Abstract：
:A micropipette-system was used to investigate intracranial self-injection of morphine in the rat. The system consisted of a glass micropipette (tip dia 5 microns) connected by flexible tubing and a swivel to a pressure source. Using nose-poking through a hole in one wall of the cage as the operant, rats self-injected quantities as small as 50 ng/5 nl of morphine into the ventral tegmental area. In contrast, rats in the saline-treated group and yoked-control group did not increase their rates of nose-poking behaviour above baseline levels. Intermittent reinforcement in the morphine-treated group resulted in a further increase in the rate of nose-poking. Histological inspection of the site of injection revealed minimal damage to brain tissue and likely confinement of the injected solution to the area around the tip of the pipette.
journal_name
Neuropharmacologyjournal_title
Neuropharmacologyauthors
Welzl H,Kuhn G,Huston JPdoi
10.1016/0028-3908(89)90112-3subject
Has Abstractpub_date
1989-10-01 00:00:00pages
1017-23issue
10eissn
0028-3908issn
1873-7064journal_volume
28pub_type
杂志文章abstract：:Many studies have described potent effects of BDNF, 17β-estradiol or androgen on hippocampal synapses and their plasticity. Far less information is available about the interactions between 17β-estradiol and BDNF in hippocampus, or interactions between androgen and BDNF in hippocampus. Here we review the regulation of ...
journal_title：Neuropharmacology
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journal_title：Neuropharmacology
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journal_title：Neuropharmacology
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journal_title：Neuropharmacology
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journal_title：Neuropharmacology
pub_type： 杂志文章
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pub_type： 杂志文章,评审
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journal_title：Neuropharmacology
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journal_title：Neuropharmacology
pub_type： 杂志文章
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更新日期：2017-03-01 00:00:00
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journal_title：Neuropharmacology
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journal_title：Neuropharmacology
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doi：10.1016/j.neuropharm.2013.08.029
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pub_type： 杂志文章
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journal_title：Neuropharmacology
pub_type： 杂志文章
doi：10.1016/0028-3908(91)90123-s
更新日期：1991-08-01 00:00:00
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journal_title：Neuropharmacology
pub_type： 杂志文章
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更新日期：1998-01-01 00:00:00
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journal_title：Neuropharmacology
pub_type： 杂志文章
doi：10.1016/j.neuropharm.2007.07.014
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journal_title：Neuropharmacology
pub_type： 杂志文章
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pub_type： 杂志文章,评审
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journal_title：Neuropharmacology
pub_type： 杂志文章
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更新日期：2019-01-01 00:00:00
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journal_title：Neuropharmacology
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journal_title：Neuropharmacology
pub_type： 杂志文章
doi：10.1016/j.neuropharm.2009.01.003
更新日期：2009-03-01 00:00:00
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journal_title：Neuropharmacology
pub_type： 杂志文章
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journal_title：Neuropharmacology
pub_type： 杂志文章
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journal_title：Neuropharmacology
pub_type： 杂志文章
doi：10.1016/0028-3908(82)90067-3
更新日期：1982-08-01 00:00:00
abstract：:The effect of drugs which down-regulate the function of GABA at the level of the GABA/benzodiazepine receptor complex was studied on the conflict test in the rat. The GABA receptor antagonist, bicuculline, and the blockers of the GABA-receptor-coupled chloride channel, picrotoxin and pentylenetetrazol, produced a dose...
journal_title：Neuropharmacology
pub_type： 杂志文章
doi：10.1016/0028-3908(86)90181-4
更新日期：1986-05-01 00:00:00
