Abstract:
:Cocaine produces a motor-stimulant response in part by its actions within the mesolimbic dopamine system. Repeated exposure to cocaine induces an augmented motor activity response which is termed behavioral sensitization, or reverse tolerance. Previous studies have suggested that sensitization may result from increased dopamine neuronal activity in the A10 region; the origin of the mesolimbic dopamine system. However, the exact mechanisms involved in the development of behavioral sensitization remain to be elucidated. Studies on other forms of sensitization in the nervous system suggest a critical role for increased protein kinase C (PKC) activity in the development of the sensitized response. As a first step in examining the role of PKC in cocaine-induced behavioral sensitization, the effect of intra-A10 administration of a PKC inhibitor, H7, on the acute motor-stimulant response to cocaine was studied. Intra-A10 injections of H7 dose-dependently (1.0-30.0 nmol/side) inhibited cocaine (15.0 mg/kg)-induced motor activity. Pretreatment with H7 (30.0 nmol/side) also blocked the cocaine-induced rise of extracellular dopamine in a terminal region of the mesolimbic dopamine system, the nucleus accumbens, as measured by in vivo microdialysis. These data suggest that activation of protein kinases may be important in cocaine-induced motor activity.
journal_name
Neuropharmacologyjournal_title
Neuropharmacologyauthors
Steketee JDdoi
10.1016/0028-3908(93)90023-vsubject
Has Abstractpub_date
1993-12-01 00:00:00pages
1289-97issue
12eissn
0028-3908issn
1873-7064journal_volume
32pub_type
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journal_title:Neuropharmacology
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journal_title:Neuropharmacology
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journal_title:Neuropharmacology
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journal_title:Neuropharmacology
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journal_title:Neuropharmacology
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更新日期:2007-03-01 00:00:00
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pub_type: 杂志文章
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journal_title:Neuropharmacology
pub_type: 杂志文章
doi:10.1016/j.neuropharm.2014.03.007
更新日期:2014-07-01 00:00:00
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journal_title:Neuropharmacology
pub_type: 杂志文章
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更新日期:1993-12-01 00:00:00
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更新日期:2002-08-01 00:00:00
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journal_title:Neuropharmacology
pub_type: 杂志文章
doi:10.1016/j.neuropharm.2006.05.027
更新日期:2006-09-01 00:00:00
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journal_title:Neuropharmacology
pub_type: 杂志文章
doi:10.1016/j.neuropharm.2015.11.031
更新日期:2016-04-01 00:00:00
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journal_title:Neuropharmacology
pub_type: 杂志文章
doi:10.1016/s0028-3908(02)00054-0
更新日期:2002-06-01 00:00:00
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journal_title:Neuropharmacology
pub_type: 杂志文章
doi:10.1016/s0028-3908(99)00126-4
更新日期:1999-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:1994-07-01 00:00:00
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journal_title:Neuropharmacology
pub_type: 杂志文章
doi:10.1016/s0028-3908(02)00081-3
更新日期:2002-09-01 00:00:00
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journal_title:Neuropharmacology
pub_type: 杂志文章
doi:10.1016/s0028-3908(00)00035-6
更新日期:2000-06-08 00:00:00
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journal_title:Neuropharmacology
pub_type: 杂志文章
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journal_title:Neuropharmacology
pub_type: 杂志文章
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更新日期:1993-11-01 00:00:00
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journal_title:Neuropharmacology
pub_type: 杂志文章
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更新日期:2013-03-01 00:00:00
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journal_title:Neuropharmacology
pub_type: 杂志文章
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更新日期:2013-07-01 00:00:00
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journal_title:Neuropharmacology
pub_type: 杂志文章
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更新日期:1982-10-01 00:00:00
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journal_title:Neuropharmacology
pub_type: 杂志文章
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更新日期:1993-01-01 00:00:00
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journal_title:Neuropharmacology
pub_type: 杂志文章
doi:10.1016/j.neuropharm.2004.10.011
更新日期:2005-03-01 00:00:00
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journal_title:Neuropharmacology
pub_type: 杂志文章
doi:10.1016/s0028-3908(11)80015-8
更新日期:1991-12-01 00:00:00
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journal_title:Neuropharmacology
pub_type: 杂志文章
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更新日期:1983-09-01 00:00:00
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journal_title:Neuropharmacology
pub_type: 杂志文章,评审
doi:10.1016/j.neuropharm.2018.09.023
更新日期:2019-02-01 00:00:00
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journal_title:Neuropharmacology
pub_type: 杂志文章
doi:10.1016/j.neuropharm.2010.02.005
更新日期:2010-06-01 00:00:00
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journal_title:Neuropharmacology
pub_type: 杂志文章,评审
doi:10.1016/j.neuropharm.2017.11.018
更新日期:2018-07-01 00:00:00
abstract::The present study used pharmacological and gene ablation techniques to examine the involvement of kappa opioid receptors (KOPr) in modulating the convulsant effects of two mechanistically different drugs: cocaine and pentylenetetrazol (PTZ; GABA-A receptor antagonist) in mice. Systemic administration of the selective ...
journal_title:Neuropharmacology
pub_type: 杂志文章
doi:10.1016/j.neuropharm.2006.10.007
更新日期:2007-03-01 00:00:00