Prenatal exposure to the cannabinoid receptor agonist WIN 55,212-2 increases glutamate uptake through overexpression of GLT1 and EAAC1 glutamate transporter subtypes in rat frontal cerebral cortex.

abstract：:Efficient transcytosis across the blood-brain-barrier (BBB) is an important strategy for accessing drug targets within the central nervous system (CNS). Despite extensive research the number of studies reporting successful delivery of macromolecules or macromolecular complexes to the CNS has remained very low. In orde...

journal_title：Neuropharmacology

authors： Mäger I,Meyer AH,Li J,Lenter M,Hildebrandt T,Leparc G,Wood MJA

更新日期：2017-07-01 00:00:00

abstract：:The group II metabotropic glutamate (mGlu) receptors comprised of the mGlu2 and mGlu3 receptor subtypes have gained recognition in recent years as potential targets for psychiatric disorders, including anxiety and schizophrenia. In addition to studies already indicating which subtype mediates the anxiolytic and anti-p...

journal_title：Neuropharmacology

authors： Sanger H,Hanna L,Colvin EM,Grubisha O,Ursu D,Heinz BA,Findlay JD,Vivier RG,Sher E,Lodge D,Monn JA,Broad LM

更新日期：2013-03-01 00:00:00

abstract：:Antidepressants up-regulate the cAMP response element binding protein (CREB) and the brain-derived neurotrophic factor (BDNF) in hippocampus and these effects contribute to the protection of hippocampal neurons from stressful stimuli such as high glucocorticoid levels. CREB can be activated by both protein kinase A an...

journal_title：Neuropharmacology

authors： Vinet J,Carra S,Blom JM,Brunello N,Barden N,Tascedda F

更新日期：2004-12-01 00:00:00

abstract：:Ginsenoside Rg1 (Rg1) is a major bioactive ingredient in Panax ginseng that has low toxicity and has been shown to have neuroprotective effects. The objectives of the present study were to explore the potential of the application of Rg1 for the treatment of Parkinson's disease (PD) and to determine whether its neuropr...

journal_title：Neuropharmacology

authors： Zhou T,Zu G,Zhang X,Wang X,Li S,Gong X,Liang Z,Zhao J

更新日期：2016-02-01 00:00:00

abstract：:In the cerebellum of juvenile mice or rats, endocannabinoids are shown to mediate depolarization-induced suppression of excitation (DSE) and retrograde suppression induced by activation of type 1 metabotropic glutamate receptor (mGluR1) at parallel fiber (PF) to Purkinje cell (PC) synapses. However, recent studies sho...

journal_title：Neuropharmacology

authors： Tanimura A,Kawata S,Hashimoto K,Kano M

更新日期：2009-08-01 00:00:00

abstract：:Fluorescence based probes provide a novel way to study the dynamic internalization process of G protein-coupled receptors (GPCRs). Recent advances in the rational design of fluorescent ligands for GPCRs have been used here to generate new fluorescent agonists containing tripeptide linkers for the adenosine A3 receptor...

journal_title：Neuropharmacology

authors： Stoddart LA,Vernall AJ,Briddon SJ,Kellam B,Hill SJ

更新日期：2015-11-01 00:00:00

abstract：:Systemic treatment with cholecystokinin octapeptide (CCK-8, 2.5-10 micrograms/kg, s.c.), a non-selective CCK agonist, decreased the exploratory activity of mice in an elevated plus-maze. At higher doses (5-10 micrograms/kg) CCK-8 reduced the frequency of rearing, but only 10 micrograms/kg of CCK-8 significantly inhibi...

journal_title：Neuropharmacology

authors： Vasar E,Lang A,Harro J,Bourin M,Bradwejn J

更新日期：1994-06-01 00:00:00

abstract：:A range of antipsychotic drugs, both "typical" and "atypical", was administered to rats over a time course and at several different dosages. The mRNA levels of dopamine D1, D2 and D3 receptor were measured in either whole brain or dissected brain regions. D3 receptor mRNA was up-regulated in whole brain by clozapine (...

journal_title：Neuropharmacology

authors： D'Souza U,McGuffin P,Buckland PR

更新日期：1997-11-01 00:00:00

abstract：:D-Tubocurarine is a potent competitive antagonist of two members of the ligand-gated ion channel family, the muscle-type nicotinic acetylcholine receptor (AChR) and serotonin type-3 receptor (5HT3R). We have used a series of analogs of D-tubocurarine to determine the effects of methylation, stereoisomerization and hal...

journal_title：Neuropharmacology

authors： Yan D,Pedersen SE,White MM

更新日期：1998-01-01 00:00:00

abstract：:Rats injected intrastriatally with kainic acid (KA), in contrast to sham-treated (control) animals, showed no tolerance toward catalepsy induced by chronic haloperidol treatment (28 days). After termination of chronic haloperidol treatment in control animals, apomorphine-induced stereotypy was significantly enhanced a...

journal_title：Neuropharmacology

authors： Zarkovsky AM,Nurk AM,Rägo LK,Allikmets LH

更新日期：1982-02-01 00:00:00

abstract：:The effects of the pure narcotic antagonists, naloxone and naltrexone, and their quaternary derivatives, methylnaloxone and methylnaltrexone, were examined in reversing the catalepsy induced by morphine in rats. Morphine, 20 mg/kg, induced rigid catalepsy which attained a peak effect (as manifested by duration of cata...

journal_title：Neuropharmacology

authors： Brown DR,Robertson MJ,Goldberg LI

更新日期：1983-03-01 00:00:00

abstract：:Destruction of the ventral noradrenergic pathway elicited by administration of 6-hydroxydopamine (6-OHDA, 5 micrograms into each side of the ventral pons) reduced the content of norepinephrine (NE) in the anterior hypothalamus (-80%) and induced an increase in arterial blood pressure (ABP) and in heart rate. These hyp...

journal_title：Neuropharmacology

authors： Benarroch EE,Balda MS,Finkielman S,Nahmod VE

更新日期：1983-01-01 00:00:00

abstract：:Basic neurobiological studies have led to great progress in our understanding of the mechanisms of action of drugs of abuse. Much has been learned about the brain response from the moment a psychoactive drug enters the organism onwards, including the psychological, neurobiological and peripheral effects of repeated dr...

journal_title：Neuropharmacology

authors： Kabbaj M,Evans S,Watson SJ,Akil H

更新日期：2004-01-01 00:00:00

abstract：:The present study was designed to examine the possible involvement of both an anti-serotonin action and a catecholamine-stimulating action in the mechanism of the inhibition of the muricide in rats with lesions of the midbrain raphe. Serotonin antagonists, such as cyproheptadine (10 mg/kg), cinanserin (10 mg/kg) and p...

journal_title：Neuropharmacology

authors： Yamamoto T,Ohno M,Takao K,Ueki S

更新日期：1988-02-01 00:00:00

abstract：:Intrathecal (IT) injection of neostigmine (a cholinesterase inhibitor) has been reported to produce a significant anti-nociceptive effect in a number of inflammatory pain models. However, a potential anti-inflammatory effect of IT neostigmine in these models has not been investigated. In the present study, we have exa...

journal_title：Neuropharmacology

authors： Yoon SY,Kwon YB,Kim HW,Roh DH,Kang SY,Kim CY,Han HJ,Kim KW,Yang IS,Beitz AJ,Lee JH

更新日期：2005-09-01 00:00:00

abstract：:An important feature of cocaine addiction in humans is the emergence of negative affect (e.g., dysphoria, irritability, anhedonia), postulated to play a key role in craving and relapse. Indeed, the DSM-IV recognizes that social, occupational and/or recreational activities become reduced as a consequence of repeated dr...

journal_title：Neuropharmacology

authors： Carelli RM,West EA

更新日期：2014-01-01 00:00:00

abstract：:Adrenergic-sensitive adenylate cyclase was found to be present in the nucleus accumbens and ventral caudate of the rabbit, but displayed less activity in the dorsal caudate. In general, stimulation of the enzyme by dopamine (DA) was most sensitive to inhibition by fluphenazine while norepinephrine (NE)-stimulated acti...

journal_title：Neuropharmacology

authors： Christie-Pope BC,Palmer GC,Chronister RB

更新日期：1984-07-01 00:00:00

abstract：:The effects of thyrotropin-releasing hormone (TRH) were examined on the monosynaptic reflex and on the activity of motoneurons in the spinal cord of the neonatal rat to elucidate the mechanism of action of TRH and its ability to reverse the spinal depression caused by phencyclidine and ketamine. Phencyclidine (2-32 mi...

journal_title：Neuropharmacology

authors： Ohno Y,Warnick JE

更新日期：1988-10-01 00:00:00

abstract：:In human populations, there is a well-defined sequence of involvement in drugs of abuse, in which the use of nicotine or alcohol precedes the use of marijuana, which in turn, precedes the use of cocaine. The term "Gateway Hypothesis" describes this developmental sequence of drug involvement. In prior work, we have dev...

journal_title：Neuropharmacology

authors： Huang YY,Kandel DB,Kandel ER,Levine A

更新日期：2013-11-01 00:00:00

abstract：:In the present study, the effects of bilateral injections of the GABAergic receptor agents into the dorsal hippocampal CA1 regions (intra-CA1) on morphine-induced amnesia were examined in morphine sensitized-mice. Pre-training subcutaneous (s.c.) administration of morphine (5 mg/kg) suppressed the learning of a one-tr...

journal_title：Neuropharmacology

authors： Zarrindast MR,Hoghooghi V,Rezayof A

更新日期：2008-03-01 00:00:00

abstract：:This study analyzed and compared the effects of EGCG treatment on the expression of NTFs and NTF receptors expression in the sciatic nerve and the L3-L6 spinal cord segments at the early phase of regeneration following sciatic nerve crush injury. Analysis of BDNF, GDNF and NT3 neurotropic factors and Trk-B, Trk-C and ...

journal_title：Neuropharmacology

authors： Renno WM,Khan KM,Benov L

更新日期：2016-03-01 00:00:00

abstract：:Cocaine administration can be both rewarding and aversive. While much effort has gone to investigating the rewarding effect, the mechanisms underlying cocaine-induced aversion remain murky. There is increasing evidence that the lateral habenula (LHb), a small epithalamic structure, plays a critical role in the aversiv...

journal_title：Neuropharmacology

authors： Zuo W,Chen L,Wang L,Ye JH

更新日期：2013-07-01 00:00:00

abstract：:1-Methyl-4-(2'-aminophenyl)-1,2,3,6-tetrahydropyridine (2'-NH2-MPTP) causes long-term depletions in cortical and hippocampal serotonin (5-HT) and norepinephrine (NE) that are accompanied by acute elevations in glial fibrillary acidic protein (GFAP) and argyrophilia. To further investigate the hypothesis that these cha...

journal_title：Neuropharmacology

authors： Luellen BA,Szapacs ME,Materese CK,Andrews AM

更新日期：2006-03-01 00:00:00

abstract：:Stroke is one of the leading causes of death and serious disability in Westernized societies. The risk of stroke approximately doubles with each decade after the age of 55. Therefore, even though the incidence of stroke is declining, mostly because of the efforts to lower blood pressure and reduce smoking, the overall...

journal_title：Neuropharmacology

authors： Darsalia V,Klein T,Nyström T,Patrone C

更新日期：2018-07-01 00:00:00

abstract：:In the present study we have examined the role of presynaptic group I metabotropic glutamate (mGlu) receptors in the control of neuronal glutamate release using rat forebrain slices pre-loaded with [(3)H]D-aspartate. We have also addressed the question of which group I mGlu receptor subtype, mGlu(1) or mGlu(5), mediat...

journal_title：Neuropharmacology

authors： Thomas LS,Jane DE,Harris JR,Croucher MJ

更新日期：2000-07-10 00:00:00

abstract：:Effects of cations on binding of 0.1-10 nM 3H-ADTN to calf caudate membranes included decreased apparent Bmax by [Na+] greater than or equal to 100 mM, little effect on Kd or on affinity of other dopamine (DA) agonists (DA and apomorphine), decreased slopes of inhibition curves produced by agonists, but increased affi...

journal_title：Neuropharmacology

authors： Lamont JS,Kula NS,Baldessarini RJ

更新日期：1987-06-01 00:00:00

abstract：:One proposed factor contributing to the increased frequency of opioid overdose deaths is the emergence of novel synthetic opioids, including illicit fentanyl and fentanyl analogues. A treatment strategy currently under development to address the ongoing opioid crisis is immunopharmacotherapies or opioid-targeted vacci...

journal_title：Neuropharmacology

authors： Tenney RD,Blake S,Bremer PT,Zhou B,Hwang CS,Poklis JL,Janda KD,Banks ML

更新日期：2019-11-01 00:00:00

abstract：:Serotonin (5-HT) neurons are involved in wake promotion and exert a strong inhibitory influence on rapid eye movement (REM) sleep. Such effects have been ascribed, at least in part to the action of 5-HT at post-synaptic 5-HT1A receptors (5-HT1AR) in the brainstem, a major wake/REM sleep regulatory center. However, the...

journal_title：Neuropharmacology

authors： Chazalon M,Dumas S,Bernard JF,Sahly I,Tronche F,de Kerchove d'Exaerde A,Hamon M,Adrien J,Fabre V,Bonnavion P

更新日期：2018-08-01 00:00:00

abstract：:Urocortin 3 (Ucn3) is an anorexigenic neuropeptide with high affinity for the type 2 corticotropin-releasing factor receptor (CRF₂-R). How the expression of hypothalamic Ucn3 is regulated by fasting and refeeding in genetically obese (fa/fa) Zucker rats is not known. Obese Zucker rats develop early hyperphagia associa...

journal_title：Neuropharmacology

authors： Poulin AM,Lenglos C,Mitra A,Timofeeva E

更新日期：2012-07-01 00:00:00

abstract：:The present study used a radiotelemetric method to compare the muscle relaxant, hypothermic and locomotor depressant actions of the imidazopyridine zolpidem, with those of the benzodiazepines lorazepam and diazepam. Rats, n=7 per group, were divided into 3 dose-dependent treatment groups (highest, middle, and lowest)....

journal_title：Neuropharmacology

authors： Elliot EE,White JM

更新日期：2001-04-01 00:00:00