Pharmacoresistance - Epidemiology, mechanisms, and impact on epilepsy treatment.

abstract：:Alzheimer's disease (AD) is the most common cause of dementia, clinically characterized by loss of memory and progressive deficits in different cognitive domains. An emerging disease-modifying approach to face the multifactorial nature of AD may be represented by the development of Multi-Target Directed Ligands (MTDLs...

journal_title：Neuropharmacology

authors： Minarini A,Milelli A,Tumiatti V,Rosini M,Simoni E,Bolognesi ML,Andrisano V,Bartolini M,Motori E,Angeloni C,Hrelia S

更新日期：2012-02-01 00:00:00

abstract：:The influence of the subunit composition of human GABA(A) receptors upon the GABA-modulatory properties of 5alpha-pregnan-3alpha-ol-20-one (5alpha,3alpha) has been examined using the Xenopus laevis oocyte expression system and the two electrode voltage-clamp technique. Steroid potency (EC(50)) is modestly influenced b...

journal_title：Neuropharmacology

authors： Belelli D,Casula A,Ling A,Lambert JJ

更新日期：2002-09-01 00:00:00

abstract：:In general, N-methyl-D-aspartate (NMDA) receptor antagonists inhibit learning and long term potentiation (LTP). However, it has been suggested that direct tonic, i.e. non-temporal, activation of NMDA receptors, in contrast to learning, may lead to an increase in synaptic "noise" and, in turn, to a loss of association ...

journal_title：Neuropharmacology

authors： Zajaczkowski W,Frankiewicz T,Parsons CG,Danysz W

更新日期：1997-07-01 00:00:00

abstract：:P2Y receptors are G-protein-coupled receptors (GPCRs) for extracellular nucleotides. There are eight mammalian P2Y receptor subtypes (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13, and P2Y14). P2Y receptors are widely expressed and play important roles in physiology and pathophysiology. One important example is the ADP-...

journal_title：Neuropharmacology

authors： von Kügelgen I,Hoffmann K

更新日期：2016-05-01 00:00:00

abstract：:Several studies on humans and mice support oxytocin's role in improving social behaviour, but its use in pharmacotherapy presents some important limiting factors. To date, it is emerging a pharmacological potential for melanocortin 4 receptor (MC4R) agonism in social deficits treatment. Recently, we demonstrated that ...

journal_title：Neuropharmacology

authors： Mastinu A,Premoli M,Maccarinelli G,Grilli M,Memo M,Bonini SA

更新日期：2018-05-01 00:00:00

abstract：:1-Methyl-4-(2'-aminophenyl)-1,2,3,6-tetrahydropyridine (2'-NH2-MPTP) causes long-term depletions in cortical and hippocampal serotonin (5-HT) and norepinephrine (NE) that are accompanied by acute elevations in glial fibrillary acidic protein (GFAP) and argyrophilia. To further investigate the hypothesis that these cha...

journal_title：Neuropharmacology

authors： Luellen BA,Szapacs ME,Materese CK,Andrews AM

更新日期：2006-03-01 00:00:00

abstract：:The ability of GABAA and GABAB receptors in the shell of the nucleus accumbens to modulate distinct types of turning behaviour was investigated in freely moving rats, using the unilateral injection technique. The GABAA receptor agonist muscimol and the GABAA receptor antagonist bicuculline did not produce turning beha...

journal_title：Neuropharmacology

authors： Akiyama G,Ikeda H,Matsuzaki S,Sato M,Moribe S,Koshikawa N,Cools AR

更新日期：2004-06-01 00:00:00

abstract：:The majority of the fibroblast growth factor receptor 1-serotonin 1 A receptor (FGFR1-5-HT1AR) heterocomplexes in the hippocampus appeared to be located mainly in the neuronal networks and a relevant target for antidepressant drugs. Through a neurochemical and electrophysiological analysis it was therefore tested in t...

journal_title：Neuropharmacology

authors： Narváez M,Andrade-Talavera Y,Valladolid-Acebes I,Fredriksson M,Siegele P,Hernandez-Sosa A,Fisahn A,Fuxe K,Borroto-Escuela DO

更新日期：2020-06-15 00:00:00

abstract：:The involvement of metabotropic glutamate receptor group II (mGluRII) in the induction of long-term depression (LTD) was investigated in the medial perforant path of the rat dentate gyrus, a region with a very high density of mGluRII. Perfusion of either of two potent mGluRII agonists, (2S,1R,2R,3R)-2-(2S, 1'R, 2'R, 3...

journal_title：Neuropharmacology

authors： Huang L,Killbride J,Rowan MJ,Anwyl R

更新日期：1999-01-01 00:00:00

abstract：:gamma-Aminobutyric acid (GABA, half-maximal inhibitory concentration, IC50 = 9.9 microM) and (-)-baclofen (IC50 = 4.5 microM) but not 10(-4) M muscimol, exerted a presynaptic inhibitory effect on cholinergic transmission in field-stimulated guinea-pig taenia coli preparations, in vitro. The antagonism by 10(-5) M (1S,...

journal_title：Neuropharmacology

authors： Rónai AZ,Kardos J,Simonyi M

更新日期：1987-11-01 00:00:00

abstract：:In rat brain, the number of beta-adrenoceptors and activity of noradrenaline-dependent adenylate cyclase were examined after treatment with desipramine (7.5 mg kg-1 day-1) for three days alone or in combination with the alpha 2-adrenoceptor antagonist, yohimbine (2 mg kg-1 12 hr-1), or with phenoxybenzamine (7.5 mg kg...

journal_title：Neuropharmacology

authors： Campbell IC,McKernan RM,Smokcum RW,Stephenson JD,Weeramanthri TB

更新日期：1984-12-01 00:00:00

abstract：:Alpidem is a new anxiolytic of imidazopyridine structure which has a high affinity for the omega 1 (BZ1) modulatory site of the GABAA receptor. The present study investigated whether tolerance and physical dependence develop after repeated treatment with alpidem, as is observed with benzodiazepines. Mice were given al...

journal_title：Neuropharmacology

authors： Perrault G,Morel E,Sanger DJ,Zivkovic B

更新日期：1993-09-01 00:00:00

abstract：:Drugs that alter the function of gamma-aminobutyric acid (GABA) neurotransmission seem to reduce cocaine reinforcement, and as such may be useful in pharmacologically treating cocaine addiction. In the present experiment, the anti-cocaine effects of CGP 44532, a phosphinic acid analogue of GABA, and a highly selective...

journal_title：Neuropharmacology

authors： Dobrovitsky V,Pimentel P,Duarte A,Froestl W,Stellar JR,Trzcińska M

更新日期：2002-04-01 00:00:00

abstract：:Neuropeptide S (NPS) is a peptide recently recognized to be present in the CNS, and believed to play a role in vigilance and mood control, as behavioral studies have shown it promotes arousal and has an anxiolytic effect. Although NPS precursor is found in very few neurons, NPS positive fibers are present throughout t...

journal_title：Neuropharmacology

authors： Roncacè V,Polli FS,Zojicic M,Kohlmeier KA

更新日期：2017-11-01 00:00:00

abstract：:The effect of U-50,488H, a selective kappa opioid receptor agonist on the intake of food in food-deprived and non-deprived spontaneously hypertensive and normotensive Wistar-Kyoto rats was determined. In food deprived Wistar-Kyoto rats, intraperitoneal administration of U-50,488H, produced a bell-shaped curve on the i...

journal_title：Neuropharmacology

authors： Bhargava HN,Ramarao P,Richter CM,Bieniarz AA

更新日期：1989-01-01 00:00:00

abstract：:An elevated plus-maze, used to identify anxiolytic effects of drugs (Pellow et al., 1985), reflected as increased open-arm exploration, was employed in cycling and ovariectomised rats, to determine the effect of diazepam on the cycle and, after ovariectomy, to investigate possible influences of treatment with oestradi...

journal_title：Neuropharmacology

authors： Nomikos GG,Spyraki C

更新日期：1988-07-01 00:00:00

abstract：:A striking observation among veterans returning from the recent conflicts in Iraq and Afghanistan has been the co-occurrence of blast-related mild traumatic brain injury (mTBI) and post-traumatic stress disorder (PTSD). PTSD and mTBI might coexist due to additive effects of independent psychological and physical traum...

journal_title：Neuropharmacology

authors： Perez-Garcia G,Gama Sosa MA,De Gasperi R,Tschiffely AE,McCarron RM,Hof PR,Gandy S,Ahlers ST,Elder GA

更新日期：2019-02-01 00:00:00

abstract：:Similar to patients with ventromedial prefrontal cortex (VMPC) lesions, substance abusers show altered decision-making, characterized by a tendency to choose the immediate reward, at the expense of negative future consequences. The somatic marker model proposes that decision-making depends on neural substrates that re...

journal_title：Neuropharmacology

authors： Verdejo-García A,Bechara A

更新日期：2009-01-01 00:00:00

abstract：:Reserpine (5 mg/kg s.c.) was given to rats kept under a reversed light-dark cycle and 5-hydroxytryptamine (5-HT) and 5-hydroxyindole acetic acid (5-HIAA) determined in frontal cortex tissue and dialysate at various times after drug treatment. The decline and return of spontaneous locomotor activity was also measured. ...

journal_title：Neuropharmacology

authors： Heslop KE,Curzon G

更新日期：1994-03-01 00:00:00

abstract：:Many studies have demonstrated that negative allosteric modulators (NAM) of metabotropic glutamate receptor 5 (mGlu5) reduce cocaine and methamphetamine seeking in extinction-reinstatement animal models of addiction. Less is known about effects of mGlu5 NAMs in abstinence models, particularly for methamphetamine. We u...

journal_title：Neuropharmacology

authors： Murray CH,Christian DT,Milovanovic M,Loweth JA,Hwang EK,Caccamise AJ,Funke JR,Wolf ME

更新日期：2021-01-12 00:00:00

abstract：:Exposure to abused drugs and stressful experience, two factors that promote the development of addiction, also modify synaptic function in the mesolimbic dopamine system. Here, we show that exposure to a novel environment produces functional synaptic adaptations in the nucleus accumbens (NAc) that mirror the effect of...

journal_title：Neuropharmacology

authors： Rothwell PE,Kourrich S,Thomas MJ

更新日期：2011-12-01 00:00:00

abstract：:Venlafaxine, a novel 2-phenyl-2-(1-hydroxycycloalkyl) ethylamine, is a potent inhibitor of 5-hydroxytryptamine and noradrenaline reuptake and exhibits a profile of activity in pre-clinical in vitro biochemical studies predictive of antidepressant activity. The studies described here examined the effects of acute and c...

journal_title：Neuropharmacology

authors： Mitchell PJ,Fletcher A

更新日期：1993-10-01 00:00:00

abstract：:Attention-deficit hyperactivity disorder (ADHD) is a clinically and genetically heterogeneous syndrome which is comorbid with childhood conduct disorder, alcoholism, substance abuse, dis-social personality disorder, and affective disorders. A small but consistent overlap with autistic symptoms has also been establishe...

journal_title：Neuropharmacology

authors： Sharp SI,McQuillin A,Gurling HM

更新日期：2009-12-01 00:00:00

abstract：:The present study investigated the possibility of multiple 5-HT(1) autoreceptor subtypes in the rostral raphé nuclei. Slices (350 microm) of rat dorsal or median raphé nucleus (DRN/MRN) were taken from male Wistar rats and superfused with artificial cerebrospinal fluid at 32 degrees C. Fast cyclic voltammetry at carbo...

journal_title：Neuropharmacology

authors： Hopwood SE,Stamford JA

更新日期：2001-03-01 00:00:00

abstract：:Gastrin-releasing peptide (GRP) receptor-expressing (GRPR)+ neurons have a central role in the spinal transmission of itch. Because their fundamental regulatory mechanisms are not yet understood, it is important to determine how such neurons are excited and integrate itch sensation. In this study, we investigated the ...

journal_title：Neuropharmacology

authors： Kiguchi N,Uta D,Ding H,Uchida H,Saika F,Matsuzaki S,Fukazawa Y,Abe M,Sakimura K,Ko MC,Kishioka S

更新日期：2020-06-15 00:00:00

abstract：:The possible synergism between caffeine and muscarinic antagonists to inhibit haloperidol-induced catalepsy was investigated with the bar test in rats. Pretreatment with low doses of caffeine (1-3 mg/kg), a non-selective adenosine antagonist, dose dependently reduced the intensity and increased the onset latency of ca...

journal_title：Neuropharmacology

authors： Moo-Puc RE,Góngora-Alfaro JL,Alvarez-Cervera FJ,Pineda JC,Arankowsky-Sandoval G,Heredia-López F

更新日期：2003-09-01 00:00:00

abstract：:In isolation-reared mice, social encounter stimulation induces locomotor hyperactivity and activation of the dorsal raphe nucleus (DRN), suggesting that dysregulation of dorsal raphe function may be involved in abnormal behaviors. In this study, we examined the involvement of dorsal raphe GABAergic dysregulation in th...

journal_title：Neuropharmacology

authors： Araki R,Hiraki Y,Nishida S,Kuramoto N,Matsumoto K,Yabe T

更新日期：2016-02-01 00:00:00

abstract：:The anticonvulsant action and the long-term effects on learning, memory and behavior of the new generation antiepileptic drug gabapentin (GBP) were investigated in immature animals. Kainic acid (KA) was administered to rats on postnatal day (P) 35. Animals were treated with GBP or saline from P36 to P75 and spontaneou...

journal_title：Neuropharmacology

authors： Cilio MR,Bolanos AR,Liu Z,Schmid R,Yang Y,Stafstrom CE,Mikati MA,Holmes GL

更新日期：2001-01-01 00:00:00

abstract：:Studies described here tested the hypothesis that phosphodiesterase 10A inhibition by a selective antagonist, MP-10, activates the dopamine D2 receptor expressing medium spiny neurons to a greater extent than the D1 receptor expressing neurons. We used regional pattern of c-Fos induction in the neostriatal subregions ...

journal_title：Neuropharmacology

authors： Wilson JM,Ogden AM,Loomis S,Gilmour G,Baucum AJ 2nd,Belecky-Adams TL,Merchant KM

更新日期：2015-12-01 00:00:00

abstract：:C57BL/6J mice were introduced to a nine arm radial maze without prior habituation and trained in the acquisition of a working memory task in 16 sessions, one session per day. In this maze mice need to climb onto an upward inclined bridge in order to reach and cross onto an arm. They received in each session an i.p. in...

journal_title：Neuropharmacology

authors： Ennaceur A,Michalikova S,van Rensburg R,Chazot PL

更新日期：2011-10-01 00:00:00