Intrastriatal injection of kainic acid prevents the development of postsynaptic dopamine receptor hypersensitivity after chronic haloperidol treatment.

abstract：:Chronic nicotine administration in animals, and smoking in humans, causes up-regulation of α4β2* neuronal nicotinic receptors (nAChRs), which has been hypothesized to contribute to the addictive actions of nicotine. We used a rat model to test whether such up-regulatory effects differ in adolescents versus adults, and...

journal_title：Neuropharmacology

authors： Hoegberg BG,Lomazzo E,Lee NH,Perry DC

更新日期：2015-12-01 00:00:00

abstract：:Thyroid hormone deficiency during early developmental stages causes a multitude of functional and morphological deficits in the brain. In the present study we investigate the effects of a mutated thyroid hormone receptor TR alpha 1 and the resulting receptor-mediated hypothyroidism on the development of GABAergic neur...

journal_title：Neuropharmacology

authors： Hadjab-Lallemend S,Wallis K,van Hogerlinden M,Dudazy S,Nordström K,Vennström B,Fisahn A

更新日期：2010-06-01 00:00:00

abstract：:Phenytoin (DPH) is a clinically useful sodium (Na) channel blocker with efficacy against partial and generalized seizures. We have developed a novel hydantoin compound (HA) using comparative molecular field analysis (CoMFA) and evaluated its effects on hNa(v)1.2 channels. Both DPH and HA demonstrated affinity for rest...

journal_title：Neuropharmacology

authors： Lenkowski PW,Batts TW,Smith MD,Ko SH,Jones PJ,Taylor CH,McCusker AK,Davis GC,Hartmann HA,White HS,Brown ML,Patel MK

更新日期：2007-03-01 00:00:00

abstract：:Hypoxic-ischemic encephalopathy (HI) accounts for the majority of developmental, motor and cognitive deficits in children, leading to life-long neurological impairments. Since the plasmamembrane sodium/calcium exchanger (NCX) plays a fundamental role in maintaining ionic homeostasis during adult brain ischemia, in the...

journal_title：Neuropharmacology

authors： Cerullo P,Brancaccio P,Anzilotti S,Vinciguerra A,Cuomo O,Fiorino F,Severino B,Di Vaio P,Di Renzo G,Annunziato L,Pignataro G

更新日期：2018-06-01 00:00:00

abstract：:Increasing evidence suggests that oxidative stress may be implicated in the degeneration of dopaminergic neurons in Parkinson's disease (PD), and anti-oxidation have been shown to be effective to PD treatment. Myricetin has been reported to have the biological functions of anti-oxidation, anti-apoptosis, anti-inflamma...

journal_title：Neuropharmacology

authors： Zhang K,Ma Z,Wang J,Xie A,Xie J

更新日期：2011-07-01 00:00:00

abstract：:The effects of oxytocin (OXT) and of dipeptides derived from the C-terminal portion of oxytocin (Z-prolyl-leucine and Z-prolyl-D-leucine) on the development of acute and chronic tolerance to, and dependence on morphine were tested in the mouse. Oxytocin and the dipeptides attenuated the development of acute and chroni...

journal_title：Neuropharmacology

authors： Kovács GL,Horváth Z,Sarnyai Z,Faludi M,Telegdy G

更新日期：1985-05-01 00:00:00

abstract：:In the current study, we investigated the effect of the activation of the alpha-7 nicotinic acetylcholine receptor (α7 nAchR) on dextran sulphate sodium (DSS)-induced colitis and referred mechanical hyperalgesia in mice. Colitis was induced in CD1 male mice through the intake of 4% DSS in tap water for 7 days. Control...

journal_title：Neuropharmacology

authors： Costa R,Motta EM,Manjavachi MN,Cola M,Calixto JB

更新日期：2012-10-01 00:00:00

abstract：:(+)-2-Methyl-4-carboxyphenylglycine (LY367385), a potent and selective antagonist of mGlu1a metabotropic glutamate receptors, was neuroprotective in the following in vitro and in vivo models of excitotoxic death: (i) mixed cultures of murine cortical cells transiently exposed to N-methyl-D-aspartate (NMDA); (ii) rats ...

journal_title：Neuropharmacology

authors： Bruno V,Battaglia G,Kingston A,O'Neill MJ,Catania MV,Di Grezia R,Nicoletti F

更新日期：1999-02-01 00:00:00

abstract：:This study confirms and extends an earlier report that acute administration of the serotonin (5-HT) antagonist, mianserin, caused a marked decrease in the density of 5-HT2 binding sites in brain of the rat (Blackshear and Sanders-Bush, 1982). Using [3H]ketanserin, a selective ligand for the 5-HT2 site, the present stu...

journal_title：Neuropharmacology

authors： Blackshear MA,Martin LL,Sanders-Bush E

更新日期：1986-11-01 00:00:00

abstract：:The impairment of social behaviors induced by social defeat stress exposure as juveniles is resistant to some antidepressants and an antipsychotic, although the underlying mechanisms and/or therapeutic target are not yet clear. In this study, we investigated the involvement of the glutamatergic neuronal system in the ...

journal_title：Neuropharmacology

authors： Hasegawa S,Yoshimi A,Mouri A,Uchida Y,Hida H,Mishina M,Yamada K,Ozaki N,Nabeshima T,Noda Y

更新日期：2019-04-01 00:00:00

abstract：:Retinal bipolar cells receive glutamatergic transmission from photoreceptors and mediate a key process in segregating visual signals into ON-center and OFF-center pathways. The segregation of ON responses involves a G protein-coupled metabotropic glutamate receptor (mGluR). The mGluR6 subtype is expressed restrictedly...

journal_title：Neuropharmacology

authors： Iwakabe H,Katsuura G,Ishibashi C,Nakanishi S

更新日期：1997-02-01 00:00:00

abstract：:The effects of intracerebroventricular administration of morphine, the selective mu-agonist DAMGO, the delta-agonist DPDPE, the kappa-preferring peptide dynorphin A(1-13) and the kappa-agonist U50,488H on locomotor behaviour in the guinea pig were investigated. Morphine (total dose = 0.01, 0.1, 1, 10, 200 nmol), DAMGO...

journal_title：Neuropharmacology

authors： Bot G,Chahl LA,Brent PJ,Johnston PA

更新日期：1992-09-01 00:00:00

abstract：:The N-methyl-D-aspartate (NMDA) antagonist ifenprodil and several structurally related compounds are highly selective for the NR2B-containing receptor subtype. This selectivity could provide an explanation for the reported difference of the analgesic and side-effect profile of ifenprodil-like compounds from other NMDA...

journal_title：Neuropharmacology

authors： Chizh BA,Reissmüller E,Schlütz H,Scheede M,Haase G,Englberger W

更新日期：2001-01-01 00:00:00

abstract：:Alcohol use disorder (AUD) affects all sexes, however women who develop AUD may be particularly susceptible to cravings and other components of the disease. While many brain regions are involved in AUD etiology, proper prefrontal cortex (PFC) function is particularly important for top-down craving management and the m...

journal_title：Neuropharmacology

authors： Joffe ME,Winder DG,Conn PJ

更新日期：2020-11-01 00:00:00

abstract：:Acute morphine administration produces analgesia and reward, but prolonged use may lead to analgesic tolerance in patients chronically treated for pain and to compulsive intake in opioid addicts. Moreover, long-term exposure may induce physical dependence, manifested as somatic withdrawal symptoms in the absence of th...

journal_title：Neuropharmacology

authors： Contet C,Filliol D,Matifas A,Kieffer BL

更新日期：2008-03-01 00:00:00

abstract：:Quinine and quinidine are reported to potentiate the behavioural effects of serotonergic agents and monoamine uptake inhibitors. We have therefore investigated the presynaptic actions of quinine and quinidine on monoamine uptake and release in rat brain tissue in vitro. Quinidine evoked the release of [3H]5-HT, [3H]no...

journal_title：Neuropharmacology

authors： Clement EM,Grahame-Smith DG,Elliott JM

更新日期：1998-07-01 00:00:00

abstract：:Recent studies suggest a role for the arachidonic acid-derived epoxyeicosatrienoic acids (EETs) in attenuating epileptic seizures. However, their effect on neurotransmission has never been investigated in detail. Here, we studied how 11,12- and 14,15 EET affect excitability and excitatory neurotransmission in mouse hi...

journal_title：Neuropharmacology

authors： Mule NK,Orjuela Leon AC,Falck JR,Arand M,Marowsky A

更新日期：2017-09-01 00:00:00

abstract：:Serotonin (5-HT)1A and σ1 receptors have been implicated in psychiatric disorders. We previously found that combined 5-HT reuptake inhibition and σ1 receptor activation has a synergistic effect on prefrontal dopaminergic transmission in adrenalectomized/castrated mice lacking circulating steroid hormones. In the prese...

journal_title：Neuropharmacology

authors： Hiramatsu N,Ago Y,Hasebe S,Nishimura A,Mori K,Takuma K,Matsuda T

更新日期：2013-12-01 00:00:00

abstract：:The aim of the present study was to evaluate, by means of quantitative and multivariate analyses, the effects of diazepam on the behavioral structure of the rat's response to pain in the hot-plate test as well as whether such changes are associated with drug-induced effects on anxiety and/or nociception. To this purpo...

journal_title：Neuropharmacology

authors： Casarrubea M,Sorbera F,Santangelo A,Crescimanno G

更新日期：2012-08-01 00:00:00

abstract：:Basal ganglia, an ensemble of interconnected subcortical nuclei, are involved in adaptive motor planning and procedural learning. Striatum, the primary input nucleus of basal ganglia, extracts the pertinent cortical and thalamic information from background noise in relation with the environmental stimuli and motivatio...

journal_title：Neuropharmacology

authors： Fino E,Venance L

更新日期：2011-04-01 00:00:00

abstract：:Orexins are neuropeptides that are exclusively produced by hypothalamic neurons, which project throughout the entire brain. Orexin, also known as hypocretins, were initially identified to play a fundamental role in food intake, arousal and the regulation of sleep and wakefulness. Recent studies identified orexins to b...

journal_title：Neuropharmacology

authors： Sargin D

更新日期：2019-08-01 00:00:00

abstract：:Of the ionotropic glutamatergic receptors, the NMDA receptor is clearly implicated in the acute and chronic effects of ethanol; however, the role of the AMPA receptor in mediating the effects of ethanol in vivo is as yet unclear. Using mice deficient in the AMPA receptor subunit GluR1 (GluR1-/- mice), we investigated ...

journal_title：Neuropharmacology

authors： Cowen MS,Schroff KC,Gass P,Sprengel R,Spanagel R

更新日期：2003-09-01 00:00:00

abstract：:Imaging studies of serotonin transporter binding or tryptophan retention in autistic patients suggest that the brain serotonin system is decreased. However, treatment with drugs which increase serotonin (5-HT) levels, specific serotonin reuptake inhibitors (SSRIs), commonly produce a worsening of the symptoms. In this...

journal_title：Neuropharmacology

authors： Azmitia EC,Singh JS,Whitaker-Azmitia PM

更新日期：2011-06-01 00:00:00

abstract：:The present review gives an overview of current pharmacological treatment options of tic disorders and Tourette Syndrome (TS). After a short summary on phenomenology, clinical course and comorbid conditions we review indications for pharmacological treatment in detail. Unfortunately, standardized and large enough drug...

journal_title：Neuropharmacology

authors： Roessner V,Schoenefeld K,Buse J,Bender S,Ehrlich S,Münchau A

更新日期：2013-05-01 00:00:00

abstract：:Peristaltic reflex activity in the guinea-pig isolated ileum was elicited by slow intraluminal infusion of Tyrode solution. The reflex was abolished by the ganglionic blocking drug hexamethonium. However, in more than half of the preparations, the peristaltic reflex was restored by the opioid antagonist naloxone. Hexa...

journal_title：Neuropharmacology

authors： Barthó L,Holzer P,Lembeck F

更新日期：1987-11-01 00:00:00

abstract：:Direct GABA agonists that suppress spikes induced by penicillin in cats failed to do so in rats. Phenytoin and large doses of THIP increased the rate of spiking activity of the penicillin focus. Only progabide caused marked, initial, short-lasting suppression and a modest reduction of frequency of spikes for 1 hr. Hom...

journal_title：Neuropharmacology

authors： Golden GT,Fariello RG

更新日期：1984-09-01 00:00:00

abstract：:Aggression is a common symptom of several human psychiatric disorders. However, the drugs available to treat aggression are non-specific and can have unwanted side effects. The zebrafish is an ideal model for behavioural pharmacology. They are small, aggression can be measured reliably, and drugs can be applied by imm...

journal_title：Neuropharmacology

authors： Norton WHJ

更新日期：2019-09-15 00:00:00

abstract：:Chronic pain states are highly prevalent and yet poorly controlled by currently available analgesics, representing an enormous clinical, societal, and economic burden. Existing pain medications have significant limitations and adverse effects including tolerance, dependence, gastrointestinal dysfunction, cognitive imp...

journal_title：Neuropharmacology

authors： Woodhams SG,Chapman V,Finn DP,Hohmann AG,Neugebauer V

更新日期：2017-09-15 00:00:00

abstract：:Extracts of the skin of Pseudophryne coriacea displayed a powerful stimulant action on the leech helical muscle, both in vitro and in vivo. In the isolated dorsal muscle, the extract caused the appearance of vigorous phasic movements, accompanied by rapid increase in tonus, up to intense spasm. Hyoscine, physostigmine...

journal_title：Neuropharmacology

authors： Falconieri Erspamer G,Farruggia G

更新日期：1986-08-01 00:00:00

abstract：:Carbenoxolone (CBX), the succinyl ester of glycyrrhetinic acid, is an inhibitor of gap junctional intercellular communication. Systemic administration of CBX was able to decrease the seizure severity score and to increase the latency time of seizure onset in genetically epilepsy prone rats (GEPRs). In particular, intr...

journal_title：Neuropharmacology

authors： Gareri P,Condorelli D,Belluardo N,Russo E,Loiacono A,Barresi V,Trovato-Salinaro A,Mirone MB,Ferreri Ibbadu G,De Sarro G

更新日期：2004-12-01 00:00:00