Abstract：
:Activation of 5-HT2C receptors in limbic structures such as the amygdala and hippocampus increases anxiety. Indirect evidence obtained with non-selective 5-HT2C-interacting drugs suggests that the same may occur in the dPAG, a brainstem region consistently implicated in the genesis/regulation of panic attacks. In this study we used more selective agonists and antagonists to unveil the role played by dPAG 5-HT2C receptors in the regulation of anxiety- and panic-related defensive behaviors. Our results showed that intra-dPAG microinjection of the endogenous agonist 5-HT (20 nmol) or the 5-HT2C receptor agonists MK-212 (1 and 10 nmol) and RO-600175 (40 nmol) significantly increased inhibitory avoidance acquisition in rats tested in the elevated T-maze, suggesting an anxiogenic effect. 5-HT, but not the two 5-HT2C receptor agonists, inhibited escape performance. In the elevated T-maze, inhibitory avoidance and escape responses have been related to generalized anxiety and panic attacks, respectively. The behavioral effects caused by 5-HT and MK-212 were fully blocked by previous local microinjection of the 5-HT2C receptor antagonist SB-242084. Intra-dPAG injection of MK-212 also failed to affect escape expression in another test relating this behavior to panic, the electrical stimulation of the dPAG. Overall, the results indicate that 5-HT2C receptors in the dPAG are preferentially involved in the regulation of defensive behaviors related to anxiety, but not panic. This finding extends to the dPAG the prominent role that has been attributed to 5-HT2C receptors in anxiety generation.
journal_name
Neuropharmacologyjournal_title
Neuropharmacologyauthors
Yamashita PS,de Bortoli VC,Zangrossi H Jrdoi
10.1016/j.neuropharm.2010.09.001subject
Has Abstractpub_date
2011-02-01 00:00:00pages
216-22issue
2-3eissn
0028-3908issn
1873-7064pii
S0028-3908(10)00222-4journal_volume
60pub_type
杂志文章abstract：:The obesity epidemic is one of the biggest health challenges globally and rates have tripled since 1975. Overeating is the largest determinant of obesity, yet little is understood of the neural mechanisms underlying why individuals consume food regardless of satiety. The lateral hypothalamic (LH) input to the ventral ...
journal_title：Neuropharmacology
pub_type： 杂志文章,评审
doi：10.1016/j.neuropharm.2019.05.014
更新日期：2019-08-01 00:00:00
abstract：:Zatosetron (13 mg or 0.19 mg/kg), a potent and selective 5-HT3 receptor antagonist was studied with a 30 min infusion in a crossover double-blind placebo-controlled trial for acute migraine therapy. Groups receiving zatosetron and placebo were demographically similar and zatosetron was well-tolerated in all patients w...
journal_title：Neuropharmacology
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期：1994-03-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/s0028-3908(01)00033-8
更新日期：2001-06-01 00:00:00
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journal_title：Neuropharmacology
pub_type： 杂志文章
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journal_title：Neuropharmacology
pub_type： 杂志文章
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journal_title：Neuropharmacology
pub_type： 杂志文章
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更新日期：2016-04-01 00:00:00
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pub_type： 杂志文章
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journal_title：Neuropharmacology
pub_type： 杂志文章
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更新日期：1990-01-01 00:00:00
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journal_title：Neuropharmacology
pub_type： 杂志文章
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更新日期：1991-01-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
doi：10.1016/j.neuropharm.2006.10.017
更新日期：2007-03-01 00:00:00
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pub_type： 杂志文章
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更新日期：2019-11-25 00:00:00
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journal_title：Neuropharmacology
pub_type： 杂志文章,评审
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更新日期：2016-07-01 00:00:00
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journal_title：Neuropharmacology
pub_type： 杂志文章
doi：10.1016/j.neuropharm.2005.08.015
更新日期：2005-11-01 00:00:00
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journal_title：Neuropharmacology
pub_type： 杂志文章
doi：10.1016/j.neuropharm.2005.10.013
更新日期：2006-04-01 00:00:00
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pub_type： 杂志文章
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journal_title：Neuropharmacology
pub_type： 杂志文章
doi：10.1016/j.neuropharm.2013.05.047
更新日期：2014-01-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章,评审
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journal_title：Neuropharmacology
pub_type： 杂志文章
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journal_title：Neuropharmacology
pub_type： 杂志文章
doi：10.1016/j.neuropharm.2017.06.031
更新日期：2017-10-01 00:00:00
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journal_title：Neuropharmacology
pub_type： 杂志文章
doi：10.1016/j.neuropharm.2006.08.012
更新日期：2007-02-01 00:00:00
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journal_title：Neuropharmacology
pub_type： 杂志文章
doi：10.1016/j.neuropharm.2005.04.008
更新日期：2005-09-01 00:00:00
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journal_title：Neuropharmacology
pub_type： 杂志文章
doi：10.1016/j.neuropharm.2003.11.031
更新日期：2004-05-01 00:00:00
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journal_title：Neuropharmacology
pub_type： 杂志文章
doi：10.1016/j.neuropharm.2013.04.036
更新日期：2013-09-01 00:00:00
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journal_title：Neuropharmacology
pub_type： 杂志文章
doi：10.1016/j.neuropharm.2008.08.004
更新日期：2009-01-01 00:00:00
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journal_title：Neuropharmacology
pub_type： 杂志文章
doi：10.1016/j.neuropharm.2018.10.001
更新日期：2018-12-01 00:00:00
abstract：:Using in vivo dialysis and voltammetry, the effect of acute administration of (-)-nicotine (0.8 mg/kg free base, s.c.) on extracellular levels of dopamine, 3,4-dihydroxyphenylacetic acid, 5-hydroxy-indoleacetic acid and ascorbic acid in the nucleus accumbens and caudate-putamen of chloral hydrate-anaesthetised rats ha...
journal_title：Neuropharmacology
pub_type： 杂志文章
doi：10.1016/0028-3908(90)90042-p
更新日期：1990-12-01 00:00:00
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journal_title：Neuropharmacology
pub_type： 杂志文章
doi：10.1016/s0028-3908(03)00232-6
更新日期：2003-10-01 00:00:00
abstract：:Selective central benzodiazepine agonists, such as clonazepam, are known to modify serotonin and 5-hydroxyindoleacetic content in the brain. In order to further study the effect of this benzodiazepine on serotonin turnover rate, rats received clonazepam, 10 mg/kg for 10 days, and the concentrations of serotonin and 5-...
journal_title：Neuropharmacology
pub_type： 杂志文章
doi：10.1016/0028-3908(95)00103-d
更新日期：1995-10-01 00:00:00
