An interaction domain in Slob necessary for its binding to the slowpoke calcium-dependent potassium channel.

abstract：:Previous investigations have shown that mGlu receptors would be involved in the amphetamine-induced motor response. However, data are somewhat controversial across studies where methodological protocols vary. The aim of the present study was to determine the involvement of mGlu receptors in the NAcc in the locomotor-a...

journal_title：Neuropharmacology

authors： David HN,Abraini JH

更新日期：2003-05-01 00:00:00

abstract：:miR-132 and miR-212 are structurally-related microRNAs that are expressed from the same non-coding transcript. Accumulating evidence has shown that the dysregulation of these microRNAs contributes to aberrant neuronal plasticity and gene expression in the mammalian brain. Consistent with this, altered expression of mi...

journal_title：Neuropharmacology

authors： Aten S,Page CE,Kalidindi A,Wheaton K,Niraula A,Godbout JP,Hoyt KR,Obrietan K

更新日期：2019-01-01 00:00:00

abstract：:Consistent experimental evidence supports an important role of the glutamatergic system in the etiopathogenesis of schizophrenia. Numerous studies propose that blockade of the NMDA receptor by its antagonist ketamine impairs cognition and can mimic certain aspects of positive and negative symptoms of schizophrenia in ...

journal_title：Neuropharmacology

authors： Zoupa E,Gravanis A,Pitsikas N

更新日期：2019-06-01 00:00:00

abstract：:In rodents, insufficient adenosine produces behavioral and physiological symptoms consistent with several comorbidities of autism. In rodents and humans, stimuli postulated to increase adenosine can ameliorate these comorbidities. Because adenosine is a broad homeostatic regulator of cell function and nervous system a...

journal_title：Neuropharmacology

authors： Masino SA,Kawamura M Jr,Cote JL,Williams RB,Ruskin DN

更新日期：2013-05-01 00:00:00

abstract：:NMDA receptors have been known to play a central role in long-term potentiation at glutamatergic synapses in principal cells for thirty years. In contrast, their roles in the development and activity-dependent plasticity of synapses in inhibitory circuits have only recently begun to be understood. Progress has, to a g...

journal_title：Neuropharmacology

authors： Moreau AW,Kullmann DM

更新日期：2013-11-01 00:00:00

abstract：:The effects of (S)-4-amino-5-[(4,4-dimethylcyclohexyl)amino]-5-oxo-pentanoic acid ((S)CR 2249), a new chemical entity selected among a series of glutamic acid derivatives, were investigated on N-methyl-D-aspartate (NMDA)-evoked release of [3H]noradrenaline from rat hippocampal slices. (S)CR 2249 facilitated glycine-me...

journal_title：Neuropharmacology

authors： Lanza M,Bonnafous C,Colombo S,Revel L,Makovec F

更新日期：1997-08-01 00:00:00

abstract：:Research on the actions of ethanol at the GABAergic synapse has traditionally focused on postsynaptic mechanisms, but recent data demonstrate that ethanol also increases both evoked and spontaneous GABA release in many brain regions. Using whole-cell voltage-clamp recordings, we previously showed that ethanol increase...

journal_title：Neuropharmacology

authors： Kelm MK,Weinberg RJ,Criswell HE,Breese GR

更新日期：2010-06-01 00:00:00

abstract：:We previously reported that elevated pressure induces axonal swelling and facilitates the synthesis of the neurosteroid, allopregnanolone (AlloP), in the ex vivo rat retina. Exogenously applied AlloP attenuates the axonal swelling, suggesting that the neurosteroid plays a neuroprotective role against glaucomatous pres...

journal_title：Neuropharmacology

authors： Ishikawa M,Yoshitomi T,Covey DF,Zorumski CF,Izumi Y

更新日期：2016-12-01 00:00:00

abstract：:In three experiments, rats were injected once daily with 5.0 mg/kg apomorphine or vehicle and tested for locomotor activity for 10-14 days. In each experiment, apomorphine produced behavioral sensitization, characterized by a progressively greater increase in locomotor activity with each succeeding injection. On day 1...

journal_title：Neuropharmacology

authors： Rowlett JK,Mattingly BA,Bardo MT

更新日期：1991-02-01 00:00:00

abstract：:Tuberous Sclerosis Complex (TSC) is a multisystem genetic disorder caused by mutation in either Tsc1 or Tsc2 genes that leads to the hyper activation of the mTOR pathway, a key signalling pathway for synaptic plasticity. TSC is characterized by benign tumors arising in different organs and severe neuropsychiatric symp...

journal_title：Neuropharmacology

authors： Cambiaghi M,Cursi M,Magri L,Castoldi V,Comi G,Minicucci F,Galli R,Leocani L

更新日期：2013-04-01 00:00:00

abstract：:Anandamide and 2-arachidonoyl glycerol, referred to as endocannabinoids (eCBs), are the endogenous agonists for the cannabinoid receptor type 1 (CB1). Several pieces of evidence support a role for eCBs in the attenuation of anxiety-related behaviours, although the precise mechanism has remained uncertain. The fatty ac...

journal_title：Neuropharmacology

authors： Moreira FA,Kaiser N,Monory K,Lutz B

更新日期：2008-01-01 00:00:00

abstract：:Dopamine (DA) is a classical neurotransmitter modulating various brain functions by acting on its specific receptors. In addition, DA is a reactive molecule that has been implicated in neurodegeneration, especially in Parkinson's disease. Here we show that DA inhibited cell growth of dopamine transporter transfected c...

journal_title：Neuropharmacology

authors： Woldman I,Reither H,Kattinger A,Hornykiewicz O,Pifl C

更新日期：2005-03-01 00:00:00

abstract：:The role of the adenosine A(2A) receptor in the hypnotic effects of ethanol was assessed in mice. The duration of the loss of righting reflex following acute ethanol administration was shorter for A(2A) receptor-deficient mice (A(2A)R KO) than for wild-type mice (A(2A)R WT), whereas the fall in body temperature was no...

journal_title：Neuropharmacology

authors： El Yacoubi M,Ledent C,Parmentier M,Costentin J,Vaugeois JM

更新日期：2003-12-01 00:00:00

abstract：:In the present study, we studied the interaction between serotonergic (5-HTergic) and gamma-aminobutyric acid (GABA)-ergic systems in the modulation of analgesia from morphine, a mu-opioid agonist, and U50,488, a kappa-opioid agonist. All experiments were performed in mice using the 49 degrees C tail-withdrawal assay....

journal_title：Neuropharmacology

authors： Nemmani KV,Mogil JS

更新日期：2003-03-01 00:00:00

abstract：:Serotonin (5-HT) modulates the hypothalamic-pituitary-adrenal (HPA) axis response to stress. We examined the effect of chronic restraint stress (CRS; 20 min/day) as compared to control (CTRL) conditions for 14 days, on: 1) restraint-induced ACTH and corticosterone (CORT) secretion in rats pretreated with vehicle or SB...

journal_title：Neuropharmacology

authors： García-Iglesias BB,Mendoza-Garrido ME,Gutiérrez-Ospina G,Rangel-Barajas C,Noyola-Díaz M,Terrón JA

更新日期：2013-08-01 00:00:00

abstract：:Chloralose-anesthetized rats, spinalized at C1, were used to investigate the effects of spinal infusion of dopamine on renal sympathetic nerve activity (RSNA). A subarachnoid spinal superfusion technique was used to localize dopamine in the spinal cord while renal sympathetic nerve activity was recorded from the left ...

journal_title：Neuropharmacology

authors： Simon OR,Schramm LP

更新日期：1983-03-01 00:00:00

abstract：:Anxiety and depression are considered as stress-related disorders, which present considerable sex differentiation. In animal models of anxiety and depression sex differences have been described and linked to the sexually dimorphic hypothalamus-pituitary-adrenals (HPA) axis. The present study aimed to adjust corticoste...

journal_title：Neuropharmacology

authors： Kokras N,Dalla C,Sideris AC,Dendi A,Mikail HG,Antoniou K,Papadopoulou-Daifoti Z

更新日期：2012-01-01 00:00:00

abstract：:Intraventricular administration of substance P (SP), of the heptapeptide SP5-11 and of DiMe-C7, a stable analogue of SP5-11 induced locomotor activation in rats and in mice. The activating effect of substance P was longer-lasting in mice than in rats, whereas the effect of the two heptapeptides appears to be more mark...

journal_title：Neuropharmacology

authors： Naranjo JR,Del Rio J

更新日期：1984-10-01 00:00:00

abstract：:Recent genetic and pharmacological studies have implicated the α3, β4 and α5 subunits of the nicotinic acetylcholine receptor (nAChR) in dependence to nicotine and other abused drugs and nicotine withdrawal. The α3β4* nAChR subtype has been shown to co-assemble with the α5 or β3 nAChR subunits, and is found mainly in ...

journal_title：Neuropharmacology

authors： Wu J,Perry DC,Bupp JE,Jiang F,Polgar WE,Toll L,Zaveri NT

更新日期：2014-02-01 00:00:00

abstract：:Changes in the levels of mRNA for the NR1 subunit of the glutamate NMDA receptor and in NMDA-sensitive glutamate binding were investigated in consecutive sections of the prefrontal cortex and striatum of control and Parkinson's disease (PD) post-mortem brain using in-situ hybridisation and receptor autoradiography. Bo...

journal_title：Neuropharmacology

authors： Meoni P,Bunnemann BH,Kingsbury AE,Trist DG,Bowery NG

更新日期：1999-05-01 00:00:00

abstract：:The nucleus tractus solitarius (NTS) region in the rat has been shown to receive arginine vasopressin (AVP) and oxytocin (OT) neurophysin-containing neuronal projections from the suprachiasmatic (SNC) and paraventricular nucleus (PVN). Thus, vasopressin and oxytocin might have central influences on the circulation. Th...

journal_title：Neuropharmacology

authors： Matsuguchi H,Sharabi FM,Gordon FJ,Johnson AK,Schmid PG

更新日期：1982-07-01 00:00:00

abstract：:In slices of cerebral cortex from rat preloaded with [3H]GABA, muscimol produced a concentration-related inhibition of K(+)-evoked release of tritium with a pIC25 value of 7.80 +/- 0.39. Dimethylbarbituric acid (10 and 100 microM) and pentobarbitone (100 microM) significantly increased this value to 8.31 +/- 0.09, 9.9...

journal_title：Neuropharmacology

authors： Ennis C,Minchin MC

更新日期：1993-04-01 00:00:00

abstract：:The anticonvulsant phenytoin has been reported to block anoxia-induced losses of synaptic activity in the rat hippocampal slice and experimental ischemia-induced losses of synaptic activity in the guinea pig hippocampal slice. We examined phenytoin in our rat hippocampal slice model of experimental ischemia (anoxia +2...

journal_title：Neuropharmacology

authors： Watson GB,Lanthorn TH

更新日期：1995-05-01 00:00:00

abstract：:Amyotrophic Lateral Sclerosis (ALS) mostly affects motor neurons, but non-motor neural and cognitive alterations have been reported in ALS mouse models and patients. Here, we evaluated if time-dependent biphasic changes in synaptic transmission and plasticity occur in hippocampal synapses of ALS SOD1G93A mice. Recordi...

journal_title：Neuropharmacology

authors： Rei N,Rombo DM,Ferreira MF,Baqi Y,Müller CE,Ribeiro JA,Sebastião AM,Vaz SH

更新日期：2020-07-01 00:00:00

abstract：:Marijuana impairs learning and memory through actions of its psychoactive constituent, delta-9-tetrahydrocannabinol (Delta(9)-THC), in the hippocampus, through activation of cannabinoid CB1 receptors (CB1R). CB1Rs are found on glutamate and GABA neuron axon terminals in the hippocampus where they control neurotransmit...

journal_title：Neuropharmacology

authors： Laaris N,Good CH,Lupica CR

更新日期：2010-07-01 00:00:00

abstract：:Neuronal Cl- homeostasis is regulated by the activity of two cation chloride co-transporters (CCCs), the K+-Cl- cotransporter KCC2 and the Na+-K+-Cl- cotransporter NKCC1, which are primarily extruding and importing chloride in neurons, respectively. Several neurological and psychiatric disorders including epilepsy, ne...

journal_title：Neuropharmacology

authors： Côme E,Marques X,Poncer JC,Lévi S

更新日期：2020-06-01 00:00:00

abstract：:Traumatic injuries to peripheral nerves are frequent, however, specific pharmacological treatments are currently lacking. Curcumin has antioxidant, anti-inflammatory and neuroprotective properties but high oral doses are required for therapeutic use, particularly due to its low bioavailability. The aim of the present ...

journal_title：Neuropharmacology

authors： Caillaud M,Chantemargue B,Richard L,Vignaud L,Favreau F,Faye PA,Vignoles P,Sturtz F,Trouillas P,Vallat JM,Desmoulière A,Billet F

更新日期：2018-09-01 00:00:00

abstract：:Dopaminergic innervation of the extended amygdala regulates anxiety-like behavior and stress responsivity. A portion of this dopamine input arises from dopamine neurons located in the ventral lateral periaqueductal gray (vlPAG) and rostral (RLi) and caudal linear nuclei of the raphe (CLi). These neurons receive substa...

journal_title：Neuropharmacology

authors： Williams MA,Li C,Kash TL,Matthews RT,Winder DG

更新日期：2014-11-01 00:00:00

abstract：:Systemic treatment with cholecystokinin octapeptide (CCK-8, 2.5-10 micrograms/kg, s.c.), a non-selective CCK agonist, decreased the exploratory activity of mice in an elevated plus-maze. At higher doses (5-10 micrograms/kg) CCK-8 reduced the frequency of rearing, but only 10 micrograms/kg of CCK-8 significantly inhibi...

journal_title：Neuropharmacology

authors： Vasar E,Lang A,Harro J,Bourin M,Bradwejn J

更新日期：1994-06-01 00:00:00

abstract：:It is known that changes in gene expression within the nucleus accumbens (NAc) occur during cocaine dependence development. However, identification of specific genes involved in cocaine conditioning awaits further investigation. We conducted a high throughput gene expression profile analysis of the NAc, during differe...

journal_title：Neuropharmacology

authors： Rodríguez-Borrero E,Rivera-Escalera F,Candelas F,Montalvo J,Muñoz-Miranda WJ,Walker JR,Maldonado-Vlaar CS

更新日期：2010-01-01 00:00:00