Ouabain increases neuronal branching in hippocampus and improves spatial memory.

abstract：:There is poor experimental evidence concerning the effects of anesthetic doses of the non-competitive NMDA receptor antagonist ketamine on rodents' memory abilities. The present study was designed to investigate a) the long-term consequences of anesthetic ketamine on rats' non-spatial and spatial recognition memory; b...

journal_title：Neuropharmacology

authors： Pitsikas N,Boultadakis A

更新日期：2009-07-01 00:00:00

abstract：:The present study investigated the metabolism of serotonin (5-HT) in rats made hypertensive by treatment with DOCA/NaCl. 5-Hydroxytryptamine and its major metabolite, 5-hydroxyindoleacetic acid (5-HIAA) were significantly elevated in a number of regions of the brain in rats treated for 2 weeks with DOCA/NaCl. Elevatio...

journal_title：Neuropharmacology

authors： Dawson R Jr,Nagamhama S,Oparil S

更新日期：1988-04-01 00:00:00

abstract：:Inhibitory glycine receptors (GlyRs) are widely expressed in spinal cord and brain stem. They are also expressed in the nucleus Accumbens (nAc) where they have been implicated in the release of dopamine from the ventral tegmental area to the nAc in the presence of ethanol. One of the major types of neurons in the nAc ...

journal_title：Neuropharmacology

authors： Gallegos S,Muñoz B,Araya A,Aguayo LG

更新日期：2019-12-01 00:00:00

abstract：:Ligand-gated ion channels play a role in mediating fast synaptic transmission for communication between neurons. However, the structural basis for the functional coupling of the binding and pore domains, resulting in channel opening, remains a topic of intense investigation. Here, a series of α7 nicotinic receptor mut...

journal_title：Neuropharmacology

authors： Yan H,Pan N,Xue F,Zheng Y,Li C,Chang Y,Xu Z,Yang H,Zhang J

更新日期：2015-08-01 00:00:00

abstract：:Acamprosate is clinically used to treat alcohol-dependent patients. While the molecular and pharmacological mechanisms of acamprosate remain unclear, it has been shown to regulate γ-aminobutyric acid (GABA) or glutamate levels in the cortex and striatum. To investigate the effect of acamprosate on brain metabolites in...

journal_title：Neuropharmacology

authors： Hinton DJ,Lee MR,Jacobson TL,Mishra PK,Frye MA,Mrazek DA,Macura SI,Choi DS

更新日期：2012-06-01 00:00:00

abstract：:Histidine injected intraperitoneally into rats in doses from 400 to 800 mg/kg induced a dose-dependent bizarre behaviour. The behaviour after histidine was similar to that observed after L-DOPA and peripheral decarboxylase inhibition. The bizarre behaviour was antagonized by chloropyramine, ketotifen, clemastine and p...

journal_title：Neuropharmacology

authors： Pilc A,Rogóz Z,Skuza G

更新日期：1982-08-01 00:00:00

abstract：:6-[(1S)-1-[1-[5-(2-hydroxyethoxy)-2-pyridyl]pyrazol-3-yl]ethyl]-3H-1,3-benzothiazol-2-one (LY3130481 or CERC-611) is a selective antagonist of AMPA receptors containing transmembrane AMPA receptor regulatory protein (TARP) γ-8. This molecule has been characterized as a potent and efficacious anticonvulsant in an array...

journal_title：Neuropharmacology

authors： Witkin JM,Li J,Gilmour G,Mitchell SN,Carter G,Gleason SD,Seidel WF,Eastwood BJ,McCarthy A,Porter WJ,Reel J,Gardinier KM,Kato AS,Wafford KA

更新日期：2017-11-01 00:00:00

abstract：:Neurones isolated from the CA1 region of rat hippocampal slices by the "vibrodissociation" method were voltage-clamped in the whole-cell configuration. The currents through N-methyl-D-aspartate (NMDA) channels were recorded in response to the rapid application (solution exchange time <30 msec) of 100 microM aspartate ...

journal_title：Neuropharmacology

authors： Sobolevsky A,Koshelev S,Khodorov BI

更新日期：1997-03-01 00:00:00

abstract：:The 15q25 gene cluster contains genes that code for the α5, α3, and β4 nicotinic acetylcholine receptor (nAChRs) subunits, and in human genetic studies, has shown the most robust association with smoking behavior and nicotine dependence to date. The limited available animal studies implicate a role for the α5 and β4 n...

journal_title：Neuropharmacology

authors： Jackson KJ,Sanjakdar SS,Muldoon PP,McIntosh JM,Damaj MI

更新日期：2013-07-01 00:00:00

abstract：:Glutamate may be a key transmitter in the emetic reflex arc. The present investigation focussed on the involvement of the NMDA subtype of glutamate receptors in cisplatin-induced emesis. Ferrets were injected with cisplatin (10 mg/kg i.v.) and either of the non-competitive NMDA receptor antagonists dextromethorphan or...

journal_title：Neuropharmacology

authors： Lehmann A,Kärrberg L

更新日期：1996-04-01 00:00:00

abstract：:Human genetic variation in the gene CACNA1C, which codes for the alpha-1c subunit of Cav1.2 L-type calcium channels (LTCCs), has been broadly associated with enhanced risk for neuropsychiatric disorders including major depression, bipolar and schizophrenia. Little is known about the specific neural circuits through wh...

journal_title：Neuropharmacology

authors： Ehlinger DG,Commons KG

更新日期：2019-01-01 00:00:00

abstract：:A study has been undertaken to identify the category of receptors mediating the inhibitory effects of adenosine on evoked activity in slices of olfactory cortex in the rat. The approach has been to measure the relative potencies of adenosine and a range of structural analogues [2-chloroadenosine, 2' deoxyadenosine, cy...

journal_title：Neuropharmacology

authors： Collins GG,Anson J

更新日期：1985-11-01 00:00:00

abstract：:Cadmium (Cd) is a highly toxic metal that affects the central nervous system. Recently we have demonstrated that inhibition of mTOR by rapamycin rescues neuronal cells from Cd-poisoning. Here we show that rapamycin inhibited Cd-induced mitochondrial ROS-dependent neuronal apoptosis. Intriguingly, rapamycin remarkably ...

journal_title：Neuropharmacology

authors： Xu C,Wang X,Zhu Y,Dong X,Liu C,Zhang H,Liu L,Huang S,Chen L

更新日期：2016-06-01 00:00:00

abstract：:Treatment-related sexual dysfunction is a common side effect of antidepressants and contributes to patient non-compliance or treatment cessation. However, the multimodal antidepressant, vortioxetine, demonstrates low sexual side effects in depressed patients. To investigate the mechanisms involved, sexual behavior was...

journal_title：Neuropharmacology

authors： Li Y,Pehrson AL,Oosting RS,Gulinello M,Olivier B,Sanchez C

更新日期：2017-07-15 00:00:00

abstract：:Tobacco addiction is highly co-morbid with a variety of mental health conditions, including schizophrenia, mood and anxiety disorders. Nicotine, the primary psychoactive compound in tobacco-related products is known to functionally modulate brain circuits that are disturbed in these disorders. Nicotine can potently re...

journal_title：Neuropharmacology

authors： Laviolette SR

更新日期：2021-02-15 00:00:00

abstract：:To study individual differences in nicotine preference and intake, male and female rats were given free access to a choice of oral nicotine (10 or 20 mg/L) or water for 24 h/day for periods of at least six weeks, starting at adolescence or adulthood. A total of 341 rats, were used in four different experiments; weight...

journal_title：Neuropharmacology

authors： Nesil T,Kanit L,Collins AC,Pogun S

更新日期：2011-07-01 00:00:00

abstract：:In Huntington's disease (HD), dysfunctional affective processes emerge as key symptoms of disturbances. In human HD and transgenic rat models of the disease, the amygdala was previously shown to have a reduced volume and to carry a high load of mutant huntingtin (mHTT) aggregates. In search of the pathophysiology of a...

journal_title：Neuropharmacology

authors： Lamirault C,Yu-Taeger L,Doyère V,Riess O,Nguyen HP,El Massioui N

更新日期：2017-09-01 00:00:00

abstract：:In recent years, neuroscientists have produced profound conceptual and mechanistic advances on the neurocircuitry of reward and substance use disorders. Here, we will provide a brief review of intracranial drug self-administration and optogenetic self-stimulation studies that identified brain regions and neurotransmit...

journal_title：Neuropharmacology

authors： Ikemoto S,Bonci A

更新日期：2014-01-01 00:00:00

abstract：:Kindling is a form of experimental epilepsy in which periodic electrical stimulation of a brain pathway induces a permanently hyperexcitable state. A previous study demonstrated that kindling enhances the sensitivity of hippocampal CA3 pyramidal cells to NMDA (N-methyl-D-aspartate), consistent with a greater expressio...

journal_title：Neuropharmacology

authors： Nadler JV,Thompson MA,McNamara JO

更新日期：1994-02-01 00:00:00

abstract：:In human populations, there is a well-defined sequence of involvement in drugs of abuse, in which the use of nicotine or alcohol precedes the use of marijuana, which in turn, precedes the use of cocaine. The term "Gateway Hypothesis" describes this developmental sequence of drug involvement. In prior work, we have dev...

journal_title：Neuropharmacology

authors： Huang YY,Kandel DB,Kandel ER,Levine A

更新日期：2013-11-01 00:00:00

abstract：:Cholecystokinin (CCK) is the most abundant neuropeptide in the central nervous system. In the hippocampal CA1 region, CCK is co-localized with GABA in a subset of interneurons that synapse on pyramidal cell somata and apical dendrites. CCK-containing interneurons also uniquely express a high level of the cannabinoid r...

journal_title：Neuropharmacology

authors： Karson MA,Whittington KC,Alger BE

更新日期：2008-01-01 00:00:00

abstract：:5-hydroxytryptamine 1 (5-HT1) receptor blockade in combination with serotonin reuptake inhibition may provide a more rapid elevation of synaptic 5-HT compared to serotonin reuptake alone, by blocking the inhibitory effect of 5-HT1 receptor activation on serotonin release. GSK588045 is a novel compound with antagonist ...

journal_title：Neuropharmacology

authors： Comley RA,van der Aart J,Gulyás B,Garnier M,Iavarone L,Halldin C,Rabiner EA

更新日期：2015-05-01 00:00:00

abstract：:Recent studies indicated that epigenetic modification, especially DNA methylation, play an important role in the persistence of addiction-related memory. 5-aza-2-deoxycytidine (5-aza), an inhibitor of DNA methyltransferases, was approved for clinical treatment. However, it is not clear whether 5-aza is involved in opi...

journal_title：Neuropharmacology

authors： Zhang JJ,Han J,Sui N

更新日期：2014-11-01 00:00:00

abstract：:The fatty-acid ethanolamide, oleoylethanolamide (OEA), is a naturally occurring lipid that regulates feeding and body weight [Rodriguez de Fonseca, F., Navarro, M., Gomez, R., Escuredo, L., Nava, F., Fu, J., Murillo-Rodriguez, E., Giuffrida, A., LoVerme, J., Gaetani, S., Kathuria, S., Gall, C., Piomelli, D., 2001. An ...

journal_title：Neuropharmacology

authors： Fu J,Oveisi F,Gaetani S,Lin E,Piomelli D

更新日期：2005-06-01 00:00:00

abstract：:Addiction involves drug-induced neuroplasticity in the circuitry of motivated behavior, which includes the medial forebrain bundle and the lateral hypothalamic area. Emerging at the forefront of neuroplasticity regulation are specialized extracellular matrix (ECM) structures that form perineuronal nets (PNNs) around c...

journal_title：Neuropharmacology

authors： Blacktop JM,Todd RP,Sorg BA

更新日期：2017-05-15 00:00:00

abstract：:Dopamine (DA) efflux from terminals of the mesocorticolimbic system is linked to incentive motivation, drug dependency and schizophrenia. Strategies for modulating dopaminergic activity have focused on transmitter receptors or the DA transporter, not on DA release, largely due to lack of systemically available drugs a...

journal_title：Neuropharmacology

authors： Belardetti F,Ahn S,So K,Snutch TP,Phillips AG

更新日期：2009-05-01 00:00:00

abstract：:Recent evidence suggests an early involvement of dopaminergic (DA) processes and terminals in Parkinson's disease (PD). The arborization of neurons depends on the actin cytoskeleton, which in turn is regulated by small GTPases of the Rho family, encompassing Rho, Rac and Cdc42 subfamilies. Indeed, some reports point t...

journal_title：Neuropharmacology

authors： Musilli M,Ciotti MT,Pieri M,Martino A,Borrelli S,Dinallo V,Diana G

更新日期：2016-10-01 00:00:00

abstract：:Rats exhibited a marked suppression of motor activity when placed in the same chamber where they had been given electric shocks. Administration of apomorphine-HCl (0.1, 0.5 and 1.0 mg/kg, i.p.) attenuated the conditioned suppression, dose-dependently, but did not facilitate motor activity of control (i.e. non-shocked)...

journal_title：Neuropharmacology

authors： Kameyama T,Nagasaka M

更新日期：1983-07-01 00:00:00

abstract：:Cyclic nucleotide-gated (CNG) channels, which are directly activated by cAMP and cGMP, have long been known to play a key role in retinal and olfactory signal transduction. Emerging evidence indicates that CNG channels are also involved in signaling pathways important for pain processing. Here, we found that the expre...

journal_title：Neuropharmacology

authors： Kallenborn-Gerhardt W,Metzner K,Lu R,Petersen J,Kuth MS,Heine S,Drees O,Paul M,Becirovic E,Kennel L,Flauaus C,Gross T,Wack G,Hohmann SW,Nemirovski D,Del Turco D,Biel M,Geisslinger G,Michalakis S,Schmidtko A

更新日期：2020-07-01 00:00:00

abstract：:The effects of Substance P (SP) and of a specific nonpeptide antagonist of the NK1 receptor (RP 67580) on preovulatory gonadotropin surges and on the in vitro GnRH induced LH surge were investigated in cycling female rats. A subcutaneous injection of SP (0.5 mg/kg body weight) at 12.00 h on the proestrous day signific...

journal_title：Neuropharmacology

authors： Duval P,Lenoir V,Garret C,Kerdelhue B

更新日期：1996-01-01 00:00:00