当前位置： SCI文献检索 > NEUROPHARMACOLOGY期刊下所有文献 > NMDA-induced potentiation of mGluR5 is mediated by activation of protein phosphatase 2B/calcineurin.

NMDA-induced potentiation of mGluR5 is mediated by activation of protein phosphatase 2B/calcineurin.

Abstract：

:Previous reports have shown that activation of N-methyl-D-aspartate (NMDA) receptors potentiates responses to activation of the group I metabotropic glutamate receptor mGluR5 by reversing PKC-mediated desensitization of this receptor. NMDA-induced reversal of mGluR5 desensitization is dependent on activation of protein phosphatases. However, the specific protein phosphatase involved and the precise mechanism by which NMDA receptor activation reduces mGluR desensitization are not known. We have performed a series of molecular, biochemical, and genetic studies to show that NMDA-induced regulation of mGluR5 is dependent on activation of calcium-dependent protein phosphatase 2B/calcineurin (PP2B/CaN). Furthermore, we report that purified calcineurin directly dephosphorylates the C-terminal tail of mGluR5 at sites that are phosphorylated by PKC. Finally, immunoprecipitation and GST fusion protein pull-down experiments reveal that calcineurin interacts with mGluR5, suggesting that these proteins could be colocalized in a signaling complex. Taken together with previous studies, these data suggest that activation of NMDA receptors leads to activation of calcineurin and that calcineurin modulates mGluR5 function by directly dephosphorylating mGluR5 at PKC sites that are involved in desensitization of this receptor.

journal_name

Neuropharmacology

journal_title

Neuropharmacology

authors

Alagarsamy S,Saugstad J,Warren L,Mansuy IM,Gereau RW 4th,Conn PJ

doi

10.1016/j.neuropharm.2005.05.005

subject

Has Abstract

pub_date

2005-01-01 00:00:00

pages

135-45

eissn

0028-3908

issn

1873-7064

pii

S0028-3908(05)00188-7

journal_volume

49 Suppl 1

pub_type

杂志文章

相关文献

NEUROPHARMACOLOGY文献大全
  • Influence of excitatory amino acid receptor antagonists and of baclofen on synaptic transmission in the optic nerve to the suprachiasmatic nucleus in slices of rat hypothalamus.

    abstract：:Electrical stimulation of the optic nerve evoked two positive waves with short latency, followed by a large negative wave in the suprachiasmatic nucleus of slices of hypothalamus of the rat. The latency to peak of the two positive waves and the large negative wave were 2.7 +/- 0.1, 6.1 +/- 0.1 and 10.3 +/- 0.5 msec, r...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/0028-3908(86)90235-2

    authors： Shibata S,Liou SY,Ueki S

    更新日期：1986-04-01 00:00:00

  • Reprint of Pharmacological and molecular characterization of the positive allosteric modulators of metabotropic glutamate receptor 2.

    abstract：:The metabotropic glutamate receptor 2 (mGlu2) plays an important role in the presynaptic control of glutamate release and several mGlu2 positive allosteric modulators (PAMs) have been under assessment for their potential as antipsychotics. The binding mode of mGlu2 PAMs is better characterized in functional terms whil...

    journal_title：Neuropharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuropharm.2016.08.040

    authors： Lundström L,Bissantz C,Beck J,Dellenbach M,Woltering TJ,Wichmann J,Gatti S

    更新日期：2017-03-15 00:00:00

  • Benzodiazepine-GABA receptor-ionophore complex. Current concepts.

    abstract：:The benzodiazepine--gamma-aminobutyric acid (GABA) receptor--ionophore system is an oligomeric complex, composed of at least three interacting components. These three components have been well characterized in vitro by radioreceptor binding assays. A variety of centrally acting anxiolytic, depressant, anticonvulsant a...

    journal_title：Neuropharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/0028-3908(83)90114-4

    authors： Ticku MK

    更新日期：1983-12-01 00:00:00

  • Effects of behaviorally active doses of thyrotropin-releasing hormone and its analog MK-771 on dopaminergic neuronal systems in the brain of the rat.

    abstract：:The effects of thyrotropin-releasing hormone (TRH) and an analog of this hormone, MK-771, were determined on body shaking behavior and on biochemical estimates of the activity of dopamine (DA) neurons in the rat. Both compounds elicited dose-related episodes of "wet-dog shakes". A dose of TRH (20 mg/kg, i.p.) which ca...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/0028-3908(84)90105-9

    authors： Yamada K,Demarest KT,Moore KE

    更新日期：1984-07-01 00:00:00

  • Serotonin modulation of cell excitability and of [3H]GABA and [3H]D-aspartate efflux in primary cultures of rat cortical neurons.

    abstract：:The effects of 5-hydroxytryptamine (5-HT) on neuronal excitability, evaluated as depolarization-induced firing rate, and on amino acid release, measured as electrically-evoked [(3)H]GABA and [(3)H]d-aspartate efflux, were investigated in rat primary cortical neuronal cultures. 5-HT displayed a concentration-dependent,...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2006.10.017

    authors： Bianchi C,Marani L,Marino S,Barbieri M,Nazzaro C,Beani L,Siniscalchi A

    更新日期：2007-03-01 00:00:00

  • Favorable amphiphilicity of nimodipine facilitates its interactions with brain membranes.

    abstract：:Nimodipine is a 1,4-dihydropyridine (DHP) calcium channel blocker which is used in the treatment of neurological deficits associated with subarachnoid hemorrhage. Small angle x-ray diffraction, differential scanning calorimetry, and equilibrium and kinetic binding techniques were used to study the interaction of nimod...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/0028-3908(94)90015-9

    authors： Herbette LG,Mason PE,Sweeney KR,Trumbore MW,Mason RP

    更新日期：1994-02-01 00:00:00

  • Effects of natural and synthetic isothiocyanate-based H2S-releasers against chemotherapy-induced neuropathic pain: Role of Kv7 potassium channels.

    abstract：:Hydrogen sulfide (H2S) is a crucial signaling molecule involved in several physiological and pathological processes. Nonetheless, the role of this gasotransmitter in the pathogenesis and treatment of neuropathic pain is controversial. The aim of the present study was to investigate the pain relieving profile of a seri...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2017.04.029

    authors： Di Cesare Mannelli L,Lucarini E,Micheli L,Mosca I,Ambrosino P,Soldovieri MV,Martelli A,Testai L,Taglialatela M,Calderone V,Ghelardini C

    更新日期：2017-07-15 00:00:00

  • Inhibition by nystatin of Kv1.3 channels expressed in Chinese hamster ovary cells.

    abstract：:The patch-clamp technique was used to study the effects of nystatin on a cloned delayed rectifier potassium channel (Kv1.3) expressed in Chinese hamster ovary (CHO) cells. Kv1.3 currents recorded in the whole-cell configuration, using an intracellular solution containing nystatin, were subjected to a time- and concent...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/0028-3908(96)00094-9

    authors： Hahn SJ,Wang LY,Kaczmarek LK

    更新日期：1996-01-01 00:00:00

  • Serotonin induces depolarization in lateral amygdala neurons by activation of TRPC-like current and inhibition of GIRK current depending on 5-HT(2C) receptor.

    abstract：:Regional differences are known in the serotonin-induced modulation of neuronal activity within the amygdala. This in vitro study in rats focuses on analyzing the ionic mechanism underlying serotonin-induced depolarization in the lateral amygdala. Serotonin depolarized membrane potential by 5 mV, which is underlain by ...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2014.03.007

    authors： Yamamoto R,Hatano N,Sugai T,Kato N

    更新日期：2014-07-01 00:00:00

  • Aβ pathology downregulates brain mGluR5 density in a mouse model of Alzheimer.

    abstract：:The aim of the present study was to evaluate functional changes of mGluR5 expression in advanced Alzheimer's disease (AD) using positron emission tomography (PET) with an mGluR5 specific radiotracer ([18F]FPEB) in 5xFAD AD model. Subsequently, in the same animal, mGluR5 expression was quantified by immunoassay techniq...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2018.02.003

    authors： Lee M,Lee HJ,Park IS,Park JA,Kwon YJ,Ryu YH,Kim CH,Kang JH,Hyun IY,Lee KC,Choi JY

    更新日期：2018-05-01 00:00:00

  • Existence of FGFR1-5-HT1AR heteroreceptor complexes in hippocampal astrocytes. Putative link to 5-HT and FGF2 modulation of hippocampal gamma oscillations.

    abstract：:The majority of the fibroblast growth factor receptor 1-serotonin 1 A receptor (FGFR1-5-HT1AR) heterocomplexes in the hippocampus appeared to be located mainly in the neuronal networks and a relevant target for antidepressant drugs. Through a neurochemical and electrophysiological analysis it was therefore tested in t...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2020.108070

    authors： Narváez M,Andrade-Talavera Y,Valladolid-Acebes I,Fredriksson M,Siegele P,Hernandez-Sosa A,Fisahn A,Fuxe K,Borroto-Escuela DO

    更新日期：2020-06-15 00:00:00

  • A triheptanoin-supplemented diet rescues hippocampal hyperexcitability and seizure susceptibility in FoxG1+/- mice.

    abstract：:The Forkhead Box G1 (FOXG1) gene encodes a transcription factor with an essential role in mammalian telencephalon development. FOXG1-related disorders, caused by deletions, intragenic mutations or duplications, are usually associated with severe intellectual disability, autistic features, and, in 87% of subjects, epil...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2019.01.005

    authors： Testa G,Mainardi M,Olimpico F,Pancrazi L,Cattaneo A,Caleo M,Costa M

    更新日期：2019-04-01 00:00:00

  • Increased number of hypothalamic [3H] (+)-amphetamine binding sites in genetically obese (ob/ob) mice.

    abstract：:In genetically obese (ob/ob) mice the development of obesity was correlated with the binding of [3H] (+)-amphetamine to the hypothalamus. In 39-day-old ob/ob mice, which had obtained a body weight greater than 150% of their lean littermates, hypothalamic [3H] (+)-amphetamine binding had increased by approximately 60% ...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/0028-3908(86)90260-1

    authors： Hauger R,Hulihan-Giblin B,Paul SM

    更新日期：1986-03-01 00:00:00

  • An autoradiographic study of the differential effects of N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) on striatal and extrastriatal D-1 and D-2 dopamine receptors in the rat.

    abstract：:The effect of in vivo administration of the alkylating agent N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) on striatal and extrastriatal D-1 and D-2 dopamine (DA) receptors was investigated in the rat. N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline treatment reduced specific [3H]SCH 23390 (7-chloro-8-hydroxy-2...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/0028-3908(94)90170-8

    authors： Gnanalingham KK,Hunter AJ,Jenner P,Marsden CD

    更新日期：1994-05-01 00:00:00

  • Sensitivity of rodent skeletal muscles to dicholines: dependence on innervation and age.

    abstract：:Depolarizations provoked by acetylcholine (ACh) and three dicholines, succinylcholine (SCh), glutarylcholine (GCh) and azelainylcholine (AzCh) were measured in normal and 3-7 days denervated muscles of adult, and in normal muscles of 0-27 days old mice and rats. Soleus and flexor digitorum superficialis muscles were m...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/0028-3908(89)90032-4

    authors： Lorković H

    更新日期：1989-04-01 00:00:00

  • Glutamate transport system as a key constituent of glutamosome: Molecular pathology and pharmacological modulation in chronic pain.

    abstract：:Neural uptake of glutamate is executed by the structurally related members of the SLC1A family of solute transporters: GLAST/EAAT1, GLT-1/EAAT2, EAAC1/EAAT3, EAAT4, ASCT2. These plasma membrane proteins ensure supply of glutamate, aspartate and some neutral amino acids, including glutamine and cysteine, for synthetic,...

    journal_title：Neuropharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuropharm.2019.04.029

    authors： Gegelashvili G,Bjerrum OJ

    更新日期：2019-12-15 00:00:00

  • CRF1 receptor-deficiency increases cocaine reward.

    abstract：:Stimulant drugs produce reward but also activate stress-responsive systems. The corticotropin-releasing factor (CRF) and the related hypothalamus-pituitary-adrenal (HPA) axis stress-responsive systems are activated by stimulant drugs. However, their role in stimulant drug-induced reward remains poorly understood. Here...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2017.01.024

    authors： Contarino A,Kitchener P,Vallée M,Papaleo F,Piazza PV

    更新日期：2017-05-01 00:00:00

  • GABAergic involvement in motor effects of an adenosine A(2A) receptor agonist in mice.

    abstract：:Adenosine A(2A) agonists are known to induce catalepsy and inhibit dopamine mediated motor hyperactivity. An antagonistic interaction between adenosine A(2A) and dopamine D(2) receptors is known to regulate GABA-mediated neurotransmission in striatopallidal neurons. Stimulation of adenosine A(2A) and dopamine D(2) rec...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/s0028-3908(99)00187-2

    authors： Khisti RT,Chopde CT,Abraham E

    更新日期：2000-04-03 00:00:00

  • Both pre- and post-synaptic alterations contribute to aberrant cholinergic transmission in superior cervical ganglia of APP(-/-) mice.

    abstract：:Though amyloid precursor protein (APP) can potentially be cleaved to generate the pathological amyloid β peptide (Aβ), APP itself plays an important role in regulating neuronal activity. APP deficiency causes functional impairment in cholinergic synaptic transmission and cognitive performance. However, the mechanisms ...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2016.08.021

    authors： Cai ZL,Zhang JJ,Chen M,Wang JZ,Xiao P,Yang L,Long C

    更新日期：2016-11-01 00:00:00

  • Impaired migration signaling in the hippocampus following prenatal hypoxia.

    abstract：:Prenatal hypoxia ischemia is a major cause of neurodevelopmental impairment in the newborn, associated with risk for motor, behavioral and cognitive impaired outcomes. We used an established mouse model of maternal hypoxia to examine the immediate molecular responses of signaling pathways associated with both cell dea...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2009.07.028

    authors： Golan MH,Mane R,Molczadzki G,Zuckerman M,Kaplan-Louson V,Huleihel M,Perez-Polo JR

    更新日期：2009-10-01 00:00:00

  • The neurotoxin 2'-NH2-MPTP degenerates serotonin axons and evokes increases in hippocampal BDNF.

    abstract：:1-Methyl-4-(2'-aminophenyl)-1,2,3,6-tetrahydropyridine (2'-NH2-MPTP) causes long-term depletions in cortical and hippocampal serotonin (5-HT) and norepinephrine (NE) that are accompanied by acute elevations in glial fibrillary acidic protein (GFAP) and argyrophilia. To further investigate the hypothesis that these cha...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2005.09.006

    authors： Luellen BA,Szapacs ME,Materese CK,Andrews AM

    更新日期：2006-03-01 00:00:00

  • Proteomic analysis of the nucleus accumbens of rats with different vulnerability to cocaine addiction.

    abstract：:Vulnerability to the addictive effects of drugs of abuse varies among individuals, but the biological basis of these differences are poorly known. This work tries to increase this knowledge by comparing the brain proteome of animals with different rate of extinction of cocaine-seeking behaviour. To achieve this goal, ...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2009.04.005

    authors： del Castillo C,Morales L,Alguacil LF,Salas E,Garrido E,Alonso E,Pérez-García C

    更新日期：2009-07-01 00:00:00

  • Analysis by HPLC-EC of metabolites of monoamines in fetal and postnatal rat brain.

    abstract：:High performance liquid chromatography with electrochemical detection (HPLC-EC) was adapted for the analysis of metabolites of monoamines (MA) in the developing brain of the rat. 3-Methoxy-4-hydroxy-phenyl-ethylene glycol (MOPEG), dihydroxy phenylacetic acid (DOPAC), homovanillic acid (HVA) and 5-hydroxy-3-indoleaceti...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/0028-3908(86)90191-7

    authors： Ribary U,Schlumpf M,Lichtensteiger W

    更新日期：1986-09-01 00:00:00

  • Anti-inflammatory properties of cholinergic up-regulation: A new role for acetylcholinesterase inhibitors.

    abstract：:We investigated the anti-inflammatory effects of acetylcholinesterase inhibitors (AChEI) at the cellular and molecular levels. AChEI suppressed lymphocyte proliferation and pro-inflammatory cytokine production, as well as extracellular esterase activity. Anti-inflammatory activity was mediated by the alpha7 nicotinic ...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2005.10.013

    authors： Nizri E,Hamra-Amitay Y,Sicsic C,Lavon I,Brenner T

    更新日期：2006-04-01 00:00:00

  • Binding of buprenorphine to opiate receptors. Regulation by guanyl nucleotides and metal ions.

    abstract：:The effects of guanosine-5'-triphosphate (GTP), sodium chloride and manganese chloride on the binding of buprenorphine to opiate receptors present in rat brain has been studied. Manganese chloride significantly decreased the affinity of binding of both [3H] buprenorphine and unlabelled buprenorphine to morphine and en...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/0028-3908(84)90201-6

    authors： Villiger JW

    更新日期：1984-03-01 00:00:00

  • GABA(B) receptor activation inhibits dopamine D1 receptor-mediated facilitation of [(3)H]GABA release in substantia nigra pars reticulata.

    abstract：:GABA(B) receptors inhibit and dopamine D1 receptors stimulate the release of GABA from striatal terminals in the pars reticulata of the substantia nigra. Here we have studied the interaction between both classes of receptors by exploring the effect of GABA(B) receptors upon the stimulation of depolarization-induced [(...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2007.07.014

    authors： Nava-Asbell C,Paz-Bermudez F,Erlij D,Aceves J,Florán B

    更新日期：2007-10-01 00:00:00

  • The cPLA2α inhibitor efipladib decreases nociceptive responses without affecting PGE2 levels in the cerebral spinal fluid.

    abstract：:The contribution of central PGE(2) levels to the nociceptive response in rats was assessed and the effects of the selective cPLA(2)α inhibitor efipladib, and pain therapies of different classes on these responses was determined. An inflammatory pain model was optimized in rats so that PGE(2) levels in the cerebrospina...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2010.11.025

    authors： Nickerson-Nutter CL,Goodwin D,Shen MW,Damphousse C,Duan W,Samad TA,McKew JC,Lee KL,Zaleska MM,Mollova N,Clark JD

    更新日期：2011-03-01 00:00:00

  • Repeated but not acute clomipramine decreases the effect of N-methyl-D-aspartate receptor activation on serotonergic transmission between the raphe nuclei and frontal cortex.

    abstract：:The effect of acute or repeated treatment with the antidepressant clomipramine (CIM) on N-methyl-D-aspartate (NMDA) evoked changes in extracellular 5-hydroxytryptamine (5-HT) in the raphe nuclei and frontal cortex of the same rat has been studied using microdialysis. Acute injection of CIM (10 or 20 mg/kg) caused an i...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/s0028-3908(01)00078-8

    authors： Pallotta M,Segieth J,Sadideen F,Whitton PS

    更新日期：2001-09-01 00:00:00

  • Post-ischemic administration [correction of administeration] but not pre-ischemic administration [correction of administeration] of NG-nitro-L-arginine prevents spatial memory impairments and apoptosis by an inhibition of a delayed increase in NOx- in the

    abstract：:In the present study, we investigated the effects of N(G)-nitro-L-arginine (L-NAME), an inhibitor of nitric oxide synthase, on repeated cerebral ischemia-induced impairment of spatial memory of the 8-arm radial maze in rats. Repeated ischemia (10 min ischemia x 2 times with 1 h interval) impaired the spatial memory in...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/s0028-3908(02)00404-5

    authors： Mishima K,Pu F,Kaneko T,Egashira N,Iwasaki K,Fujiwara M

    更新日期：2003-03-01 00:00:00

  • N-acetylcysteine treatment blocks the development of ethanol-induced behavioural sensitization and related ΔFosB alterations.

    abstract：:Ethanol addiction is a serious public health problem that still needs more effective pharmacological treatment. A key factor in the development and maintenance of this disease is the advent of neuroadaptations in the mesocorticolimbic brain pathway upon chronic ethanol abuse. In general, these neuroadaptations are mal...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2016.07.009

    authors： Morais-Silva G,Alves GC,Marin MT

    更新日期：2016-11-01 00:00:00