The endozepine ODN stimulates [3H]thymidine incorporation in cultured rat astrocytes.

abstract：:Vasopressin V1a receptors in the rat brain have been studied for their role in modulating aggression and anxiety. In the current study blood-oxygen-level-dependent (BOLD) functional MRI was used to test whether V1a receptors modulate neural processing in the maternal brain when dams are exposed to a male intruder. Pri...

journal_title：Neuropharmacology

authors： Caffrey MK,Nephew BC,Febo M

更新日期：2010-01-01 00:00:00

abstract：:We evaluated the anticonvulsant efficacy of the antiepileptic drugs (AEDs) lamotrigine (LTG) and felbamate (FBM) in amygdala kindled rats that had been preselected with respect to their response to phenytoin. Anticonvulsant response was tested by determining the afterdischarge threshold (ADT), i.e., a sensitive measur...

journal_title：Neuropharmacology

authors： Ebert U,Reissmüller E,Löscher W

更新日期：2000-07-24 00:00:00

abstract：:Dopamine (DA) is a major catecholamine neurotransmitter in the mammalian brain that controls neural circuits involved in the cognitive, emotional, and motor aspects of goal-directed behavior. Accordingly, perturbations in DA neurotransmission play a central role in several neuropsychiatric disorders. Somewhat surprisi...

journal_title：Neuropharmacology

authors： Covey DP,Mateo Y,Sulzer D,Cheer JF,Lovinger DM

更新日期：2017-09-15 00:00:00

abstract：:There is no in situ evidence hitherto for a modulation by ATP of the glutamatergic excitatory transmission onto medium spiny neurons (MSNs) in the rat striatum. In order to resolve this question, we used the patch-clamp technique in brain slice preparations to record excitatory postsynaptic currents (EPSCs) evoked by ...

journal_title：Neuropharmacology

authors： Tautenhahn M,Leichsenring A,Servettini I,Pesic M,Sperlagh B,Nörenberg W,Illes P

更新日期：2012-03-01 00:00:00

abstract：:JAK4D, a first-in-class thyrotropin-releasing hormone (TRH)-based compound, is a prospective therapeutic candidate offering a multifaceted approach to treating neurodegeneration and other CNS conditions. The purpose of these studies was to determine the ability of JAK4D to bind to TRH receptors in human brain and to e...

journal_title：Neuropharmacology

authors： Kelly JA,Boyle NT,Cole N,Slator GR,Colivicchi MA,Stefanini C,Gobbo OL,Scalabrino GA,Ryan SM,Elamin M,Walsh C,Vajda A,Goggin MM,Campbell M,Mash DC,O'Mara SM,Brayden DJ,Callanan JJ,Tipton KF,Della Corte L,Hunter J,

更新日期：2015-02-01 00:00:00

abstract：:The guinea-pig substantia nigra receives a 5-hydroxytryptaminergic (5-HT ergic) projection from the dorsal raphé nucleus. In this study we have attempted to identify the 5-HT receptor subtype mediating release of acetylcholinesterase (AChE) from nigral neurones, measured by assay of perfusate obtained via chronically ...

journal_title：Neuropharmacology

authors： Dickie BG,Greenfield SA

更新日期：1995-09-01 00:00:00

abstract：:Long-term memory formation is known to be critically dependent upon de novo gene expression in the brain. As a consequence, pharmacological enhancement of the transcriptional processes mediating long-term memory formation provides a potential therapeutic strategy for cognitive disorders involving aberrant neuroplastic...

journal_title：Neuropharmacology

authors： Fass DM,Reis SA,Ghosh B,Hennig KM,Joseph NF,Zhao WN,Nieland TJ,Guan JS,Kuhnle CE,Tang W,Barker DD,Mazitschek R,Schreiber SL,Tsai LH,Haggarty SJ

更新日期：2013-01-01 00:00:00

abstract：:The objective of this study was to compare nAChR-mediated neurotransmitter release from slices of rat striatum, frontal cortex and hippocampus following chronic (-)-nicotine (Nic) administration (tartrate salt, 2 mg/kg twice daily for 10 days). Binding studies were also conducted to measure changes in receptor density...

journal_title：Neuropharmacology

authors： Jacobs I,Anderson DJ,Surowy CS,Puttfarcken PS

更新日期：2002-10-01 00:00:00

abstract：:In this study, the P2 receptor-mediated modulation of [3H]glutamate and [3H]noradrenaline release were examined in rat spinal cord slices. Adenosine 5'-triphosphate (ATP), adenosine 5'-diphosphate (ADP), and 2-methylthioadenosine 5'-diphosphate (2-MeSADP) decreased the electrical stimulation-evoked [3H]glutamate efflu...

journal_title：Neuropharmacology

authors： Heinrich A,Kittel A,Csölle C,Sylvester Vizi E,Sperlágh B

更新日期：2008-02-01 00:00:00

abstract：:The serotonin transporter (SERT) facilitates high affinity reuptake of 5-HT from the extracellular fluid and dysregulation of transporter function has been implicated in a range of mood disorders including depression. Recent studies have linked immune system activation to depression as well as to altered serotonin tra...

journal_title：Neuropharmacology

authors： Brown E,Mc Veigh CJ,Santos L,Gogarty M,Müller HK,Elfving B,Brayden DJ,Haase J

更新日期：2018-07-15 00:00:00

abstract：:In fixed tissue, neuronal NADPH-diaphorase staining results from nitric oxide synthase (NOS) activity. Neuronal NOS only synthesizes nitric oxide once activated by the binding of Ca2+/calmodulin. We show here that neuronal NADPH-diaphorase staining is also dependent on Ca2+/calmodulin, implying that only activated NOS...

journal_title：Neuropharmacology

authors： Morris BJ,Simpson CS,Mundell S,Maceachern K,Johnston HM,Nolan AM

更新日期：1997-11-01 00:00:00

abstract：:Depolarisation of [3H]inositol prelabelled slices of cerebral cortex of the rat, with elevated extracellular K+ or the alkaloid veratrine, induced a marked accumulation of [3H]inositol monophosphate in the presence of 5 mM Li+. The effects of these stimuli were concentration-related with maximal responses obtained at ...

journal_title：Neuropharmacology

authors： Kendall DA,Nahorski SR

更新日期：1987-06-01 00:00:00

abstract：:It has been shown that endogenous adenosine 5'-triphosphate (ATP) as well as its exogenously applied structural analogue, 2-methylthio ATP (2-MeSATP), facilitate the release of dopamine from axon terminals in the rat nucleus accumbens (NAc) by activating ATP-sensitive P2 receptors. In the present study, reversed micro...

journal_title：Neuropharmacology

authors： Krügel U,Kittner H,Franke H,Illes P

更新日期：2001-06-01 00:00:00

abstract：:Neurons treated with sub-lethal concentrations of amyloid-beta1-42 developed phenotypic changes and selectively bound a CD14-IgG chimera; in co-cultures, microglia recognised and killed these amyloid-beta1-42 -damaged neurons. Pre-treatment with the platelet-activating factor (PAF) antagonists (Hexa-PAF, CV6209 or gin...

journal_title：Neuropharmacology

authors： Bate C,Kempster S,Williams A

更新日期：2006-08-01 00:00:00

abstract：:N-methyl-D-aspartate (NMDA) receptor antagonists have therapeutic potential in numerous CNS disorders ranging from acute neurodegeneration (e.g. stroke and trauma), chronic neurodegeneration (e.g. Parkinson's disease, Alzheimer's disease, Huntington's disease, ALS) to symptomatic treatment (e.g. epilepsy, Parkinson's ...

journal_title：Neuropharmacology

authors： Parsons CG,Danysz W,Quack G

更新日期：1999-06-01 00:00:00

abstract：:Visual cues that become associated with the consumption of psychostimulant drugs energize craving and the intake of the drug by mechanisms of which little is known. In two experiments using in vivo microdialysis in freely moving rats we compared the effects of visual and auditory stimulation with that of cocaine (0, 5...

journal_title：Neuropharmacology

authors： Müller CP,De Souza Silva MA,Huston JP

更新日期：2007-03-01 00:00:00

abstract：:Morphine was shown to enhance dopamine release in the rat olfactory tubercle, nucleus accumbens, prefrontal cortex and pyriform cortex, as assessed by increased 3-methoxytyramine (3-MT) levels and 3-MT accumulation after pargyline treatment. In contrast, both 3-MT levels and accumulation after pargyline were unaffecte...

journal_title：Neuropharmacology

authors： Wood PL,Rao TS

更新日期：1991-04-01 00:00:00

abstract：:Animal models of inflammatory pain are characterized by the release of inflammatory mediators such as cytokines and neurotrophic factors, and enhanced analgesic sensitivity to opioids. In this study, we examine the mechanisms underlying this effect, in particular the roles of cholecystokinin (CCK) and nerve growth fac...

journal_title：Neuropharmacology

authors： Xanthos DN,Kumar N,Theodorsson E,Coderre TJ

更新日期：2009-03-01 00:00:00

abstract：:Orexin contributes to the expression of the cardiovascular and behavioural response of some forms of stress, including novelty stress. Thus, Almorexant, a dual receptor antagonist that blocks the two known orexin receptors, Ox1R and Ox2R, reduces these responses. However, it is not known if the reduction results from ...

journal_title：Neuropharmacology

authors： Beig MI,Dampney BW,Carrive P

更新日期：2015-02-01 00:00:00

abstract：:Rabbits anesthetized with volatile anesthetics were given bolus doses of the n-methyl-D-aspartate (NMDA) receptor antagonist MK-801. Following observation and recording of the hemodynamic and electroencephalographic effects of MK-801, the animals were tested for requirements of volatile anesthetic to prevent movement ...

journal_title：Neuropharmacology

authors： Scheller MS,Zornow MH,Fleischer JE,Shearman GT,Greber TF

更新日期：1989-07-01 00:00:00

abstract：:The acute effects of simvastatin lactone (lipophilic) and simvastatin acid (hydrophilic) on transient focal ischemia were assessed using the isolated guinea pig brain maintained in vitro by arterial perfusion. This new model of cerebral ischemia allows the assessment of the very early phase of the ischemic process, wi...

journal_title：Neuropharmacology

authors： Beretta S,Pastori C,Sala G,Piazza F,Ferrarese C,Cattalini A,de Curtis M,Librizzi L

更新日期：2011-05-01 00:00:00

abstract：:Considerable biochemical evidence suggests that the protein kinase C (PKC) signaling cascade may be a convergent point for the actions of anti-manic agents, and that excessive PKC activation can disrupt prefrontal cortical regulation of thinking and behavior. To date, however, brain protein targets of PKC's anti-manic...

journal_title：Neuropharmacology

authors： Szabo ST,Machado-Vieira R,Yuan P,Wang Y,Wei Y,Falke C,Cirelli C,Tononi G,Manji HK,Du J

更新日期：2009-01-01 00:00:00

abstract：:Desensitization of the nicotinic acetylcholine receptor (nAChR) containing the β2 subunit is a potentially critical mechanism underlying the body weight (BW) reducing effects of nicotine. The purpose of this study was a) to determine the α subunit(s) that partners with the β2 subunit to form the nAChR subtype that end...

journal_title：Neuropharmacology

authors： Dezfuli G,Olson TT,Martin LM,Keum Y,Siegars BA,Desai A,Uitz M,Sahibzada N,Gillis RA,Kellar KJ

更新日期：2020-04-01 00:00:00

abstract：:The activity of tianeptine (2.5 and 5.0 mg/kg twice daily, i.p.) and of sertraline (5.0 mg/kg, twice daily, i.p.) were assessed in three animal models of depression. In the Behavioural Despair Test, acute treatment with sertraline or tianeptine (5.0 mg/kg) significantly reduced the immobility time. In the olfactory bu...

journal_title：Neuropharmacology

authors： Kelly JP,Leonard BE

更新日期：1994-08-01 00:00:00

abstract：:The stable transcription factor ΔFosB is induced in the nucleus accumbens (NAc) by chronic exposure to several drugs of abuse, and transgenic expression of ΔFosB in the striatum enhances the rewarding properties of morphine and cocaine. However, the mechanistic basis for these observations is incompletely understood. ...

journal_title：Neuropharmacology

authors： Sim-Selley LJ,Cassidy MP,Sparta A,Zachariou V,Nestler EJ,Selley DE

更新日期：2011-12-01 00:00:00

abstract：:Extensive evidence indicates that noradrenergic activation of the basolateral amygdala (BLA) is essential for mediating emotional arousal effects on memory consolidation in different target regions. However, the mechanism by which BLA activation regulates such information storage processes remains largely elusive. Her...

journal_title：Neuropharmacology

authors： Chen Y,Barsegyan A,Nadif Kasri N,Roozendaal B

更新日期：2018-10-01 00:00:00

abstract：:GABA(B) receptor antagonists have been shown to have antidepressant-like properties in animal models and thus, could represent a novel approach for the treatment of depression. The neurobiological mechanisms underlying these effects are currently unknown. Adult hippocampal neurogenesis (the birth of new neurons) is th...

journal_title：Neuropharmacology

authors： Felice D,O'Leary OF,Pizzo RC,Cryan JF

更新日期：2012-12-01 00:00:00

abstract：:This study examined the role of cannabinoid CB1 receptors (CB1r) in aggressive behavior. Social encounters took place in grouped and isolated mice lacking CB1r (CB1KO) and in wild-type (WT) littermates. Cognitive impulsivity was evaluated in the delayed reinforcement task (DRT). Gene expression analyses of monoaminoox...

journal_title：Neuropharmacology

authors： Rodriguez-Arias M,Navarrete F,Daza-Losada M,Navarro D,Aguilar MA,Berbel P,Miñarro J,Manzanares J

更新日期：2013-12-01 00:00:00

abstract：:Whole-cell patch clamp recording and immunohistochemistry were used to investigate the expression of P2X receptors on rat parasympathetic ganglion neurons of the otic, sphenopalatine, submandibular, intracardiac and paratracheal ganglia. Neurons from all five ganglia responded to ATP with a rapidly activating, sustain...

journal_title：Neuropharmacology

authors： Ma B,Ruan HZ,Burnstock G,Dunn PM

更新日期：2005-04-01 00:00:00

abstract：:Presynaptic nicotinic acetylcholine receptors on striatal nerve terminals modulate the release of dopamine. Using rat striatal synaptosomes loaded with [3H]dopamine, we have characterized the action of the selective nicotinic agonist, (+/-)anatoxin-a, with respect to [3H]dopamine release, in order to explore the mecha...

journal_title：Neuropharmacology

authors： Soliakov L,Gallagher T,Wonnacott S

更新日期：1995-11-01 00:00:00