Serotonergic modulation of carbachol-induced rhythmic activity in hippocampal slices.

abstract：:Acute morphine administration produces analgesia and reward, but prolonged use may lead to analgesic tolerance in patients chronically treated for pain and to compulsive intake in opioid addicts. Moreover, long-term exposure may induce physical dependence, manifested as somatic withdrawal symptoms in the absence of th...

journal_title：Neuropharmacology

authors： Contet C,Filliol D,Matifas A,Kieffer BL

更新日期：2008-03-01 00:00:00

abstract：:Slob modulates the activity of the Drosophila Slowpoke calcium-dependent potassium channel (dSlo) via its direct binding to the channel. To characterize the molecular detail of the protein-protein interaction between Slob and dSlo, we constructed a series of Slob mutants that are progressively truncated at either the ...

journal_title：Neuropharmacology

authors： Zhou Y,Fei H,Levitan IB

更新日期：2003-11-01 00:00:00

abstract：:Stimulant drugs produce reward but also activate stress-responsive systems. The corticotropin-releasing factor (CRF) and the related hypothalamus-pituitary-adrenal (HPA) axis stress-responsive systems are activated by stimulant drugs. However, their role in stimulant drug-induced reward remains poorly understood. Here...

journal_title：Neuropharmacology

authors： Contarino A,Kitchener P,Vallée M,Papaleo F,Piazza PV

更新日期：2017-05-01 00:00:00

abstract：:The serotonin transporter (SERT) facilitates high affinity reuptake of 5-HT from the extracellular fluid and dysregulation of transporter function has been implicated in a range of mood disorders including depression. Recent studies have linked immune system activation to depression as well as to altered serotonin tra...

journal_title：Neuropharmacology

authors： Brown E,Mc Veigh CJ,Santos L,Gogarty M,Müller HK,Elfving B,Brayden DJ,Haase J

更新日期：2018-07-15 00:00:00

abstract：:A range of antipsychotic drugs, both "typical" and "atypical", was administered to rats over a time course and at several different dosages. The mRNA levels of dopamine D1, D2 and D3 receptor were measured in either whole brain or dissected brain regions. D3 receptor mRNA was up-regulated in whole brain by clozapine (...

journal_title：Neuropharmacology

authors： D'Souza U,McGuffin P,Buckland PR

更新日期：1997-11-01 00:00:00

abstract：:Marijuana smoking is recognised to impair human cognition and learning, but the mechanisms by which this occurs are not well characterised. This article focuses exclusively on the hippocampus to review the effects of cannabinoids on hippocampal function and evaluate the evidence that hippocampal cannabinoid receptors ...

journal_title：Neuropharmacology

authors： Davies SN,Pertwee RG,Riedel G

更新日期：2002-06-01 00:00:00

abstract：:Bilateral injection of gamma-aminobutyric acid (GABA, 10-300 micrograms) into the substantia nigra (pars reticulata) of rats produced stereotyped sniffing and had an analgesic-like effect on the hot-plate but not on the tail-flick test. These effects of GABA (30 micrograms) were suppressed by simultaneous administrati...

journal_title：Neuropharmacology

authors： Baumeister AA,Hawkins MF,Anderson-Moore LL,Anticich TG,Higgins TD,Griffin P

更新日期：1988-08-01 00:00:00

abstract：:Cyclic nucleotides cAMP and cGMP cooperate to ensure memory acquisition and consolidation. Increasing their levels by phosphodiesterase inhibitors (PDE-Is) enhanced cognitive functions and rescued memory loss in different models of aging and Alzheimer's disease (AD). However, side effects due to the high doses used li...

journal_title：Neuropharmacology

authors： Gulisano W,Tropea MR,Arancio O,Palmeri A,Puzzo D

更新日期：2018-08-01 00:00:00

abstract：:The present studies examined the relationship between protein kinase C (PKC) and L-type voltage-dependent calcium channels in modulating the release of neurotransmitter from K(+)-depolarized rat spinal cord synaptosomes. Activators of PKC, such as phorbol 12-myristate 13-acetate (PMA), mezerein and oleoyl acetylglycer...

journal_title：Neuropharmacology

authors： Gandhi VC,Jones DJ

更新日期：1992-11-01 00:00:00

abstract：:Activation of peroxisome proliferator-activated receptor beta/delta (PPAR-β/δ), a nuclear receptor acting as a transcription factor, was shown to be protective in various models of neurological diseases. However, there is no information about the role of PPAR-β/δ as well as its molecular mechanisms in neonatal hypoxia...

journal_title：Neuropharmacology

authors： Gamdzyk M,Doycheva DM,Malaguit J,Enkhjargal B,Tang J,Zhang JH

更新日期：2018-09-15 00:00:00

abstract：:Changes in brain reward and control systems of frontal cortical areas including the orbitofrontal cortex (OFC) are associated with alcohol use disorders (AUD). The OFC is extensively innervated by monoamines, and drugs that target monoamine receptors have been used to treat a number of neuropsychiatric diseases, inclu...

journal_title：Neuropharmacology

authors： Nimitvilai S,Lopez MF,Woodward JJ

更新日期：2018-07-15 00:00:00

abstract：:A micropipette-system was used to investigate intracranial self-injection of morphine in the rat. The system consisted of a glass micropipette (tip dia 5 microns) connected by flexible tubing and a swivel to a pressure source. Using nose-poking through a hole in one wall of the cage as the operant, rats self-injected ...

journal_title：Neuropharmacology

authors： Welzl H,Kuhn G,Huston JP

更新日期：1989-10-01 00:00:00

abstract：:Orexins are neuropeptides that are exclusively produced by hypothalamic neurons, which project throughout the entire brain. Orexin, also known as hypocretins, were initially identified to play a fundamental role in food intake, arousal and the regulation of sleep and wakefulness. Recent studies identified orexins to b...

journal_title：Neuropharmacology

authors： Sargin D

更新日期：2019-08-01 00:00:00

abstract：:The central amygdala (CeA) is a critical regulator of emotional behavior that has been implicated in psychiatric illnesses, including anxiety disorders and addiction. The CeA corticotropin releasing factor receptor 1 (CRF1) system has been implicated in alcohol use disorder (AUD) and mood disorders, and has been shown...

journal_title：Neuropharmacology

authors： Agoglia AE,Tella J,Herman MA

更新日期：2020-12-01 00:00:00

abstract：:Alcohol use disorder (AUD) affects all sexes, however women who develop AUD may be particularly susceptible to cravings and other components of the disease. While many brain regions are involved in AUD etiology, proper prefrontal cortex (PFC) function is particularly important for top-down craving management and the m...

journal_title：Neuropharmacology

authors： Joffe ME,Winder DG,Conn PJ

更新日期：2020-11-01 00:00:00

abstract：:Transmission at the parallel fibre-Purkinje neurone synapse of the cerebellum can be depressed by a number of presynaptic receptors: endocannabinoid (CB1), metabotropic glutamate (mGluR4), adenosine (A1) and GABA (GABA(B)), which have been implicated in both short- and long-term synaptic plasticity. Stimulation of par...

journal_title：Neuropharmacology

authors： Bellamy TC

更新日期：2007-02-01 00:00:00

abstract：:Neuropeptide S (NPS) is a peptide recently recognized to be present in the CNS, and believed to play a role in vigilance and mood control, as behavioral studies have shown it promotes arousal and has an anxiolytic effect. Although NPS precursor is found in very few neurons, NPS positive fibers are present throughout t...

journal_title：Neuropharmacology

authors： Roncacè V,Polli FS,Zojicic M,Kohlmeier KA

更新日期：2017-11-01 00:00:00

abstract：:Compound IG20 is a newly synthesised sulphated glycolipid that promotes neuritic outgrowth and myelinisation, at the time it causes the inhibition of glial proliferation and facilitates exocytosis in chromaffin cells. Here we have shown that IG20 at 0.3-10 μM afforded neuroprotection in rat hippocampal slices stressed...

journal_title：Neuropharmacology

authors： Punzón E,García-Alvarado F,Maroto M,Fernández-Mendívil C,Michalska P,García-Álvarez I,Arranz-Tagarro JA,Buendia I,López MG,León R,Gandía L,Fernández-Mayoralas A,García AG

更新日期：2017-04-01 00:00:00

abstract：:Amyloid-beta (Abeta) deposition is a defining feature of Alzheimer's disease (AD). The toxicity of Abeta aggregation is thought to contribute to clinical deficits including progressive memory loss and cognitive dysfunction. Therefore, Abeta peptide has become the focus of many therapeutic approaches for the treatment ...

journal_title：Neuropharmacology

authors： Dong J,Revilla-Sanchez R,Moss S,Haydon PG

更新日期：2010-09-01 00:00:00

abstract：:We have examined the effects of a variety of classical and atypical neuroleptic drugs on mitochondrial NADH ubiquinone oxido-reductase (complex I) activity. Sagittal slices of mouse brain incubated in vitro with haloperidol (10 nM) showed time- and concentration-dependent inhibition of complex I. Similar concentration...

journal_title：Neuropharmacology

authors： Balijepalli S,Boyd MR,Ravindranath V

更新日期：1999-04-01 00:00:00

abstract：:In rats with cannulae permanently implanted into the third cerebral ventricle, the effects of different pharmacological manipulations affecting dopaminergic mechanisms, were studied on behaviour and electrocorticographic (ECoG) activity, continuously quantified in its spectrum power. The intraventricular injection (0....

journal_title：Neuropharmacology

authors： Bagetta G,Corasaniti MT,Strongoli MC,Sakurada S,Nisticò G

更新日期：1987-08-01 00:00:00

abstract：:The effects of intracerebroventricular administration of morphine, the selective mu-agonist DAMGO, the delta-agonist DPDPE, the kappa-preferring peptide dynorphin A(1-13) and the kappa-agonist U50,488H on locomotor behaviour in the guinea pig were investigated. Morphine (total dose = 0.01, 0.1, 1, 10, 200 nmol), DAMGO...

journal_title：Neuropharmacology

authors： Bot G,Chahl LA,Brent PJ,Johnston PA

更新日期：1992-09-01 00:00:00

abstract：:beta-Endorphin is the putative precursor molecule of gamma- and alpha-endorphin. To investigate whether long-term changes in the activity of cells producing beta-endorphin are paralleled by alterations in the enzymatic processing of beta-endorphin, the effects of chronic treatment of rats with dopamine (DA) receptor l...

journal_title：Neuropharmacology

authors： Sweep CG,Boersma CJ,Wiegant VM

更新日期：1990-01-01 00:00:00

abstract：:Nicotine elicits several behavioural effects on mood as well as on stress and anxiety processes. Recently, it was found that the higher order components of the sensory cortex, such as the secondary auditory cortex Te2, are essential for the long-term storage of remote fear memories. Therefore, in the present study, we...

journal_title：Neuropharmacology

authors： Cambiaghi M,Grosso A,Renna A,Concina G,Sacchetti B

更新日期：2015-12-01 00:00:00

abstract：:Gastrin-releasing peptide (GRP) receptor-expressing (GRPR)+ neurons have a central role in the spinal transmission of itch. Because their fundamental regulatory mechanisms are not yet understood, it is important to determine how such neurons are excited and integrate itch sensation. In this study, we investigated the ...

journal_title：Neuropharmacology

authors： Kiguchi N,Uta D,Ding H,Uchida H,Saika F,Matsuzaki S,Fukazawa Y,Abe M,Sakimura K,Ko MC,Kishioka S

更新日期：2020-06-15 00:00:00

abstract：:Tuberous Sclerosis Complex (TSC) is a multisystem genetic disorder caused by mutation in either Tsc1 or Tsc2 genes that leads to the hyper activation of the mTOR pathway, a key signalling pathway for synaptic plasticity. TSC is characterized by benign tumors arising in different organs and severe neuropsychiatric symp...

journal_title：Neuropharmacology

authors： Cambiaghi M,Cursi M,Magri L,Castoldi V,Comi G,Minicucci F,Galli R,Leocani L

更新日期：2013-04-01 00:00:00

abstract：:The binding of three, structurally distinct, 5-hydroxytryptamine3 (5-HT3) receptor radioligands was characterized in rat cerebral cortex, rabbit ileum myenteric plexus and NG-108-15 neuroblastoma cells. The density of sites labeled by the three ligands in rat cortex or in rabbit ileum was markedly different. [3H]Quipa...

journal_title：Neuropharmacology

authors： Wong EH,Bonhaus DW,Lee JA,Wu I,Loury DN,Eglen RM

更新日期：1993-09-01 00:00:00

abstract：:Maternal behavior and anxiety are potently modulated by the brain corticotropin-releasing factor (CRF) system postpartum. Downregulation of CRF in limbic brain regions is essential for appropriate maternal behavior and an adaptive anxiety response. Here, we focus our attention on arguably the most important brain regi...

journal_title：Neuropharmacology

authors： Klampfl SM,Schramm MM,Gaßner BM,Hübner K,Seasholtz AF,Brunton PJ,Bayerl DS,Bosch OJ

更新日期：2018-05-01 00:00:00

abstract：:The effect of various doses of tianeptine on the extracellular concentrations of dopamine was studied in the striatum and nucleus accumbens of the rat. At 5 (but not 2.5) mg/kg intraperitoneally, tianeptine increased the extracellular dopamine only in the nucleus accumbens. At 10 mg/kg, the effect was also seen in the...

journal_title：Neuropharmacology

authors： Invernizzi R,Pozzi L,Garattini S,Samanin R

更新日期：1992-03-01 00:00:00

abstract：:Hypoxic-ischemic encephalopathy (HI) accounts for the majority of developmental, motor and cognitive deficits in children, leading to life-long neurological impairments. Since the plasmamembrane sodium/calcium exchanger (NCX) plays a fundamental role in maintaining ionic homeostasis during adult brain ischemia, in the...

journal_title：Neuropharmacology

authors： Cerullo P,Brancaccio P,Anzilotti S,Vinciguerra A,Cuomo O,Fiorino F,Severino B,Di Vaio P,Di Renzo G,Annunziato L,Pignataro G

更新日期：2018-06-01 00:00:00