Diversity in the lateral hypothalamic input to the ventral tegmental area.

abstract：:We have examined the regulation of neuronal nitric oxide synthase (NOS) by phosphorylation with cyclic-GMP (PKG) and cyclic-AMP-dependent (PKA) protein kinases. In vitro phosphorylation studies indicate that both PKG and PKA phosphorylate NOS on a single site. Phosphoamino-acid analysis and peptide mapping demonstrate...

journal_title：Neuropharmacology

authors： Dinerman JL,Steiner JP,Dawson TM,Dawson V,Snyder SH

更新日期：1994-11-01 00:00:00

abstract：:Vesicular glutamate transporter 2 (VGLUT2)-which uptakes glutamate into presynaptic vesicles-is a fundamental component of the glutamate neurotransmitter system. Although several lines of evidence from genetically modified mice suggest a possible association of VGLUT2 with neuropathic pain, the specific role of VGLUT2...

journal_title：Neuropharmacology

authors： Zhang ZL,Yu G,Peng J,Wang HB,Li YL,Liang XN,Su RB,Gong ZH

更新日期：2020-03-01 00:00:00

abstract：:Orexin/hypocretin signaling at the orexin 1 receptor (OX(1)R) has recently been implicated in addiction and relapse. We examined the role of the orexin system in cocaine-seeking elicited by a drug-associated context following abstinence or extinction from chronic cocaine self-administration. Male Sprague-Dawley rats s...

journal_title：Neuropharmacology

authors： Smith RJ,Tahsili-Fahadan P,Aston-Jones G

更新日期：2010-01-01 00:00:00

abstract：:NMDA receptors (NMDAr) are widely expressed throughout the brain on many cell types, and loss of function of these receptors (ie: NMDAr hypofunction) is a candidate mechanism explaining working memory impairment in schizophrenia. However, the cellular source driving the working memory deficits caused by NMDAr hypofunc...

journal_title：Neuropharmacology

authors： Sokolenko E,Nithianantharajah J,Jones NC

更新日期：2020-07-01 00:00:00

abstract：:Cannabinoid CB2 receptors (CB2Rs) are emerging as important therapeutic targets in brain disorders that typically involve neurometabolic alterations. We here addressed the possible role of CB2Rs in the regulation of glucose uptake in the mouse brain. To that aim, we have undertaken 1) measurement of (3)H-deoxyglucose ...

journal_title：Neuropharmacology

authors： Köfalvi A,Lemos C,Martín-Moreno AM,Pinheiro BS,García-García L,Pozo MA,Valério-Fernandes Â,Beleza RO,Agostinho P,Rodrigues RJ,Pasquaré SJ,Cunha RA,de Ceballos ML

更新日期：2016-11-01 00:00:00

abstract：:Mice that were rendered heterozygous for the γ2 subunit of GABAA receptors (γ2(+/-) mice) have been characterized extensively as a model for major depressive disorder. The phenotype of these mice includes behavior indicative of heightened anxiety, despair, and anhedonia, as well as defects in hippocampus-dependent pat...

journal_title：Neuropharmacology

authors： Ren Z,Sahir N,Murakami S,Luellen BA,Earnheart JC,Lal R,Kim JY,Song H,Luscher B

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Nucleus accumbens (NAc) and prefrontal cortex (PFC) dopaminergic and glutamatergic systems are involved in fear/anxiety-related behaviors; meanwhile NAc dopaminergic system activity is mediated by PFC via NAc glutamatergic projections. This study has investigated the involvement of NAc shell dopaminergic sys...

journal_title：Neuropharmacology

authors： Ahmadi H,Nasehi M,Rostami P,Zarrindast MR

更新日期：2013-08-01 00:00:00

abstract：:The effects of a stimulation of dopamine D1 receptors by using (+/-)SKF 38393 on the cortical EEG in rats which were chronically implanted with electrodes were studied. Administration of SKF 38393 (3 or 9 mg/kg, s.c.) produced alterations suggesting an arousal in the EEG: the power in all of the frequency bands decrea...

journal_title：Neuropharmacology

authors： Kropf W,Kuschinsky K

更新日期：1993-05-01 00:00:00

abstract：:Anxiety disorders contribute to the pathophysiology of psychiatric diseases, including major depression, substance abuse, and schizophrenia. The hippocampus is important for anxiety modulation. However, the mechanisms that control the neuronal activity of the hippocampus in anxiety are still not clear. We found that E...

journal_title：Neuropharmacology

authors： Chen M,Shu S,Yan HH,Pei L,Wang ZF,Wan Q,Bi LL

更新日期：2017-05-15 00:00:00

abstract：:Cannabinoid CB(1) receptors mediate, in part, the neuroprotectant properties of endocannabinoids, and altered signalling via the CB(1) receptor may contribute to the pathogenesis of diabetic neuropathy. We investigated CB(1) receptor function in PC12 cells differentiated into a neuronal phenotype with nerve growth fac...

journal_title：Neuropharmacology

authors： Zhang F,Challapalli SC,Smith PJ

更新日期：2009-08-01 00:00:00

abstract：:An elevated plus-maze, used to identify anxiolytic effects of drugs (Pellow et al., 1985), reflected as increased open-arm exploration, was employed in cycling and ovariectomised rats, to determine the effect of diazepam on the cycle and, after ovariectomy, to investigate possible influences of treatment with oestradi...

journal_title：Neuropharmacology

authors： Nomikos GG,Spyraki C

更新日期：1988-07-01 00:00:00

abstract：:Studies with heterologous expression systems have shown that the α4β2 nicotinic acetylcholine receptor (nAChR) subtype can exist in two stoichiometries (with two [(α4)2(β2)3] or three [(α4)3(β2)2] copies of the α subunit in the receptor pentamer) which have different pharmacological and functional properties and are d...

journal_title：Neuropharmacology

authors： Fasoli F,Moretti M,Zoli M,Pistillo F,Crespi A,Clementi F,Mc Clure-Begley T,Marks MJ,Gotti C

更新日期：2016-09-01 00:00:00

abstract：:The increased pro-inflammatory cytokine production was previously observed in Alzheimer's disease (AD). We sought to explore whether acetylcholinesterase inhibitor (AChEI) therapy ameliorates clinical symptoms in AD through down-regulation of inflammation. Expression and release of monocyte chemotactic protein-1 (MCP-...

journal_title：Neuropharmacology

authors： Reale M,Iarlori C,Gambi F,Feliciani C,Isabella L,Gambi D

更新日期：2006-04-01 00:00:00

abstract：:Recent observations from synaptosome preparations have questioned the tetrodotoxin (TTX) insensitivity of nicotine-evoked release in the striatum, a characteristic previously considered diagnostic of presynaptically located nicotinic acetylcholine receptors (nAChRs). Therefore, we have undertaken a comparison of nicot...

journal_title：Neuropharmacology

authors： Marshall D,Soliakov L,Redfern P,Wonnacott S

更新日期：1996-01-01 00:00:00

abstract：:Endocannabinoids are suggested to control pain, even though their clinical use is not fully validated and the underlying mechanisms are incompletely understood. To clarify the targets of endocannabinoid actions, we studied how activation of the endocannabinoid CB1 receptor (CB1R) affects neuronal responses in two in v...

journal_title：Neuropharmacology

authors： Eroli F,Loonen ICM,van den Maagdenberg AMJM,Tolner EA,Nistri A

更新日期：2018-03-15 00:00:00

abstract：:Tuberous Sclerosis Complex (TSC) is a multisystem genetic disorder caused by mutation in either Tsc1 or Tsc2 genes that leads to the hyper activation of the mTOR pathway, a key signalling pathway for synaptic plasticity. TSC is characterized by benign tumors arising in different organs and severe neuropsychiatric symp...

journal_title：Neuropharmacology

authors： Cambiaghi M,Cursi M,Magri L,Castoldi V,Comi G,Minicucci F,Galli R,Leocani L

更新日期：2013-04-01 00:00:00

abstract：:Both short-term (48 h) exposure to the neuroactive steroid 3alpha,5alpha[beta]-THP and its withdrawal increase expression of the benzodiazepine (BDZ)-insensitive GABAA receptor (GABAR) alpha4 subunit in hippocampus. This increase in alpha4 subunit expression was associated with a relative insensitivity of CA1 hippocam...

journal_title：Neuropharmacology

authors： Smith SS,Gong QH

更新日期：2004-07-01 00:00:00

abstract：:The aim of the present work was to clarify whether heterotrimeric P2X2/3 receptors have a fixed subunit stoichiometry consisting of one P2X2 and two P2X3 subunits as previously suggested, or a flexible stoichiometry containing also the inverse subunit composition. For this purpose we transfected HEK293 cells with P2X2...

journal_title：Neuropharmacology

authors： Kowalski M,Hausmann R,Schmid J,Dopychai A,Stephan G,Tang Y,Schmalzing G,Illes P,Rubini P

更新日期：2015-12-01 00:00:00

abstract：:The kynurenine pathway (KP) of tryptophan metabolism has emerged in recent years as a key regulator of the production of both neuroprotective (e.g. kynurenic and picolinic acid, and the essential cofactor NAD+) and neurotoxic metabolites (e.g. quinolinic acid, 3-hydroxykynurenine). The balance between the production o...

journal_title：Neuropharmacology

authors： Lovelace MD,Varney B,Sundaram G,Lennon MJ,Lim CK,Jacobs K,Guillemin GJ,Brew BJ

更新日期：2017-01-01 00:00:00

abstract：:(+)-2-Methyl-4-carboxyphenylglycine (LY367385), a potent and selective antagonist of mGlu1a metabotropic glutamate receptors, was neuroprotective in the following in vitro and in vivo models of excitotoxic death: (i) mixed cultures of murine cortical cells transiently exposed to N-methyl-D-aspartate (NMDA); (ii) rats ...

journal_title：Neuropharmacology

authors： Bruno V,Battaglia G,Kingston A,O'Neill MJ,Catania MV,Di Grezia R,Nicoletti F

更新日期：1999-02-01 00:00:00

abstract：:The effects of d-amphetamine (0.03-10.0 mg/kg), caffeine (0.3-100.0 mg/kg), nicotine (0.003-10.0 mg/kg) and cocaine (0.03-56.0 mg/kg) were compared on responding maintained under three different schedules of food presentation in mice. Cumulative doses of d-amphetamine, nicotine and cocaine only decreased responding ma...

journal_title：Neuropharmacology

authors： Glowa JR

更新日期：1986-10-01 00:00:00

abstract：:Maternal aggression is highly expressed during lactation and serves to protect the developing young from intruders that may injure the offspring. One neurochemical modulator of maternal aggression appears to be arginine vasopressin (AVP). Earlier research supports a role for AVP in maternal aggression in rats as treat...

journal_title：Neuropharmacology

authors： Nephew BC,Byrnes EM,Bridges RS

更新日期：2010-01-01 00:00:00

abstract：:Evidence indicates that angiotensin II type 2 receptors (AT2R) exert cerebroprotective actions during stroke. A selective non-peptide AT2R agonist, Compound 21 (C21), has been shown to exert beneficial effects in models of cardiac and renal disease, as well as hemorrhagic stroke. Here, we hypothesize that C21 may exer...

journal_title：Neuropharmacology

authors： Joseph JP,Mecca AP,Regenhardt RW,Bennion DM,Rodríguez V,Desland F,Patel NA,Pioquinto DJ,Unger T,Katovich MJ,Steckelings UM,Sumners C

更新日期：2014-06-01 00:00:00

abstract：:The effects of the putative, selective dopamine autoreceptor antagonist (+)-AJ 76 on yawning, penile grooming and mouth movements induced by small doses of apomorphine in male rats were examined. Yawning induced by 0.05mg/kg apomorphine was dose dependently blocked by (+)-AJ-76, significant decreases being observed at...

journal_title：Neuropharmacology

authors： Dourish CT,Herbert EN,Iversen SD

更新日期：1989-12-01 00:00:00

abstract：:Tobacco use is prevalent in the adolescent population. It is a major concern because tobacco is highly addictive and has also been linked to illicit drug use. There is not much research, however, on the interaction between nicotine and other stimulant drugs in animal models of early adolescence. This study examined th...

journal_title：Neuropharmacology

authors： Collins SL,Izenwasser S

更新日期：2004-03-01 00:00:00

abstract：:Inhibition of 5-HT(6) receptors has been shown to improve memory consolidation, thus we tested whether a novel tryptamine analog with high affinity for 5-HT(6) receptors, BGC20-761 (5-methoxy-2-phenyl-N,N-dimethyltryptamine, PMDT), can enhance long-term memory. BGC20-761 (10 mg/kg i.p.) alone had no effect on social r...

journal_title：Neuropharmacology

authors： Mitchell ES,Hoplight BJ,Lear SP,Neumaier JF

更新日期：2006-03-01 00:00:00

abstract：:We have previously demonstrated that an acute dose of Δ9-tetrahydrocanninbinol (THC), administered prior to extinction learning, facilitates later recall of extinction learning and modulates the underlying neural circuitry, including the ventromedial prefrontal cortex (vmPFC), hippocampus (HPC), and amygdala (AMYG). I...

journal_title：Neuropharmacology

authors： Rabinak CA,Peters C,Marusak HA,Ghosh S,Phan KL

更新日期：2018-12-01 00:00:00

abstract：:Tropomyosin (Tm) in non-muscle cells is involved in stabilisation of the actin cytoskeleton. Some of the 40 isoforms described are found in the brain and exhibit spatial and developmental regulation. Non-muscle isoforms from the gamma Tm gene can be subdivided into three subsets of isoforms differing at the C-terminus...

journal_title：Neuropharmacology

authors： Vrhovski B,Lemckert F,Gunning P

更新日期：2004-10-01 00:00:00

abstract：:The present review gives an overview of current pharmacological treatment options of tic disorders and Tourette Syndrome (TS). After a short summary on phenomenology, clinical course and comorbid conditions we review indications for pharmacological treatment in detail. Unfortunately, standardized and large enough drug...

journal_title：Neuropharmacology

authors： Roessner V,Schoenefeld K,Buse J,Bender S,Ehrlich S,Münchau A

更新日期：2013-05-01 00:00:00

abstract：:In nonhuman primates, anxiety levels are typically assessed by observing social hierarchies or behavior in an intruder task. As measures of anxiety might influence performance on a particular cognitive task, it is important to analyze these measures in the same room as used for the cognitive task. As we use a playroom...

journal_title：Neuropharmacology

authors： Haley GE,McGuire A,Berteau-Pavy D,Weiss A,Patel R,Messaoudi I,Urbanski HF,Raber J

更新日期：2012-01-01 00:00:00