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The role of the orexin system in stress response.

Abstract：

:Orexins are neuropeptides that are exclusively produced by hypothalamic neurons, which project throughout the entire brain. Orexin, also known as hypocretins, were initially identified to play a fundamental role in food intake, arousal and the regulation of sleep and wakefulness. Recent studies identified orexins to be critical for diverse physiological processes including motivation, reward, attention, emotional regulation, stress and anxiety. Here, I review recent findings that indicate orexin has an important role in acute and chronic stress. I also summarize the recent optogenetic and chemogenetic studies that have advanced our understanding of the orexin system. I will conclude by discussing clinical studies that implicate orexins in mental health disorders. This article is part of the Special Issue entitled 'Hypothalamic Control of Homeostasis'.

journal_name

Neuropharmacology

journal_title

Neuropharmacology

authors

Sargin D

doi

10.1016/j.neuropharm.2018.09.034

subject

Has Abstract

pub_date

2019-08-01 00:00:00

pages

68-78

eissn

0028-3908

issn

1873-7064

pii

S0028-3908(18)30697-X

journal_volume

154

pub_type

杂志文章,评审

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