Neurotensin in reward processes.

abstract：:Neural circuit engagement within the nucleus accumbens (NAc) shell is implicated in the regulation of both negative and positive affect. Classically, the dynorphin/kappa opioid receptor (KOR) system in the NAc was believed to promote aversion, while dopamine was viewed as interacting with reward behavior, and KOR acti...

journal_title：Neuropharmacology

authors： Pirino BE,Spodnick MB,Gargiulo AT,Curtis GR,Barson JR,Karkhanis AN

更新日期：2020-12-15 00:00:00

abstract：:Application of capsaicin (CAP), bradykinin (BK) or nicotine (NIC) to intraluminally perfused rat tracheas induced an increase in calcitonin gene-related peptide (CGRP) levels in the perfusates. Depletion of sensory afferent CGRP with systemic CAP pretreatment resulted in a significant reduction of CGRP release evoked ...

journal_title：Neuropharmacology

authors： Hua XY,Jinno S,Back SM,Tam EK,Yaksh TL

更新日期：1994-10-01 00:00:00

abstract：:Previous reports have shown that activation of N-methyl-D-aspartate (NMDA) receptors potentiates responses to activation of the group I metabotropic glutamate receptor mGluR5 by reversing PKC-mediated desensitization of this receptor. NMDA-induced reversal of mGluR5 desensitization is dependent on activation of protei...

journal_title：Neuropharmacology

authors： Alagarsamy S,Saugstad J,Warren L,Mansuy IM,Gereau RW 4th,Conn PJ

更新日期：2005-01-01 00:00:00

abstract：:Consistent experimental evidence supports an important role of the glutamatergic system in the etiopathogenesis of schizophrenia. Numerous studies propose that blockade of the NMDA receptor by its antagonist ketamine impairs cognition and can mimic certain aspects of positive and negative symptoms of schizophrenia in ...

journal_title：Neuropharmacology

authors： Zoupa E,Gravanis A,Pitsikas N

更新日期：2019-06-01 00:00:00

abstract：:Endogenous interferon beta (IFNβ) is an important cytokine involved in several chronic inflammatory diseases, such as Multiple Sclerosis (MS). In spite of the numerous therapeutic approaches available for MS patients, the administration of recombinant IFNβ continues being one of the first line treatment to these patie...

journal_title：Neuropharmacology

authors： Suardíaz M,Clemente D,Marin-Bañasco C,Orpez T,Hurtado-Guerrero I,Pavía J,Pinto-Medel MJ,De Castro F,Leyva L,Fernández O,Oliver B

更新日期：2016-11-01 00:00:00

abstract：:Several studies on humans and mice support oxytocin's role in improving social behaviour, but its use in pharmacotherapy presents some important limiting factors. To date, it is emerging a pharmacological potential for melanocortin 4 receptor (MC4R) agonism in social deficits treatment. Recently, we demonstrated that ...

journal_title：Neuropharmacology

authors： Mastinu A,Premoli M,Maccarinelli G,Grilli M,Memo M,Bonini SA

更新日期：2018-05-01 00:00:00

abstract：:Antipsychotic drug treatment increases neurotensin (NT) neurotransmission, and the exogenous administration of NT produces antipsychotic-like effects in rodents. In order to investigate whether "endogenous" NT may act as a natural occurring antipsychotic or may mediate antipsychotic drug activity, the effects of the s...

journal_title：Neuropharmacology

authors： Casti P,Marchese G,Casu G,Ruiu S,Pani L

更新日期：2004-07-01 00:00:00

abstract：:In Huntington's disease (HD), dysfunctional affective processes emerge as key symptoms of disturbances. In human HD and transgenic rat models of the disease, the amygdala was previously shown to have a reduced volume and to carry a high load of mutant huntingtin (mHTT) aggregates. In search of the pathophysiology of a...

journal_title：Neuropharmacology

authors： Lamirault C,Yu-Taeger L,Doyère V,Riess O,Nguyen HP,El Massioui N

更新日期：2017-09-01 00:00:00

abstract：:Administration of stimulant and non-stimulant drugs that inhibit monoamine reuptake is known to improve cognitive and behavioral symptoms of attention deficit hyperactivity disorder (ADHD). Although this may reflect acute actions of these drugs, clinical observations suggest that prolonged treatment with these agents ...

journal_title：Neuropharmacology

authors： Seu E,Jentsch JD

更新日期：2009-12-01 00:00:00

abstract：:Recent evidence suggests an early involvement of dopaminergic (DA) processes and terminals in Parkinson's disease (PD). The arborization of neurons depends on the actin cytoskeleton, which in turn is regulated by small GTPases of the Rho family, encompassing Rho, Rac and Cdc42 subfamilies. Indeed, some reports point t...

journal_title：Neuropharmacology

authors： Musilli M,Ciotti MT,Pieri M,Martino A,Borrelli S,Dinallo V,Diana G

更新日期：2016-10-01 00:00:00

abstract：:Orexin contributes to the expression of the cardiovascular and behavioural response of some forms of stress, including novelty stress. Thus, Almorexant, a dual receptor antagonist that blocks the two known orexin receptors, Ox1R and Ox2R, reduces these responses. However, it is not known if the reduction results from ...

journal_title：Neuropharmacology

authors： Beig MI,Dampney BW,Carrive P

更新日期：2015-02-01 00:00:00

abstract：:P2Y1 receptors mediate nerve mediated purinergic inhibitory junction potentials (IJP) and relaxations in the gastrointestinal (GI) tract in a wide range of species including rodents and humans. A new P2Y1 antagonist, with a non-nucleotide structure, BPTU, has recently been described using X-ray crystallography as the ...

journal_title：Neuropharmacology

authors： Mañé N,Jiménez-Sábado V,Jiménez M

更新日期：2016-11-01 00:00:00

abstract：:To assess a possible role for phospholipase D (PLD) in PC12 cell signal transduction and differentiation, we have investigated the expression of PLD in PC12 cells and found that the differentiation factor, nerve growth factor (NGF) increased PLD1 protein expression and phorbol 12-myristate 13 acetate (PMA)-induced PLD...

journal_title：Neuropharmacology

authors： Min DS,Ahn BH,Rhie DJ,Yoon SH,Hahn SJ,Kim MS,Jo YH

更新日期：2001-09-01 00:00:00

abstract：:Tobacco use is prevalent in the adolescent population. It is a major concern because tobacco is highly addictive and has also been linked to illicit drug use. There is not much research, however, on the interaction between nicotine and other stimulant drugs in animal models of early adolescence. This study examined th...

journal_title：Neuropharmacology

authors： Collins SL,Izenwasser S

更新日期：2004-03-01 00:00:00

abstract：:Cannabidiol (CBD), a non-euphorigenic compound derived from Cannabis, shows promise for improving recovery following cerebral ischemia and has recently been shown effective for the treatment of childhood seizures caused by Dravet and Lennox-Gastaut syndromes. Given evidence for activity to mitigate effects of CNS insu...

journal_title：Neuropharmacology

authors： Alalawi A,Dodu JC,Woolley-Roberts M,Brodie J,Di Marzo V,Soderstrom K

更新日期：2019-11-01 00:00:00

abstract：:Drug users often combine benzodiazepines with psychostimulants, such as methamphetamine. However, very little research has been conducted on this type of polydrug use, particularly in female subjects. The present study was therefore designed to examine the effects of two benzodiazepines, alprazolam and oxazepam, on th...

journal_title：Neuropharmacology

authors： Spence AL,Guerin GF,Goeders NE

更新日期：2016-03-01 00:00:00

abstract：:The effect of injection of inhibitors of GABA-transaminase into the nucleus tractus solitarius (NTS) on arterial pressure was examined in anesthetized rats. Two typical GABA-transaminase inhibitors, gamma-vinylGABA (GVG) and aminooxyacetic acid (AOAA), increased arterial pressure when injected into the NTS, a response...

journal_title：Neuropharmacology

authors： Tsukamoto K,Sved AF

更新日期：1993-06-01 00:00:00

abstract：:N-methyl-d-aspartate (NMDA) receptors composed of glycine-binding GluN1 and GluN3 subunits function as excitatory glycine receptors that respond to agonist application only with a very low efficacy. Binding of glycine to the high-affinity GluN3 subunits triggers channel opening, whereas glycine binding to the low-affi...

journal_title：Neuropharmacology

authors： Mesic I,Madry C,Geider K,Bernhard M,Betz H,Laube B

更新日期：2016-06-01 00:00:00

abstract：:Dopamine (DA) neurotransmission, particularly the ventral tegmental area-nucleus accumbens (VTA-NAcc) projection, underlies reward and aversion processing, and deficient DA function could underlie motivational impairments in psychiatric disorders. 6-hydroxydopamine (6-OHDA) injection is an established method for chron...

journal_title：Neuropharmacology

authors： Bergamini G,Sigrist H,Ferger B,Singewald N,Seifritz E,Pryce CR

更新日期：2016-10-01 00:00:00

abstract：:A challenge for theories of general anesthesia is the existence of compounds predicted to be anesthetics but which, instead, do not produce anesthesia and often elicit other behavioral effects such as convulsions. This study focused on flurothyl (bis[2,2, 2-trifluoroethyl] ether), a potent volatile convulsant, and its...

journal_title：Neuropharmacology

authors： Krasowski MD

更新日期：2000-04-27 00:00:00

abstract：:Addiction is associated with changes in synaptic plasticity mediated, in part, by alterations in the trafficking and stabilization of AMPA receptors at synapses within the nucleus accumbens. Exposure to cocaine can lead to protein kinase C-mediated phosphorylation of GluA2 AMPA subunits and this phosphorylation event ...

journal_title：Neuropharmacology

authors： Briand LA,Deutschmann AU,Ellis AS,Fosnocht AQ

更新日期：2016-12-01 00:00:00

abstract：:Nitric oxide modulates pain development. However, there is no evidence on the effect of nitroxyl (HNO/NO⁻) in nociception. Therefore, we addressed whether nitroxyl inhibits inflammatory hyperalgesia and its mechanism using the nitroxyl donor Angeli's salt (AS; Na₂N₂O₃). Mechanical hyperalgesia was evaluated using a mo...

journal_title：Neuropharmacology

authors： Zarpelon AC,Souza GR,Cunha TM,Schivo IR,Marchesi M,Casagrande R,Pinge-Filho P,Cunha FQ,Ferreira SH,Miranda KM,Verri WA Jr

更新日期：2013-08-01 00:00:00

abstract：:Regional differences are known in the serotonin-induced modulation of neuronal activity within the amygdala. This in vitro study in rats focuses on analyzing the ionic mechanism underlying serotonin-induced depolarization in the lateral amygdala. Serotonin depolarized membrane potential by 5 mV, which is underlain by ...

journal_title：Neuropharmacology

authors： Yamamoto R,Hatano N,Sugai T,Kato N

更新日期：2014-07-01 00:00:00

abstract：:The effect of (U-54494A) cis-3,4-dichloro-N-methyl-N-[2-(1-Pyrrolidinyl)- cyclohexyl] benzamide monohydrochloride, an excitatory amino acid antagonist, on N-methyl-D-aspartic acid (NMDA)- and K(+)-evoked release of [3H]acetylcholine [( 3H]ACh) from slices of striatum was investigated. For the purpose of comparison, MK...

journal_title：Neuropharmacology

authors： Sethy VH,Sage GP

更新日期：1992-02-01 00:00:00

abstract：:In low cerveau isolé transected rats, the effects of microiontophoretic application of putative serotonin 5-HT1A and 5-HT1B agonists on the spontaneous firing rate of CA1 pyramidal cells were compared to those of 5-HT. In contrast to the large current-dependent suppression of unit activity observed with 5-HT, the 5-HT...

journal_title：Neuropharmacology

authors： Sprouse JS,Aghajanian GK

更新日期：1988-07-01 00:00:00

abstract：:Transgenic mice that accumulate Aβ peptides in the CNS are commonly used to interrogate functional consequences of Alzheimer's disease-associated amyloidopathy. In addition to changes to synaptic function, there is also growing evidence that changes to intrinsic excitability of neurones can arise in these models of am...

journal_title：Neuropharmacology

authors： Kerrigan TL,Brown JT,Randall AD

更新日期：2014-04-01 00:00:00

abstract：:The alpha7 and alpha4beta2 nicotinic acetylcholine receptor (nAchR) subtypes have been shown to be involved in memory. It is also known that losses of frontal cortical nAchRs are correlated to declining memory function in Alzheimer's disease, but the subtype-specific role of frontal cortical nAchRs in memory has not b...

journal_title：Neuropharmacology

authors： Chan WK,Wong PT,Sheu FS

更新日期：2007-06-01 00:00:00

abstract：:Phosphodiesterase 2 (PDE2) plays an important role in treatment of stress-related depression through regulation of antioxidant defense and neuroprotective mechanisms. However, the causal relationship between PDE2 and the prevalence of depression and anxiety upon exposure to oxidative stress has not been investigated. ...

journal_title：Neuropharmacology

authors： Huang X,Xiaokaiti Y,Yang J,Pan J,Li Z,Luria V,Li Y,Song G,Zhu X,Zhang HT,O'Donnell JM,Xu Y

更新日期：2018-12-01 00:00:00

abstract：:These experiments examined the effects of lithium and imipramine on the regulation by norepinephrine in vivo of (Na+, K+)-ATPase in brain and heart. The binding of ouabain and the activity of K+-phosphatase were used as indices of (Na+, K+)-ATPase. In the cerebral cortex, imipramine prevented, and lithium reduced, the...

journal_title：Neuropharmacology

authors： Swann AC

更新日期：1988-03-01 00:00:00

abstract：:Cholecystokinin octapeptide (CCK-8), caerulein and seven out of ten analogues of caerulein produced in mice, after subcutaneous administration, a dose-dependent drop in rectal temperature. For the hypothermic effect, i.e. a decrease in temperature by at least 1.5 degree C, ED50's were estimated with these peptides and...

journal_title：Neuropharmacology

authors： Zetler G

更新日期：1982-08-01 00:00:00