Introduction of the 5-HT3B subunit alters the functional properties of 5-HT3 receptors native to neuroblastoma cells.

abstract：:The effects of the novel antidepressant tianeptine on behaviours induced by the serotonin (5-HT) precursor 5-hydroxytryptophan (5-HTP) and the 5-HT1A agonist 8-hydroxy-2-(di-n-propylamino)-tetralin (8-OH-DPAT) were investigated. Tianeptine (10 mg/kg, i.p.) significantly attenuated wet dog shakes (WDS) induced by 5-HTP...

journal_title：Neuropharmacology

authors： Datla KP,Curzon G

更新日期：1993-09-01 00:00:00

abstract：:This study was undertaken to determine whether 1 alpha,25-dihydroxyvitamin D3 [1 alpha,25-(OH)(2)D(3)], an active metabolite of vitamin D, protects dopaminergic neurons against the neurotoxic effects of glutamate and dopaminergic toxins using rat mesecephalic culture. Brief glutamate exposure elicited cytotoxicity in ...

journal_title：Neuropharmacology

authors： Ibi M,Sawada H,Nakanishi M,Kume T,Katsuki H,Kaneko S,Shimohama S,Akaike A

更新日期：2001-05-01 00:00:00

abstract：:The effects of guanosine-5'-triphosphate (GTP), sodium chloride and manganese chloride on the binding of buprenorphine to opiate receptors present in rat brain has been studied. Manganese chloride significantly decreased the affinity of binding of both [3H] buprenorphine and unlabelled buprenorphine to morphine and en...

journal_title：Neuropharmacology

authors： Villiger JW

更新日期：1984-03-01 00:00:00

abstract：:A large body of evidence indicates that ligand-gated channels may open spontaneously, exhibiting a basal activity in the absence of the neurotransmitter. In the present work, we were interested in studying the Ca(2+)-induced modulation of the basal channel activity of unliganded human L248Talpha7 receptors expressed i...

journal_title：Neuropharmacology

authors： Tonini R,Renzi M,Eusebi F

更新日期：2004-04-01 00:00:00

abstract：:The contribution of central PGE(2) levels to the nociceptive response in rats was assessed and the effects of the selective cPLA(2)α inhibitor efipladib, and pain therapies of different classes on these responses was determined. An inflammatory pain model was optimized in rats so that PGE(2) levels in the cerebrospina...

journal_title：Neuropharmacology

authors： Nickerson-Nutter CL,Goodwin D,Shen MW,Damphousse C,Duan W,Samad TA,McKew JC,Lee KL,Zaleska MM,Mollova N,Clark JD

更新日期：2011-03-01 00:00:00

abstract：:Selective serotonin (5-HT) re-uptake inhibitors (SSRIs) are commonly used in the treatment of generalized anxiety disorder in Humans. However, because only few animal models display overt anxious-like behavior, detailed preclinical studies of the anxiolytic properties of antidepressants are still lacking. Here, we stu...

journal_title：Neuropharmacology

authors： Guilloux JP,David DJ,Xia L,Nguyen HT,Rainer Q,Guiard BP,Repérant C,Deltheil T,Toth M,Hen R,Gardier AM

更新日期：2011-09-01 00:00:00

abstract：:Chronic activity perturbations in neurons induce homeostatic plasticity through modulation of synaptic strength or other intrinsic properties to maintain the correct physiological range of excitability. Although similar plasticity can also occur at the population level, what molecular mechanisms are involved remain un...

journal_title：Neuropharmacology

authors： Jewett KA,Lee KY,Eagleman DE,Soriano S,Tsai NP

更新日期：2018-08-01 00:00:00

abstract：:Rats were given daily injections of increasing doses of morphine sulfate (40-100 mg/kg, s.c.), for 4 days. Twenty hours after the last injection of morphine, the animals received bilateral injections of naloxone (1-10 micrograms) into the substantia nigra, ventral tegmental area or sites 2 mm rostral, caudal or dorsal...

journal_title：Neuropharmacology

authors： Baumeister AA,Anticich TG,Hebert G,Hawkins MF,Nagy M

更新日期：1989-11-01 00:00:00

abstract：:The effects of risperidone, a new antipsychotic with potent 5-hydroxytryptamine2 (5-HT2) and dopamine-D2 (DA-D2) antagonistic properties, were studied on sleep-wakefulness patterns in rats. Administration of low doses (0.01-0.16 mg/kg i.p.) resulted in a significant increase of deep slow wave sleep (SWS2) and a decrea...

journal_title：Neuropharmacology

authors： Dugovic C,Wauquier A,Janssen PA

更新日期：1989-12-01 00:00:00

abstract：:Hippocampal Long-Term Potentiation (LTP) is facilitated by BDNF, through the activation of tropomyosin-related kinase B (TrkB) receptors. However, an influence of BDNF upon Long-Term Depression (LTD) was also shown. The present work aimed to further evaluate the effect of BDNF and TrkB receptors upon CA1 hippocampal L...

journal_title：Neuropharmacology

authors： Rodrigues TM,Jerónimo-Santos A,Sebastião AM,Diógenes MJ

更新日期：2014-04-01 00:00:00

abstract：:Opiates addiction is characterized by its long-term persistence. In order to study the enduring changes in long-term memory in hippocampus, a pivotal region for this process, we used suppression subtractive hybridization to compare hippocampal gene expression in morphine and saline-treated rats. Animals were subjected...

journal_title：Neuropharmacology

authors： Marie-Claire C,Courtin C,Robert A,Gidrol X,Roques BP,Noble F

更新日期：2007-02-01 00:00:00

abstract：:Direct GABA agonists that suppress spikes induced by penicillin in cats failed to do so in rats. Phenytoin and large doses of THIP increased the rate of spiking activity of the penicillin focus. Only progabide caused marked, initial, short-lasting suppression and a modest reduction of frequency of spikes for 1 hr. Hom...

journal_title：Neuropharmacology

authors： Golden GT,Fariello RG

更新日期：1984-09-01 00:00:00

abstract：:mGlu7 receptors are coupled to Gi/Go-proteins and activate multiple transduction pathways, including inhibition of adenylyl cyclase activity and stimulation of ERK1/2 and JNK pathways. mGlu7 receptors play an important role in cognition and emotion and are involved in stress-related disorders such as anxiety and depre...

journal_title：Neuropharmacology

authors： Iacovelli L,Felicioni M,Nisticò R,Nicoletti F,De Blasi A

更新日期：2014-02-01 00:00:00

abstract：:Activation of peroxisome proliferator-activated receptor beta/delta (PPAR-β/δ), a nuclear receptor acting as a transcription factor, was shown to be protective in various models of neurological diseases. However, there is no information about the role of PPAR-β/δ as well as its molecular mechanisms in neonatal hypoxia...

journal_title：Neuropharmacology

authors： Gamdzyk M,Doycheva DM,Malaguit J,Enkhjargal B,Tang J,Zhang JH

更新日期：2018-09-15 00:00:00

abstract：:NMDA receptor (NMDAR) dysfunction has emerged as a common theme in several major nervous system disorders, including ischemic brain injury, chronic neurodegenerative diseases, pain, depression and schizophrenia. Either hyperactivity or hypofunction of NMDARs could contribute to disease pathophysiology. It is likely th...

journal_title：Neuropharmacology

authors： Zhou Q,Sheng M

更新日期：2013-11-01 00:00:00

abstract：:Attention-deficit hyperactivity disorder (ADHD) is a clinically and genetically heterogeneous syndrome which is comorbid with childhood conduct disorder, alcoholism, substance abuse, dis-social personality disorder, and affective disorders. A small but consistent overlap with autistic symptoms has also been establishe...

journal_title：Neuropharmacology

authors： Sharp SI,McQuillin A,Gurling HM

更新日期：2009-12-01 00:00:00

abstract：:Allopregnanolone (ALLO), a potent positive-allosteric modulator of the action of GABA at GABA(A) receptors, is synthesized in the brain from progesterone by the sequential action of two enzymes: 5alpha-reductase and 3alpha-hydroxysteroidoxidoreductase. The concentration of ALLO in various parts of the mouse brain vari...

journal_title：Neuropharmacology

authors： Pinna G,Uzunova V,Matsumoto K,Puia G,Mienville JM,Costa E,Guidotti A

更新日期：2000-01-28 00:00:00

abstract：:Amphetamine-type stimulants (ATS) are the second most consumed illicit drug worldwide and lack good treatments for associated substance use disorders, lagging behind other addictive drugs. For this reason, a deeper understanding of the pharmacodynamics of ATS is required. The present study seeks to determine amphetami...

journal_title：Neuropharmacology

authors： Garton DR,Ross SG,Maldonado-Hernández R,Quick M,Lasalde-Dominicci JA,Lizardi-Ortiz JE

更新日期：2019-01-01 00:00:00

abstract：:We generated transgenic (Thy1alpha6) mice in which the GABA(A) receptor alpha6 subunit, whose expression is usually confined to granule cells of cerebellum and cochlear nuclei, is ectopically expressed under the control of the pan-neuronal Thy-1.2 promoter. Strong Thy1alpha6 subunit expression occurs, for example, in ...

journal_title：Neuropharmacology

authors： Wisden W,Cope D,Klausberger T,Hauer B,Sinkkonen ST,Tretter V,Lujan R,Jones A,Korpi ER,Mody I,Sieghart W,Somogyi P

更新日期：2002-09-01 00:00:00

abstract：:The mechanisms underlying 3,4-methylenedioxymethamphetamine (MDMA)-induced serotonergic (5-HT) toxicity remain unclear. It has been suggested that MDMA depletes 5-HT by increasing brain tyrosine levels, which via non-enzymatic hydroxylation leads to DA-derived free radical formation. Because this hypothesis assumes th...

journal_title：Neuropharmacology

authors： Goñi-Allo B,Puerta E,Mathúna BO,Hervias I,Lasheras B,de la Torre R,Aguirre N

更新日期：2008-04-01 00:00:00

abstract：:Over one hundred years ago, Sir Charles Sherrington described a population of spinal cord interneurons (INs) that connect multiple spinal cord segments and participate in complex or 'long' motor reflexes. These neurons were subsequently termed propriospinal neurons (PNs) and are known to play a crucial role in motor c...

journal_title：Neuropharmacology

authors： Flynn JR,Graham BA,Galea MP,Callister RJ

更新日期：2011-04-01 00:00:00

abstract：:The role of dopamine in spinal motor transmission was investigated using spinal reflexes in acutely spinalized rats. Intravenous administration of a relatively high dose of the dopamine receptor agonist apomorphine-HCl (3 mg/kg) or the D2 receptor agonist bromocriptine mesylate (1 mg/kg) reduced the amplitude of the m...

journal_title：Neuropharmacology

authors： Kamijo N,Nagao T,Ono H

更新日期：1993-08-01 00:00:00

abstract：:Application of capsaicin (CAP), bradykinin (BK) or nicotine (NIC) to intraluminally perfused rat tracheas induced an increase in calcitonin gene-related peptide (CGRP) levels in the perfusates. Depletion of sensory afferent CGRP with systemic CAP pretreatment resulted in a significant reduction of CGRP release evoked ...

journal_title：Neuropharmacology

authors： Hua XY,Jinno S,Back SM,Tam EK,Yaksh TL

更新日期：1994-10-01 00:00:00

abstract：:Tarantula Chilobrachys jingzhao is one of the most venomous species distributed in China. In this study, we have isolated and characterized a novel neurotoxin named Jingzhaotoxin-IX (JZTX-IX) from the venom of the tarantula. JZTX-IX is a C-terminally amidated peptide composed of 35 amino acid residues. The toxin shows...

journal_title：Neuropharmacology

authors： Deng M,Kuang F,Sun Z,Tao H,Cai T,Zhong L,Chen Z,Xiao Y,Liang S

更新日期：2009-08-01 00:00:00

abstract：:Protease activity correlates with depressive or suicidal behaviors, with calpain activation being especially implicated in depression-like behaviors. However, the role of calpain in depression-like behaviors is currently unknown. In this study, the lipopolysaccharide (LPS) - and chronic unpredictable mild stress (CUMS...

journal_title：Neuropharmacology

authors： Song Z,Shen F,Zhang Z,Wu S,Zhu G

更新日期：2020-09-01 00:00:00

abstract：:The majority of the fibroblast growth factor receptor 1-serotonin 1 A receptor (FGFR1-5-HT1AR) heterocomplexes in the hippocampus appeared to be located mainly in the neuronal networks and a relevant target for antidepressant drugs. Through a neurochemical and electrophysiological analysis it was therefore tested in t...

journal_title：Neuropharmacology

authors： Narváez M,Andrade-Talavera Y,Valladolid-Acebes I,Fredriksson M,Siegele P,Hernandez-Sosa A,Fisahn A,Fuxe K,Borroto-Escuela DO

更新日期：2020-06-15 00:00:00

abstract：:The lateral habenula (LHb) is critical for modulation of negative reinforcement, punishment and aversive responses. In light of the success of deep-brain-stimulation (DBS) in the treatment of neurological disorders, we explored the use of LHb DBS as a method of intervention in cocaine self-administration, extinction, ...

journal_title：Neuropharmacology

authors： Friedman A,Lax E,Dikshtein Y,Abraham L,Flaumenhaft Y,Sudai E,Ben-Tzion M,Ami-Ad L,Yaka R,Yadid G

更新日期：2010-11-01 00:00:00

abstract：:Akt is a serine/threonine kinase, which is dramatically reduced in the prefrontal cortex (PFC) of patients with schizophrenia, and a deficiency in Akt1 results in PFC function abnormalities. Although the importance of Akt in dopamine (DA) transmission is well established, how impaired Akt signaling affects the DA modu...

journal_title：Neuropharmacology

authors： Li YC,Yang SS,Gao WJ

更新日期：2016-09-01 00:00:00

abstract：:The effects of d-amphetamine (0.03-10.0 mg/kg), caffeine (0.3-100.0 mg/kg), nicotine (0.003-10.0 mg/kg) and cocaine (0.03-56.0 mg/kg) were compared on responding maintained under three different schedules of food presentation in mice. Cumulative doses of d-amphetamine, nicotine and cocaine only decreased responding ma...

journal_title：Neuropharmacology

authors： Glowa JR

更新日期：1986-10-01 00:00:00

abstract：:One proposed factor contributing to the increased frequency of opioid overdose deaths is the emergence of novel synthetic opioids, including illicit fentanyl and fentanyl analogues. A treatment strategy currently under development to address the ongoing opioid crisis is immunopharmacotherapies or opioid-targeted vacci...

journal_title：Neuropharmacology

authors： Tenney RD,Blake S,Bremer PT,Zhou B,Hwang CS,Poklis JL,Janda KD,Banks ML

更新日期：2019-11-01 00:00:00