Structural and molecular aspects of betaine-GABA transporter 1 (BGT1) and its relation to brain function.

abstract：:Biogenic monoamines are involved in the regulation of various processes in both neural and non-neural cells during development. The present study aimed to identify the regulatory effects of serotonin (5-HT) and its precursors (l-tryptophan and 5-hydroxytryptophan, 5-HTP) on proliferation and cell death in mouse embryo...

journal_title：Neuropharmacology

authors： Gordeeva O,Safandeev V

更新日期：2019-11-25 00:00:00

abstract：:We used rats with a sciatic nerve chronic constrictive injury (CCI) and combined behavioural, molecular and morphological approaches to assess the involvement of mGlu5 receptors in neuropathic pain-associated hyperalgesia and spinal cord neuron apoptosis. Mechanical and thermal hyperalgesia developed 2-3 days after su...

journal_title：Neuropharmacology

authors： de Novellis V,Siniscalco D,Galderisi U,Fuccio C,Nolano M,Santoro L,Cascino A,Roth KA,Rossi F,Maione S

更新日期：2004-03-01 00:00:00

abstract：:The aim of the present work was to clarify whether heterotrimeric P2X2/3 receptors have a fixed subunit stoichiometry consisting of one P2X2 and two P2X3 subunits as previously suggested, or a flexible stoichiometry containing also the inverse subunit composition. For this purpose we transfected HEK293 cells with P2X2...

journal_title：Neuropharmacology

authors： Kowalski M,Hausmann R,Schmid J,Dopychai A,Stephan G,Tang Y,Schmalzing G,Illes P,Rubini P

更新日期：2015-12-01 00:00:00

abstract：:Oxytocin (100 ng) injected unilaterally into the ventral subiculum of the hippocampus induces penile erection episodes, which started 30 min after treatment and were abolished by the prior injection of d(CH(2))(5)Tyr(Me)(2)-Orn(8)-vasotocin (2 μg), an oxytocin receptor antagonist, into the ventral subiculum. Oxytocin-...

journal_title：Neuropharmacology

authors： Succu S,Sanna F,Argiolas A,Melis MR

更新日期：2011-07-01 00:00:00

abstract：:γ-Aminobutyric acid type A receptors that contain the δ subunit (δGABAA receptors) are expressed in multiple types of neurons throughout the central nervous system, where they generate a tonic conductance that shapes neuronal excitability and synaptic plasticity. These receptors regulate a variety of important behavio...

journal_title：Neuropharmacology

authors： Whissell PD,Lecker I,Wang DS,Yu J,Orser BA

更新日期：2015-01-01 00:00:00

abstract：:Acamprosate is clinically used to treat alcohol-dependent patients. While the molecular and pharmacological mechanisms of acamprosate remain unclear, it has been shown to regulate γ-aminobutyric acid (GABA) or glutamate levels in the cortex and striatum. To investigate the effect of acamprosate on brain metabolites in...

journal_title：Neuropharmacology

authors： Hinton DJ,Lee MR,Jacobson TL,Mishra PK,Frye MA,Mrazek DA,Macura SI,Choi DS

更新日期：2012-06-01 00:00:00

abstract：:Neuronal nicotinic acetylcholine receptors (nAChRs) are widely distributed in the nervous system and are implicated in many normal and pathological processes. The structural determinants of allostery in nAChRs are not well understood. One class of nAChR allosteric modulators, including the small molecule morantel (Mor...

journal_title：Neuropharmacology

authors： Short CA,Cao AT,Wingfield MA,Doers ME,Jobe EM,Wang N,Levandoski MM

更新日期：2015-04-01 00:00:00

abstract：:Following its binding to somatodendritic receptors, the neuropeptide neurotensin (NT) internalizes via a clathrin-mediated process. In the present study, we investigated whether NT also internalizes presynaptically using synaptosomes from rat neostriatum, a region in which NT1 receptors are virtually all presynaptic. ...

journal_title：Neuropharmacology

authors： Nguyen HM,Cahill CM,McPherson PS,Beaudet A

更新日期：2002-06-01 00:00:00

abstract：:The aim of the present study was to determine the influence of thyroid hormone, T3, on the regulation of hippocampal BDNF expression by 5-HT receptor agonists. Chronic T3 administration prior to treatment with the 5-HT(1A) agonist, 8-OH-DPAT, significantly decreased BDNF mRNA in the dentate gyrus region of the hippoca...

journal_title：Neuropharmacology

authors： Vaidya VA,Castro ME,Pei Q,Sprakes ME,Grahame-Smith DG

更新日期：2001-01-01 00:00:00

abstract：:The present review gives an overview of current pharmacological treatment options of tic disorders and Tourette Syndrome (TS). After a short summary on phenomenology, clinical course and comorbid conditions we review indications for pharmacological treatment in detail. Unfortunately, standardized and large enough drug...

journal_title：Neuropharmacology

authors： Roessner V,Schoenefeld K,Buse J,Bender S,Ehrlich S,Münchau A

更新日期：2013-05-01 00:00:00

abstract：:Ginsenoside Rg1 (Rg1) acts as a neuroprotective agent against various insults, however, the underlying mechanism has not been fully elucidated yet. Here, we report that Rg1 protects primary rat cerebrocortical neurons against β-amyloid peptide₂₅₋₃₅ (Aβ₂₅₋₃₅) injury via estrogen receptor α (ERα) and glucocorticoid rece...

journal_title：Neuropharmacology

authors： Wu J,Pan Z,Wang Z,Zhu W,Shen Y,Cui R,Lin J,Yu H,Wang Q,Qian J,Yu Y,Zhu D,Lou Y

更新日期：2012-09-01 00:00:00

abstract：:There is increasing evidence that oxidative stress is critically involved in the pathogenesis of Parkinson's disease (PD), suggesting that pharmacological targeting of the antioxidant machinery may have therapeutic value. Naringenin, a natural flavonoid compound, has been reported to possess neuroprotective effect aga...

journal_title：Neuropharmacology

authors： Lou H,Jing X,Wei X,Shi H,Ren D,Zhang X

更新日期：2014-04-01 00:00:00

abstract：:The inhibitory effects of 4-phenyl-1,2,3,4-tetrahydroisoquinoline (4-PTIQ) on methamphetamine-induced increases in dopamine and locomotion were investigated. Methamphetamine hydrochloride (10 micrograms) microinjected into the nucleus accumbens increased both locomotor activity and extracellular dopamine levels, measu...

journal_title：Neuropharmacology

authors： Tateyama M,Ohta S,Nagao T,Hirobe M,Ono H

更新日期：1993-08-01 00:00:00

abstract：:The effects of risperidone, a new antipsychotic with potent 5-hydroxytryptamine2 (5-HT2) and dopamine-D2 (DA-D2) antagonistic properties, were studied on sleep-wakefulness patterns in rats. Administration of low doses (0.01-0.16 mg/kg i.p.) resulted in a significant increase of deep slow wave sleep (SWS2) and a decrea...

journal_title：Neuropharmacology

authors： Dugovic C,Wauquier A,Janssen PA

更新日期：1989-12-01 00:00:00

abstract：:Opioids evoke analgesia through activation of opioid receptors (predominantly the μ opioid receptor) in the central nervous system. Opioid receptors are abundant in multiple regions of the central nervous system and the peripheral nervous system including enteric neurons. Opioid-related adverse effects such as constip...

journal_title：Neuropharmacology

authors： Imam MZ,Kuo A,Ghassabian S,Smith MT

更新日期：2018-03-15 00:00:00

abstract：:Centrally-administered opioid peptides produce elevations in levels of catecholamines in plasma in conscious rats. To investigate the opioid receptor involved in mediating this response, morphine (3.5-105 nmol), [D-Ala2-D-Leu5]enkephalin (DADL, 1.05-35 nmol) and U50, 488H (35-1160 nmol), relatively selective ligands f...

journal_title：Neuropharmacology

authors： Conway EL,Brown MJ,Dollery CT

更新日期：1984-11-01 00:00:00

abstract：:Cholecystokinin (CCK) is the most abundant neuropeptide in the central nervous system. In the hippocampal CA1 region, CCK is co-localized with GABA in a subset of interneurons that synapse on pyramidal cell somata and apical dendrites. CCK-containing interneurons also uniquely express a high level of the cannabinoid r...

journal_title：Neuropharmacology

authors： Karson MA,Whittington KC,Alger BE

更新日期：2008-01-01 00:00:00

abstract：:Due to the claim that lithium (Li+) reduces morphine self-administration in dependent rats, the effects of acute and chronic Li+ treatments on naloxone-precipitated withdrawal syndrome and physical dependence development to morphine in mice chronically treated with morphine, were evaluated. Morphine dependency was ind...

journal_title：Neuropharmacology

authors： Dehpour AR,Farsam H,Azizabadi-Farahani M

更新日期：1995-01-01 00:00:00

abstract：:Neural progenitor cells (NPCs) are found in the subventricular zone (SVZ) of the adult brain, a specialized neurogenic niche that might provide a substrate for brain repair after injury. The incomplete knowledge of how NPCs in the niche respond to local signals limits the use of cultured NPCs in the development of cel...

journal_title：Neuropharmacology

authors： Castiglione M,Calafiore M,Costa L,Sortino MA,Nicoletti F,Copani A

更新日期：2008-09-01 00:00:00

abstract：:Serotonin (5-HT) modulates the hypothalamic-pituitary-adrenal (HPA) axis response to stress. We examined the effect of chronic restraint stress (CRS; 20 min/day) as compared to control (CTRL) conditions for 14 days, on: 1) restraint-induced ACTH and corticosterone (CORT) secretion in rats pretreated with vehicle or SB...

journal_title：Neuropharmacology

authors： García-Iglesias BB,Mendoza-Garrido ME,Gutiérrez-Ospina G,Rangel-Barajas C,Noyola-Díaz M,Terrón JA

更新日期：2013-08-01 00:00:00

abstract：:The Erwinia ligand-gated ion channel (ELIC) is a bacterial homologue of vertebrate Cys-loop ligand-gated ion channels. It is activated by GABA, and this property, combined with its structural similarity to GABA(A) and other Cys-loop receptors, makes it potentially an excellent model to probe their structure and functi...

journal_title：Neuropharmacology

authors： Thompson AJ,Alqazzaz M,Ulens C,Lummis SC

更新日期：2012-09-01 00:00:00

abstract：:Recently, the presence of two high affinity binding sites for phencyclidine were described in guinea pig brain, with one site coupled to the glutamate excitatory amino acid receptor, specifically activated by N-methyl-D-aspartate (NMDA) (site 1) and the other site associated with the dopamine (DA) reuptake carrier (si...

journal_title：Neuropharmacology

authors： Reid AA,Mattson MV,de Costa BR,Thurkauf A,Jacobson AE,Monn JA,Rice KC,Rothman RB

更新日期：1990-09-01 00:00:00

abstract：:The hippocampal slice is a popular model system in which to study the cellular properties of long-term potentiation (LTP). Synaptogenesis induced by exposure to ice-cold artificial cerebrospinal fluid (ACSF), however, raises the concern that morphological correlates of LTP might be obscured, especially in mature slice...

journal_title：Neuropharmacology

authors： Bourne JN,Kirov SA,Sorra KE,Harris KM

更新日期：2007-01-01 00:00:00

abstract：:Rats were trained to recognize a discriminative stimulus (DS) elicited by the preferential dopamine D3 receptor agonists, PD128,907 (0.16 mg/kg, i.p.) and 7-OH-DPAT (0.16 mg/kg, i.p.). PD128,907 and 7-OH-DPAT showed "full" (> or = 80%) and mutual generalization. Chemically-diverse, preferential D3 versus D2 agonists, ...

journal_title：Neuropharmacology

authors： Millan MJ,Girardon S,Monneyron S,Dekeyne A

更新日期：2000-02-14 00:00:00

abstract：:Methylphenidate (MPH, Ritalin©) is widely used in the treatment of Attention Deficit Hyperactivity Disorder and recently as a drug of abuse. Although the effect of MPH has been studied in brain regions such as striatum and prefrontal cortex (PFC), the hippocampus has received relatively little attention. It is known t...

journal_title：Neuropharmacology

authors： Rozas C,Carvallo C,Contreras D,Carreño M,Ugarte G,Delgado R,Zeise ML,Morales B

更新日期：2015-12-01 00:00:00

abstract：:Regional differences are known in the serotonin-induced modulation of neuronal activity within the amygdala. This in vitro study in rats focuses on analyzing the ionic mechanism underlying serotonin-induced depolarization in the lateral amygdala. Serotonin depolarized membrane potential by 5 mV, which is underlain by ...

journal_title：Neuropharmacology

authors： Yamamoto R,Hatano N,Sugai T,Kato N

更新日期：2014-07-01 00:00:00

abstract：:The ventromedial nucleus of the hypothalamus (VMH) plays an important role in feeding and energy homeostasis. Electroconvulsive seizure (ECS) therapy is highly effective in the treatment of several psychiatric diseases, including depression, but may also have beneficial effects in other neurological diseases. Although...

journal_title：Neuropharmacology

authors： Segi-Nishida E,Sukeno M,Imoto Y,Kira T,Sakaida M,Tsuchiya S,Sugimoto Y,Okuno Y

更新日期：2013-08-01 00:00:00

abstract：:A history of intermittent exposures to drugs of abuse can cause long-term changes in acute behavioural responses to a subsequent drug exposure. In drug-naive rats, morphine can elicit intermittent cataleptic postures followed by sustained increases in locomotor activity. Chronic intermittent morphine treatment can red...

journal_title：Neuropharmacology

authors： Hamlin AS,McNally GP,Westbrook RF,Osborne PB

更新日期：2009-03-01 00:00:00

abstract：:JAK4D, a first-in-class thyrotropin-releasing hormone (TRH)-based compound, is a prospective therapeutic candidate offering a multifaceted approach to treating neurodegeneration and other CNS conditions. The purpose of these studies was to determine the ability of JAK4D to bind to TRH receptors in human brain and to e...

journal_title：Neuropharmacology

authors： Kelly JA,Boyle NT,Cole N,Slator GR,Colivicchi MA,Stefanini C,Gobbo OL,Scalabrino GA,Ryan SM,Elamin M,Walsh C,Vajda A,Goggin MM,Campbell M,Mash DC,O'Mara SM,Brayden DJ,Callanan JJ,Tipton KF,Della Corte L,Hunter J,

更新日期：2015-02-01 00:00:00

abstract：:The uptake of norepinephrine into cortical punches from the brain of the rat was studied in the presence of buffer and plasma from patients containing bupropion and its metabolites. Even though bupropion and its metabolite (compound II) were equipotent in inhibiting the uptake of NE in buffer, compound II was twice as...

journal_title：Neuropharmacology

authors： Perumal AS,Smith TM,Suckow RF,Cooper TB

更新日期：1986-02-01 00:00:00