Alterations in brain Protein Kinase A activity and reversal of morphine tolerance by two fragments of native Protein Kinase A inhibitor peptide (PKI).

abstract：:In genetically obese (ob/ob) mice the development of obesity was correlated with the binding of [3H] (+)-amphetamine to the hypothalamus. In 39-day-old ob/ob mice, which had obtained a body weight greater than 150% of their lean littermates, hypothalamic [3H] (+)-amphetamine binding had increased by approximately 60% ...

journal_title：Neuropharmacology

authors： Hauger R,Hulihan-Giblin B,Paul SM

更新日期：1986-03-01 00:00:00

abstract：:The excitatory amino acid antagonist, D-alpha-aminoadipate, was found to be a potent antagonist of responses to N-methyl-D-aspartate and L-aspartate, but less potent against L-glutamate responses of neurones in the rat caudal trigeminal nucleus. The responses to quisqualate and kainate were relatively unaffected by D-...

journal_title：Neuropharmacology

authors： Salt TE,Hill RG

更新日期：1982-05-01 00:00:00

abstract：:Cannabidiol (CBD), the main non-psychotomimetic component of marihuana, exhibits anxiolytic-like properties in many behavioural tests, although its potential for treating major depression has been poorly explored. Moreover, the mechanism of action of CBD remains unclear. Herein, we have evaluated the effects of CBD fo...

journal_title：Neuropharmacology

authors： Linge R,Jiménez-Sánchez L,Campa L,Pilar-Cuéllar F,Vidal R,Pazos A,Adell A,Díaz Á

更新日期：2016-04-01 00:00:00

abstract：:Under conditions in which NG-nitro-L-arginine (NOArg) treatment prevents morphine tolerance, NOArg induces a slow progressive inhibition of nitric oxide synthase (NOS), starting at approx. 20% after a single treatment and increasing to approx. 65% after 10 days. Studies designed to examine potential changes in NOS lev...

journal_title：Neuropharmacology

authors： Babey AM,Kolesnikov Y,Cheng J,Inturrisi CE,Trifilletti RR,Pasternak GW

更新日期：1994-11-01 00:00:00

abstract：:Peristaltic reflex activity in the guinea-pig isolated ileum was elicited by slow intraluminal infusion of Tyrode solution. The reflex was abolished by the ganglionic blocking drug hexamethonium. However, in more than half of the preparations, the peristaltic reflex was restored by the opioid antagonist naloxone. Hexa...

journal_title：Neuropharmacology

authors： Barthó L,Holzer P,Lembeck F

更新日期：1987-11-01 00:00:00

abstract：:The pharmacological profile of (S)-(+)-2-(3'-carboxybicyclo[1.1.1]pentyl)-glycine (CBPG) and of other group 1 metabotropic glutamate (mGlu) receptor agents were studied in BHK cells transfected with mGlu receptor subtypes or in native receptors in brain slices by measuring second messenger responses. The mGlu receptor...

journal_title：Neuropharmacology

authors： Mannaioni G,Attucci S,Missanelli A,Pellicciari R,Corradetti R,Moroni F

更新日期：1999-07-01 00:00:00

abstract：:The influence of the subunit composition of human GABA(A) receptors upon the GABA-modulatory properties of 5alpha-pregnan-3alpha-ol-20-one (5alpha,3alpha) has been examined using the Xenopus laevis oocyte expression system and the two electrode voltage-clamp technique. Steroid potency (EC(50)) is modestly influenced b...

journal_title：Neuropharmacology

authors： Belelli D,Casula A,Ling A,Lambert JJ

更新日期：2002-09-01 00:00:00

abstract：:The gender difference in behavioral and hormonal response to stress is well known, but the underlying mechanism remains elusive. Arginine-vasopressin (AVP) and corticotrophin-releasing hormone (CRH) are two major regulatory peptides in the brain involved in stress regulation. Their response to stress has been shown to...

journal_title：Neuropharmacology

authors： Huang Q,Zhu H,Fischer DF,Zhou JN

更新日期：2008-06-01 00:00:00

abstract：:Based on significant amount of evidence, it is now generally believed, that one underlying cause for neurodegenerative diseases, could be dysregulation in inflammatory processes. The actual mechanisms involved are not yet well understood. Several studies have demonstrated the potent analgesic and anti-inflammatory act...

journal_title：Neuropharmacology

authors： Safieh-Garabedian B,Jabbur SJ,Dardenne M,Saadé NE

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND:Atypical antipsychotic drugs, particularly olanzapine, represent a mainstay in the treatment of psychoses; however, their use is commonly associated with weight gain and diabetes. The aim of this study was to determine whether combined administration of olanzapine and zonisamide can be used to prevent olanza...

journal_title：Neuropharmacology

authors： Stefanidis A,Watt MJ,Cowley MA,Oldfield BJ

更新日期：2017-09-01 00:00:00

abstract：:Histamine is an aminergic neurotransmitter, which regulates wakefulness, arousal and attention in the central nervous system. Histamine receptors have been the target of efforts to develop pro-cognitive drugs to treat disorders such as Alzheimer's disease and schizophrenia. Cognitive functions including attention are ...

journal_title：Neuropharmacology

authors： Andersson R,Galter D,Papadia D,Fisahn A

更新日期：2017-05-15 00:00:00

abstract：:Inhibition of 5-HT(6) receptors has been shown to improve memory consolidation, thus we tested whether a novel tryptamine analog with high affinity for 5-HT(6) receptors, BGC20-761 (5-methoxy-2-phenyl-N,N-dimethyltryptamine, PMDT), can enhance long-term memory. BGC20-761 (10 mg/kg i.p.) alone had no effect on social r...

journal_title：Neuropharmacology

authors： Mitchell ES,Hoplight BJ,Lear SP,Neumaier JF

更新日期：2006-03-01 00:00:00

abstract：:The subtype-selectivity of racemic [(3)H]CP-101,606, a novel high-affinity NMDA receptor radioligand was determined using defined recombinant NMDA receptor subunits expressed in HEK 293 cells. [(3)H]CP-101,606 binds to adult rodent forebrain and NR1/NR2B receptors expressed in HEK 293 cells with K(D)=4.2 nM and 6.0 nM...

journal_title：Neuropharmacology

authors： Chazot PL,Lawrence S,Thompson CL

更新日期：2002-03-01 00:00:00

abstract：:The activation of Group I metabotropic glutamate receptors (GI mGluRs) in the hippocampus results in the appearance of persistent bursts of synchronised neuronal activity. In response to other stimuli, such activity is known to cause the release of the purines ATP and its neuroactive metabolite, adenosine. We have thu...

journal_title：Neuropharmacology

authors： Lopatář J,Dale N,Frenguelli BG

更新日期：2015-06-01 00:00:00

abstract：:In the present study we examined the effect of MPEP [2-methyl-6-(phenylethynyl)-pyridine] a potent, selective and systemically active metabotropic glutamate receptor (mGluR) type I (subtype mGluR5) antagonist on conditioned morphine reward in mice. In an unbiased version of conditioned place preference (CPP) paradigm,...

journal_title：Neuropharmacology

authors： Popik P,Wróbel M

更新日期：2002-12-01 00:00:00

abstract：:Gliomas are the leading cause of cancer-related mortality worldwide, and the incidence is increasing. Because gliomas often become resistant to radiation treatment, it is urgent to develop novel therapeutic methods that are more effective and less toxic than current therapies so as to enhance patient survival and qual...

journal_title：Neuropharmacology

authors： Luo Z,Bai M,Xiao X,Zhang W,Liu X,Yang X,Li S,Huan Y,Wu Z,Zhang X,Cao W

更新日期：2015-02-01 00:00:00

abstract：:The presence of ethanol, 100 microM, in the superfusate enhanced the spontaneous release of previously uptaken [3H]-dopamine from slices of rat corpus striatum, but produced a small inhibition of K+-stimulated release. The concomitant presence of picrotoxin, 10 microM, in the superfusate prevented the enhancement of s...

journal_title：Neuropharmacology

authors： Samuel D,Lynch MA,Littleton JM

更新日期：1983-12-01 00:00:00

abstract：:Bradykinin interacts with the bradykinin B2 receptor on dorsal root ganglion (DRG) neurons, setting off a series of reactions inside the cells that ultimately make the vanilloid receptor 1 more sensitive to a normal stimulus by activating various enzymes coupled with second messenger signaling cascades. Zaltoprofen, a...

journal_title：Neuropharmacology

authors： Tang HB,Inoue A,Oshita K,Hirate K,Nakata Y

更新日期：2005-06-01 00:00:00

abstract：:Chronic pain states are highly prevalent and yet poorly controlled by currently available analgesics, representing an enormous clinical, societal, and economic burden. Existing pain medications have significant limitations and adverse effects including tolerance, dependence, gastrointestinal dysfunction, cognitive imp...

journal_title：Neuropharmacology

authors： Woodhams SG,Chapman V,Finn DP,Hohmann AG,Neugebauer V

更新日期：2017-09-15 00:00:00

abstract：:Accumulating evidence indicates that exposure to general anesthetics during infancy and childhood can cause persistent cognitive impairment, alterations in synaptic plasticity, and, to a lesser extent, increased incidence of behavioral disorders. Unfortunately, the developmental parameters of susceptibility to general...

journal_title：Neuropharmacology

authors： Landin JD,Palac M,Carter JM,Dzumaga Y,Santerre-Anderson JL,Fernandez GM,Savage LM,Varlinskaya EI,Spear LP,Moore SD,Swartzwelder HS,Fleming RL,Werner DF

更新日期：2019-05-15 00:00:00

abstract：:Administration of 0.13% lead acetate solution as drinking fluid to breeding mice was without significant effect on the numbers of live or dead births or on weight of pups at 1 day. The appearance of fur was delayed and the body weights at 21 days and 31-38 weeks were smaller than in controls. On weaning, the treated o...

journal_title：Neuropharmacology

authors： Donald JM,Cutler MG,Moore MR,Bradley M

更新日期：1986-02-01 00:00:00

abstract：:It has previously been shown that the neuropeptide galanin plays a role in the age-dependent regulation of hippocampal synaptic plasticity and spatial memory. Here, we further extend these studies by demonstrating that galanin knockout mice also have deficits in an object-in-place spatial memory task. In contrast howe...

journal_title：Neuropharmacology

authors： Massey PV,Warburton EC,Wynick D,Brown MW,Bashir ZI

更新日期：2003-01-01 00:00:00

abstract：:Ifenprodil, which is clinically used as a cerebral vasodilator, inhibited rat brain type A (MAO-A) and type B (MAO-B) monoamine oxidase activity. It did not, however, affect rat lung semicarbazide-sensitive amine oxidase. The degree of inhibition of either form of MAO was not changed by 30 min preincubation of the enz...

journal_title：Neuropharmacology

authors： Arai Y,Nakazato K,Kinemuchi H,Tadano T,Satoh N,Oyama K,Kisara K

更新日期：1991-07-01 00:00:00

abstract：:Mutations in hundreds of genes contribute to cognitive and behavioral dysfunction associated with developmental brain disorders (DBDs). Due to the sheer number of risk factors available for study combined with the cost of developing new animal models, it remains an open question how genes should be prioritized for in-...

journal_title：Neuropharmacology

authors： Ogden KK,Ozkan ED,Rumbaugh G

更新日期：2016-01-01 00:00:00

abstract：:Compound IG20 is a newly synthesised sulphated glycolipid that promotes neuritic outgrowth and myelinisation, at the time it causes the inhibition of glial proliferation and facilitates exocytosis in chromaffin cells. Here we have shown that IG20 at 0.3-10 μM afforded neuroprotection in rat hippocampal slices stressed...

journal_title：Neuropharmacology

authors： Punzón E,García-Alvarado F,Maroto M,Fernández-Mendívil C,Michalska P,García-Álvarez I,Arranz-Tagarro JA,Buendia I,López MG,León R,Gandía L,Fernández-Mayoralas A,García AG

更新日期：2017-04-01 00:00:00

abstract：:In rat brain, the number of beta-adrenoceptors and activity of noradrenaline-dependent adenylate cyclase were examined after treatment with desipramine (7.5 mg kg-1 day-1) for three days alone or in combination with the alpha 2-adrenoceptor antagonist, yohimbine (2 mg kg-1 12 hr-1), or with phenoxybenzamine (7.5 mg kg...

journal_title：Neuropharmacology

authors： Campbell IC,McKernan RM,Smokcum RW,Stephenson JD,Weeramanthri TB

更新日期：1984-12-01 00:00:00

abstract：:L-AP4 is an agonist at the presynaptic metabotropic receptor subtypes mGluR4, mGluR6 and mGluR7. In vitro, L-AP4 has been shown to reduce glutamate release and thereby suppress hippocampal excitatory transmission. Little data is available with regard to the actions of this compound in vivo. This study examined the eff...

journal_title：Neuropharmacology

authors： Manahan-Vaughan D,Reymann KG

更新日期：1995-08-01 00:00:00

abstract：:Thyroid hormone deficiency during early developmental stages causes a multitude of functional and morphological deficits in the brain. In the present study we investigate the effects of a mutated thyroid hormone receptor TR alpha 1 and the resulting receptor-mediated hypothyroidism on the development of GABAergic neur...

journal_title：Neuropharmacology

authors： Hadjab-Lallemend S,Wallis K,van Hogerlinden M,Dudazy S,Nordström K,Vennström B,Fisahn A

更新日期：2010-06-01 00:00:00

abstract：:Binge alcohol (ethanol) drinking is associated with profound adverse effects on our health and society. Rimonabant (SR141716A), a CB1 receptor inverse agonist, was previously shown to be effective for nicotine cessation and obesity. However, studies using rimonabant were discontinued as it was associated with an incre...

journal_title：Neuropharmacology

authors： Balla A,Dong B,Shilpa BM,Vemuri K,Makriyannis A,Pandey SC,Sershen H,Suckow RF,Vinod KY

更新日期：2018-03-15 00:00:00

abstract：:This study shows that the selective GABAB antagonist CGP 35348 had no effect on body temperature in mice in doses up to 300 mg/kg i.p. However, the highest dose abolished the hypothermia induced by the GABAB agonist baclofen (10 mg/kg i.p.) but not that produced by the GABA-mimetic progabide (200 mg/kg i.p.); the benz...

journal_title：Neuropharmacology

authors： Jackson HC,Nutt DJ

更新日期：1991-05-01 00:00:00