-state fluorescence anisotropy of the probe diphenylhexatriene (DPH) and its phenylpropionic derivative (PA-DPH) were used to study the effects of several organochlorine insecticides of the chlorophenylethane, chlorinated cycloh...

journal_title：Neuropharmacology

authors： Massol RH,Antollini SS,Barrantes FJ

更新日期：2000-04-03 00:00:00

abstract：:The posterior hypothalamic receptors involved in the cardiovascular responses to electrical stimulation of the rostral ventrolateral medulla were investigated in urethane-anaesthetized rats. Electrical stimulation of the rostral ventrolateral medulla produced a significant increase in systolic blood pressure. This res...

journal_title：Neuropharmacology

authors： Bachelard H,Rivest R,Marsden CA

更新日期：1991-07-01 00:00:00

abstract：:In nonhuman primates, anxiety levels are typically assessed by observing social hierarchies or behavior in an intruder task. As measures of anxiety might influence performance on a particular cognitive task, it is important to analyze these measures in the same room as used for the cognitive task. As we use a playroom...

journal_title：Neuropharmacology

authors： Haley GE,McGuire A,Berteau-Pavy D,Weiss A,Patel R,Messaoudi I,Urbanski HF,Raber J

更新日期：2012-01-01 00:00:00

abstract：:The basic unsolved questions concerning GABAA receptors are: "How many receptor subtypes exist?", "What subtypes are used by which types of neuron and where are they located on the cell?", and "What are the functions of the different subtypes?" As described in this Review, the cerebellum is an ideal vertebrate brain r...

journal_title：Neuropharmacology

authors： Wisden W,Korpi ER,Bahn S

更新日期：1996-01-01 00:00:00

abstract：:Oxytocin (100 ng) injected unilaterally into the ventral subiculum of the hippocampus induces penile erection episodes, which started 30 min after treatment and were abolished by the prior injection of d(CH(2))(5)Tyr(Me)(2)-Orn(8)-vasotocin (2 μg), an oxytocin receptor antagonist, into the ventral subiculum. Oxytocin-...

journal_title：Neuropharmacology

authors： Succu S,Sanna F,Argiolas A,Melis MR

更新日期：2011-07-01 00:00:00

abstract：:Hippocampal Long-Term Potentiation (LTP) is facilitated by BDNF, through the activation of tropomyosin-related kinase B (TrkB) receptors. However, an influence of BDNF upon Long-Term Depression (LTD) was also shown. The present work aimed to further evaluate the effect of BDNF and TrkB receptors upon CA1 hippocampal L...

journal_title：Neuropharmacology

authors： Rodrigues TM,Jerónimo-Santos A,Sebastião AM,Diógenes MJ

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:Alcohol use disorder (AUD) develops after chronic and heavy use of alcohol. Insomnia, a hallmark of AUD, plays a crucial role in the development of AUD. However, the causal mechanisms are unknown. Since chronic alcohol reduces acetylated histones and disrupts the epigenome, we hypothesized that chronic alcoh...

journal_title：Neuropharmacology

authors： Sharma R,Sahota P,Thakkar MM

更新日期：2020-12-01 00:00:00

abstract：:Hypotheses are scaffoldings erected in front of a building and then dismantled when the building is finished. They are indispensable for the workman; but you mustn't mistake the scaffolding for the building. Johann Wolfgang von Goethe. The neurogenesis hypothesis of affective disorders - in its simplest form - postula...

journal_title：Neuropharmacology

authors： Petrik D,Lagace DC,Eisch AJ

更新日期：2012-01-01 00:00:00

abstract：:Tryptophan (Trp) availability for the kynurenine pathway (KP) across the life span is discussed. Free (non-albumin-bound) plasma Trp is the major determinant of the flux of Trp down the KP. Flux is the major determinant of kynurenine metabolite formation and is more effective than induction of hepatic Trp 2,3-dioxygen...

journal_title：Neuropharmacology

authors： Badawy AA

更新日期：2017-01-01 00:00:00

abstract：:Dopamine (DA) is a classical neurotransmitter modulating various brain functions by acting on its specific receptors. In addition, DA is a reactive molecule that has been implicated in neurodegeneration, especially in Parkinson's disease. Here we show that DA inhibited cell growth of dopamine transporter transfected c...

journal_title：Neuropharmacology

authors： Woldman I,Reither H,Kattinger A,Hornykiewicz O,Pifl C

更新日期：2005-03-01 00:00:00

abstract：:While evidence indicates that sigma-1 receptors (Sig-1Rs) play an important role in the induction of peripheral neuropathic pain, there is limited understanding of the role that the neurosteroidogenic enzymes, which produce Sig-1R endogenous ligands, play during the development of neuropathic pain. We examined whether...

journal_title：Neuropharmacology

authors： Choi SR,Roh DH,Yoon SY,Choi HS,Kang SY,Han HJ,Beitz AJ,Lee JH

更新日期：2019-05-01 00:00:00

abstract：:We previously reported that elevated pressure induces axonal swelling and facilitates the synthesis of the neurosteroid, allopregnanolone (AlloP), in the ex vivo rat retina. Exogenously applied AlloP attenuates the axonal swelling, suggesting that the neurosteroid plays a neuroprotective role against glaucomatous pres...

journal_title：Neuropharmacology

authors： Ishikawa M,Yoshitomi T,Covey DF,Zorumski CF,Izumi Y

更新日期：2016-12-01 00:00:00

abstract：:Glioblastoma (GBM), the most aggressive brain tumor, has a poor prognosis due to the ease of migration to surrounding healthy brain tissue. Recent studies have shown that bradykinin receptors are involved in the progression of various cancers. However, the molecular mechanism and pathological role of bradykinin recept...

journal_title：Neuropharmacology

authors： Liu YS,Hsu JW,Lin HY,Lai SW,Huang BR,Tsai CF,Lu DY

更新日期：2019-01-01 00:00:00

abstract：:The electrophysiological properties and cataleptogenicity of YM-09151-2 (N-[(2RS, 3RS)-1-benzyl-2-methyl-3-pyrrolidinyl]-5-chloro-2-methoxy-4-methylaminobenzamide) were studied in the cat. This drug inhibited the EEG arousal response to electrical stimulation of the mesencephalic reticular formation with the same pote...

journal_title：Neuropharmacology

authors： Yamamoto M,Usuda S,Tachikawa S,Maeno H

更新日期：1982-10-01 00:00:00

abstract：:Mice were found to exhibit a marked suppression of motor activity when placed into the same experimental chamber in which they had previously received electrical shocks. This suppression was found to be a stable response when mice, 6-8 weeks of age, received shocks of frequencies of 1/10 or 1/30 Hz, and their motility...

journal_title：Neuropharmacology

authors： Kameyama T,Nagasaka M

更新日期：1982-12-01 00:00:00

abstract：:In the cerebellum of juvenile mice or rats, endocannabinoids are shown to mediate depolarization-induced suppression of excitation (DSE) and retrograde suppression induced by activation of type 1 metabotropic glutamate receptor (mGluR1) at parallel fiber (PF) to Purkinje cell (PC) synapses. However, recent studies sho...

journal_title：Neuropharmacology

authors： Tanimura A,Kawata S,Hashimoto K,Kano M

更新日期：2009-08-01 00:00:00

abstract：:Metabotropic glutamate (mGlu) receptors are implicated in many neurological and psychiatric diseases and are the targets of therapeutic agents currently in clinical development. Their activation has diverse effects in the central nervous system (CNS) that includes an involvement in synaptic plasticity. We previously r...

journal_title：Neuropharmacology

authors： Lodge D,Tidball P,Mercier MS,Lucas SJ,Hanna L,Ceolin L,Kritikos M,Fitzjohn SM,Sherwood JL,Bannister N,Volianskis A,Jane DE,Bortolotto ZA,Collingridge GL

更新日期：2013-11-01 00:00:00

abstract：:Aggression is a common symptom of several human psychiatric disorders. However, the drugs available to treat aggression are non-specific and can have unwanted side effects. The zebrafish is an ideal model for behavioural pharmacology. They are small, aggression can be measured reliably, and drugs can be applied by imm...

journal_title：Neuropharmacology

authors： Norton WHJ

更新日期：2019-09-15 00:00:00

abstract：:Rats exhibited a marked suppression of motor activity when placed in the same chamber where they had been given electric shocks. Administration of apomorphine-HCl (0.1, 0.5 and 1.0 mg/kg, i.p.) attenuated the conditioned suppression, dose-dependently, but did not facilitate motor activity of control (i.e. non-shocked)...

journal_title：Neuropharmacology

authors： Kameyama T,Nagasaka M

更新日期：1983-07-01 00:00:00

abstract：:Behavioural studies can help to validate, modify and refine schemes for classifying receptors that are developed from electrophysiological and biochemical experiments. Drug discrimination constitutes one family of behavioural techniques that is being extensively used for studying subtypes of receptors, mainly because ...

journal_title：Neuropharmacology

authors： Stolerman IP,Stephenson JD,Rauch RJ

更新日期：1987-07-01 00:00:00

abstract：:Human studies suggest that a variety of prenatal stressors are related to high risk for cognitive and behavioral abnormalities associated with psychiatric illness (Markham and Koenig, 2011). Recently, a downregulation in the expression of GABAergic genes (i.e., glutamic acid decarboxylase 67 and reelin) associated wit...

journal_title：Neuropharmacology

authors： Matrisciano F,Tueting P,Dalal I,Kadriu B,Grayson DR,Davis JM,Nicoletti F,Guidotti A

更新日期：2013-05-01 00:00:00

abstract：:Dieting induces depression and anxiety among other emotional symptoms. Animal models indicate that repeated access to palatable foods such as sugar induces depression and anxiety-like behavior when the food is no longer available. However, the neurobiological mechanisms of how dietary restriction influences mood have ...

journal_title：Neuropharmacology

authors： Kim S,Shou J,Abera S,Ziff EB

更新日期：2018-03-01 00:00:00

abstract：:Selegiline is an irreversible inhibitor of monoamine oxidase B with trophic and neuroprotective effects. Because of evidence for decreased dopaminergic function during the withdrawal syndromes associated with opiates and other medications with potential for abuse, we investigated effects of treatment with selegiline o...

journal_title：Neuropharmacology

authors： Grasing K,Ghosh S

更新日期：1998-08-01 00:00:00

abstract：:Neurogenesis requires the balance between the proliferation of newly formed progenitor cells and subsequent death of surplus cells. RT-PCR and immunocytochemistry demonstrated the presence of P2X7 receptor mRNA and immunoreactivity in cultured neural progenitor cells (NPCs) prepared from the adult mouse subventricular...

journal_title：Neuropharmacology

authors： Messemer N,Kunert C,Grohmann M,Sobottka H,Nieber K,Zimmermann H,Franke H,Nörenberg W,Straub I,Schaefer M,Riedel T,Illes P,Rubini P

更新日期：2013-10-01 00:00:00

abstract：:The monosynaptic reflex (MSR), recorded in vitro from the neonatal rat spinal cord, was depressed by 5-hydroxytryptamine (5-HT) and 5-HT receptor agonists. The results, together with our previous findings, indicate an apparent rank order of potency: 5-carboxamidotryptamine (5-CT) > sumatriptan > methysergide > 5-HT > ...

journal_title：Neuropharmacology

authors： Crick H,Manuel NA,Wallis DI

更新日期：1994-07-01 00:00:00

abstract：:The influence of the subunit composition of human GABA(A) receptors upon the GABA-modulatory properties of 5alpha-pregnan-3alpha-ol-20-one (5alpha,3alpha) has been examined using the Xenopus laevis oocyte expression system and the two electrode voltage-clamp technique. Steroid potency (EC(50)) is modestly influenced b...

journal_title：Neuropharmacology

authors： Belelli D,Casula A,Ling A,Lambert JJ

更新日期：2002-09-01 00:00:00

abstract：:Phylogenetic research can help to elucidate the structure of the GABA/benzodiazepine receptor complex. In this study the evolution of the beta-carboline binding site was traced to see whether it paralleled that of the benzodiazepine binding site. The ratio of [3H]ethyl-beta-carboline-3-carboxylate (beta-CCE) to [3H]fl...

journal_title：Neuropharmacology

authors： Friedl W,Hebebrand J,Rabe S,Propping P

更新日期：1988-02-01 00:00:00