Cyclic nucleotide dependent phosphorylation of neuronal nitric oxide synthase inhibits catalytic activity.

abstract：:High levels of the inflammatory molecule S100B protein have been identified in sera from several perinatal inflammatory conditions involving myelin damage and associated with an adverse prognosis or the emergence of sequelea. S100B is essential for oligodendrocyte (OL) differentiation and maturation, but it remains to...

journal_title：Neuropharmacology

authors： Santos G,Barateiro A,Gomes CM,Brites D,Fernandes A

更新日期：2018-02-01 00:00:00

abstract：:In urethane-chloralose anesthetized, neuromuscularly blocked, ventilated rats, microinjection of NMDA (12 pmol) into the right fourth thoracic segment (T4) spinal intermediolateral nucleus (IML) immediately increased ipsilateral brown adipose tissue (BAT) sympathetic nerve activity (SNA; peak +492% of control), expire...

journal_title：Neuropharmacology

authors： Madden CJ,Morrison SF

更新日期：2008-03-01 00:00:00

abstract：:Systemic treatment with cholecystokinin octapeptide (CCK-8, 2.5-10 micrograms/kg, s.c.), a non-selective CCK agonist, decreased the exploratory activity of mice in an elevated plus-maze. At higher doses (5-10 micrograms/kg) CCK-8 reduced the frequency of rearing, but only 10 micrograms/kg of CCK-8 significantly inhibi...

journal_title：Neuropharmacology

authors： Vasar E,Lang A,Harro J,Bourin M,Bradwejn J

更新日期：1994-06-01 00:00:00

abstract：:We have examined the effects of a variety of classical and atypical neuroleptic drugs on mitochondrial NADH ubiquinone oxido-reductase (complex I) activity. Sagittal slices of mouse brain incubated in vitro with haloperidol (10 nM) showed time- and concentration-dependent inhibition of complex I. Similar concentration...

journal_title：Neuropharmacology

authors： Balijepalli S,Boyd MR,Ravindranath V

更新日期：1999-04-01 00:00:00

abstract：:Histidine injected intraperitoneally into rats in doses from 400 to 800 mg/kg induced a dose-dependent bizarre behaviour. The behaviour after histidine was similar to that observed after L-DOPA and peripheral decarboxylase inhibition. The bizarre behaviour was antagonized by chloropyramine, ketotifen, clemastine and p...

journal_title：Neuropharmacology

authors： Pilc A,Rogóz Z,Skuza G

更新日期：1982-08-01 00:00:00

abstract：:The effects of the anxiolytic drug chlordiazepoxide (CDZ) on general activity and anxiety-related behaviour of male and female Swiss-Webster mice were investigated in the triple test, which combines the open field (OF), elevated-plus maze (EPM) and the light-dark box (LDB). Mice were injected with saline or CDZ (1.0, ...

journal_title：Neuropharmacology

authors： Hussin AT,Fraser LM,Ramos A,Brown RE

更新日期：2012-10-01 00:00:00

abstract：:Rat hearts were labelled with [3H]norepinephrine in vivo. Slices of ventricles were prepared, preincubated in Krebs-HCO3 medium (KRB), and then incubated in a Na+-deficient, choline+-Krebs HCO3 (Ch+-Ca2+). The choline+-Krebs HCO3 medium induced a delayed neurosecretion which could be inhibited by either one of the blo...

journal_title：Neuropharmacology

authors： Bogdanski DF

更新日期：1985-01-01 00:00:00

abstract：:Although selective activation of the M1 muscarinic acetylcholine receptor (mAChR) subtype has been shown to improve cognitive function in animal models of neuropsychiatric disorders, recent evidence suggests that enhancing M4 mAChR function can also improve memory performance. Positive allosteric modulators (PAMs) tar...

journal_title：Neuropharmacology

authors： Gould RW,Grannan MD,Gunter BW,Ball J,Bubser M,Bridges TM,Wess J,Wood MW,Brandon NJ,Duggan ME,Niswender CM,Lindsley CW,Conn PJ,Jones CK

更新日期：2018-01-01 00:00:00

abstract：:The effect of the D1 dopamine receptor antagonist SCH 23390 on sleep patterns was studied in rats by means of the electroencephalographic (EEG) technique. Haloperidol, an established D2 antagonist neuroleptic, was used for comparison. Over a very small dose range (0.003-0.03 mg/kg, subcutaneously), SCH 23390 significa...

journal_title：Neuropharmacology

authors： Trampus M,Ongini E

更新日期：1990-10-01 00:00:00

abstract：:Although the etiology of Alzheimer's disease (AD) is not fully understood, multiple lines of evidence suggests the importance of amyloid-beta (Abeta) in the initiation/progression of the disease. In this study, we investigated protective effects of erythropoietin (EPO) on Abeta(25-35)-induced cell death in cultured ra...

journal_title：Neuropharmacology

authors： Ma R,Xiong N,Huang C,Tang Q,Hu B,Xiang J,Li G

更新日期：2009-05-01 00:00:00

abstract：:Whole-cell patch clamp recording and immunohistochemistry were used to investigate the expression of P2X receptors on rat parasympathetic ganglion neurons of the otic, sphenopalatine, submandibular, intracardiac and paratracheal ganglia. Neurons from all five ganglia responded to ATP with a rapidly activating, sustain...

journal_title：Neuropharmacology

authors： Ma B,Ruan HZ,Burnstock G,Dunn PM

更新日期：2005-04-01 00:00:00

abstract：:Mutations in LRRK2 (leucine-rich repeat kinase 2) are found associated with both sporadic and familial Parkinson's disease (PD). Pathogenic mutations are localized to the catalytic domains of LRRK2, including kinase and GTPase domains. Altered catalytic activity correlates with neurotoxicity, indicating that targeting...

journal_title：Neuropharmacology

authors： Gómez-Suaga P,Fdez E,Fernández B,Martínez-Salvador M,Blanca Ramírez M,Madero-Pérez J,Rivero-Ríos P,Fuentes JM,Hilfiker S

更新日期：2014-10-01 00:00:00

abstract：:ɣ-aminobutyric-acid (GABA) functions as the principal inhibitory neurotransmitter in the central nervous system. Imbalances in GABAergic neurotransmission are involved in the pathophysiology of various neurological diseases such as epilepsy, Alzheimer's disease and stroke. GABA transporters (GATs) facilitate the termi...

journal_title：Neuropharmacology

authors： Kickinger S,Hellsberg E,Frølund B,Schousboe A,Ecker GF,Wellendorph P

更新日期：2019-12-15 00:00:00

abstract：:Visual cues that become associated with the consumption of psychostimulant drugs energize craving and the intake of the drug by mechanisms of which little is known. In two experiments using in vivo microdialysis in freely moving rats we compared the effects of visual and auditory stimulation with that of cocaine (0, 5...

journal_title：Neuropharmacology

authors： Müller CP,De Souza Silva MA,Huston JP

更新日期：2007-03-01 00:00:00

abstract：:In a cell line (C2D7) stably expressing the human N-type calcium channel encoded by the subunits alpha1B-a, beta1b, alpha2bdelta, we have analysed the Ca2+ currents produced by a range of action potential-like voltage protocols (APVPs). Such protocols consistently produced robust inward currents that could be eliminat...

journal_title：Neuropharmacology

authors： McNaughton NC,Bleakman D,Randall AD

更新日期：1998-01-01 00:00:00

abstract：:The alpha7 and alpha4beta2 nicotinic acetylcholine receptor (nAchR) subtypes have been shown to be involved in memory. It is also known that losses of frontal cortical nAchRs are correlated to declining memory function in Alzheimer's disease, but the subtype-specific role of frontal cortical nAchRs in memory has not b...

journal_title：Neuropharmacology

authors： Chan WK,Wong PT,Sheu FS

更新日期：2007-06-01 00:00:00

abstract：:Brief exposure to an elevated plus-maze has been shown to induce antinociception in male mice, a reaction that is not attenuated by manipulations of opiate receptors but which is fully blocked by diazepam. The present study examined the effects of the benzodiazepine receptor antagonist, flumazenil (5-20 mg/kg), on beh...

journal_title：Neuropharmacology

authors： Lee C,Rodgers RJ

更新日期：1991-12-01 00:00:00

abstract：:Although sigma 1 (σ(1)) receptors and mitogen-activated protein kinases (MAPKs) are known modulators of neuroprotection, a role for MAPK signaling pathways in σ receptor-mediated neuroprotection has not been investigated in detail.The present study aims to investigate the possible link between σ(1) receptors and MAPKs...

journal_title：Neuropharmacology

authors： Tan F,Guio-Aguilar PL,Downes C,Zhang M,O'Donovan L,Callaway JK,Crack PJ

更新日期：2010-11-01 00:00:00

abstract：:Fluorescence based probes provide a novel way to study the dynamic internalization process of G protein-coupled receptors (GPCRs). Recent advances in the rational design of fluorescent ligands for GPCRs have been used here to generate new fluorescent agonists containing tripeptide linkers for the adenosine A3 receptor...

journal_title：Neuropharmacology

authors： Stoddart LA,Vernall AJ,Briddon SJ,Kellam B,Hill SJ

更新日期：2015-11-01 00:00:00

abstract：:The present experiments investigated the ability of LY392098, a novel positive allosteric modulator of AMPA receptors, to potentiate AMPA receptor-mediated currents of neurons in the prefrontal cortex (PFC). Co-application of LY392098 (0.03-10 microM) with AMPA (5 microM) enhanced current through AMPA receptor/channel...

journal_title：Neuropharmacology

authors： Baumbarger P,Muhlhauser M,Yang CR,Nisenbaum ES

更新日期：2001-06-01 00:00:00

abstract：:The importance of h5-HT1B receptor selectivity for 5-HT terminal autoreceptor activity was investigated with the selective h5-HT1B receptor ligands SB 219085, SB 220272, SB 224289 and SB 216641. The studies employed measurement of compound affinity and efficacy in vitro and the measurement of extracellular 5-HT in the...

journal_title：Neuropharmacology

authors： Roberts C,Price GW,Gaster L,Jones BJ,Middlemiss DN,Routledge C

更新日期：1997-04-01 00:00:00

abstract：:The present review gives an overview of current pharmacological treatment options of tic disorders and Tourette Syndrome (TS). After a short summary on phenomenology, clinical course and comorbid conditions we review indications for pharmacological treatment in detail. Unfortunately, standardized and large enough drug...

journal_title：Neuropharmacology

authors： Roessner V,Schoenefeld K,Buse J,Bender S,Ehrlich S,Münchau A

更新日期：2013-05-01 00:00:00

abstract：:The effects of the pure narcotic antagonists, naloxone and naltrexone, and their quaternary derivatives, methylnaloxone and methylnaltrexone, were examined in reversing the catalepsy induced by morphine in rats. Morphine, 20 mg/kg, induced rigid catalepsy which attained a peak effect (as manifested by duration of cata...

journal_title：Neuropharmacology

authors： Brown DR,Robertson MJ,Goldberg LI

更新日期：1983-03-01 00:00:00

abstract：:5-HT(1A) receptors are implicated in the modulation of cognitive processes including encoding of fear learning. However, their exact role has remained unclear due to contrasting contributions of pre- vs. postsynaptic 5-HT(1A) receptors. Therefore, their role in fear conditioning was studied in mice using the selective...

journal_title：Neuropharmacology

authors： Youn J,Misane I,Eriksson TM,Millan MJ,Ogren SO,Verhage M,Stiedl O

更新日期：2009-10-01 00:00:00

abstract：:Trazodone is one of the most commonly prescribed medicines for treating depression and insomnia. However, the pharmacological mechanism of action underlying trazodone's unique effects is unclear. Despite its nanomolar affinity for 5HT(2A) receptors, histamine(1) receptors and alpha(1) adrenoceptors the drug is given a...

journal_title：Neuropharmacology

authors： Kraus RL,Li Y,Jovanovska A,Renger JJ

更新日期：2007-08-01 00:00:00

abstract：:Hippocampal volume reductions and functional impairments are reliable findings in posttraumatic stress disorder (PTSD) imaging studies. However, it is not clear if and how hippocampal dysfunction contributes to the etiology and maintenance of PTSD. Individuals with PTSD are often described as showing fear responses to...

journal_title：Neuropharmacology

authors： Acheson DT,Gresack JE,Risbrough VB

更新日期：2012-02-01 00:00:00

abstract：:The role of orexin receptors in the nucleus accumbens shell in rat turning behaviour of rats was studied. Unilateral injection of neither the orexin 1 and 2 receptor agonist orexin A (2 microg) nor the orexin 1 receptor antagonist SB 334867 (20 ng) into the nucleus accumbens shell elicited turning behaviour. Unilatera...

journal_title：Neuropharmacology

authors： Kotani A,Ikeda H,Koshikawa N,Cools AR

更新日期：2008-03-01 00:00:00

abstract：:Thiamethoxam (TMX) is a second-generation neonicotinoid which is known to induce toxic effects on insects and mammalians. Recently, it has been proposed that TMX is a poor agonist of insect nicotinic acetylcholine receptors (nAChRs) on isolated cell bodies. Here, we have studied its effect on synaptic transmission. Ou...

journal_title：Neuropharmacology

authors： Thany SH

更新日期：2011-03-01 00:00:00

abstract：:The cognitive impairments and negative symptoms experienced by schizophrenia patients still await effective treatment. Alpha7 nicotinic acetylcholine receptors (α7 nAChRs) have gain considerable attention in this regard. It has been recently proposed that positive allosteric modulators (PAMs) of α7 nAChRs may represen...

journal_title：Neuropharmacology

authors： Potasiewicz A,Hołuj M,Kos T,Popik P,Arias HR,Nikiforuk A

更新日期：2017-02-01 00:00:00

abstract：:N-Methyl-D-aspartate (NMDA) receptors are important CNS target sites of alcohols, but the site and mechanism of action of alcohols on NMDA receptors remains unclear. In CHO-K1 cells transfected with NR1/NR2B NMDA receptor subunits, ethanol inhibited NMDA-activated current with an IC(50) of 138 mM. Truncation of the in...

journal_title：Neuropharmacology

authors： Peoples RW,Stewart RR

更新日期：2000-07-24 00:00:00