Self-administration of small amounts of morphine through glass micropipettes into the ventral tegmental area of the rat.

Abstract:

:A micropipette-system was used to investigate intracranial self-injection of morphine in the rat. The system consisted of a glass micropipette (tip dia 5 microns) connected by flexible tubing and a swivel to a pressure source. Using nose-poking through a hole in one wall of the cage as the operant, rats self-injected quantities as small as 50 ng/5 nl of morphine into the ventral tegmental area. In contrast, rats in the saline-treated group and yoked-control group did not increase their rates of nose-poking behaviour above baseline levels. Intermittent reinforcement in the morphine-treated group resulted in a further increase in the rate of nose-poking. Histological inspection of the site of injection revealed minimal damage to brain tissue and likely confinement of the injected solution to the area around the tip of the pipette.

journal_name

Neuropharmacology

journal_title

Neuropharmacology

authors

Welzl H,Kuhn G,Huston JP

doi

10.1016/0028-3908(89)90112-3

subject

Has Abstract

pub_date

1989-10-01 00:00:00

pages

1017-23

issue

10

eissn

0028-3908

issn

1873-7064

journal_volume

28

pub_type

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