Cross-sensitization to the excitatory effect of morphine in post-dependent rats.

abstract：:Hemokinin-1 (HK-1) is a recently described mouse tachykinin peptide whose biological functions are not fully understood. To date, a unique receptor for HK-1 has not been identified. Recent studies suggest HK-1 may have a role in immunological functions, but there has been little characterization of HK-1's effects in t...

journal_title：Neuropharmacology

authors： Duffy RA,Hedrick JA,Randolph G,Morgan CA,Cohen-Williams ME,Vassileva G,Lachowicz JE,Laverty M,Maguire M,Shan LS,Gustafson E,Varty GB

更新日期：2003-08-01 00:00:00

abstract：:Effects of alaproclate, an inhibitor of the uptake of serotonin, on muscarinic cholinergic responses in N1E-115 neuroblastoma cells were studied using intracellular recording techniques. Application of carbachol activates an inward calcium channel, through an action on muscarinic receptors. The influx of calcium activ...

journal_title：Neuropharmacology

authors： Hedlund B

更新日期：1987-10-01 00:00:00

abstract：:Application of capsaicin (CAP), bradykinin (BK) or nicotine (NIC) to intraluminally perfused rat tracheas induced an increase in calcitonin gene-related peptide (CGRP) levels in the perfusates. Depletion of sensory afferent CGRP with systemic CAP pretreatment resulted in a significant reduction of CGRP release evoked ...

journal_title：Neuropharmacology

authors： Hua XY,Jinno S,Back SM,Tam EK,Yaksh TL

更新日期：1994-10-01 00:00:00

abstract：:The hippocampal slice is a popular model system in which to study the cellular properties of long-term potentiation (LTP). Synaptogenesis induced by exposure to ice-cold artificial cerebrospinal fluid (ACSF), however, raises the concern that morphological correlates of LTP might be obscured, especially in mature slice...

journal_title：Neuropharmacology

authors： Bourne JN,Kirov SA,Sorra KE,Harris KM

更新日期：2007-01-01 00:00:00

abstract：:Cholecystokinin octapeptide (CCK-8), caerulein and seven out of ten analogues of caerulein produced in mice, after subcutaneous administration, a dose-dependent drop in rectal temperature. For the hypothermic effect, i.e. a decrease in temperature by at least 1.5 degree C, ED50's were estimated with these peptides and...

journal_title：Neuropharmacology

authors： Zetler G

更新日期：1982-08-01 00:00:00

abstract：:Traumatic injuries to peripheral nerves are frequent, however, specific pharmacological treatments are currently lacking. Curcumin has antioxidant, anti-inflammatory and neuroprotective properties but high oral doses are required for therapeutic use, particularly due to its low bioavailability. The aim of the present ...

journal_title：Neuropharmacology

authors： Caillaud M,Chantemargue B,Richard L,Vignaud L,Favreau F,Faye PA,Vignoles P,Sturtz F,Trouillas P,Vallat JM,Desmoulière A,Billet F

更新日期：2018-09-01 00:00:00

abstract：:In recent years, neuroscientists have produced profound conceptual and mechanistic advances on the neurocircuitry of reward and substance use disorders. Here, we will provide a brief review of intracranial drug self-administration and optogenetic self-stimulation studies that identified brain regions and neurotransmit...

journal_title：Neuropharmacology

authors： Ikemoto S,Bonci A

更新日期：2014-01-01 00:00:00

abstract：:Prenatal cocaine exposure has been reported to result in abnormal neurobehavioral development, both in animals and humans. In this study, outbred CD-1 mice were exposed in utero to cocaine hydrochloride administered daily as i.p. injections to dams from day 10 of gestation to day 16, at the dose 0, 5 or 50 mg/kg. Coca...

journal_title：Neuropharmacology

authors： Laviola G,Fiore M,Loggi G,Alleva E

更新日期：1994-06-01 00:00:00

abstract：:Tobacco use is prevalent in the adolescent population. It is a major concern because tobacco is highly addictive and has also been linked to illicit drug use. There is not much research, however, on the interaction between nicotine and other stimulant drugs in animal models of early adolescence. This study examined th...

journal_title：Neuropharmacology

authors： Collins SL,Izenwasser S

更新日期：2004-03-01 00:00:00

abstract：:Alcohol use disorder (AUD) is a serious public health problem that results in tremendous social, legal and medical costs to society. Unlike other addictive drugs, there is no specific molecular target for ethanol (EtOH). Here, we report a novel molecular target that mediates EtOH effects at concentrations below those ...

journal_title：Neuropharmacology

authors： Gao F,Chen D,Ma X,Sudweeks S,Yorgason JT,Gao M,Turner D,Eaton JB,McIntosh JM,Lukas RJ,Whiteaker P,Chang Y,Steffensen SC,Wu J

更新日期：2019-05-01 00:00:00

abstract：:Data have been collected indicating possible functions for histamine in brain but there are only a very few data, collected exclusively with behavioural tests, about the effects of histamine on the perception of the pain, an important aspect in the homeostasis of the human body. The purpose of the present study was to...

journal_title：Neuropharmacology

authors： Braga PC,Sibilia V,Guidobono E,Pecile A,Netti C

更新日期：1992-09-01 00:00:00

abstract：:Purines are ubiquitous endogenous metabolites, and their roles as signalling molecules, especially in the case of adenosine and ATP, are well documented. The release of purines is increased when cells are highly activated, stressed or damaged, and this is known to have profound effects on various organ systems. Recent...

journal_title：Neuropharmacology

authors： Chow SC,Kass GE,Orrenius S

更新日期：1997-09-01 00:00:00

abstract：:The preparation of an isolated hemisected spinal cord preparation, maintained in vitro, from mature (180-300 g body weight) rats is described. Sacral and coccygeal segments (S2-Co1) gave consistent ventral root reflexes (DR-VRP) from electrical stimulation of dorsal roots. The mean latency and amplitude of the fastest...

journal_title：Neuropharmacology

authors： Long SK,Evans RH,Cull L,Krijzer F,Bevan P

更新日期：1988-05-01 00:00:00

abstract：:The NMDA receptor is a major target of alcohol action in the CNS, and recent behavioral and cellular studies have pointed to the importance of the GluN2B subunit in alcohol action. We and others have previously characterized four amino acid positions in the third and fourth membrane-associated (M) domains of the NMDA ...

journal_title：Neuropharmacology

authors： Zhao Y,Ren H,Dwyer DS,Peoples RW

更新日期：2015-10-01 00:00:00

abstract：:Propofol has been shown to attenuate brain injury in experimental ischemia models, but few studies have focused on the direct effect of propofol on mitochondrial dysfunction. In this study, we observed the effects of propofol on multiple aspects of mitochondrial dysfunction by studying the mitochondria isolated from r...

journal_title：Neuropharmacology

authors： Li J,Yu W,Li XT,Qi SH,Li B

更新日期：2014-02-01 00:00:00

abstract：:Excessive glutamate-mediated synaptic transmission and secondary excitotoxicity have been proposed as key determinants of neurodegeneration in many neurological diseases. Soluble mediators of inflammation have recently gained attention owing to their ability to enhance glutamate transmission and affect synaptic sensit...

journal_title：Neuropharmacology

authors： Rossi S,Motta C,Musella A,Centonze D

更新日期：2015-09-01 00:00:00

abstract：:Parkinson's disease (PD) is a neurodegenerative disease characterized by the progressive loss of dopaminergic neurons in the substantia nigra, leading to motor symptoms. Despite the remarkable improvements in the management of PD in recent decades, many patients remain significantly disabled. Metformin is a primary me...

journal_title：Neuropharmacology

authors： Ryu YK,Go J,Park HY,Choi YK,Seo YJ,Choi JH,Rhee M,Lee TG,Lee CH,Kim KS

更新日期：2020-09-15 00:00:00

abstract：:The ability of GABAA and GABAB receptors in the shell of the nucleus accumbens to modulate distinct types of turning behaviour was investigated in freely moving rats, using the unilateral injection technique. The GABAA receptor agonist muscimol and the GABAA receptor antagonist bicuculline did not produce turning beha...

journal_title：Neuropharmacology

authors： Akiyama G,Ikeda H,Matsuzaki S,Sato M,Moribe S,Koshikawa N,Cools AR

更新日期：2004-06-01 00:00:00

abstract：:Parasympathetic preganglionic cardiac vagal neurons (CVNs) which dominate the control of heart rate are located within the nucleus ambiguus (NA). Serotonin (5HT), and in particular 5HT2 receptors, play an important role in cardiovascular function in the brainstem. However, there is a lack of information on the mechani...

journal_title：Neuropharmacology

authors： Dergacheva O,Wang X,Kamendi H,Cheng Q,Pinol RM,Jameson H,Gorini C,Mendelowitz D

更新日期：2008-06-01 00:00:00

abstract：:Depolarizing, hyperpolarizing and biphasic muscarinic responses have been described in hippocampal inhibitory interneurons, but the receptor subtypes and activity patterns required to synaptically activate muscarinic responses in interneurons have not been completely characterized. Using optogenetics combined with who...

journal_title：Neuropharmacology

authors： Bell LA,Bell KA,McQuiston AR

更新日期：2013-10-01 00:00:00

abstract：:To date, there are no interventions that impede the inexorable progression of Alzheimer's disease (AD), and currently-available drugs cholinesterase (AChE) inhibitors and the N-Methyl-d-Aspartate receptor antagonist, memantine, offer only modest symptomatic benefit. Moreover, a range of mechanistically-diverse agents ...

journal_title：Neuropharmacology

authors： Millan MJ,Dekeyne A,Gobert A,Brocco M,Mannoury la Cour C,Ortuno JC,Watson D,Fone KCF

更新日期：2020-10-15 00:00:00

abstract：:The posterior hypothalamic receptors involved in the cardiovascular responses to electrical stimulation of the rostral ventrolateral medulla were investigated in urethane-anaesthetized rats. Electrical stimulation of the rostral ventrolateral medulla produced a significant increase in systolic blood pressure. This res...

journal_title：Neuropharmacology

authors： Bachelard H,Rivest R,Marsden CA

更新日期：1991-07-01 00:00:00

abstract：:We have examined the effects of a variety of classical and atypical neuroleptic drugs on mitochondrial NADH ubiquinone oxido-reductase (complex I) activity. Sagittal slices of mouse brain incubated in vitro with haloperidol (10 nM) showed time- and concentration-dependent inhibition of complex I. Similar concentration...

journal_title：Neuropharmacology

authors： Balijepalli S,Boyd MR,Ravindranath V

更新日期：1999-04-01 00:00:00

abstract：:Benzodiazepines (BZDs) are widely used in the treatment of a variety of neurological and psychiatric conditions including anxiety, insomnia and epilepsy. BZDs are thought to act predominantly by affecting the gating of GABAA receptor channels, resulting in enhanced GABA-mediated currents in neurons. However, mutations...

journal_title：Neuropharmacology

authors： Lévi S,Le Roux N,Eugène E,Poncer JC

更新日期：2015-01-01 00:00:00

abstract：:Rats were trained to recognize a discriminative stimulus (DS) elicited by the dopamine D(2)/D(3) receptor agonist, PD128,907 (0.16 mg/kg, i.p.), which suppressed frontocortical release of dopamine (DA) but not 5-HT. The selective 5-HT1A receptor agonists, 8-OH-DPAT and flesinoxan, dose-dependently generalized to PD128...

journal_title：Neuropharmacology

authors： Dekeyne A,Rivet JM,Gobert A,Millan MJ

更新日期：2001-06-01 00:00:00

abstract：:Protease activity correlates with depressive or suicidal behaviors, with calpain activation being especially implicated in depression-like behaviors. However, the role of calpain in depression-like behaviors is currently unknown. In this study, the lipopolysaccharide (LPS) - and chronic unpredictable mild stress (CUMS...

journal_title：Neuropharmacology

authors： Song Z,Shen F,Zhang Z,Wu S,Zhu G

更新日期：2020-09-01 00:00:00

abstract：:Antidepressants up-regulate the cAMP response element binding protein (CREB) and the brain-derived neurotrophic factor (BDNF) in hippocampus and these effects contribute to the protection of hippocampal neurons from stressful stimuli such as high glucocorticoid levels. CREB can be activated by both protein kinase A an...

journal_title：Neuropharmacology

authors： Vinet J,Carra S,Blom JM,Brunello N,Barden N,Tascedda F

更新日期：2004-12-01 00:00:00

abstract：BACKGROUND:Bipolar disorder (BD) mania patients exhibit poor cognition and reward-seeking/hypermotivation, negatively impacting a patient's quality of life. Current treatments (e.g., lithium), do not treat such deficits. Treatment development has been limited due to a poor understanding of the neural mechanisms underly...

journal_title：Neuropharmacology

authors： Milienne-Petiot M,Kesby JP,Graves M,van Enkhuizen J,Semenova S,Minassian A,Markou A,Geyer MA,Young JW

更新日期：2017-02-01 00:00:00

abstract：:As postsynaptic metabotropic subtype 1 (mGlu1) receptors are present in the thalamus, we have investigated the effect of potentiating and antagonising mGlu1 receptors on responses of thalamic neurones to noxious sensory stimulation. Extracellular recordings were made in vivo with multi-barrel iontophoretic electrodes ...

journal_title：Neuropharmacology

authors： Salt TE,Jones HE,Copeland CS,Sillito AM

更新日期：2014-04-01 00:00:00

abstract：:mGlu7 receptors are coupled to Gi/Go-proteins and activate multiple transduction pathways, including inhibition of adenylyl cyclase activity and stimulation of ERK1/2 and JNK pathways. mGlu7 receptors play an important role in cognition and emotion and are involved in stress-related disorders such as anxiety and depre...

journal_title：Neuropharmacology

authors： Iacovelli L,Felicioni M,Nisticò R,Nicoletti F,De Blasi A

更新日期：2014-02-01 00:00:00