Abstract：
:The effects of thyrotropin-releasing hormone (TRH) were examined on the monosynaptic reflex and on the activity of motoneurons in the spinal cord of the neonatal rat to elucidate the mechanism of action of TRH and its ability to reverse the spinal depression caused by phencyclidine and ketamine. Phencyclidine (2-32 microM) and ketamine (25-200 microM) produced a concentration-dependent depression of the monosynaptic reflex with a 50% inhibitory concentration (IC50) of 8.4 and 77.5 microM, respectively. This depression, however, was significantly attenuated by simultaneous application of TRH (0.03-1 microM) in a concentration-dependent manner. The dose-response curves for phencylidine and ketamine were shifted to the right in the presence of TRH (0.1 microM) with an increase in the respective IC50 of 2- to 3-fold. The incidence of generation of motoneuron spikes, elicited by dorsal root stimulation, was significantly increased by TRH in each neuron tested, concomitantly with an increase in the spontaneous firing rate. These results suggest that TRH directly excites alpha-motoneurons to reverse the spinal depression produced by phencylidine and ketamine.
journal_name
Neuropharmacologyjournal_title
Neuropharmacologyauthors
Ohno Y,Warnick JEdoi
10.1016/0028-3908(88)90061-5subject
Has Abstractpub_date
1988-10-01 00:00:00pages
1013-8issue
10eissn
0028-3908issn
1873-7064journal_volume
27pub_type
杂志文章abstract：:Limited information exists on the link between purinergic class P2X7 receptors (P2X7Rs) and calcium ion channels in epilepsy; no data has been reported regarding the interaction between P2X7Rs and T-type calcium ion channels in epilepsy. Thus, this study is an evaluation of the role that T-type calcium ion channels pl...
journal_title：Neuropharmacology
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更新日期：2019-05-01 00:00:00
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journal_title：Neuropharmacology
pub_type： 杂志文章
doi：10.1016/j.neuropharm.2014.03.010
更新日期：2014-07-01 00:00:00
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更新日期：1990-08-01 00:00:00
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journal_title：Neuropharmacology
pub_type： 杂志文章
doi：10.1016/j.neuropharm.2020.108360
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journal_title：Neuropharmacology
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更新日期：2004-12-01 00:00:00
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journal_title：Neuropharmacology
pub_type： 杂志文章
doi：10.1016/j.neuropharm.2017.04.016
更新日期：2017-07-15 00:00:00
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journal_title：Neuropharmacology
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doi：10.1016/j.neuropharm.2004.10.003
更新日期：2005-02-01 00:00:00
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journal_title：Neuropharmacology
pub_type： 杂志文章
doi：10.1016/s0028-3908(03)00254-5
更新日期：2003-12-01 00:00:00
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journal_title：Neuropharmacology
pub_type： 杂志文章
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更新日期：2016-02-01 00:00:00
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journal_title：Neuropharmacology
pub_type： 杂志文章
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更新日期：2004-06-01 00:00:00
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journal_title：Neuropharmacology
pub_type： 杂志文章
doi：10.1016/s0028-3908(00)00195-7
更新日期：2001-06-01 00:00:00
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journal_title：Neuropharmacology
pub_type： 杂志文章
doi：10.1016/0028-3908(95)00155-7
更新日期：1996-01-01 00:00:00
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journal_title：Neuropharmacology
pub_type： 杂志文章
doi：10.1016/j.neuropharm.2004.12.021
更新日期：2005-04-01 00:00:00
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journal_title：Neuropharmacology
pub_type： 杂志文章
doi：10.1016/s0028-3908(97)00166-4
更新日期：1997-11-01 00:00:00
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journal_title：Neuropharmacology
pub_type： 杂志文章
doi：10.1016/j.neuropharm.2011.10.023
更新日期：2012-02-01 00:00:00
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journal_title：Neuropharmacology
pub_type： 杂志文章,评审
doi：10.1016/s0028-3908(99)00019-2
更新日期：1999-06-01 00:00:00
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journal_title：Neuropharmacology
pub_type： 杂志文章
doi：10.1016/0028-3908(84)90047-9
更新日期：1984-11-01 00:00:00
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journal_title：Neuropharmacology
pub_type： 杂志文章
doi：10.1016/j.neuropharm.2017.06.025
更新日期：2017-11-01 00:00:00
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journal_title：Neuropharmacology
pub_type： 杂志文章
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更新日期：1986-04-01 00:00:00
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journal_title：Neuropharmacology
pub_type： 杂志文章
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更新日期：1998-10-01 00:00:00
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journal_title：Neuropharmacology
pub_type： 杂志文章
doi：10.1016/0028-3908(93)90185-6
更新日期：1993-08-01 00:00:00
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journal_title：Neuropharmacology
pub_type： 杂志文章
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更新日期：1989-06-01 00:00:00
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journal_title：Neuropharmacology
pub_type： 杂志文章
doi：10.1016/s0028-3908(02)00020-5
更新日期：2002-04-01 00:00:00
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journal_title：Neuropharmacology
pub_type： 杂志文章
doi：10.1016/j.neuropharm.2018.12.013
更新日期：2019-04-01 00:00:00
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pub_type： 杂志文章
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更新日期：2018-06-01 00:00:00
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journal_title：Neuropharmacology
pub_type： 杂志文章
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更新日期：2001-09-01 00:00:00
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journal_title：Neuropharmacology
pub_type： 杂志文章,评审
doi：10.1016/j.neuropharm.2019.05.021
更新日期：2019-12-15 00:00:00
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journal_title：Neuropharmacology
pub_type： 杂志文章
doi：10.1016/j.neuropharm.2008.10.005
更新日期：2009-02-01 00:00:00
abstract：:Extensive evidence indicates that noradrenergic activation of the basolateral amygdala (BLA) is essential for mediating emotional arousal effects on memory consolidation in different target regions. However, the mechanism by which BLA activation regulates such information storage processes remains largely elusive. Her...
journal_title：Neuropharmacology
pub_type： 杂志文章
doi：10.1016/j.neuropharm.2018.08.018
更新日期：2018-10-01 00:00:00
abstract：:In this study, we analysed the implication of superoxide (O2-.) and nitric oxide (NO.) free radicals and their resulting product peroxynitrite (ONOO-) in the neuronal death induced by the activation of the glutamatergic receptor of the N-methyl-D-aspartate (NMDA) subtype using cultured cerebellar granule cells. The NO...
journal_title：Neuropharmacology
pub_type： 杂志文章
doi：10.1016/0028-3908(93)90020-4
更新日期：1993-11-01 00:00:00
