Substance P in the lumbar spinal cord of the rat affects the motor response to 5-HTP and TRH.

abstract：:Orexin/hypocretin signaling at the orexin 1 receptor (OX(1)R) has recently been implicated in addiction and relapse. We examined the role of the orexin system in cocaine-seeking elicited by a drug-associated context following abstinence or extinction from chronic cocaine self-administration. Male Sprague-Dawley rats s...

journal_title：Neuropharmacology

authors： Smith RJ,Tahsili-Fahadan P,Aston-Jones G

更新日期：2010-01-01 00:00:00

abstract：:Elimination of brain cholesterol occurs in the form of 24S-hydroxycholesterol (24S-HCh) that may modulate physiological processes outside the brain. Here, using microelectrode recording of postsynaptic responses (end-plate potentials, EPPs) and fluorescent marker (FM1-43) for endo-exocytosis we studied the effects of ...

journal_title：Neuropharmacology

authors： Mukhutdinova KA,Kasimov MR,Zakyrjanova GF,Gumerova MR,Petrov AM

更新日期：2019-05-15 00:00:00

abstract：:In rat brain, the number of beta-adrenoceptors and activity of noradrenaline-dependent adenylate cyclase were examined after treatment with desipramine (7.5 mg kg-1 day-1) for three days alone or in combination with the alpha 2-adrenoceptor antagonist, yohimbine (2 mg kg-1 12 hr-1), or with phenoxybenzamine (7.5 mg kg...

journal_title：Neuropharmacology

authors： Campbell IC,McKernan RM,Smokcum RW,Stephenson JD,Weeramanthri TB

更新日期：1984-12-01 00:00:00

abstract：:In this study, we evaluated the gastric effects of methylnaltrexone, an opioid receptor antagonist that does not cross the blood-brain barrier in vivo, on mu, kappa and delta opioid agonists induced brainstem unitary responses in an in vitro neonatal rat brainstem-gastric preparation. Single units in the medial subnuc...

journal_title：Neuropharmacology

authors： Yuan CS,Foss JF

更新日期：1999-03-01 00:00:00

abstract：:Exposure to abused drugs and stressful experience, two factors that promote the development of addiction, also modify synaptic function in the mesolimbic dopamine system. Here, we show that exposure to a novel environment produces functional synaptic adaptations in the nucleus accumbens (NAc) that mirror the effect of...

journal_title：Neuropharmacology

authors： Rothwell PE,Kourrich S,Thomas MJ

更新日期：2011-12-01 00:00:00

abstract：:Mice were found to exhibit a marked suppression of motor activity when placed into the same experimental chamber in which they had previously received electrical shocks. This suppression was found to be a stable response when mice, 6-8 weeks of age, received shocks of frequencies of 1/10 or 1/30 Hz, and their motility...

journal_title：Neuropharmacology

authors： Kameyama T,Nagasaka M

更新日期：1982-12-01 00:00:00

abstract：:Adenosine A2a receptors (A2aRs) are highly and selectively expressed in D2-medium spiny neurons (D2-MSNs) that also express a high level of dopamine D2 receptors (D2Rs). However, it was not established how A2aR activity affects D2-MSN excitability, let alone the ion channels involved. We have performed two sets of exp...

journal_title：Neuropharmacology

authors： Wang Q,Zhou FM

更新日期：2019-04-01 00:00:00

abstract：:The serotonin transporter (SERT) facilitates high affinity reuptake of 5-HT from the extracellular fluid and dysregulation of transporter function has been implicated in a range of mood disorders including depression. Recent studies have linked immune system activation to depression as well as to altered serotonin tra...

journal_title：Neuropharmacology

authors： Brown E,Mc Veigh CJ,Santos L,Gogarty M,Müller HK,Elfving B,Brayden DJ,Haase J

更新日期：2018-07-15 00:00:00

abstract：:The electrophysiological properties and cataleptogenicity of YM-09151-2 (N-[(2RS, 3RS)-1-benzyl-2-methyl-3-pyrrolidinyl]-5-chloro-2-methoxy-4-methylaminobenzamide) were studied in the cat. This drug inhibited the EEG arousal response to electrical stimulation of the mesencephalic reticular formation with the same pote...

journal_title：Neuropharmacology

authors： Yamamoto M,Usuda S,Tachikawa S,Maeno H

更新日期：1982-10-01 00:00:00

abstract：:Depression is a leading cause of mortality and morbidity. Selective serotonin reuptake inhibitors, such as fluoxetine, are the most commonly prescribed antidepressant medication. SSRIs produce their therapeutic effects by elevating extracellular concentrations of serotonin. Although this elevation occurs rapidly, ther...

journal_title：Neuropharmacology

authors： Van Dyke AM,Francis TC,Chen H,Bailey AM,Thompson SM

更新日期：2019-05-15 00:00:00

abstract：:Although depression is a severe and life-threatening psychiatric illness, its pathogenesis still is essentially unknown. Recent studies highlighted the influence of environmental stress factors on an individual's genetic predisposition to develop mood disorders. In the present study, we employed a well-validated stres...

journal_title：Neuropharmacology

authors： Mallei A,Giambelli R,Gass P,Racagni G,Mathé AA,Vollmayr B,Popoli M

更新日期：2011-06-01 00:00:00

abstract：:Bradykinin interacts with the bradykinin B2 receptor on dorsal root ganglion (DRG) neurons, setting off a series of reactions inside the cells that ultimately make the vanilloid receptor 1 more sensitive to a normal stimulus by activating various enzymes coupled with second messenger signaling cascades. Zaltoprofen, a...

journal_title：Neuropharmacology

authors： Tang HB,Inoue A,Oshita K,Hirate K,Nakata Y

更新日期：2005-06-01 00:00:00

abstract：:We report in this study a 2-aminoethoxydiphenyl borate (2-APB) activated Ca2+ pathway in NG115-401L (401L) neuronal cells bearing resemblance to hormonal and ryanodine receptor activated pathways. We observed that 2-APB, in contrast to much earlier work, did not inhibit store operated Ca2+ channel (SOC) function, but ...

journal_title：Neuropharmacology

authors： Bose DD,Thomas DW

更新日期：2006-04-01 00:00:00

abstract：:The role of the sympathetic nervous system in the mediation of cardiovascular function, following administration of histamine centrally was investigated. Intracerebroventricular (i.c.v.) injections of histamine into the lateral ventricle of conscious rats caused a dose-dependent increase in blood pressure as well as a...

journal_title：Neuropharmacology

authors： Klein MC,Gertner SB

更新日期：1983-09-01 00:00:00

abstract：:Alpha2-adrenergic drugs modulate cortical arousal and EEG. However, the role of individual alpha2-adrenoceptor (alpha(2)-AR) subtypes in these functions is not clear. We investigated the role of alpha(2C)-ARs in the modulation of baseline cortical EEG activity and EEG responses to the alpha(2)-AR selective agonist, de...

journal_title：Neuropharmacology

authors： Puoliväli J,Björklund M,Holmberg M,Ihalainen JA,Scheinin M,Tanila H

更新日期：2002-12-01 00:00:00

abstract：:The binding of three, structurally distinct, 5-hydroxytryptamine3 (5-HT3) receptor radioligands was characterized in rat cerebral cortex, rabbit ileum myenteric plexus and NG-108-15 neuroblastoma cells. The density of sites labeled by the three ligands in rat cortex or in rabbit ileum was markedly different. [3H]Quipa...

journal_title：Neuropharmacology

authors： Wong EH,Bonhaus DW,Lee JA,Wu I,Loury DN,Eglen RM

更新日期：1993-09-01 00:00:00

abstract：:Trace Amine-Associated Receptor 1 (TAAR1) is a G protein-coupled receptor (GPCR) expressed in several mammalian brain areas and activated by "trace amines" (TAs). TAs role is unknown; however, discovery of their receptors provided an opportunity to investigate their functions. In vivo evidence has indicated an inhibit...

journal_title：Neuropharmacology

authors： Leo D,Mus L,Espinoza S,Hoener MC,Sotnikova TD,Gainetdinov RR

更新日期：2014-06-01 00:00:00

abstract：:The properties of central ATP-mediated synaptic currents were studied using whole-cell patch-clamp recording in rat medial habenula slices. Release was shown to be calcium dependent with a Hill coefficient of approximately 2. The voltage dependence of synaptic current amplitudes was approximately linear. Some reductio...

journal_title：Neuropharmacology

authors： Edwards FA,Robertson SJ,Gibb AJ

更新日期：1997-09-01 00:00:00

abstract：:Dopamine (DA)-replacement therapy utilizing l-DOPA is the gold standard symptomatic treatment for Parkinson's disease (PD). A critical complication of this therapy is the development of l-DOPA-induced dyskinesia (LID). The endogenous opioid peptides, including enkephalins and dynorphin, are co-transmitters of dopamine...

journal_title：Neuropharmacology

authors： Flores AJ,Bartlett MJ,Root BK,Parent KL,Heien ML,Porreca F,Polt R,Sherman SJ,Falk T

更新日期：2018-10-01 00:00:00

abstract：:Efflux of exogenous [3H]taurine from superfused slices of cerebral cortex of rat was enhanced by the calcium chelators EDTA and EGTA and by large concentrations of unlabelled taurine and histidine. The enhancement by EDTA and EGTA could be totally blocked by excess calcium, but that by the amino acids only partially. ...

journal_title：Neuropharmacology

authors： Korpi ER,Oja SS

更新日期：1984-03-01 00:00:00

abstract：:Interferon injection in morphine dependent rats prior to naloxone treatment eliminates 7 behavioral sings of the abstinence (withdrawal) phenomenon. When a single injection of interferon was given prior to chronic morphine treatment it reduces opiate addiction liability. ...

journal_title：Neuropharmacology

authors： Dafny N

更新日期：1983-05-01 00:00:00

abstract：:Radioligand binding studies were performed in membranes of human cerebellum using [125I][Tyr3]octreotide also known as [125I]204-090, [125I]LTT-SRIF-28 ([Leu8, D-Trp22, 125I-Tyr25]SRIF-28) and [125I]CGP 23996 ([125I]c[Asu-Lys-Asn-Phe-Trp-Lys-Thr-Tyr-Thr-Ser]) to characterize the nature of cerebellar somatostatin recep...

journal_title：Neuropharmacology

authors： Piwko C,Thoss VS,Probst A,Hoyer D

更新日期：1996-06-01 00:00:00

abstract：:An infusion of dopamine for 13 days into the nucleus accumbens of rat caused biphasic peaks of hyperactivity responding during infusion and an enhanced locomotor responsiveness to the dopamine agonist (-)N-n-propylnorapomorphine [(-)NPA] after the infusion when rats where initially preselected as low activity responde...

journal_title：Neuropharmacology

authors： Costall B,Domeney AM,Naylor RJ

更新日期：1985-03-01 00:00:00

abstract：:Intraperitoneal administration of 5-10 mg/kg of THIP (4,5,6,7 tetrahydroxyisoxazolo (4,5,c) pyridine 3-ol) induced a transient, reliable model of bilaterally synchronous spikes and waves in rats. The paroxysmal bursts elicited by THIP had similar topographical distribution to the spontaneously-occurring spike and wave...

journal_title：Neuropharmacology

authors： Fariello RG,Golden GT

更新日期：1987-02-01 00:00:00

abstract：:Flavopiridol was developed as a drug for cancer therapy due to its ability to inhibit cell cycle progression by targeting cyclin-dependent kinases (CDKs). In this study, we show that flavopiridol may also have a neuroprotective action. We show that at therapeutic dosage (or at micromolar range), flavopiridol almost co...

journal_title：Neuropharmacology

authors： Jorda EG,Verdaguer E,Canudas AM,Jiménez A,Bruna A,Caelles C,Bravo R,Escubedo E,Pubill D,Camarasa J,Pallàs M,Camins A

更新日期：2003-10-01 00:00:00

abstract：:In three experiments, rats were injected once daily with 5.0 mg/kg apomorphine or vehicle and tested for locomotor activity for 10-14 days. In each experiment, apomorphine produced behavioral sensitization, characterized by a progressively greater increase in locomotor activity with each succeeding injection. On day 1...

journal_title：Neuropharmacology

authors： Rowlett JK,Mattingly BA,Bardo MT

更新日期：1991-02-01 00:00:00

abstract：:Long-term L-DOPA treatment for Parkinson's disease (PD) is limited by motor complications, particularly L-DOPA-induced dyskinesia (LID). A therapy with the ability to ameliorate LID without reducing anti-parkinsonian benefit would be of great value. We assessed the ability of TC-8831, an agonist at nicotinic acetylcho...

journal_title：Neuropharmacology

authors： Johnston TH,Huot P,Fox SH,Koprich JB,Szeliga KT,James JW,Graef JD,Letchworth SR,Jordan KG,Hill MP,Brotchie JM

更新日期：2013-10-01 00:00:00

abstract：:Methamphetamine is a neurotoxic drug of abuse known to cause cell death both in vitro and in vivo. Nevertheless, the molecular and cellular mechanisms involved in this process remain to be clarified. Herein, we show that methamphetamine-induced apoptosis is associated with early (2 h) overexpression of bax, decreases ...

journal_title：Neuropharmacology

authors： Deng X,Cai NS,McCoy MT,Chen W,Trush MA,Cadet JL

更新日期：2002-05-01 00:00:00

abstract：:Metabotropic glutamate (mGlu) receptors in the basal ganglia motor loop may increase cell excitability (Group I) or modulate neurotransmitter release (Group I, II and III). Nigrostriatal tract degeneration in Parkinson's disease (PD) produces downstream pathological disturbances in glutamate and GABA transmission. The...

journal_title：Neuropharmacology

authors： Messenger MJ,Dawson LG,Duty S

更新日期：2002-08-01 00:00:00

abstract：:The effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on nicotinic acetylcholine (ACh) receptor channels were studied in cultured myocytes of 1-day-old Xenopus embryos. The amplitude and decay time of iontophoretic ACh-induced currents were reduced by MPTP in a concentration-dependent manner. The inhibito...

journal_title：Neuropharmacology

authors： Hsu KS,Fu WM,Lin-Shiau SY

更新日期：1994-01-01 00:00:00