Inhibition of the morphine withdrawal syndrome and the development of physical dependence by lithium in mice.


:Due to the claim that lithium (Li+) reduces morphine self-administration in dependent rats, the effects of acute and chronic Li+ treatments on naloxone-precipitated withdrawal syndrome and physical dependence development to morphine in mice chronically treated with morphine, were evaluated. Morphine dependency was induced by the ingestion of morphine through drinking water in increasing doses for 10 days. Physical dependence to morphine was observed by precipitating an abstinence syndrome with naloxone (2 mg/kg, i.p.). In the acute experiments, Li+ (1 and 10 mg/kg, i.p.) was administered 1 hr prior to challenge with naloxone to morphine-dependent mice whereas for chronic studies, mice received morphine concomitant with Li+ (1200 mg/l) as drinking fluid for 10 days. Results obtained indicate that acute Li+ administration significantly reduced the withdrawal signs, and we were unable to induce some degree of morphine dependency in co-administration of Li+ to mice receiving chronic morphine treatment as compared to chronic morphine administration alone. The present study revealed that even in mice with very much lower serum Li+ levels than the commonly accepted therapeutic range there was a significant reduction in the withdrawal signs. It has been shown that Li+ and morphine have diverse effects on the transmembrane signal control systems. The interaction of Li+ and morphine might be through these systems.






Dehpour AR,Farsam H,Azizabadi-Farahani M




Has Abstract


1995-01-01 00:00:00














  • Voluntary wheel running effects on intra-accumbens opioid driven diet preferences in male and female rats.

    abstract::Palatability driven feeding and voluntary physical activity are mediated by and influence similar neural mechanisms, notably through the actions of opioids within the nucleus accumbens. Recent studies suggest that access to a voluntary running wheel results in sex dependent behavioral and physiological adaptations rel...


    pub_type: 杂志文章


    authors: Lee JR,Tapia MA,Weise VN,Bathe EL,Vieira-Potter VJ,Booth FW,Will MJ

    更新日期:2019-09-01 00:00:00

  • Interaction of corticosterone and nicotine in regulation of prepulse inhibition in mice.

    abstract::The aim of the present study was to investigate if different levels of circulating corticosterone (CORT) modulate the effect of nicotine on prepulse inhibition (PPI), a measure of sensorimotor gating that is disrupted in schizophrenia and other mental illnesses. Four groups of mice were investigated: sham-operated, ad...


    pub_type: 杂志文章


    authors: Ingram N,Martin S,Wang JH,van der Laan S,Loiacono R,van den Buuse M

    更新日期:2005-01-01 00:00:00

  • Expression of GFP-tagged neuronal glutamate transporters in cerebellar Purkinje neurons.

    abstract::Of the five excitatory amino acid transporters (EAATs) identified, two genes are expressed by neurons (EAAT3 and EAAT4) and give rise to transporters confined to neuronal cell bodies and dendrites. At an ultrastructural level, EAAT3 and EAAT4 proteins are clustered at the edges of postsynaptic densities of excitatory ...


    pub_type: 杂志文章


    authors: Meera P,Dodson PD,Karakossian MH,Otis TS

    更新日期:2005-11-01 00:00:00

  • Existence of FGFR1-5-HT1AR heteroreceptor complexes in hippocampal astrocytes. Putative link to 5-HT and FGF2 modulation of hippocampal gamma oscillations.

    abstract::The majority of the fibroblast growth factor receptor 1-serotonin 1 A receptor (FGFR1-5-HT1AR) heterocomplexes in the hippocampus appeared to be located mainly in the neuronal networks and a relevant target for antidepressant drugs. Through a neurochemical and electrophysiological analysis it was therefore tested in t...


    pub_type: 杂志文章


    authors: Narváez M,Andrade-Talavera Y,Valladolid-Acebes I,Fredriksson M,Siegele P,Hernandez-Sosa A,Fisahn A,Fuxe K,Borroto-Escuela DO

    更新日期:2020-06-15 00:00:00

  • Age-related change in alpha-adrenergic responsiveness of the urinary bladder of the rat is regionally specific.

    abstract::The effects of age on the responsiveness of the body of the urinary bladder and base of the bladder to alpha-adrenergic agonists were studied. Regions of the bladder were isolated from Fischer 344 rats, ages 7, 16, and 27 months. Maximum isotonic contractions elicited by potassium chloride (KCl) in both regions of the...


    pub_type: 杂志文章


    authors: Ordway GA,Kolta MG,Gerald MC,Wallace LJ

    更新日期:1986-12-01 00:00:00

  • Intrastriatal injection of kainic acid prevents the development of postsynaptic dopamine receptor hypersensitivity after chronic haloperidol treatment.

    abstract::Rats injected intrastriatally with kainic acid (KA), in contrast to sham-treated (control) animals, showed no tolerance toward catalepsy induced by chronic haloperidol treatment (28 days). After termination of chronic haloperidol treatment in control animals, apomorphine-induced stereotypy was significantly enhanced a...


    pub_type: 杂志文章


    authors: Zarkovsky AM,Nurk AM,Rägo LK,Allikmets LH

    更新日期:1982-02-01 00:00:00

  • Block of calcium channels in rat neurons by synthetic omega-Aga-IVA.

    abstract::We investigated block of voltage-dependent Ca channels in freshly dissociated rat central and peripheral neurons by the synthetic peptide omega-Aga-IVA. Synthetic omega-Aga-IVA blocked approximately 90% of the high-threshold Ca current in cerebellar Purkinje neurons with an estimated Kd of approximately 1.5 nM, slight...


    pub_type: 杂志文章


    authors: Mintz IM,Bean BP

    更新日期:1993-11-01 00:00:00

  • Dopamine D3 receptor-modulated neuroprotective effects of lisuride.

    abstract::Dopamine (DA) contributes to the regulation of voluntary movement, and a deficiency in DAergic neurons leads to movement disorders. The objective of this study was to examine the neuroprotective effect of DA D2-like receptor agonist, lisuride, and the role of DA receptors in this protection. Treatment with lisuride al...


    pub_type: 杂志文章


    authors: Kim M,Lee S,Cho J,Kim G,Won C

    更新日期:2017-05-01 00:00:00

  • Expression of D2 receptor isoforms in cultured neurons reveals equipotent autoreceptor function.

    abstract::Alternative splicing of the dopamine D2 receptor gene produces two distinct isoforms referred to as D2long (D2L) and D2short (D2S). In mesencephalic dopamine neurons, inhibition of the firing rate through activation of somatodendritic D2 receptors and blockade of neurotransmitter release through stimulation of termina...


    pub_type: 杂志文章


    authors: Jomphe C,Tiberi M,Trudeau LE

    更新日期:2006-04-01 00:00:00

  • Evaluation of the effect of chronic antidepressant treatment on neurokinin-1 receptor expression in the rat brain.

    abstract::Clinically effective antidepressants are thought to exert their therapeutic effects by facilitating central monoamine neurotransmission. However, recent data showing that neurokinin-1 receptor (NK1R) antagonists have antidepressant properties in both animal and clinical studies raise the possibility that classical ant...


    pub_type: 杂志文章


    authors: Sartori SB,Burnet PWJ,Sharp T,Singewald N

    更新日期:2004-06-01 00:00:00

  • Ca/calmodulin-dependent kinase II inhibitor KN62 attenuates glutamate release by inhibiting voltage-dependent Ca(2+)-channels.

    abstract::The effect of KN62 (1-[N,O-bis(5-isoquinolinesulphonyl)-N -methyl-L-tyrosyl]-4-phenylpiperazine), a putative inhibitor of Ca/calmodulin-dependent kinase II (Ca/CaM-K II), on glutamate release from isolated nerve-terminals (synaptosomes) was examined. The drug caused a potent inhibition of KCl- and 4-aminopyridine-evok...


    pub_type: 杂志文章


    authors: Sihra TS,Pearson HA

    更新日期:1995-07-01 00:00:00

  • Cyclic nucleotide dependent phosphorylation of neuronal nitric oxide synthase inhibits catalytic activity.

    abstract::We have examined the regulation of neuronal nitric oxide synthase (NOS) by phosphorylation with cyclic-GMP (PKG) and cyclic-AMP-dependent (PKA) protein kinases. In vitro phosphorylation studies indicate that both PKG and PKA phosphorylate NOS on a single site. Phosphoamino-acid analysis and peptide mapping demonstrate...


    pub_type: 杂志文章


    authors: Dinerman JL,Steiner JP,Dawson TM,Dawson V,Snyder SH

    更新日期:1994-11-01 00:00:00

  • Activation of 5-HT6 receptors inhibits corticostriatal glutamatergic transmission.

    abstract::We investigated the effect of 5-HT6 receptor subtype activation on glutamatergic transmission by means of whole-cell patch-clamp electrophysiological recordings from medium spiny neurons of the striatum and layer V pyramidal neurons of the prefrontal cortex. To this aim, we took advantage of a novel ligand, ST1936, sh...


    pub_type: 杂志文章


    authors: Tassone A,Madeo G,Schirinzi T,Vita D,Puglisi F,Ponterio G,Borsini F,Pisani A,Bonsi P

    更新日期:2011-09-01 00:00:00

  • Proconvulsant and anticonvulsant effects in mice of acute and chronic treatment with cocaine.

    abstract::The proconvulsant and anticonvulsant effects of acute and chronic exposure to cocaine were investigated in adult, male, CF-1 mice. The proconvulsant effects of cocaine in mice only manifested themselves after daily exposure to motor-stimulant doses. Although daily treatment decreased electroshock convulsion threshold,...


    pub_type: 杂志文章


    authors: Karler R,Petty C,Calder L,Turkanis SA

    更新日期:1989-07-01 00:00:00

  • Neuropathic and cAMP-induced pain behavior is ameliorated in mice lacking CNGB1.

    abstract::Cyclic nucleotide-gated (CNG) channels, which are directly activated by cAMP and cGMP, have long been known to play a key role in retinal and olfactory signal transduction. Emerging evidence indicates that CNG channels are also involved in signaling pathways important for pain processing. Here, we found that the expre...


    pub_type: 杂志文章


    authors: Kallenborn-Gerhardt W,Metzner K,Lu R,Petersen J,Kuth MS,Heine S,Drees O,Paul M,Becirovic E,Kennel L,Flauaus C,Gross T,Wack G,Hohmann SW,Nemirovski D,Del Turco D,Biel M,Geisslinger G,Michalakis S,Schmidtko A

    更新日期:2020-07-01 00:00:00

  • Central nervous system supersensitivity and withdrawal from long-term treatment with barbital.

    abstract::The effects of withdrawal from long-term treatment with increasing concentrations of sodium barbital in the drinking water were studied in rats. Animals were tested 72 hr after the removal of the drug. Withdrawal of barbital induced a significant leftward displacement of the dose-response curves obtained for the convu...


    pub_type: 杂志文章


    authors: Sandoval MR,Palermo-Neto J

    更新日期:1985-12-01 00:00:00

  • Posterior hypothalamic receptors involved in the cardiovascular changes elicited by electrical stimulation of the rostral ventrolateral medulla.

    abstract::The posterior hypothalamic receptors involved in the cardiovascular responses to electrical stimulation of the rostral ventrolateral medulla were investigated in urethane-anaesthetized rats. Electrical stimulation of the rostral ventrolateral medulla produced a significant increase in systolic blood pressure. This res...


    pub_type: 杂志文章


    authors: Bachelard H,Rivest R,Marsden CA

    更新日期:1991-07-01 00:00:00

  • Midazolam inhibits long-term potentiation through modulation of GABAA receptors.

    abstract::Benzodiazepine drugs (BZ) are used for anxiety, insomnia, and seizures. They worsen memory, especially in large doses, but the mechanism of this action is uncertain. In micromolar concentrations, benzodiazepines have been shown to reduce long-term potentiation (LTP), which could be a cellular basis for their amnesic a...


    pub_type: 杂志文章


    authors: Evans MS,Viola-McCabe KE

    更新日期:1996-03-01 00:00:00

  • Multiple mechanisms for the effects of capsaicin, bradykinin and nicotine on CGRP release from tracheal afferent nerves: role of prostaglandins, sympathetic nerves and mast cells.

    abstract::Application of capsaicin (CAP), bradykinin (BK) or nicotine (NIC) to intraluminally perfused rat tracheas induced an increase in calcitonin gene-related peptide (CGRP) levels in the perfusates. Depletion of sensory afferent CGRP with systemic CAP pretreatment resulted in a significant reduction of CGRP release evoked ...


    pub_type: 杂志文章


    authors: Hua XY,Jinno S,Back SM,Tam EK,Yaksh TL

    更新日期:1994-10-01 00:00:00

  • Individual differences in oral nicotine intake in rats.

    abstract::To study individual differences in nicotine preference and intake, male and female rats were given free access to a choice of oral nicotine (10 or 20 mg/L) or water for 24 h/day for periods of at least six weeks, starting at adolescence or adulthood. A total of 341 rats, were used in four different experiments; weight...


    pub_type: 杂志文章


    authors: Nesil T,Kanit L,Collins AC,Pogun S

    更新日期:2011-07-01 00:00:00

  • Regional differences in the effects of isoflurane on neurotransmitter release.

    abstract::Stimulus evoked neurotransmitter release requires that Na(+) channel-dependent nerve terminal depolarization be transduced into synaptic vesicle exocytosis. Inhaled anesthetics block presynaptic Na(+) channels and selectively inhibit glutamate over GABA release from isolated nerve terminals, indicating mechanistic dif...


    pub_type: 杂志文章


    authors: Westphalen RI,Kwak NB,Daniels K,Hemmings HC Jr

    更新日期:2011-09-01 00:00:00

  • Drug interactions on spontaneous locomotor activity in rats. Neuroleptics and amphetamine-induced hyperactivity.

    abstract::The locomotor activity of female rats was recorded during 10-min sessions in a circular open-field apparatus after the administration of vehicle or drug. Dose-response curves were obtained for seven neuroleptic drugs both alone (spontaneous activity) and in combination with 1.0 mg/kg of d-amphetamine. Haloperidol, pim...


    pub_type: 杂志文章


    authors: Schaefer GJ,Michael RP

    更新日期:1984-08-01 00:00:00

  • The roles of nerve growth factor and cholecystokinin in the enhancement of morphine analgesia in a rodent model of central nervous system inflammation.

    abstract::Animal models of inflammatory pain are characterized by the release of inflammatory mediators such as cytokines and neurotrophic factors, and enhanced analgesic sensitivity to opioids. In this study, we examine the mechanisms underlying this effect, in particular the roles of cholecystokinin (CCK) and nerve growth fac...


    pub_type: 杂志文章


    authors: Xanthos DN,Kumar N,Theodorsson E,Coderre TJ

    更新日期:2009-03-01 00:00:00

  • The influence of subunit composition on the interaction of neurosteroids with GABA(A) receptors.

    abstract::The influence of the subunit composition of human GABA(A) receptors upon the GABA-modulatory properties of 5alpha-pregnan-3alpha-ol-20-one (5alpha,3alpha) has been examined using the Xenopus laevis oocyte expression system and the two electrode voltage-clamp technique. Steroid potency (EC(50)) is modestly influenced b...


    pub_type: 杂志文章


    authors: Belelli D,Casula A,Ling A,Lambert JJ

    更新日期:2002-09-01 00:00:00

  • Effects of behaviorally active doses of thyrotropin-releasing hormone and its analog MK-771 on dopaminergic neuronal systems in the brain of the rat.

    abstract::The effects of thyrotropin-releasing hormone (TRH) and an analog of this hormone, MK-771, were determined on body shaking behavior and on biochemical estimates of the activity of dopamine (DA) neurons in the rat. Both compounds elicited dose-related episodes of "wet-dog shakes". A dose of TRH (20 mg/kg, i.p.) which ca...


    pub_type: 杂志文章


    authors: Yamada K,Demarest KT,Moore KE

    更新日期:1984-07-01 00:00:00

  • Comparison of opioid and GABA receptor control of excitability and membrane conductance in hippocampal CA1 pyramidal cells in rat.

    abstract::Opioids are thought to increase the excitability of hippocampal pyramidal cells by decreasing release of neurotransmitter from inhibitory interneurons. This study compared the actions of the opioid agonist normorphine, and the GABA receptor antagonist bicuculline, on the responses of CA1 pyramidal cells to afferent st...


    pub_type: 杂志文章


    authors: Swearengen E,Chavkin C

    更新日期:1989-07-01 00:00:00

  • 5HT2 receptor activation facilitates P2X receptor mediated excitatory neurotransmission to cardiac vagal neurons in the nucleus ambiguus.

    abstract::Parasympathetic preganglionic cardiac vagal neurons (CVNs) which dominate the control of heart rate are located within the nucleus ambiguus (NA). Serotonin (5HT), and in particular 5HT2 receptors, play an important role in cardiovascular function in the brainstem. However, there is a lack of information on the mechani...


    pub_type: 杂志文章


    authors: Dergacheva O,Wang X,Kamendi H,Cheng Q,Pinol RM,Jameson H,Gorini C,Mendelowitz D

    更新日期:2008-06-01 00:00:00

  • GABAergic drugs, morphine and morphine tolerance: a study in relation to nociception and gastrointestinal transit in mice.

    abstract::Agonists and antagonists of gamma-aminobutyric acid, i.e. GABAergic drugs, such as muscimol, baclofen or bicuculline, alone or in combination, exhibited analgesic effects per se and enhanced the analgesia induced by morphine. The analgesic effects of GABAergic drugs were unaffected by administration of naloxone in a d...


    pub_type: 杂志文章


    authors: Sivam SP,Ho IK

    更新日期:1983-06-01 00:00:00

  • Picrotoxin inhibits the effect of ethanol on the spontaneous efflux of [3H]-dopamine from superfused slices of rat corpus striatum.

    abstract::The presence of ethanol, 100 microM, in the superfusate enhanced the spontaneous release of previously uptaken [3H]-dopamine from slices of rat corpus striatum, but produced a small inhibition of K+-stimulated release. The concomitant presence of picrotoxin, 10 microM, in the superfusate prevented the enhancement of s...


    pub_type: 杂志文章


    authors: Samuel D,Lynch MA,Littleton JM

    更新日期:1983-12-01 00:00:00

  • Centrally administered hemokinin-1 (HK-1), a neurokinin NK1 receptor agonist, produces substance P-like behavioral effects in mice and gerbils.

    abstract::Hemokinin-1 (HK-1) is a recently described mouse tachykinin peptide whose biological functions are not fully understood. To date, a unique receptor for HK-1 has not been identified. Recent studies suggest HK-1 may have a role in immunological functions, but there has been little characterization of HK-1's effects in t...


    pub_type: 杂志文章


    authors: Duffy RA,Hedrick JA,Randolph G,Morgan CA,Cohen-Williams ME,Vassileva G,Lachowicz JE,Laverty M,Maguire M,Shan LS,Gustafson E,Varty GB

    更新日期:2003-08-01 00:00:00