Abstract：
:SKF 83959 that has a unique antiparkinson profile in animal models of Parkinson's disease is an in vitro dopamine D1 antagonist of receptors coupled to adenylyl cyclase. We hypothesized that SKF 83959, among others, interacts with dopamine D1 receptors coupled to adenylyl cyclase in the nucleus accumbens and the prefrontal cortex. Effects of intra-accumbal injections of SKF 83959 on locomotor activity were compared to effects of the dopamine D1 agonist SKF 81297 and the dopamine D1 antagonist SCH 39166. Similarly to SCH 39166, SKF 83959 did not affect locomotor activity, but counteracted SKF 81297-induced locomotor activity. Effects of unilateral intra-prefrontal injections of SKF 83959 on rotational behaviour were compared to the effects of the dopamine D1 agonist SKF 81297 and the dopamine D1 antagonists SCH 23390 and SCH 39166 in rats selected on basis of their high locomotor response to novelty and pretreated with a subcutaneous injection of 0.75 mg/kg dexamphetamine. Like SCH 39166 and SCH 23390, SKF 83959 induced a bias for contralateral rotating and blocked the SKF 81297-induced bias for ipsilateral rotating. In conclusion, SKF 83959 is an in vivo antagonist of dopamine D1 receptors that are coupled to adenylyl cyclase in the nucleus accumbens and the prefrontal cortex. The role of these receptors in the antiparkinson profile of SKF 83959 is discussed.
journal_name
Neuropharmacologyjournal_title
Neuropharmacologyauthors
Cools AR,Lubbers L,van Oosten RV,Andringa Gdoi
10.1016/s0028-3908(01)00169-1subject
Has Abstractpub_date
2002-02-01 00:00:00pages
237-45issue
2eissn
0028-3908issn
1873-7064pii
S0028390801001691journal_volume
42pub_type
杂志文章abstract：:The identification of a second 5-HT(3) (5-HT(3B)) subunit provides an explanation for 5-HT(3) receptor heterogeneity. We investigated whether introduction of recombinant 5-HT(3B) subunits would alter the functional properties of mouse neuroblastoma 5-HT(3) receptors. RT-PCR analysis revealed that NB41A3 cells contain ...
journal_title：Neuropharmacology
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doi：10.1016/s0028-3908(02)00376-3
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journal_title：Neuropharmacology
pub_type： 杂志文章,评审
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journal_title：Neuropharmacology
pub_type： 临床试验,杂志文章
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journal_title：Neuropharmacology
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更新日期：2011-10-01 00:00:00
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journal_title：Neuropharmacology
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journal_title：Neuropharmacology
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journal_title：Neuropharmacology
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journal_title：Neuropharmacology
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journal_title：Neuropharmacology
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journal_title：Neuropharmacology
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更新日期：2011-12-01 00:00:00
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journal_title：Neuropharmacology
pub_type： 杂志文章
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更新日期：1998-04-01 00:00:00
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journal_title：Neuropharmacology
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journal_title：Neuropharmacology
pub_type： 杂志文章,评审
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更新日期：2012-02-01 00:00:00
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journal_title：Neuropharmacology
pub_type： 杂志文章
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journal_title：Neuropharmacology
pub_type： 杂志文章
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更新日期：1983-06-01 00:00:00
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journal_title：Neuropharmacology
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更新日期：1997-11-01 00:00:00
