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Double dissociating effects of sensory stimulation and cocaine on serotonin activity in the occipital and temporal cortices.

Abstract：

:Visual cues that become associated with the consumption of psychostimulant drugs energize craving and the intake of the drug by mechanisms of which little is known. In two experiments using in vivo microdialysis in freely moving rats we compared the effects of visual and auditory stimulation with that of cocaine (0, 5, 10, 20mg/kg; i.p.) on the extracellular serotonin (5-HT) activity in the occipital and temporal cortices in relation to behavior. Visual stimulation increased 5-HT in the occipital, but not temporal cortex, parallel to an increase in locomotion. Auditory stimulation decreased 5-HT in the auditory, but not occipital cortex, thus, showing a double dissociated 5-HT response. These data suggest that a locally restricted 5-HT response to sensory stimulation may gate behavioral activity sense-modality selectively. Cocaine affected 5-HT in the occipital cortex and behavioral activity in the same direction as visual stimulation, but in an amplified and prolonged way. In the temporal cortex cocaine also caused an increase in 5-HT. The findings demonstrate common effects of visual stimulation and cocaine on 5-HT activity in the occipital cortex in relation to locomotor activity. The results suggest that concepts of how neutral visual cues become powerful energizers of addiction-related behaviors should be expanded to incorporate not only an acute enhancement of reward processing mechanisms, but, in parallel, also an amplified processing of visual stimuli in the occipital cortex.

journal_name

Neuropharmacology

journal_title

Neuropharmacology

authors

Müller CP,De Souza Silva MA,Huston JP

doi

10.1016/j.neuropharm.2006.10.002

subject

Has Abstract

pub_date

2007-03-01 00:00:00

pages

854-62

issue

3

eissn

0028-3908

issn

1873-7064

pii

S0028-3908(06)00357-1

journal_volume

52

pub_type

杂志文章

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