Abstract:
:A micropipette-system was used to investigate intracranial self-injection of morphine in the rat. The system consisted of a glass micropipette (tip dia 5 microns) connected by flexible tubing and a swivel to a pressure source. Using nose-poking through a hole in one wall of the cage as the operant, rats self-injected quantities as small as 50 ng/5 nl of morphine into the ventral tegmental area. In contrast, rats in the saline-treated group and yoked-control group did not increase their rates of nose-poking behaviour above baseline levels. Intermittent reinforcement in the morphine-treated group resulted in a further increase in the rate of nose-poking. Histological inspection of the site of injection revealed minimal damage to brain tissue and likely confinement of the injected solution to the area around the tip of the pipette.
journal_name
Neuropharmacologyjournal_title
Neuropharmacologyauthors
Welzl H,Kuhn G,Huston JPdoi
10.1016/0028-3908(89)90112-3subject
Has Abstractpub_date
1989-10-01 00:00:00pages
1017-23issue
10eissn
0028-3908issn
1873-7064journal_volume
28pub_type
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