Abstract：
:Retinal bipolar cells receive glutamatergic transmission from photoreceptors and mediate a key process in segregating visual signals into ON-center and OFF-center pathways. The segregation of ON responses involves a G protein-coupled metabotropic glutamate receptor (mGluR). The mGluR6 subtype is expressed restrictedly at the postsynaptic site of retinal ON-bipolar cells. Ablation of mGluR6 in the ON-bipolar cells by gene targeting results in a loss of ON responses but unchanged OFF responses in visual transmission. Thus, mGluR6 is essential for inducing ON responses. The aims of this study are analyses of visual responsiveness and possible visual dysfunction in mGluR6-deficient mice. We report here that mGluR6-deficient mice have unaltered locomotor activity in a daily light-dark cycle and exhibit light-stimulated induction of Fos immunoreactivity in the suprachiasmatic nucleus. These findings indicate that mGluR6-deficient mice are capable or responding to light stimulation. The mGluR6 deficiency, however, markedly reduces the sensitivity of pupillary responses to light stimulus and severely impairs the ability to drive optokinetic nystagmus in response to visual contrasts. This study thus demonstrates that mGluR6 contributes to discrimination of visual contrasts.
journal_name
Neuropharmacologyjournal_title
Neuropharmacologyauthors
Iwakabe H,Katsuura G,Ishibashi C,Nakanishi Sdoi
10.1016/s0028-3908(96)00167-0subject
Has Abstractpub_date
1997-02-01 00:00:00pages
135-43issue
2eissn
0028-3908issn
1873-7064pii
S0028390896001670journal_volume
36pub_type
杂志文章abstract：:5-hydroxytryptamine 1 (5-HT1) receptor blockade in combination with serotonin reuptake inhibition may provide a more rapid elevation of synaptic 5-HT compared to serotonin reuptake alone, by blocking the inhibitory effect of 5-HT1 receptor activation on serotonin release. GSK588045 is a novel compound with antagonist ...
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更新日期：1994-11-01 00:00:00
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更新日期：2010-01-01 00:00:00
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journal_title：Neuropharmacology
pub_type： 杂志文章
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更新日期：1997-03-01 00:00:00
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更新日期：2017-02-01 00:00:00
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journal_title：Neuropharmacology
pub_type： 杂志文章
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更新日期：1995-04-01 00:00:00
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journal_title：Neuropharmacology
pub_type： 杂志文章
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