Abstract：
:To identify the enzymes involved in the induction of N-methyl-D-aspartate (NMDA) receptor-dependent long-term potentiation (LTP) at CA1 synapses of two-week-old rats we have tested various kinase inhibitors. Surprisingly, given the large body of evidence supporting a role for calcium/calmodulin-dependent protein kinase II (CaMKII) in LTP, inhibition of this enzyme did not affect the induction of LTP at this age. Similarly inhibition of protein kinase A (PKA) or protein kinase C (PKC) was also without effect. However, inhibition of CaMKII together with inhibition of either PKA or PKC fully blocked the induction of LTP. These experiments reveal, unexpectedly, the existence of two parallel kinase pathways, one involving CaMKII and the other PKA and PKC, either of which can fully support the induction of LTP, at this stage of development.
journal_name
Neuropharmacologyjournal_title
Neuropharmacologyauthors
Wikström MA,Matthews P,Roberts D,Collingridge GL,Bortolotto ZAdoi
10.1016/s0028-3908(03)00336-8subject
Has Abstractpub_date
2003-11-01 00:00:00pages
828-36issue
6eissn
0028-3908issn
1873-7064pii
S0028390803003368journal_volume
45pub_type
杂志文章abstract：:There are no pharmacological interventions to prevent the development of epilepsy, although many promising compounds have been identified in the animal laboratory. Clinical trials to validate their effectiveness, however, would currently be prohibitively expensive due to the large subject population and duration of fo...
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更新日期：2008-04-01 00:00:00
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