Abstract：
:Application of capsaicin (CAP), bradykinin (BK) or nicotine (NIC) to intraluminally perfused rat tracheas induced an increase in calcitonin gene-related peptide (CGRP) levels in the perfusates. Depletion of sensory afferent CGRP with systemic CAP pretreatment resulted in a significant reduction of CGRP release evoked by CAP, BK or NIC. Chemical destruction of sympathetic nerve fibres by systemic pretreatment with 6-hydroxydopamine reduced CGRP release evoked by NIC, but did not alter the release produced by CAP or BK. Elimination of the tracheal mast cell population by pretreatment with compound 48/80 did not alter the effects of CAP, BK or NIC. CGRP release evoked by BK and NIC, but not CAP, was diminished by indomethacin, suggesting that cyclooxygenase products mediate the actions of BK and NIC. Prostaglandins, PGE1, PGE2, PGF2 alpha and PGI2, displayed stimulatory effects on CGRP release in the trachea. There are evidently multiple mechanisms mediating CGRP release from sensory terminals in rat trachea. It appears that CAP exerts a direct action on sensory nerves, while the effects of BK and NIC are mediated by PG synthesis. Sympathetic activation may be involved in NIC, but not BK, induced PG-mediated CGRP release.
journal_name
Neuropharmacologyjournal_title
Neuropharmacologyauthors
Hua XY,Jinno S,Back SM,Tam EK,Yaksh TLdoi
10.1016/s0028-3908(05)80004-8subject
Has Abstractpub_date
1994-10-01 00:00:00pages
1147-54issue
10eissn
0028-3908issn
1873-7064journal_volume
33pub_type
杂志文章abstract：:Ginsenoside Rg1 (Rg1) is a major bioactive ingredient in Panax ginseng that has low toxicity and has been shown to have neuroprotective effects. The objectives of the present study were to explore the potential of the application of Rg1 for the treatment of Parkinson's disease (PD) and to determine whether its neuropr...
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journal_title：Neuropharmacology
pub_type： 杂志文章
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journal_title：Neuropharmacology
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journal_title：Neuropharmacology
pub_type： 杂志文章
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journal_title：Neuropharmacology
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更新日期：1989-10-01 00:00:00
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pub_type： 杂志文章
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journal_title：Neuropharmacology
pub_type： 杂志文章
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更新日期：2007-06-01 00:00:00
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journal_title：Neuropharmacology
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pub_type： 杂志文章
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更新日期：1985-09-01 00:00:00
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journal_title：Neuropharmacology
pub_type： 杂志文章
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更新日期：2017-05-01 00:00:00
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journal_title：Neuropharmacology
pub_type： 杂志文章
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更新日期：2015-10-01 00:00:00
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journal_title：Neuropharmacology
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journal_title：Neuropharmacology
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journal_title：Neuropharmacology
pub_type： 杂志文章
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更新日期：2001-08-01 00:00:00
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journal_title：Neuropharmacology
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更新日期：2009-07-01 00:00:00
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journal_title：Neuropharmacology
pub_type： 杂志文章,评审
doi：10.1016/j.neuropharm.2019.03.014
更新日期：2020-06-01 00:00:00
abstract：:The anticonvulsant action and the long-term effects on learning, memory and behavior of the new generation antiepileptic drug gabapentin (GBP) were investigated in immature animals. Kainic acid (KA) was administered to rats on postnatal day (P) 35. Animals were treated with GBP or saline from P36 to P75 and spontaneou...
journal_title：Neuropharmacology
pub_type： 杂志文章
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更新日期：2001-01-01 00:00:00
