Galanin regulates spatial memory but not visual recognition memory or synaptic plasticity in perirhinal cortex.

abstract：:GABA(B) receptor antagonists have been shown to have antidepressant-like properties in animal models and thus, could represent a novel approach for the treatment of depression. The neurobiological mechanisms underlying these effects are currently unknown. Adult hippocampal neurogenesis (the birth of new neurons) is th...

journal_title：Neuropharmacology

authors： Felice D,O'Leary OF,Pizzo RC,Cryan JF

更新日期：2012-12-01 00:00:00

abstract：:Activation of microglia has been implicated in many neurological conditions including Alzheimer's disease and neuropathic pain. Recent studies provide evidence that P2X ATP receptors on the surface of microglia play a crucial role in initiation of inflammatory cascades. We investigated changes in surface P2X receptors...

journal_title：Neuropharmacology

authors： Raouf R,Chabot-Doré AJ,Ase AR,Blais D,Séguéla P

更新日期：2007-09-01 00:00:00

abstract：:Clinical studies have reported that the nicotinic receptor agonist varenicline improves balance and coordination in patients with several types of ataxia, but confirmation in an animal model has not been demonstrated. This study investigated whether varenicline and nicotine could attenuate the ataxia induced in rats f...

journal_title：Neuropharmacology

authors： Wecker L,Engberg ME,Philpot RM,Lambert CS,Kang CW,Antilla JC,Bickford PC,Hudson CE,Zesiewicz TA,Rowell PP

更新日期：2013-10-01 00:00:00

abstract：:Gliomas are the leading cause of cancer-related mortality worldwide, and the incidence is increasing. Because gliomas often become resistant to radiation treatment, it is urgent to develop novel therapeutic methods that are more effective and less toxic than current therapies so as to enhance patient survival and qual...

journal_title：Neuropharmacology

authors： Luo Z,Bai M,Xiao X,Zhang W,Liu X,Yang X,Li S,Huan Y,Wu Z,Zhang X,Cao W

更新日期：2015-02-01 00:00:00

abstract：:Neurons in thalamic midline and paraventricular nuclei (PVT) display a unique slow afterhyperpolarizing potential (sAHP) following the low threshold spike (LTS) generated by activation of their low voltage Ca(2+) channels. We evaluated the conductances underlying this sAHP using whole-cell patch-clamp recordings in ra...

journal_title：Neuropharmacology

authors： Kolaj M,Zhang L,Renaud LP

更新日期：2014-11-01 00:00:00

abstract：:The kynurenine pathway of tryptophan metabolism has been implicated in brain function, immunoregulation, anti-microbial mechanisms and pregnancy. Some of these actions are due to depletion of tryptophan and others to the formation of biologically active metabolites. This review focuses on the roles of the kynurenine p...

journal_title：Neuropharmacology

authors： Hunt NH,Too LK,Khaw LT,Guo J,Hee L,Mitchell AJ,Grau GE,Ball HJ

更新日期：2017-01-01 00:00:00

abstract：:A genetic component is associated with the development of many forms of epilepsy. Recently, mutations in the GABAA receptor have been linked to several inherited epilepsies. One of these mutations is a non-conservative change of alanine to aspartate in the third transmembrane domain of the alpha1 subunit. To determine...

journal_title：Neuropharmacology

authors： Fisher JL

更新日期：2004-04-01 00:00:00

abstract：:Some phytochemical-derived synthetic compounds have been shown to improve neurological disorders, especially in ischemic stroke. In this study, we identified a novel biscoumarin compound, known as COM 3, which had substantial antioxidant effects in neurons. Next, we found that COM 3 occupies a critical binding site be...

journal_title：Neuropharmacology

authors： Wang J,Zhang W,Lv C,Wang Y,Ma B,Zhang H,Fan Z,Li M,Li X

更新日期：2020-05-01 00:00:00

abstract：:We have used whole-cell patch clamp electrophysiology to characterise the actions of the P2 antagonist, cibacron blue, on the rat recombinant P2X4 receptor, stably expressed in human embryonic kidney 293 (HEK293) cells. In single cells, adenosine triphosphate (ATP) evoked inward currents, but the response was subject ...

journal_title：Neuropharmacology

authors： Miller KJ,Michel AD,Chessell IP,Humphrey PP

更新日期：1998-12-01 00:00:00

abstract：:The effects of (S)-4-amino-5-[(4,4-dimethylcyclohexyl)amino]-5-oxo-pentanoic acid ((S)CR 2249), a new chemical entity selected among a series of glutamic acid derivatives, were investigated on N-methyl-D-aspartate (NMDA)-evoked release of [3H]noradrenaline from rat hippocampal slices. (S)CR 2249 facilitated glycine-me...

journal_title：Neuropharmacology

authors： Lanza M,Bonnafous C,Colombo S,Revel L,Makovec F

更新日期：1997-08-01 00:00:00

abstract：:Recently we reported that fluoxetine (10 mg/kg) improves functional recovery by attenuating blood spinal cord barrier (BSCB) disruption after spinal cord injury (SCI). Here we investigated whether a low-dose of fluoxetine (1 mg/kg) and vitamin C (100 mg/kg), separately not possessing any protective effect, prevents BS...

journal_title：Neuropharmacology

authors： Lee JY,Choi HY,Yune TY

更新日期：2016-10-01 00:00:00

abstract：:Transmission at the parallel fibre-Purkinje neurone synapse of the cerebellum can be depressed by a number of presynaptic receptors: endocannabinoid (CB1), metabotropic glutamate (mGluR4), adenosine (A1) and GABA (GABA(B)), which have been implicated in both short- and long-term synaptic plasticity. Stimulation of par...

journal_title：Neuropharmacology

authors： Bellamy TC

更新日期：2007-02-01 00:00:00

abstract：:We evaluated the anticonvulsant efficacy of the antiepileptic drugs (AEDs) lamotrigine (LTG) and felbamate (FBM) in amygdala kindled rats that had been preselected with respect to their response to phenytoin. Anticonvulsant response was tested by determining the afterdischarge threshold (ADT), i.e., a sensitive measur...

journal_title：Neuropharmacology

authors： Ebert U,Reissmüller E,Löscher W

更新日期：2000-07-24 00:00:00

abstract：:Exposure to abused drugs and stressful experience, two factors that promote the development of addiction, also modify synaptic function in the mesolimbic dopamine system. Here, we show that exposure to a novel environment produces functional synaptic adaptations in the nucleus accumbens (NAc) that mirror the effect of...

journal_title：Neuropharmacology

authors： Rothwell PE,Kourrich S,Thomas MJ

更新日期：2011-12-01 00:00:00

abstract：:The effect of varying the ratio of extraction volume to tissue weight (EVR) on the apparent concentration of histamine (HA) in the hypothalamus of the rat was examined. Increasing the weight of tissue (by pooling 1, 2 or 3 hypothalami), in a constant extraction volume, resulted in progressive decreases in apparent con...

journal_title：Neuropharmacology

authors： Lewis SJ,Verberne AJ,Fennessy MR,Jarrott B

更新日期：1987-08-01 00:00:00

abstract：:Female rats were treated daily with electroconvulsive shocks (ECS) or imipramine (10 mg/kg) for 10 days. Both types of treatment enhanced behavioural responses mediated by 5-hydroxytryptamine (5-HT) and noradrenaline (NA). A behavioural response mediated by dopamine (DA) was enhanced by electroconvulsive shock-treatme...

journal_title：Neuropharmacology

authors： Bhavsar VH,Dhumal VR,Kelkar VV

更新日期：1983-06-01 00:00:00

abstract：:Valid animal models of psychopathology need to include behavioural readouts informed by human findings. In the probabilistic reversal learning (PRL) task, human subjects are confronted with serial reversal of the contingency between two operant stimuli and reward/punishment and, superimposed on this, a low probability...

journal_title：Neuropharmacology

authors： Ineichen C,Sigrist H,Spinelli S,Lesch KP,Sautter E,Seifritz E,Pryce CR

更新日期：2012-11-01 00:00:00

abstract：:The risk of Alzheimer's disease (AD) is higher in patients with type 2 diabetes mellitus (T2DM). Previous studies in high-fat diet-induced AD animal models have shown that brain insulin resistance in these animals leads to the accumulation of amyloid beta (Aβ) and the reduction in GSK-3β phosphorylation, which promote...

journal_title：Neuropharmacology

authors： Kang S,Kim CH,Jung H,Kim E,Song HT,Lee JE

更新日期：2017-02-01 00:00:00

abstract：:We used rats with a sciatic nerve chronic constrictive injury (CCI) and combined behavioural, molecular and morphological approaches to assess the involvement of mGlu5 receptors in neuropathic pain-associated hyperalgesia and spinal cord neuron apoptosis. Mechanical and thermal hyperalgesia developed 2-3 days after su...

journal_title：Neuropharmacology

authors： de Novellis V,Siniscalco D,Galderisi U,Fuccio C,Nolano M,Santoro L,Cascino A,Roth KA,Rossi F,Maione S

更新日期：2004-03-01 00:00:00

abstract：:Nicotinic acetylcholine receptors (nAChRs) are highly conserved between humans and non-human primates. Conservation exists at the level of genomic structure, protein structure and epigenetics. Overall homology of nAChRs at the protein level is 98% in macaques versus 89% in mice, which is highly relevant for evaluating...

journal_title：Neuropharmacology

authors： Shorey-Kendrick LE,Ford MM,Allen DC,Kuryatov A,Lindstrom J,Wilhelm L,Grant KA,Spindel ER

更新日期：2015-09-01 00:00:00

abstract：:It is well established that some members of the Deg/ENaC super family of amiloride sensitive ion channels can participate directly in the transduction of mechanical stimuli by sensory neurons in invertebrates. A large body of work has also implicated the acid sensing ion channels family (ASIC1-4) as participants in re...

journal_title：Neuropharmacology

authors： Omerbašić D,Schuhmacher LN,Bernal Sierra YA,Smith ES,Lewin GR

更新日期：2015-07-01 00:00:00

abstract：:γ-Aminobutyric acid type A receptors that contain the δ subunit (δGABAA receptors) are expressed in multiple types of neurons throughout the central nervous system, where they generate a tonic conductance that shapes neuronal excitability and synaptic plasticity. These receptors regulate a variety of important behavio...

journal_title：Neuropharmacology

authors： Whissell PD,Lecker I,Wang DS,Yu J,Orser BA

更新日期：2015-01-01 00:00:00

abstract：:gamma-Aminobutyric acid (GABA, half-maximal inhibitory concentration, IC50 = 9.9 microM) and (-)-baclofen (IC50 = 4.5 microM) but not 10(-4) M muscimol, exerted a presynaptic inhibitory effect on cholinergic transmission in field-stimulated guinea-pig taenia coli preparations, in vitro. The antagonism by 10(-5) M (1S,...

journal_title：Neuropharmacology

authors： Rónai AZ,Kardos J,Simonyi M

更新日期：1987-11-01 00:00:00

abstract：:gamma-Aminobutyric acid type A (GABA(A)) receptors are an important target for general anesthetics in the central nervous system. Site-directed mutagenesis techniques have identified amino acid residues that are important for the positive modulation of GABA(A) receptors by general anesthetics. In the present study, we...

journal_title：Neuropharmacology

authors： Krasowski MD,Nishikawa K,Nikolaeva N,Lin A,Harrison NL

更新日期：2001-12-01 00:00:00

abstract：:The effect of trans-(+/-)-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl) cyclohexyl]-benzene-acetamide methane sulfonate (U-50,488H), a kappa-opiate agonist-induced tolerance and abstinence on 5-HT1A receptors was determined in regions of the brain and spinal cord of the rat. The administration of U-50,488H (25 mg/kg, i....

journal_title：Neuropharmacology

authors： Reddy VP,Bhargava HN

更新日期：1992-12-01 00:00:00

abstract：:A new in vivo pharmacological method for the quantitative evaluation of alpha 1-adrenoceptor agonists and antagonists has been developed. It consists of recording the myoclonic twitch activity (MTA) of the suprahyoideal muscle of rats anesthetized with urethane. In these animals, the isomers of amphetamine elicited my...

journal_title：Neuropharmacology

authors： Menon MK,Kodama CK,Kling AS,Fitten J

更新日期：1986-05-01 00:00:00

abstract：:The phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB/Akt)/mechanistic target of rapamycin (mTOR) signaling pathway has been associated with several pathologies in the central nervous system (CNS), including epilepsy. There is evidence supporting the hypothesis that the PI3Kγ signaling pathway may mediate the...

journal_title：Neuropharmacology

authors： Lima IVA,Bellozi PMQ,Batista EM,Vilela LR,Brandão IL,Ribeiro FM,Moraes MFD,Moreira FA,de Oliveira ACP

更新日期：2020-10-01 00:00:00

abstract：:We have used a focal stimulation method to study neurotransmission at synapses onto hippocampal pyramidal neurons in cultures derived from neonatal rats. Single functional boutons were visualized by activity-dependent preloading with the fluorescent dye FM1-43, then focally stimulated by localized application of eleva...

journal_title：Neuropharmacology

authors： Liu G,Tsien RW

更新日期：1995-11-01 00:00:00

abstract：:Grip strength deficit is a measure of pain-induced functional disability in rheumatic disease. We tested whether this parameter and tactile allodynia, the standard pain measure in preclinical studies, show parallels in their response to analgesics and basic mechanisms. Mice with periarticular injections of complete Fr...

journal_title：Neuropharmacology

authors： Montilla-García Á,Tejada MÁ,Perazzoli G,Entrena JM,Portillo-Salido E,Fernández-Segura E,Cañizares FJ,Cobos EJ

更新日期：2017-10-01 00:00:00

abstract：:The proconvulsant and anticonvulsant effects of acute and chronic exposure to cocaine were investigated in adult, male, CF-1 mice. The proconvulsant effects of cocaine in mice only manifested themselves after daily exposure to motor-stimulant doses. Although daily treatment decreased electroshock convulsion threshold,...

journal_title：Neuropharmacology

authors： Karler R,Petty C,Calder L,Turkanis SA

更新日期：1989-07-01 00:00:00