Discriminative stimulus properties of the dopamine D3 receptor agonists, PD128,907 and 7-OH-DPAT: a comparative characterization with novel ligands at D3 versus D2 receptors.

abstract：:An elevated plus-maze, used to identify anxiolytic effects of drugs (Pellow et al., 1985), reflected as increased open-arm exploration, was employed in cycling and ovariectomised rats, to determine the effect of diazepam on the cycle and, after ovariectomy, to investigate possible influences of treatment with oestradi...

journal_title：Neuropharmacology

authors： Nomikos GG,Spyraki C

更新日期：1988-07-01 00:00:00

abstract：:A single oral administration of allylnitrile, crotononitrile or 2-pentenenitrile in rats induced behavioral abnormalities, such as head-twitching, head weaving, hindlimb abduction, backward pedaling and pivoting. The head-twitching, which was most consistently observed, was suppressed by serotonin (5-HT) antagonists, ...

journal_title：Neuropharmacology

authors： Tanii H,Hayashi M,Hashimoto K

更新日期：1991-08-01 00:00:00

abstract：:Recent experimental evidence indicates that in the neocortex, the manner in which each synapse releases neurotransmitter in response to trains of presynaptic action potentials is potentially unique. These unique transmission characteristics arise because of a large heterogeneity in various synaptic properties that det...

journal_title：Neuropharmacology

authors： Markram H,Pikus D,Gupta A,Tsodyks M

更新日期：1998-04-01 00:00:00

abstract：:Slob modulates the activity of the Drosophila Slowpoke calcium-dependent potassium channel (dSlo) via its direct binding to the channel. To characterize the molecular detail of the protein-protein interaction between Slob and dSlo, we constructed a series of Slob mutants that are progressively truncated at either the ...

journal_title：Neuropharmacology

authors： Zhou Y,Fei H,Levitan IB

更新日期：2003-11-01 00:00:00

abstract：:Midbrain dopamine neurons play a key role in goal-directed behaviour as well as in some psychiatric disorders. Recent studies have provided electrophysiological, anatomical and biochemical evidence that the lateral habenula (LHb) exerts strong inhibitory control over midbrain dopamine neurons. However, the behavioural...

journal_title：Neuropharmacology

authors： Gifuni AJ,Jozaghi S,Gauthier-Lamer AC,Boye SM

更新日期：2012-11-01 00:00:00

abstract：:Glioblastoma (GBM), the most aggressive brain tumor, has a poor prognosis due to the ease of migration to surrounding healthy brain tissue. Recent studies have shown that bradykinin receptors are involved in the progression of various cancers. However, the molecular mechanism and pathological role of bradykinin recept...

journal_title：Neuropharmacology

authors： Liu YS,Hsu JW,Lin HY,Lai SW,Huang BR,Tsai CF,Lu DY

更新日期：2019-01-01 00:00:00

abstract：:Post-traumatic stress disorder (PTSD) is characterized by avoidance of trauma-associated stimuli and amygdala hyperreactivity, and is highly co-morbid with alcohol use disorder (AUD). Our lab uses a predator odor (bobcat urine) stress model that produces conditioned avoidance of an odor-paired context in a subset of r...

journal_title：Neuropharmacology

authors： Weera MM,Schreiber AL,Avegno EM,Gilpin NW

更新日期：2020-04-01 00:00:00

abstract：:The Mouse Defense Test Battery (MDTB) has been designed to investigate defensive responses of Swiss-Webster mice confronted with a natural predator, a rat. These behaviors include flight, avoidance, defensive threat/attack responses, and risk assessment activities. Previous studies with the MDTB have suggested that th...

journal_title：Neuropharmacology

authors： Griebel G,Blanchard DC,Jung A,Lee JC,Masuda CK,Blanchard RJ

更新日期：1995-12-01 00:00:00

abstract：:Phosphodiesterase 2 (PDE2) plays an important role in treatment of stress-related depression through regulation of antioxidant defense and neuroprotective mechanisms. However, the causal relationship between PDE2 and the prevalence of depression and anxiety upon exposure to oxidative stress has not been investigated. ...

journal_title：Neuropharmacology

authors： Huang X,Xiaokaiti Y,Yang J,Pan J,Li Z,Luria V,Li Y,Song G,Zhu X,Zhang HT,O'Donnell JM,Xu Y

更新日期：2018-12-01 00:00:00

abstract：:Binge alcohol (ethanol) drinking is associated with profound adverse effects on our health and society. Rimonabant (SR141716A), a CB1 receptor inverse agonist, was previously shown to be effective for nicotine cessation and obesity. However, studies using rimonabant were discontinued as it was associated with an incre...

journal_title：Neuropharmacology

authors： Balla A,Dong B,Shilpa BM,Vemuri K,Makriyannis A,Pandey SC,Sershen H,Suckow RF,Vinod KY

更新日期：2018-03-15 00:00:00

abstract：:Electrophysiology, immunostaining and time lapse imaging techniques were employed to study the mechanism of long-term depression (LTD) induced by DHPG, a specific group I metabotropic glutamate receptor (mGluR) agonist. Experiments were performed in primary hippocampal culture or in the CA1 area of acute rat hippocamp...

journal_title：Neuropharmacology

authors： Xiao MY,Zhou Q,Nicoll RA

更新日期：2001-11-01 00:00:00

abstract：:Dietary supplements containing polyunsaturated fatty acids (PUFA) are frequently taken for their perceived health benefits including a possible reduction in cognitive decline in the elderly. Here we report that pre-treatment with docosahexaenoic acid (DHA) or eicosapentaenoic acid (EPA) significantly reduced the survi...

journal_title：Neuropharmacology

authors： Bate C,Marshall V,Colombo L,Diomede L,Salmona M,Williams A

更新日期：2008-05-01 00:00:00

abstract：:There is poor experimental evidence concerning the effects of anesthetic doses of the non-competitive NMDA receptor antagonist ketamine on rodents' memory abilities. The present study was designed to investigate a) the long-term consequences of anesthetic ketamine on rats' non-spatial and spatial recognition memory; b...

journal_title：Neuropharmacology

authors： Pitsikas N,Boultadakis A

更新日期：2009-07-01 00:00:00

abstract：:A new mGluR antagonist, MAP4 (the alpha-methyl derivative of L-AP4), was found to antagonize the synaptic depressant actions of L-AP4 at the lateral perforant path synapse, in rat hippocampal slices. ...

journal_title：Neuropharmacology

authors： Bushell TJ,Jane DE,Tse HW,Watkins JC,Davies CH,Garthwaite J,Collingridge GL

更新日期：1995-02-01 00:00:00

abstract：:Dopamine (DA) is a classical neurotransmitter modulating various brain functions by acting on its specific receptors. In addition, DA is a reactive molecule that has been implicated in neurodegeneration, especially in Parkinson's disease. Here we show that DA inhibited cell growth of dopamine transporter transfected c...

journal_title：Neuropharmacology

authors： Woldman I,Reither H,Kattinger A,Hornykiewicz O,Pifl C

更新日期：2005-03-01 00:00:00

abstract：:Drug users often combine benzodiazepines with psychostimulants, such as methamphetamine. However, very little research has been conducted on this type of polydrug use, particularly in female subjects. The present study was therefore designed to examine the effects of two benzodiazepines, alprazolam and oxazepam, on th...

journal_title：Neuropharmacology

authors： Spence AL,Guerin GF,Goeders NE

更新日期：2016-03-01 00:00:00

abstract：:ORL-1 agonists have been proposed as potential therapeutics for substance abuse based on their propensity to counter the effects of mu opioid agonists in several systems, and to inhibit mesolimbic dopamine release, while mostly being devoid of aversive properties. In support of this, ORL-1 agonists have been shown to ...

journal_title：Neuropharmacology

authors： Shoblock JR,Wichmann J,Maidment NT

更新日期：2005-09-01 00:00:00

abstract：BACKGROUND:Alcohol use disorder (AUD) develops after chronic and heavy use of alcohol. Insomnia, a hallmark of AUD, plays a crucial role in the development of AUD. However, the causal mechanisms are unknown. Since chronic alcohol reduces acetylated histones and disrupts the epigenome, we hypothesized that chronic alcoh...

journal_title：Neuropharmacology

authors： Sharma R,Sahota P,Thakkar MM

更新日期：2020-12-01 00:00:00

abstract：:The aim of the present study was to investigate if different levels of circulating corticosterone (CORT) modulate the effect of nicotine on prepulse inhibition (PPI), a measure of sensorimotor gating that is disrupted in schizophrenia and other mental illnesses. Four groups of mice were investigated: sham-operated, ad...

journal_title：Neuropharmacology

authors： Ingram N,Martin S,Wang JH,van der Laan S,Loiacono R,van den Buuse M

更新日期：2005-01-01 00:00:00

abstract：:4-Phenyl-1,2,3,4-tetrahydroisoquinoline (4-PTIQ) has previously been shown to have antagonistic properties to methamphetamine in the spinal cord. Administration of 4-PTIQ (5 mg/kg, s.c.) reduced the ambulation induced by methamphetamine (0.5 mg/kg, s.c.) in rats. Methamphetamine (3 micrograms), injected unilaterally i...

journal_title：Neuropharmacology

authors： Tateyama M,Ohta S,Nagao T,Hirobe M,Ono H

更新日期：1993-03-01 00:00:00

abstract：:The effects of the chronic administration of antidepressants on threshold electroconvulsive (ECS) seizures were evaluated in rats. Initially, tonic-clonic seizures were induced in 90% of the animals. Of those animals responding with tonic-clonic seizures, 42% had hindlimb extension (extensors); the remainder showed on...

journal_title：Neuropharmacology

authors： Peterson SL,Trzeciakowski JP,St Mary JS

更新日期：1985-10-01 00:00:00

abstract：:To date, there are no interventions that impede the inexorable progression of Alzheimer's disease (AD), and currently-available drugs cholinesterase (AChE) inhibitors and the N-Methyl-d-Aspartate receptor antagonist, memantine, offer only modest symptomatic benefit. Moreover, a range of mechanistically-diverse agents ...

journal_title：Neuropharmacology

authors： Millan MJ,Dekeyne A,Gobert A,Brocco M,Mannoury la Cour C,Ortuno JC,Watson D,Fone KCF

更新日期：2020-10-15 00:00:00

abstract：:The (+)-enantiomer of alpha-methyl-4-carboxyphenylglycine (MCPG) stereoslectively antagonized the depolarization of neonatal rat motoneurones and the excitation of rat thalamic neurons induced by the specific metabotropic glutamate receptor agonist (1S,3R)-1-aminocyclopentane-1,3-dicarboxylate (ACPD). (+)-MCPG prefere...

journal_title：Neuropharmacology

authors： Jane DE,Jones PL,Pook PC,Salt TE,Sunter DC,Watkins JC

更新日期：1993-07-01 00:00:00

abstract：:Clinical studies have reported that the nicotinic receptor agonist varenicline improves balance and coordination in patients with several types of ataxia, but confirmation in an animal model has not been demonstrated. This study investigated whether varenicline and nicotine could attenuate the ataxia induced in rats f...

journal_title：Neuropharmacology

authors： Wecker L,Engberg ME,Philpot RM,Lambert CS,Kang CW,Antilla JC,Bickford PC,Hudson CE,Zesiewicz TA,Rowell PP

更新日期：2013-10-01 00:00:00

abstract：:Clinical studies have shown that the major psychoactive ingredient of Cannabis sativa Δ9-tetrahydrocannabinol (THC) has some analgesic efficacy in neuropathic pain states. However, THC has a significant side effect profile. We examined whether the profile of THC could be improved by co-administering it with the first-...

journal_title：Neuropharmacology

authors： Atwal N,Casey SL,Mitchell VA,Vaughan CW

更新日期：2019-01-01 00:00:00

abstract：:Valid animal models of psychopathology need to include behavioural readouts informed by human findings. In the probabilistic reversal learning (PRL) task, human subjects are confronted with serial reversal of the contingency between two operant stimuli and reward/punishment and, superimposed on this, a low probability...

journal_title：Neuropharmacology

authors： Ineichen C,Sigrist H,Spinelli S,Lesch KP,Sautter E,Seifritz E,Pryce CR

更新日期：2012-11-01 00:00:00

abstract：:The integrity of dynamic actin structures is coupled to a variety of neurological processes. Actin-binding proteins play a critical role in regulating actin structure dynamics. A link between actin-binding proteins and receptor interacting scaffolding proteins may provide a conduit for transmitting signaling events to...

journal_title：Neuropharmacology

authors： Chen Y,Li M

更新日期：2005-12-01 00:00:00

abstract：:Ifenprodil, which is clinically used as a cerebral vasodilator, inhibited rat brain type A (MAO-A) and type B (MAO-B) monoamine oxidase activity. It did not, however, affect rat lung semicarbazide-sensitive amine oxidase. The degree of inhibition of either form of MAO was not changed by 30 min preincubation of the enz...

journal_title：Neuropharmacology

authors： Arai Y,Nakazato K,Kinemuchi H,Tadano T,Satoh N,Oyama K,Kisara K

更新日期：1991-07-01 00:00:00

abstract：:The aim of the present work was to clarify whether heterotrimeric P2X2/3 receptors have a fixed subunit stoichiometry consisting of one P2X2 and two P2X3 subunits as previously suggested, or a flexible stoichiometry containing also the inverse subunit composition. For this purpose we transfected HEK293 cells with P2X2...

journal_title：Neuropharmacology

authors： Kowalski M,Hausmann R,Schmid J,Dopychai A,Stephan G,Tang Y,Schmalzing G,Illes P,Rubini P

更新日期：2015-12-01 00:00:00

abstract：:Chloralose-anesthetized rats, spinalized at C1, were used to investigate the effects of spinal infusion of dopamine on renal sympathetic nerve activity (RSNA). A subarachnoid spinal superfusion technique was used to localize dopamine in the spinal cord while renal sympathetic nerve activity was recorded from the left ...

journal_title：Neuropharmacology

authors： Simon OR,Schramm LP

更新日期：1983-03-01 00:00:00