The THIP-induced model of bilateral synchronous spike and wave in rodents.

abstract：:To study the effects of maternal alcohol ingestion on brain adenylate cyclase in offspring, rats were given ethanol in the drinking water before, during and after gestation. Fifteen-day-old pups from alcoholic mothers had reduced body and wet brain weight and protein content with normal concentrations of DNA and RNA i...

journal_title：Neuropharmacology

authors： Salinas M,Fernández T

更新日期：1983-11-01 00:00:00

abstract：:Tobacco addiction is highly co-morbid with a variety of mental health conditions, including schizophrenia, mood and anxiety disorders. Nicotine, the primary psychoactive compound in tobacco-related products is known to functionally modulate brain circuits that are disturbed in these disorders. Nicotine can potently re...

journal_title：Neuropharmacology

authors： Laviolette SR

更新日期：2021-02-15 00:00:00

abstract：:Hippocampal damage produces spatial memory impairment and hyperactivity in animals, while reductions in hippocampal size have been associated with memory deficits in humans. There are no known treatments for the behavioral changes specifically related to reduced hippocampal size. The purpose of this study was to deter...

journal_title：Neuropharmacology

authors： Bardgett ME,Baum KT,O'Connell SM,Lee NM,Hon JC

更新日期：2006-12-01 00:00:00

abstract：:Improgan is a chemical congener of the H2 antagonist cimetidine which shows the profile of a highly effective analgesic when administered directly into the CNS. Although the improgan receptor is unknown, improgan activates analgesic pathways which are independent of opioids, but may utilize cannabinoid mechanisms. To ...

journal_title：Neuropharmacology

authors： Hough LB,de Esch IJ,Janssen E,Phillips J,Svokos K,Kern B,Trachler J,Abood ME,Leurs R,Nalwalk JW

更新日期：2006-09-01 00:00:00

abstract：:N-Methyl-D-aspartate (NMDA) receptors are important CNS target sites of alcohols, but the site and mechanism of action of alcohols on NMDA receptors remains unclear. In CHO-K1 cells transfected with NR1/NR2B NMDA receptor subunits, ethanol inhibited NMDA-activated current with an IC(50) of 138 mM. Truncation of the in...

journal_title：Neuropharmacology

authors： Peoples RW,Stewart RR

更新日期：2000-07-24 00:00:00

abstract：:The dopaminergic receptors of planaria have been studied with pharmacological and biochemical criteria. Dopamine D1 selective agonists (CY 208243 (10 micrograms/ml) and SKF 38393 (10 micrograms/ml] induced in planaria typical screw-like hyperkinesias, that were inhibited by a D1 antagonist (SCH 23390 (10 micrograms/ml...

journal_title：Neuropharmacology

authors： Venturini G,Stocchi F,Margotta V,Ruggieri S,Bravi D,Bellantuono P,Palladini G

更新日期：1989-12-01 00:00:00

abstract：:Long-term potentiation (LTP) resembles memory in that it is initially unstable and then, over about 30 min, becomes increasingly resistant to disruption. Here we present an hypothesis to account for this initial consolidation effect and consider implications that follow from it. Anatomical studies indicate that LTP is...

journal_title：Neuropharmacology

authors： Lynch G,Rex CS,Gall CM

更新日期：2007-01-01 00:00:00

abstract：:The posterior hypothalamic receptors involved in the cardiovascular responses to electrical stimulation of the rostral ventrolateral medulla were investigated in urethane-anaesthetized rats. Electrical stimulation of the rostral ventrolateral medulla produced a significant increase in systolic blood pressure. This res...

journal_title：Neuropharmacology

authors： Bachelard H,Rivest R,Marsden CA

更新日期：1991-07-01 00:00:00

abstract：:Mutations in hundreds of genes contribute to cognitive and behavioral dysfunction associated with developmental brain disorders (DBDs). Due to the sheer number of risk factors available for study combined with the cost of developing new animal models, it remains an open question how genes should be prioritized for in-...

journal_title：Neuropharmacology

authors： Ogden KK,Ozkan ED,Rumbaugh G

更新日期：2016-01-01 00:00:00

abstract：:The effects of d-amphetamine (0.03-10.0 mg/kg), caffeine (0.3-100.0 mg/kg), nicotine (0.003-10.0 mg/kg) and cocaine (0.03-56.0 mg/kg) were compared on responding maintained under three different schedules of food presentation in mice. Cumulative doses of d-amphetamine, nicotine and cocaine only decreased responding ma...

journal_title：Neuropharmacology

authors： Glowa JR

更新日期：1986-10-01 00:00:00

abstract：:C57BL/6J mice were introduced to a nine arm radial maze without prior habituation and trained in the acquisition of a working memory task in 16 sessions, one session per day. In this maze mice need to climb onto an upward inclined bridge in order to reach and cross onto an arm. They received in each session an i.p. in...

journal_title：Neuropharmacology

authors： Ennaceur A,Michalikova S,van Rensburg R,Chazot PL

更新日期：2011-10-01 00:00:00

abstract：:Exogenous brain-derived neurotrophic factor (BDNF) can regulate behavioral sensitization and conditioned place preference (CPP) when animals are exposed to repeated cocaine administration. However, it is unclear whether BDNF signaling through the TrkB receptor can mediate these behavioral responses when animals are gi...

journal_title：Neuropharmacology

authors： Crooks KR,Kleven DT,Rodriguiz RM,Wetsel WC,McNamara JO

更新日期：2010-06-01 00:00:00

abstract：:Brain inosine and hypoxanthine were measured in mice at intervals following the intraperitoneal injection of pentylenetetrazol (PTZ), 100 mg/kg. These purines increased only after myoclonic jerks appeared and were maximal at the time of tonic hindlimb extension. Phenytoin and phenobarbital, which prevent tonic hindlim...

journal_title：Neuropharmacology

authors： Lewin E,Bleck V

更新日期：1983-05-01 00:00:00

abstract：:Compound FLZ (cFLZ) is a synthetic novel derivative of natural squamosamide. Previous pharmacological study found that cFLZ improved the abnormal behavior and the decrease of dopamine content in striatum in 1-methyl-4-phenyl-1,2,3,6-tetra-hydropyridine (MPTP) model mice. 1-Methyl 4-phenylpyridinium (MPP+) is the activ...

journal_title：Neuropharmacology

authors： Zhang D,Zhang JJ,Liu GT

更新日期：2007-02-01 00:00:00

abstract：:The effects of the novel antidepressant tianeptine on behaviours induced by the serotonin (5-HT) precursor 5-hydroxytryptophan (5-HTP) and the 5-HT1A agonist 8-hydroxy-2-(di-n-propylamino)-tetralin (8-OH-DPAT) were investigated. Tianeptine (10 mg/kg, i.p.) significantly attenuated wet dog shakes (WDS) induced by 5-HTP...

journal_title：Neuropharmacology

authors： Datla KP,Curzon G

更新日期：1993-09-01 00:00:00

abstract：:In the rat subthalamic nucleus, which plays a critical role in the control of motor behaviour, specific binding of [3H]-prazosin was detected by radioligand binding to homogenates and by autoradiography in slices. [3H]-Prazosin binding to homogenates (Bmax 71 +/- 5 fmol/mg protein; Kd 0.27 +/- 0.05 nM) was competed fo...

journal_title：Neuropharmacology

authors： Arcos D,Sierra A,Nuñez A,Flores G,Aceves J,Arias-Montaño JA

更新日期：2003-12-01 00:00:00

abstract：:The effects of thyrotropin-releasing hormone (TRH) and an analog of this hormone, MK-771, were determined on body shaking behavior and on biochemical estimates of the activity of dopamine (DA) neurons in the rat. Both compounds elicited dose-related episodes of "wet-dog shakes". A dose of TRH (20 mg/kg, i.p.) which ca...

journal_title：Neuropharmacology

authors： Yamada K,Demarest KT,Moore KE

更新日期：1984-07-01 00:00:00

abstract：:The inhibitory effects of 4-phenyl-1,2,3,4-tetrahydroisoquinoline (4-PTIQ) on methamphetamine-induced increases in dopamine and locomotion were investigated. Methamphetamine hydrochloride (10 micrograms) microinjected into the nucleus accumbens increased both locomotor activity and extracellular dopamine levels, measu...

journal_title：Neuropharmacology

authors： Tateyama M,Ohta S,Nagao T,Hirobe M,Ono H

更新日期：1993-08-01 00:00:00

abstract：:Direct GABA agonists that suppress spikes induced by penicillin in cats failed to do so in rats. Phenytoin and large doses of THIP increased the rate of spiking activity of the penicillin focus. Only progabide caused marked, initial, short-lasting suppression and a modest reduction of frequency of spikes for 1 hr. Hom...

journal_title：Neuropharmacology

authors： Golden GT,Fariello RG

更新日期：1984-09-01 00:00:00

abstract：:Protein phosphorylation, controlled by the coordinated actions of phosphatases and kinases, is an important regulatory mechanism in synaptic transmission and other neurophysiological processes. Ionotropic glutamate receptors are known targets of phosphorylation on serine, threonine and tyrosine residues, with function...

journal_title：Neuropharmacology

authors： Orlando LR,Dunah AW,Standaert DG,Young AB

更新日期：2002-08-01 00:00:00

abstract：:Postsynaptic Density Protein-95 (PSD-95) is a major scaffolding protein in the excitatory synapses in the brain and a critical regulator of synaptic maturation for NMDA and AMPA receptors. PSD-95 deficiency has been linked to cognitive and learning deficits implicated in neurodevelopmental disorders such as autism and...

journal_title：Neuropharmacology

authors： McEachern EP,Coley AA,Yang SS,Gao WJ

更新日期：2020-11-15 00:00:00

abstract：:Imaging studies of serotonin transporter binding or tryptophan retention in autistic patients suggest that the brain serotonin system is decreased. However, treatment with drugs which increase serotonin (5-HT) levels, specific serotonin reuptake inhibitors (SSRIs), commonly produce a worsening of the symptoms. In this...

journal_title：Neuropharmacology

authors： Azmitia EC,Singh JS,Whitaker-Azmitia PM

更新日期：2011-06-01 00:00:00

abstract：:In rats with partial, unilateral lesions of the dopaminergic nigrostriatal pathway, synthesis of dopamine (DA) per surviving neurone was assessed by measuring the ratio of DOPA accumulated after inhibition of aromatic amino acid decarboxylase to dopamine (DOPA/DA ratio). Release of DA per surviving neurone was assesse...

journal_title：Neuropharmacology

authors： Hefti F,Enz A,Melamed E

更新日期：1985-01-01 00:00:00

abstract：:Phylogenetic research can help to elucidate the structure of the GABA/benzodiazepine receptor complex. In this study the evolution of the beta-carboline binding site was traced to see whether it paralleled that of the benzodiazepine binding site. The ratio of [3H]ethyl-beta-carboline-3-carboxylate (beta-CCE) to [3H]fl...

journal_title：Neuropharmacology

authors： Friedl W,Hebebrand J,Rabe S,Propping P

更新日期：1988-02-01 00:00:00

abstract：:Gliomas, in particular glioblastoma multiforme or grade IV astrocytoma, are the most frequent class of malignant primary brain tumours and one of the most aggressive forms of cancer. Current therapeutic strategies for the treatment of glioblastoma multiforme are usually ineffective or just palliative. During the last ...

journal_title：Neuropharmacology

authors： Velasco G,Galve-Roperh I,Sánchez C,Blázquez C,Guzmán M

更新日期：2004-09-01 00:00:00

abstract：:Previously, we have found that activation of mGlu receptors using a group I-specific mGlu receptor agonist, (RS)-3,5-DHPG, can induce long-term depression (LTD) in the CA1 region of the hippocampus and that, once established, this synaptic depression can be reversed by application of the mGlu receptor antagonist, (S)-...

journal_title：Neuropharmacology

authors： Schnabel R,Kilpatrick IC,Collingridge GL

更新日期：1999-10-01 00:00:00

abstract：:In general, N-methyl-D-aspartate (NMDA) receptor antagonists inhibit learning and long term potentiation (LTP). However, it has been suggested that direct tonic, i.e. non-temporal, activation of NMDA receptors, in contrast to learning, may lead to an increase in synaptic "noise" and, in turn, to a loss of association ...

journal_title：Neuropharmacology

authors： Zajaczkowski W,Frankiewicz T,Parsons CG,Danysz W

更新日期：1997-07-01 00:00:00

abstract：:Electrophysiological, biochemical, and behavioural studies have suggested that opiate withdrawal is mediated, at least in part, by a hyperactivity of locus coeruleus (LC) neurones. The aim of this study was to evaluate, using single-unit extracellular recordings, the role of NO in the opiate withdrawal-induced hyperac...

journal_title：Neuropharmacology

authors： Pineda J,Torrecilla M,Martín-Ruiz R,Ugedo L

更新日期：1998-06-01 00:00:00

abstract：:The objectives of this study, conducted on neonatal rat spinal cord and dorsal roots in vitro, were to characterise the actions of a range of willardiine analogues on GluR5-containing kainate receptors present in dorsal roots, to determine whether GluR5-containing receptors are also present on motoneurones, and to dif...

journal_title：Neuropharmacology

authors： Thomas NK,Hawkins LM,Miller JC,Troop HM,Roberts PJ,Jane DE

更新日期：1998-10-01 00:00:00

abstract：:Alcohol use disorder (AUD) affects all sexes, however women who develop AUD may be particularly susceptible to cravings and other components of the disease. While many brain regions are involved in AUD etiology, proper prefrontal cortex (PFC) function is particularly important for top-down craving management and the m...

journal_title：Neuropharmacology

authors： Joffe ME,Winder DG,Conn PJ

更新日期：2020-11-01 00:00:00