Behavioral syndrome induced by allylnitrile, crotononitrile or 2-pentenenitrile in rats.

abstract：:Calcium modulates the 5-HT3 receptor response by reducing peak current amplitude and increasing rates of activation, deactivation and desensitisation, but the binding site(s) and mechanism(s) of this modulation are unknown. Here we study residues that may be involved in calcium binding in two partially overlapping reg...

journal_title：Neuropharmacology

authors： Thompson AJ,Lummis SC

更新日期：2009-01-01 00:00:00

abstract：:The selective benzodiazepine antagonist RO 15-1788, labelled with carbon 11 [11C] RO 15-1788, as a specific marker, together with positron emission tomography, allows the in vivo study of benzodiazepine receptors in primates. In addition, when coupled with recordings of electroencephalographic activity, this method of...

journal_title：Neuropharmacology

authors： Hantraye P,Brouillet E,Guibert B,Chavoix C,Fukuda H,Prenant C,Crouzel M,Naquet R,Maziere M

更新日期：1987-10-01 00:00:00

abstract：:The present study was designed to examine the possible involvement of both an anti-serotonin action and a catecholamine-stimulating action in the mechanism of the inhibition of the muricide in rats with lesions of the midbrain raphe. Serotonin antagonists, such as cyproheptadine (10 mg/kg), cinanserin (10 mg/kg) and p...

journal_title：Neuropharmacology

authors： Yamamoto T,Ohno M,Takao K,Ueki S

更新日期：1988-02-01 00:00:00

abstract：:Neurones isolated from the CA1 region of rat hippocampal slices by the "vibrodissociation" method were voltage-clamped in the whole-cell configuration. The currents through N-methyl-D-aspartate (NMDA) channels were recorded in response to the rapid application (solution exchange time <30 msec) of 100 microM aspartate ...

journal_title：Neuropharmacology

authors： Sobolevsky A,Koshelev S,Khodorov BI

更新日期：1997-03-01 00:00:00

abstract：:The effects of age on the responsiveness of the body of the urinary bladder and base of the bladder to alpha-adrenergic agonists were studied. Regions of the bladder were isolated from Fischer 344 rats, ages 7, 16, and 27 months. Maximum isotonic contractions elicited by potassium chloride (KCl) in both regions of the...

journal_title：Neuropharmacology

authors： Ordway GA,Kolta MG,Gerald MC,Wallace LJ

更新日期：1986-12-01 00:00:00

abstract：:Pediatric traumatic brain injury (TBI) remains one of the leading causes of morbidity and mortality in children. Experimental and clinical studies demonstrate that the developmental age, the type of injury (diffuse vs. focal) and sex may play important roles in the response of the developing brain to a traumatic injur...

journal_title：Neuropharmacology

authors： Huh JW,Raghupathi R

更新日期：2019-02-01 00:00:00

abstract：:Quinine and quinidine are reported to potentiate the behavioural effects of serotonergic agents and monoamine uptake inhibitors. We have therefore investigated the presynaptic actions of quinine and quinidine on monoamine uptake and release in rat brain tissue in vitro. Quinidine evoked the release of [3H]5-HT, [3H]no...

journal_title：Neuropharmacology

authors： Clement EM,Grahame-Smith DG,Elliott JM

更新日期：1998-07-01 00:00:00

abstract：:Symptomatic temporal lobe epilepsy typically develops in three phases: brain damage --> epileptogenesis --> spontaneous seizures (epilepsy). The challenge is to prevent epileptogenesis after injury. We hypothesized that alleviation of damage by caspase inhibitors will reduce epileptogenesis or at least have disease-mo...

journal_title：Neuropharmacology

authors： Narkilahti S,Nissinen J,Pitkänen A

更新日期：2003-06-01 00:00:00

abstract：:Ligand-gated ion channels play a role in mediating fast synaptic transmission for communication between neurons. However, the structural basis for the functional coupling of the binding and pore domains, resulting in channel opening, remains a topic of intense investigation. Here, a series of α7 nicotinic receptor mut...

journal_title：Neuropharmacology

authors： Yan H,Pan N,Xue F,Zheng Y,Li C,Chang Y,Xu Z,Yang H,Zhang J

更新日期：2015-08-01 00:00:00

abstract：:Retinal bipolar cells receive glutamatergic transmission from photoreceptors and mediate a key process in segregating visual signals into ON-center and OFF-center pathways. The segregation of ON responses involves a G protein-coupled metabotropic glutamate receptor (mGluR). The mGluR6 subtype is expressed restrictedly...

journal_title：Neuropharmacology

authors： Iwakabe H,Katsuura G,Ishibashi C,Nakanishi S

更新日期：1997-02-01 00:00:00

abstract：:The influence of naloxone (a narcotic antagonist), bicuculline (a GABA antagonist), phentolamine (an alpha-blocking agent), propranolol (a beta-adrenergic blocking agent), haloperidol (a dopaminergic blocking agent), methysergide (a serotonergic blocking agent) and atropine (a muscarinic blocking agent), on the antino...

journal_title：Neuropharmacology

authors： Foong FW,Satoh M

更新日期：1984-06-01 00:00:00

abstract：:The role of orexin receptors in the nucleus accumbens shell in rat turning behaviour of rats was studied. Unilateral injection of neither the orexin 1 and 2 receptor agonist orexin A (2 microg) nor the orexin 1 receptor antagonist SB 334867 (20 ng) into the nucleus accumbens shell elicited turning behaviour. Unilatera...

journal_title：Neuropharmacology

authors： Kotani A,Ikeda H,Koshikawa N,Cools AR

更新日期：2008-03-01 00:00:00

abstract：:The elevation of extracellular 5-HT after systemic administration of 5-HT reuptake inhibiting drugs is strongly potentiated by agents capable of blocking 5-HT1A autoreceptors in the midbrain raphe. The present in vivo microdialysis study was aimed at assessing the relative importance of 5-HT reuptake inhibition versus...

journal_title：Neuropharmacology

authors： Hjorth S,Westlin D,Bengtsson HJ

更新日期：1997-04-01 00:00:00

abstract：:Gliomas, in particular glioblastoma multiforme or grade IV astrocytoma, are the most frequent class of malignant primary brain tumours and one of the most aggressive forms of cancer. Current therapeutic strategies for the treatment of glioblastoma multiforme are usually ineffective or just palliative. During the last ...

journal_title：Neuropharmacology

authors： Velasco G,Galve-Roperh I,Sánchez C,Blázquez C,Guzmán M

更新日期：2004-09-01 00:00:00

abstract：:The Forkhead Box G1 (FOXG1) gene encodes a transcription factor with an essential role in mammalian telencephalon development. FOXG1-related disorders, caused by deletions, intragenic mutations or duplications, are usually associated with severe intellectual disability, autistic features, and, in 87% of subjects, epil...

journal_title：Neuropharmacology

authors： Testa G,Mainardi M,Olimpico F,Pancrazi L,Cattaneo A,Caleo M,Costa M

更新日期：2019-04-01 00:00:00

abstract：:Substance P, administered intrathecally in the lumbar area of paraplegic rats activated the electromyogram (EMG) of the hindlimbs. This effect was markedly enhanced by previous denervation by 5,7-dihydroxytryptamine. Stimulation of the motoneurons by substance P was followed by a blunted response to the excitatory sub...

journal_title：Neuropharmacology

authors： Tremblay LE,Maheux R,Bédard PJ

更新日期：1986-04-01 00:00:00

abstract：:The effects of various benzodiazepine receptor ligands on the GABA autoreceptor have been studied in slices of cerebral cortex of the rat. The GABAA receptor agonist muscimol inhibited the K+-stimulated release of [3H]GABA with a pIC25 of 7.65 +/- 0.11. This effect was antagonised by the GABAA receptor antagonist bicu...

journal_title：Neuropharmacology

authors： Ennis C,Minchin MC

更新日期：1988-10-01 00:00:00

abstract：:Nimodipine is a 1,4-dihydropyridine (DHP) calcium channel blocker which is used in the treatment of neurological deficits associated with subarachnoid hemorrhage. Small angle x-ray diffraction, differential scanning calorimetry, and equilibrium and kinetic binding techniques were used to study the interaction of nimod...

journal_title：Neuropharmacology

authors： Herbette LG,Mason PE,Sweeney KR,Trumbore MW,Mason RP

更新日期：1994-02-01 00:00:00

abstract：:In this study, we analysed the implication of superoxide (O2-.) and nitric oxide (NO.) free radicals and their resulting product peroxynitrite (ONOO-) in the neuronal death induced by the activation of the glutamatergic receptor of the N-methyl-D-aspartate (NMDA) subtype using cultured cerebellar granule cells. The NO...

journal_title：Neuropharmacology

authors： Lafon-Cazal M,Culcasi M,Gaven F,Pietri S,Bockaert J

更新日期：1993-11-01 00:00:00

abstract：:Adenosine 5'-triphosphate-sensitive potassium channel (KATP channel) activator, minoxidil sulfate (MS), can selectively increase the permeability of the blood-tumor barrier (BTB); however, the mechanism by which this occurs is still under investigation. Using a rat brain glioma (C6) model, we first examined the expres...

journal_title：Neuropharmacology

authors： Gu YT,Xue YX,Wang YF,Wang JH,Chen X,ShangGuan QR,Lian Y,Zhong L,Meng YN

更新日期：2013-12-01 00:00:00

abstract：:Cyclosporine, a calcineurin inhibitor, significantly enhances spontaneous acetylcholine release after a brief tetanus and potentiates the effect of phorbol 12,13-dibutyrate. Both actions are prevented by the protein kinase C inhibitor, bisindolylmaleimide iodide. Protein kinase C and calcineurin thus play important ro...

journal_title：Neuropharmacology

authors： Lin MJ,Lin-Shiau SY

更新日期：1999-01-01 00:00:00

abstract：:Activation of peroxisome proliferator-activated receptor beta/delta (PPAR-β/δ), a nuclear receptor acting as a transcription factor, was shown to be protective in various models of neurological diseases. However, there is no information about the role of PPAR-β/δ as well as its molecular mechanisms in neonatal hypoxia...

journal_title：Neuropharmacology

authors： Gamdzyk M,Doycheva DM,Malaguit J,Enkhjargal B,Tang J,Zhang JH

更新日期：2018-09-15 00:00:00

abstract：:Addiction involves drug-induced neuroplasticity in the circuitry of motivated behavior, which includes the medial forebrain bundle and the lateral hypothalamic area. Emerging at the forefront of neuroplasticity regulation are specialized extracellular matrix (ECM) structures that form perineuronal nets (PNNs) around c...

journal_title：Neuropharmacology

authors： Blacktop JM,Todd RP,Sorg BA

更新日期：2017-05-15 00:00:00

abstract：:Postsynaptic Density Protein-95 (PSD-95) is a major scaffolding protein in the excitatory synapses in the brain and a critical regulator of synaptic maturation for NMDA and AMPA receptors. PSD-95 deficiency has been linked to cognitive and learning deficits implicated in neurodevelopmental disorders such as autism and...

journal_title：Neuropharmacology

authors： McEachern EP,Coley AA,Yang SS,Gao WJ

更新日期：2020-11-15 00:00:00

abstract：:A challenge for theories of general anesthesia is the existence of compounds predicted to be anesthetics but which, instead, do not produce anesthesia and often elicit other behavioral effects such as convulsions. This study focused on flurothyl (bis[2,2, 2-trifluoroethyl] ether), a potent volatile convulsant, and its...

journal_title：Neuropharmacology

authors： Krasowski MD

更新日期：2000-04-27 00:00:00

abstract：:Adinazolam (ADI) is a new benzodiazepine with anxiolytic and antidepressant properties. To assess its effects on the acute stress response, rats were given a single intraperitoneal injection of 2.5 or 5.0 mg/kg of ADI and stressed for 1 hr by restraint. Neither dose of ADI had any effect on heart rate, blood pressure ...

journal_title：Neuropharmacology

authors： Krieman MJ,Hershock DM,Greenberg IJ,Vogel WH

更新日期：1992-01-01 00:00:00

abstract：:The obesity epidemic is one of the biggest health challenges globally and rates have tripled since 1975. Overeating is the largest determinant of obesity, yet little is understood of the neural mechanisms underlying why individuals consume food regardless of satiety. The lateral hypothalamic (LH) input to the ventral ...

journal_title：Neuropharmacology

authors： Godfrey N,Borgland SL

更新日期：2019-08-01 00:00:00

abstract：:Recently we reported that fluoxetine (10 mg/kg) improves functional recovery by attenuating blood spinal cord barrier (BSCB) disruption after spinal cord injury (SCI). Here we investigated whether a low-dose of fluoxetine (1 mg/kg) and vitamin C (100 mg/kg), separately not possessing any protective effect, prevents BS...

journal_title：Neuropharmacology

authors： Lee JY,Choi HY,Yune TY

更新日期：2016-10-01 00:00:00

abstract：:Mefloquine continues to be a key drug used for malaria chemoprophylaxis and treatment, despite reports of adverse events like depression and anxiety. It is unknown how mefloquine acts within the central nervous system to cause depression and anxiety or why some individuals are more vulnerable. We show that intraperito...

journal_title：Neuropharmacology

authors： Heshmati M,Golden SA,Pfau ML,Christoffel DJ,Seeley EL,Cahill ME,Khibnik LA,Russo SJ

更新日期：2016-02-01 00:00:00

abstract：:In the cerebellum of juvenile mice or rats, endocannabinoids are shown to mediate depolarization-induced suppression of excitation (DSE) and retrograde suppression induced by activation of type 1 metabotropic glutamate receptor (mGluR1) at parallel fiber (PF) to Purkinje cell (PC) synapses. However, recent studies sho...

journal_title：Neuropharmacology

authors： Tanimura A,Kawata S,Hashimoto K,Kano M

更新日期：2009-08-01 00:00:00