A comparison of the release of substance P and some synthetic analogues from micropipettes by microiontophoresis or pressure.

abstract：:There is mounting evidence that inflammatory processes, including activation of microglia, are upregulated in Alzheimer's disease. The importance of this phenomenon is indicated by multiple epidemiological studies showing that patients taking non-steroidal anti-inflammatory drugs (NSAIDs) have a substantially reduced ...

journal_title：Neuropharmacology

authors： Klegeris A,Walker DG,McGeer PL

更新日期：1999-07-01 00:00:00

abstract：:Many studies have demonstrated that negative allosteric modulators (NAM) of metabotropic glutamate receptor 5 (mGlu5) reduce cocaine and methamphetamine seeking in extinction-reinstatement animal models of addiction. Less is known about effects of mGlu5 NAMs in abstinence models, particularly for methamphetamine. We u...

journal_title：Neuropharmacology

authors： Murray CH,Christian DT,Milovanovic M,Loweth JA,Hwang EK,Caccamise AJ,Funke JR,Wolf ME

更新日期：2021-01-12 00:00:00

abstract：:The effects of prostaglandin (PG) E(1) on NO neurotoxicity were examined using rat cultured spinal neurons. Rat cultured spinal neurons exposed to the NO donor, 2,2'-(hydroxynitrosohydrazono) bis-ethanamine (NOC18), showed neurotoxic effects that were accompanied by apoptotic nuclear change, free radical generation, a...

journal_title：Neuropharmacology

authors： Kikuchi S,Shinpo K,Niino M,Tsuji S,Iwabuchi K,Onoé K,Tashiro K

更新日期：2002-04-01 00:00:00

abstract：:The electrophysiological properties and cataleptogenicity of YM-09151-2 (N-[(2RS, 3RS)-1-benzyl-2-methyl-3-pyrrolidinyl]-5-chloro-2-methoxy-4-methylaminobenzamide) were studied in the cat. This drug inhibited the EEG arousal response to electrical stimulation of the mesencephalic reticular formation with the same pote...

journal_title：Neuropharmacology

authors： Yamamoto M,Usuda S,Tachikawa S,Maeno H

更新日期：1982-10-01 00:00:00

abstract：:Recently we reported that fluoxetine (10 mg/kg) improves functional recovery by attenuating blood spinal cord barrier (BSCB) disruption after spinal cord injury (SCI). Here we investigated whether a low-dose of fluoxetine (1 mg/kg) and vitamin C (100 mg/kg), separately not possessing any protective effect, prevents BS...

journal_title：Neuropharmacology

authors： Lee JY,Choi HY,Yune TY

更新日期：2016-10-01 00:00:00

abstract：:Mutations in LRRK2 (leucine-rich repeat kinase 2) are found associated with both sporadic and familial Parkinson's disease (PD). Pathogenic mutations are localized to the catalytic domains of LRRK2, including kinase and GTPase domains. Altered catalytic activity correlates with neurotoxicity, indicating that targeting...

journal_title：Neuropharmacology

authors： Gómez-Suaga P,Fdez E,Fernández B,Martínez-Salvador M,Blanca Ramírez M,Madero-Pérez J,Rivero-Ríos P,Fuentes JM,Hilfiker S

更新日期：2014-10-01 00:00:00

abstract：:Nicotinic receptors containing the alpha7 gene product are among the most abundant in the nervous system. Because of their widespread distribution and high relative permeability to calcium, the receptors regulate a diverse array of cellular events. On chick ciliary neurons the receptors are concentrated on somatic spi...

journal_title：Neuropharmacology

authors： Conroy WG,Ogden LF,Berg DK

更新日期：2000-10-01 00:00:00

abstract：:The phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB/Akt)/mechanistic target of rapamycin (mTOR) signaling pathway has been associated with several pathologies in the central nervous system (CNS), including epilepsy. There is evidence supporting the hypothesis that the PI3Kγ signaling pathway may mediate the...

journal_title：Neuropharmacology

authors： Lima IVA,Bellozi PMQ,Batista EM,Vilela LR,Brandão IL,Ribeiro FM,Moraes MFD,Moreira FA,de Oliveira ACP

更新日期：2020-10-01 00:00:00

abstract：:The benzodiazepine--gamma-aminobutyric acid (GABA) receptor--ionophore system is an oligomeric complex, composed of at least three interacting components. These three components have been well characterized in vitro by radioreceptor binding assays. A variety of centrally acting anxiolytic, depressant, anticonvulsant a...

journal_title：Neuropharmacology

authors： Ticku MK

更新日期：1983-12-01 00:00:00

abstract：:The consumption of saline and water in a two-bottle test of salt-preference was measured after the administration of sulpiride, a dopamine receptor antagonist and of naloxone, an antagonist at opiate receptors. The two drugs were injected alone, or in combination. Three concentrations of saline (0.125, 0.6 and 1.7% Na...

journal_title：Neuropharmacology

authors： Gilbert DB,Cooper SJ

更新日期：1986-07-01 00:00:00

abstract：:Enhancement of GABAA receptor function with benzodiazepine (BZ) site agonists can disrupt memory formation and hippocampal synaptic plasticity. To investigate this further the effects of the agonist, flunitrazepam, were contrasted with that of the inverse agonist, methyl-6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxyl...

journal_title：Neuropharmacology

authors： Seabrook GR,Easter A,Dawson GR,Bowery BJ

更新日期：1997-06-01 00:00:00

abstract：:The present study investigated the effect of acute and repeated administrations of amphetamine (AMPH) on dopamine (DA), 3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), and 5-hydroxyindoleacetic acid (5-HIAA) in the two main cytoarchitectonic subterritories of the medial prefrontal cortex (mPFC) (anter...

journal_title：Neuropharmacology

authors： Hedou G,Homberg J,Feldon J,Heidbreder CA

更新日期：2001-03-01 00:00:00

abstract：:Because of the claim that ibogaine suppresses the symptoms of "narcotic withdrawal" in humans, the effect of ibogaine on naltrexone-precipitated withdrawal signs in morphine-dependent rats was assessed. Morphine was administered subcutaneously through implanted silicone reservoirs for 5 days. Ibogaine (20, 40 or 80 mg...

journal_title：Neuropharmacology

authors： Glick SD,Rossman K,Rao NC,Maisonneuve IM,Carlson JN

更新日期：1992-05-01 00:00:00

abstract：:Lithium in vitro at concentrations of 1-2 mM and above inhibited cyclic AMP accumulation due to noradrenaline in cerebral cortical slices prepared from both control rats and rats rendered supersensitive for the noradrenaline response by intraperitoneal injection of reserpine. There was no difference in the concentrati...

journal_title：Neuropharmacology

authors： Newman ME,Lichtenberg P,Belmaker RH

更新日期：1985-04-01 00:00:00

abstract：:The effect of acute or repeated treatment with the antidepressant clomipramine (CIM) on N-methyl-D-aspartate (NMDA) evoked changes in extracellular 5-hydroxytryptamine (5-HT) in the raphe nuclei and frontal cortex of the same rat has been studied using microdialysis. Acute injection of CIM (10 or 20 mg/kg) caused an i...

journal_title：Neuropharmacology

authors： Pallotta M,Segieth J,Sadideen F,Whitton PS

更新日期：2001-09-01 00:00:00

abstract：BACKGROUND:Atypical antipsychotic drugs, particularly olanzapine, represent a mainstay in the treatment of psychoses; however, their use is commonly associated with weight gain and diabetes. The aim of this study was to determine whether combined administration of olanzapine and zonisamide can be used to prevent olanza...

journal_title：Neuropharmacology

authors： Stefanidis A,Watt MJ,Cowley MA,Oldfield BJ

更新日期：2017-09-01 00:00:00

abstract：:Tobacco addiction is a chronic disorder that is characterized by craving for tobacco products, withdrawal upon smoking cessation, and relapse after periods of abstinence. Previous studies demonstrated that systemic administration of α2-adrenergic receptor agonists attenuates stress-induced reinstatement of drug seekin...

journal_title：Neuropharmacology

authors： Yamada H,Bruijnzeel AW

更新日期：2011-02-01 00:00:00

abstract：:Of the five excitatory amino acid transporters (EAATs) identified, two genes are expressed by neurons (EAAT3 and EAAT4) and give rise to transporters confined to neuronal cell bodies and dendrites. At an ultrastructural level, EAAT3 and EAAT4 proteins are clustered at the edges of postsynaptic densities of excitatory ...

journal_title：Neuropharmacology

authors： Meera P,Dodson PD,Karakossian MH,Otis TS

更新日期：2005-11-01 00:00:00

abstract：:Pyrethroids, widely used insecticides with low acute toxicity in mammals, affect sodium channels in neurons. In a primary culture of rat cortical neurons, deltamethrin (DM), a type II pyrethroid, markedly enhanced the expression of brain-derived neurotrophic factor (BDNF) exon IV-IX (Bdnf eIV-IX) mRNA. In this study, ...

journal_title：Neuropharmacology

authors： Ihara D,Fukuchi M,Honma D,Takasaki I,Ishikawa M,Tabuchi A,Tsuda M

更新日期：2012-02-01 00:00:00

abstract：:Radioligand binding assays were used to demonstrate the presence of alpha 1, alpha 2 and beta receptors in rat spinal cord. Specific and saturable binding was exhibited for [3H]-WB 4101 (alpha 1), [3H]-aminoclonidine (alpha 2) and [3H]-dihydroalprenolol (beta). Binding was of high affinity and the total number of bind...

journal_title：Neuropharmacology

authors： Jones DJ,Kendall DE,Enna SJ

更新日期：1982-02-01 00:00:00

abstract：:In the present studies, an attempt was made to elucidate the role of endogenous opioid inputs to the depressor region of the caudal ventrolateral medulla in the tonic regulation of arterial pressure and to examine the subtype(s) of receptor underlying any observed effects by use of receptor-specific antagonists. The d...

journal_title：Neuropharmacology

authors： Drolet G,Morilak DA,Chalmers J

更新日期：1991-04-01 00:00:00

abstract：:Groups of hypophysectomised rats were given either an electroconvulsive shock (ECS; 125V, 1 sec) once daily for 10 days or a sham-shock. Twenty-four hours after the final treatment both groups were tested for their responses to the dopamine agonist, apomorphine, the 5-hydroxytryptamine agonist, quipazine, and the alph...

journal_title：Neuropharmacology

authors： Nutt DJ,Smith SL,Heal DJ

更新日期：1982-09-01 00:00:00

abstract：:Phylogenetic research can help to elucidate the structure of the GABA/benzodiazepine receptor complex. In this study the evolution of the beta-carboline binding site was traced to see whether it paralleled that of the benzodiazepine binding site. The ratio of [3H]ethyl-beta-carboline-3-carboxylate (beta-CCE) to [3H]fl...

journal_title：Neuropharmacology

authors： Friedl W,Hebebrand J,Rabe S,Propping P

更新日期：1988-02-01 00:00:00

abstract：:Remifentanil is commonly used clinically for perioperative pain relief, but it may induce postoperative hyperalgesia. Low doses of ketamine have remained a common choice in clinical practice, but the mechanisms of ketamine have not yet been fully elucidated. In this study, we examined the possible effects of ketamine ...

journal_title：Neuropharmacology

authors： Qi F,Liu T,Zhang X,Gao X,Li Z,Chen L,Lin C,Wang L,Wang ZJ,Tang H,Chen Z

更新日期：2020-01-01 00:00:00

abstract：:The analgesic fentanyl, having a predominantly mu-opioid agonist activity, when injected into the supraoptic or paraventricular nucleus of the hypothalamus in a water-loaded and ethanol-anesthetized rat, induced a potent antidiuretic effect in a time- and dose-dependent manner. The outflow of urine decreased to a mini...

journal_title：Neuropharmacology

authors： Tsushima H,Mori M,Matsuda T

更新日期：1990-08-01 00:00:00

abstract：:Neural sensorimotor gating mechanisms prevent the interruption of ongoing information processing routines by ensuing stimuli to permit mental integration and adaptive behavior. Prepulse inhibition (PPI), an operational measure of sensorimotor gating, is now being investigated using murine models to exploit transgenic ...

journal_title：Neuropharmacology

authors： Dulawa SC,Geyer MA

更新日期：2000-08-23 00:00:00

abstract：:We investigated the effect of 5-HT6 receptor subtype activation on glutamatergic transmission by means of whole-cell patch-clamp electrophysiological recordings from medium spiny neurons of the striatum and layer V pyramidal neurons of the prefrontal cortex. To this aim, we took advantage of a novel ligand, ST1936, sh...

journal_title：Neuropharmacology

authors： Tassone A,Madeo G,Schirinzi T,Vita D,Puglisi F,Ponterio G,Borsini F,Pisani A,Bonsi P

更新日期：2011-09-01 00:00:00

abstract：:Zatosetron (13 mg or 0.19 mg/kg), a potent and selective 5-HT3 receptor antagonist was studied with a 30 min infusion in a crossover double-blind placebo-controlled trial for acute migraine therapy. Groups receiving zatosetron and placebo were demographically similar and zatosetron was well-tolerated in all patients w...

journal_title：Neuropharmacology

authors： Chappell AS,Bay JM,Botzum GD,Cohen ML

更新日期：1994-03-01 00:00:00

abstract：:We examined the pharmacological properties of 3-methyl-aminothiophene dicarboxylic acid (3-MATIDA) by measuring second messenger responses in baby hamster kidney cells stably transfected with mGlu1a, mGlu2, mGlu4a or mGlu5a receptors and ionotropic glutamate receptor agonist-induced depolarizations in mouse cortical w...

journal_title：Neuropharmacology

authors： Moroni F,Attucci S,Cozzi A,Meli E,Picca R,Scheideler MA,Pellicciari R,Noe C,Sarichelou I,Pellegrini-Giampietro DE

更新日期：2002-05-01 00:00:00

abstract：:Compound FLZ (cFLZ) is a synthetic novel derivative of natural squamosamide. Previous pharmacological study found that cFLZ improved the abnormal behavior and the decrease of dopamine content in striatum in 1-methyl-4-phenyl-1,2,3,6-tetra-hydropyridine (MPTP) model mice. 1-Methyl 4-phenylpyridinium (MPP+) is the activ...

journal_title：Neuropharmacology

authors： Zhang D,Zhang JJ,Liu GT

更新日期：2007-02-01 00:00:00