Block of calcium channels in rat neurons by synthetic omega-Aga-IVA.

abstract：:The involvement of metabotropic glutamate receptor group II (mGluRII) in the induction of long-term depression (LTD) was investigated in the medial perforant path of the rat dentate gyrus, a region with a very high density of mGluRII. Perfusion of either of two potent mGluRII agonists, (2S,1R,2R,3R)-2-(2S, 1'R, 2'R, 3...

journal_title：Neuropharmacology

authors： Huang L,Killbride J,Rowan MJ,Anwyl R

更新日期：1999-01-01 00:00:00

abstract：:The anticonvulsant action and the long-term effects on learning, memory and behavior of the new generation antiepileptic drug gabapentin (GBP) were investigated in immature animals. Kainic acid (KA) was administered to rats on postnatal day (P) 35. Animals were treated with GBP or saline from P36 to P75 and spontaneou...

journal_title：Neuropharmacology

authors： Cilio MR,Bolanos AR,Liu Z,Schmid R,Yang Y,Stafstrom CE,Mikati MA,Holmes GL

更新日期：2001-01-01 00:00:00

abstract：:(+)-2-Methyl-4-carboxyphenylglycine (LY367385), a potent and selective antagonist of mGlu1a metabotropic glutamate receptors, was neuroprotective in the following in vitro and in vivo models of excitotoxic death: (i) mixed cultures of murine cortical cells transiently exposed to N-methyl-D-aspartate (NMDA); (ii) rats ...

journal_title：Neuropharmacology

authors： Bruno V,Battaglia G,Kingston A,O'Neill MJ,Catania MV,Di Grezia R,Nicoletti F

更新日期：1999-02-01 00:00:00

abstract：:Effects of alaproclate, an inhibitor of the uptake of serotonin, on muscarinic cholinergic responses in N1E-115 neuroblastoma cells were studied using intracellular recording techniques. Application of carbachol activates an inward calcium channel, through an action on muscarinic receptors. The influx of calcium activ...

journal_title：Neuropharmacology

authors： Hedlund B

更新日期：1987-10-01 00:00:00

abstract：:We have studied the postnatal development of GABAA receptor alpha 1 and alpha 6 subunits expressed by primary cultures of cerebellar granule cells originating from 2-day-old (postnatal day 2, P2) and 10-day-old (P10) rat neonates. At these ages, the granule cells are at distinct stages of cerebellar development. In bo...

journal_title：Neuropharmacology

authors： Thompson CL,Pollard S,Stephenson FA

更新日期：1996-01-01 00:00:00

abstract：:SB-204269 (trans-(+)-6-acetyl-4S-(4-fluorobenzoylamino)-3, 4-dihydro-2,2-dimethyl-2H-benzo[b]pyran-3R-ol) shows anticonvulsant activity in a range of animal seizure models, with a high therapeutic index and a lack of side-effects. We have previously reported the characterisation of a novel binding site for [(3)H]-SB-2...

journal_title：Neuropharmacology

authors： Herdon HJ,Godfrey FM,Chan WN

更新日期：2000-09-01 00:00:00

abstract：:The nicotinic acetylcholine receptor (nAChR) represents the prototype of ligand-gated ion channels. It is vital for neuromuscular transmission and an important regulator of neurotransmission. A variety of toxic compounds derived from diverse species target this receptor and have been of elemental importance in basic a...

journal_title：Neuropharmacology

authors： Dutertre S,Nicke A,Tsetlin VI

更新日期：2017-12-01 00:00:00

abstract：:6-[(1S)-1-[1-[5-(2-hydroxyethoxy)-2-pyridyl]pyrazol-3-yl]ethyl]-3H-1,3-benzothiazol-2-one (LY3130481 or CERC-611) is a selective antagonist of AMPA receptors containing transmembrane AMPA receptor regulatory protein (TARP) γ-8. This molecule has been characterized as a potent and efficacious anticonvulsant in an array...

journal_title：Neuropharmacology

authors： Witkin JM,Li J,Gilmour G,Mitchell SN,Carter G,Gleason SD,Seidel WF,Eastwood BJ,McCarthy A,Porter WJ,Reel J,Gardinier KM,Kato AS,Wafford KA

更新日期：2017-11-01 00:00:00

abstract：:We have previously shown that the antipsychotic drug risperidone enhances serotonin (5-HT) output in the rat frontal cortex (FC), but the precise underlying mechanism has not been revealed. Consequently, the present study using in vivo microdialysis was undertaken to (i) characterize the effects of alpha2D, 5-HT1B and...

journal_title：Neuropharmacology

authors： Hertel P,Nomikos GG,Svensson TH

更新日期：1999-08-01 00:00:00

abstract：:Electrophysiology, immunostaining and time lapse imaging techniques were employed to study the mechanism of long-term depression (LTD) induced by DHPG, a specific group I metabotropic glutamate receptor (mGluR) agonist. Experiments were performed in primary hippocampal culture or in the CA1 area of acute rat hippocamp...

journal_title：Neuropharmacology

authors： Xiao MY,Zhou Q,Nicoll RA

更新日期：2001-11-01 00:00:00

abstract：:Electrophysiological, biochemical, and behavioural studies have suggested that opiate withdrawal is mediated, at least in part, by a hyperactivity of locus coeruleus (LC) neurones. The aim of this study was to evaluate, using single-unit extracellular recordings, the role of NO in the opiate withdrawal-induced hyperac...

journal_title：Neuropharmacology

authors： Pineda J,Torrecilla M,Martín-Ruiz R,Ugedo L

更新日期：1998-06-01 00:00:00

abstract：:The excitatory amino acid antagonist, D-alpha-aminoadipate, was found to be a potent antagonist of responses to N-methyl-D-aspartate and L-aspartate, but less potent against L-glutamate responses of neurones in the rat caudal trigeminal nucleus. The responses to quisqualate and kainate were relatively unaffected by D-...

journal_title：Neuropharmacology

authors： Salt TE,Hill RG

更新日期：1982-05-01 00:00:00

abstract：:The roles of recognition sites for central neurotransmitters in the mediation of the behavioural effects of the putative 5-hydroxytryptamine (5-HT1) receptor agonist, RU 24969 [5-methoxy-3(1,2,3,6-tetrahydropyridin-4-yl)1H indole] in the rat have been examined. The drug RU 24969 was found to have high affinity for 5-H...

journal_title：Neuropharmacology

authors： Tricklebank MD,Middlemiss DN,Neill J

更新日期：1986-08-01 00:00:00

abstract：:High performance liquid chromatography with electrochemical detection (HPLC-EC) was adapted for the analysis of metabolites of monoamines (MA) in the developing brain of the rat. 3-Methoxy-4-hydroxy-phenyl-ethylene glycol (MOPEG), dihydroxy phenylacetic acid (DOPAC), homovanillic acid (HVA) and 5-hydroxy-3-indoleaceti...

journal_title：Neuropharmacology

authors： Ribary U,Schlumpf M,Lichtensteiger W

更新日期：1986-09-01 00:00:00

abstract：:Remifentanil is a powerful mu-opioid (MOP) receptor agonist used in anaesthesia with a very short half-life. However, per-operative perfusion of remifentanil was shown to increase morphine consumption during post-operative period to relieve pain. In the present study, we aimed to describe the cellular mechanisms respo...

journal_title：Neuropharmacology

authors： Nowoczyn M,Marie N,Coulbault L,Hervault M,Davis A,Hanouz JL,Allouche S

更新日期：2013-10-01 00:00:00

abstract：:The neuroactive steroid (NAS) tetrahydrodeoxycorticosterone (THDOC) increases protein kinase C (PKC) mediated phosphorylation of extrasynaptic GABAA receptor (GABAAR) subunits leading to increased surface expression of α4/β3 subunit-containing extrasynaptic GABAARs, leading to a sustained increase in GABAAR tonic curr...

journal_title：Neuropharmacology

authors： Modgil A,Parakala ML,Ackley MA,Doherty JJ,Moss SJ,Davies PA

更新日期：2017-02-01 00:00:00

abstract：:Adinazolam (ADI) is a new benzodiazepine with anxiolytic and antidepressant properties. To assess its effects on the acute stress response, rats were given a single intraperitoneal injection of 2.5 or 5.0 mg/kg of ADI and stressed for 1 hr by restraint. Neither dose of ADI had any effect on heart rate, blood pressure ...

journal_title：Neuropharmacology

authors： Krieman MJ,Hershock DM,Greenberg IJ,Vogel WH

更新日期：1992-01-01 00:00:00

abstract：:The increased pro-inflammatory cytokine production was previously observed in Alzheimer's disease (AD). We sought to explore whether acetylcholinesterase inhibitor (AChEI) therapy ameliorates clinical symptoms in AD through down-regulation of inflammation. Expression and release of monocyte chemotactic protein-1 (MCP-...

journal_title：Neuropharmacology

authors： Reale M,Iarlori C,Gambi F,Feliciani C,Isabella L,Gambi D

更新日期：2006-04-01 00:00:00

abstract：:The importance of h5-HT1B receptor selectivity for 5-HT terminal autoreceptor activity was investigated with the selective h5-HT1B receptor ligands SB 219085, SB 220272, SB 224289 and SB 216641. The studies employed measurement of compound affinity and efficacy in vitro and the measurement of extracellular 5-HT in the...

journal_title：Neuropharmacology

authors： Roberts C,Price GW,Gaster L,Jones BJ,Middlemiss DN,Routledge C

更新日期：1997-04-01 00:00:00

abstract：:Improgan is a chemical congener of the H2 antagonist cimetidine which shows the profile of a highly effective analgesic when administered directly into the CNS. Although the improgan receptor is unknown, improgan activates analgesic pathways which are independent of opioids, but may utilize cannabinoid mechanisms. To ...

journal_title：Neuropharmacology

authors： Hough LB,de Esch IJ,Janssen E,Phillips J,Svokos K,Kern B,Trachler J,Abood ME,Leurs R,Nalwalk JW

更新日期：2006-09-01 00:00:00

abstract：:The aim of the present study was to evaluate functional changes of mGluR5 expression in advanced Alzheimer's disease (AD) using positron emission tomography (PET) with an mGluR5 specific radiotracer ([18F]FPEB) in 5xFAD AD model. Subsequently, in the same animal, mGluR5 expression was quantified by immunoassay techniq...

journal_title：Neuropharmacology

authors： Lee M,Lee HJ,Park IS,Park JA,Kwon YJ,Ryu YH,Kim CH,Kang JH,Hyun IY,Lee KC,Choi JY

更新日期：2018-05-01 00:00:00

abstract：:Previously we have reported that astrocytes deprived of glucose were highly vulnerable to peroxynitrite (Choi and Kim, J. Neurosci. Res. 54 (1998) 870; Neurosci. Lett. 256 (1988) 109; Ju et al., J. Neurochem. 74 (2000) 1989). Here we report that ciclopirox, which is clinically used as an anti-fungal agent, completely ...

journal_title：Neuropharmacology

authors： Choi JJ,Kong MY,Lee SJ,Kim HC,Ko KH,Kim WK

更新日期：2002-09-01 00:00:00

abstract：:Phenytoin (DPH) is a clinically useful sodium (Na) channel blocker with efficacy against partial and generalized seizures. We have developed a novel hydantoin compound (HA) using comparative molecular field analysis (CoMFA) and evaluated its effects on hNa(v)1.2 channels. Both DPH and HA demonstrated affinity for rest...

journal_title：Neuropharmacology

authors： Lenkowski PW,Batts TW,Smith MD,Ko SH,Jones PJ,Taylor CH,McCusker AK,Davis GC,Hartmann HA,White HS,Brown ML,Patel MK

更新日期：2007-03-01 00:00:00

abstract：:Recent evidence suggests an early involvement of dopaminergic (DA) processes and terminals in Parkinson's disease (PD). The arborization of neurons depends on the actin cytoskeleton, which in turn is regulated by small GTPases of the Rho family, encompassing Rho, Rac and Cdc42 subfamilies. Indeed, some reports point t...

journal_title：Neuropharmacology

authors： Musilli M,Ciotti MT,Pieri M,Martino A,Borrelli S,Dinallo V,Diana G

更新日期：2016-10-01 00:00:00

abstract：:Rats injected intrastriatally with kainic acid (KA), in contrast to sham-treated (control) animals, showed no tolerance toward catalepsy induced by chronic haloperidol treatment (28 days). After termination of chronic haloperidol treatment in control animals, apomorphine-induced stereotypy was significantly enhanced a...

journal_title：Neuropharmacology

authors： Zarkovsky AM,Nurk AM,Rägo LK,Allikmets LH

更新日期：1982-02-01 00:00:00

abstract：OBJECTIVES:Recombinant tissue plasminogen activator (rtPA) is widely used for patients with thromboembolic disease, and increasing evidence indicates that it can directly induce neurotoxicity independent of its thrombolysis property. Here, we aimed to confirm the long-term effect of rtPA on animal's behavior, and inves...

journal_title：Neuropharmacology

authors： Dong MX,Li CM,Shen P,Hu QC,Wei YD,Ren YF,Yu J,Gui SW,Liu YY,Pan JX,Xie P

更新日期：2018-01-01 00:00:00

abstract：:The accumulation of β-amyloid (Aβ) is one of the hallmarks of Alzheimer disease (AD). Beyond the inflammatory reactions promoted by Aβ, it has been demonstrated that the prokineticin (PK) system, composed of the chemokine prokineticin 2 (PK2) and its receptors, is involved in Aβ toxicity. In this study we have analyze...

journal_title：Neuropharmacology

authors： Caioli S,Severini C,Ciotti T,Florenzano F,Pimpinella D,Petrocchi Passeri P,Balboni G,Polisca P,Lattanzi R,Nisticò R,Negri L,Zona C

更新日期：2017-04-01 00:00:00

abstract：:The effects of Substance P (SP) and of a specific nonpeptide antagonist of the NK1 receptor (RP 67580) on preovulatory gonadotropin surges and on the in vitro GnRH induced LH surge were investigated in cycling female rats. A subcutaneous injection of SP (0.5 mg/kg body weight) at 12.00 h on the proestrous day signific...

journal_title：Neuropharmacology

authors： Duval P,Lenoir V,Garret C,Kerdelhue B

更新日期：1996-01-01 00:00:00

abstract：:Interferon injection in morphine dependent rats prior to naloxone treatment eliminates 7 behavioral sings of the abstinence (withdrawal) phenomenon. When a single injection of interferon was given prior to chronic morphine treatment it reduces opiate addiction liability. ...

journal_title：Neuropharmacology

authors： Dafny N

更新日期：1983-05-01 00:00:00

abstract：:Glibenclamide (GBC), a sulfonylurea receptor 1 blocker, emerges recently as a promising neuron protectant in various neurological disorders. This study aimed to determine whether GBC improves survival and neurological outcome of status epilepticus (SE). Male Sprague-Dawley rats successfully undergoing SE for 2.5 h (n ...

journal_title：Neuropharmacology

authors： Lin Z,Huang H,Gu Y,Huang K,Hu Y,Ji Z,Wu Y,Wang S,Yang T,Pan S

更新日期：2017-07-15 00:00:00