Antagonism of the synaptic depressant actions of L-AP4 in the lateral perforant path by MAP4.

abstract：:The effect of acute or repeated treatment with the antidepressant clomipramine (CIM) on N-methyl-D-aspartate (NMDA) evoked changes in extracellular 5-hydroxytryptamine (5-HT) in the raphe nuclei and frontal cortex of the same rat has been studied using microdialysis. Acute injection of CIM (10 or 20 mg/kg) caused an i...

journal_title：Neuropharmacology

authors： Pallotta M,Segieth J,Sadideen F,Whitton PS

更新日期：2001-09-01 00:00:00

abstract：:More studies are required to develop therapeutic agents for treating spinocerebellar ataxia type 3 (SCA3), which is caused by mutant polyglutamine-expanded ataxin-3 and is the most prevalent subtype of spinocerebellar ataxias. T1-11 [N6-(4-Hydroxybenzyl) adenosine], isolated from a Chinese medicinal herb Gastordia ela...

journal_title：Neuropharmacology

authors： Chou AH,Chen YL,Chiu CC,Yuan SJ,Weng YH,Yeh TH,Lin YL,Fang JM,Wang HL

更新日期：2015-12-01 00:00:00

abstract：:The endocannabinoid system (ECS) comprises the cannabinoid receptors CB1 and CB2 and their endogenous arachidonic acid-derived agonists 2-arachidonoyl glycerol and anandamide, which play important neuromodulatory roles. Recently, a novel class of negative allosteric CB1 receptor peptide ligands, hemopressin-like pepti...

journal_title：Neuropharmacology

authors： Hofer SC,Ralvenius WT,Gachet MS,Fritschy JM,Zeilhofer HU,Gertsch J

更新日期：2015-11-01 00:00:00

abstract：:The hypothalamic-pituitary-adrenal (HPA) axis is activated by a wide range of stimuli, including drugs. Here we report that in male rats, a dose of sodium butyrate (NaBu) that is typically used to inhibit histone deacetylation (1200 mg/kg) increased the peripheral levels of HPA hormones and glucose. In a further exper...

journal_title：Neuropharmacology

authors： Gagliano H,Delgado-Morales R,Sanz-Garcia A,Armario A

更新日期：2014-04-01 00:00:00

abstract：:A genetic component is associated with the development of many forms of epilepsy. Recently, mutations in the GABAA receptor have been linked to several inherited epilepsies. One of these mutations is a non-conservative change of alanine to aspartate in the third transmembrane domain of the alpha1 subunit. To determine...

journal_title：Neuropharmacology

authors： Fisher JL

更新日期：2004-04-01 00:00:00

abstract：:Animal models of inflammatory pain are characterized by the release of inflammatory mediators such as cytokines and neurotrophic factors, and enhanced analgesic sensitivity to opioids. In this study, we examine the mechanisms underlying this effect, in particular the roles of cholecystokinin (CCK) and nerve growth fac...

journal_title：Neuropharmacology

authors： Xanthos DN,Kumar N,Theodorsson E,Coderre TJ

更新日期：2009-03-01 00:00:00

abstract：:The effects of several stress procedures on the release of 5-HT in the dorsal and median raphe nuclei (DRN and MRN, respectively) and in forebrain structures of the rat brain innervated by both nuclei have been studied using intracerebral microdialysis. Handling for 30 sec, a saline injection and forced swimming for 5...

journal_title：Neuropharmacology

authors： Adell A,Casanovas JM,Artigas F

更新日期：1997-04-01 00:00:00

abstract：:Tau hyperphosphorylation and memory deficit are characteristic alterations of Alzheimer's disease (AD), and glycogen synthase kinase-3 (GSK-3) plays a crucial role in these AD-like changes. We have reported that activation of GSK-3 through ventricular injection of wortmannin and GF-109203X (WT/GFX, 100 microM each) in...

journal_title：Neuropharmacology

authors： Peng JH,Zhang CE,Wei W,Hong XP,Pan XP,Wang JZ

更新日期：2007-06-01 00:00:00

abstract：:Postsynaptic Density Protein-95 (PSD-95) is a major scaffolding protein in the excitatory synapses in the brain and a critical regulator of synaptic maturation for NMDA and AMPA receptors. PSD-95 deficiency has been linked to cognitive and learning deficits implicated in neurodevelopmental disorders such as autism and...

journal_title：Neuropharmacology

authors： McEachern EP,Coley AA,Yang SS,Gao WJ

更新日期：2020-11-15 00:00:00

abstract：:Serotonin (5-HT)1A and σ1 receptors have been implicated in psychiatric disorders. We previously found that combined 5-HT reuptake inhibition and σ1 receptor activation has a synergistic effect on prefrontal dopaminergic transmission in adrenalectomized/castrated mice lacking circulating steroid hormones. In the prese...

journal_title：Neuropharmacology

authors： Hiramatsu N,Ago Y,Hasebe S,Nishimura A,Mori K,Takuma K,Matsuda T

更新日期：2013-12-01 00:00:00

abstract：:Recently we reported that fluoxetine (10 mg/kg) improves functional recovery by attenuating blood spinal cord barrier (BSCB) disruption after spinal cord injury (SCI). Here we investigated whether a low-dose of fluoxetine (1 mg/kg) and vitamin C (100 mg/kg), separately not possessing any protective effect, prevents BS...

journal_title：Neuropharmacology

authors： Lee JY,Choi HY,Yune TY

更新日期：2016-10-01 00:00:00

abstract：:GABAA receptor is the primary mediator of inhibition in the adult mammalian brain. Our recent studies revealed that a classic gating scheme for GABAAR needed to be updated with an intermediate step (flipping) and that the α1Phe64 mutation at the GABA binding site affects this transition. However, description of flippi...

journal_title：Neuropharmacology

authors： Kisiel M,Jatczak M,Brodzki M,Mozrzymas JW

更新日期：2018-03-15 00:00:00

abstract：:Nimodipine is a 1,4-dihydropyridine (DHP) calcium channel blocker which is used in the treatment of neurological deficits associated with subarachnoid hemorrhage. Small angle x-ray diffraction, differential scanning calorimetry, and equilibrium and kinetic binding techniques were used to study the interaction of nimod...

journal_title：Neuropharmacology

authors： Herbette LG,Mason PE,Sweeney KR,Trumbore MW,Mason RP

更新日期：1994-02-01 00:00:00

abstract：:Anesthetics exposure to neonates leads to impairment of hippocampal synaptic plasticity and cognitive functions later in life. This phenomenon complies with the concept of metaplasticity: a priming stimulation can affect induction of synaptic plasticity mins or days later. We aimed to understand whether small conducta...

journal_title：Neuropharmacology

authors： Yu X,Zhang F,Shi J

更新日期：2018-10-01 00:00:00

abstract：:Opioid drugs such as heroin interact directly with opioid receptors whilst other addictive drugs, including marijuana, alcohol and nicotine indirectly activate endogenous opioid systems to contribute to their rewarding properties. The opioid system therefore plays a key role in addiction neurobiology and continues to ...

journal_title：Neuropharmacology

authors： Kieffer BL,Evans CJ

更新日期：2009-01-01 00:00:00

abstract：:Mechanisms underlying the neuroprotective properties of the weak MAO-A inhibitor moclobemide are not understood. Increasing evidence suggests that a moderate increase in intracellular free protons may contribute to neuroprotective properties due to a proton-mediated decrease in neuronal activity. Therefore, we studied...

journal_title：Neuropharmacology

authors： Bonnet U,Leniger T,Wiemann M

更新日期：2000-08-23 00:00:00

abstract：:The kynurenine pathway of tryptophan metabolism has been implicated in brain function, immunoregulation, anti-microbial mechanisms and pregnancy. Some of these actions are due to depletion of tryptophan and others to the formation of biologically active metabolites. This review focuses on the roles of the kynurenine p...

journal_title：Neuropharmacology

authors： Hunt NH,Too LK,Khaw LT,Guo J,Hee L,Mitchell AJ,Grau GE,Ball HJ

更新日期：2017-01-01 00:00:00

abstract：:Long-term consumption of ethanol affects cortical areas that are important for learning and memory, cognition, and decision-making. Deficits in cortical function may contribute to alcohol-abuse disorders by impeding an individual's ability to control drinking. Previous studies from this laboratory show that acute etha...

journal_title：Neuropharmacology

authors： den Hartog C,Zamudio-Bulcock P,Nimitvilai S,Gilstrap M,Eaton B,Fedarovich H,Motts A,Woodward JJ

更新日期：2016-08-01 00:00:00

abstract：:This study utilised the selective 5-ht(5A) receptor antagonist, SB-699551-A (3-cyclopentyl-N-[2-(dimethylamino)ethyl]-N-[(4'-{[(2-phenylethyl)amino]methyl}-4-biphenylyl)methyl]propanamide dihydrochloride), to investigate 5-ht5A receptor function in guinea pig brain. SB-699551-A competitively antagonised 5-HT-stimulate...

journal_title：Neuropharmacology

authors： Thomas DR,Soffin EM,Roberts C,Kew JN,de la Flor RM,Dawson LA,Fry VA,Coggon SA,Faedo S,Hayes PD,Corbett DF,Davies CH,Hagan JJ

更新日期：2006-09-01 00:00:00

abstract：:Destruction of the ventral noradrenergic pathway elicited by administration of 6-hydroxydopamine (6-OHDA, 5 micrograms into each side of the ventral pons) reduced the content of norepinephrine (NE) in the anterior hypothalamus (-80%) and induced an increase in arterial blood pressure (ABP) and in heart rate. These hyp...

journal_title：Neuropharmacology

authors： Benarroch EE,Balda MS,Finkielman S,Nahmod VE

更新日期：1983-01-01 00:00:00

abstract：:Methamphetamine toxicity is associated with cell death and loss of dopamine neuron terminals in the striatum similar to what is found in some neurodegenerative diseases. Conversely, the endocannabinoid system (ECS) has been suggested to be neuroprotective in the brain, and new pharmacological tools have been developed...

journal_title：Neuropharmacology

authors： Nader J,Rapino C,Gennequin B,Chavant F,Francheteau M,Makriyannis A,Duranti A,Maccarrone M,Solinas M,Thiriet N

更新日期：2014-12-01 00:00:00

abstract：:Chronic pain states are highly prevalent and yet poorly controlled by currently available analgesics, representing an enormous clinical, societal, and economic burden. Existing pain medications have significant limitations and adverse effects including tolerance, dependence, gastrointestinal dysfunction, cognitive imp...

journal_title：Neuropharmacology

authors： Woodhams SG,Chapman V,Finn DP,Hohmann AG,Neugebauer V

更新日期：2017-09-15 00:00:00

abstract：:Dichlorvos is a synthetic insecticide that belongs to the family of chemically related organophosphate (OP) pesticides. It can be released into the environment as a major degradation product of other OPs, such as trichlorfon, naled, and metrifonate. Dichlorvos exerts its toxic effects in humans and animals by inhibiti...

journal_title：Neuropharmacology

authors： Wani WY,Gudup S,Sunkaria A,Bal A,Singh PP,Kandimalla RJ,Sharma DR,Gill KD

更新日期：2011-12-01 00:00:00

abstract：:Effects of cations on binding of 0.1-10 nM 3H-ADTN to calf caudate membranes included decreased apparent Bmax by [Na+] greater than or equal to 100 mM, little effect on Kd or on affinity of other dopamine (DA) agonists (DA and apomorphine), decreased slopes of inhibition curves produced by agonists, but increased affi...

journal_title：Neuropharmacology

authors： Lamont JS,Kula NS,Baldessarini RJ

更新日期：1987-06-01 00:00:00

abstract：:Biochemical, behavioral and electrophysiological evidence suggests interactions between pathways containing neuronal nicotinic acetylcholine receptors (NAChRs) and excitatory amino acid receptors. Recently, protective effects of nicotine against N-methyl-D-aspartate (NMDA)-induced toxicity in primary cortical cultures...

journal_title：Neuropharmacology

authors： Rao TS,Correa LD,Lloyd GK

更新日期：1997-01-01 00:00:00

abstract：:The effects of nefiracetam on GABA-induced chloride currents were studied with rat dorsal root ganglion neurons in primary culture using the whole-cell patch-clamp technique. The dose-response curve for GABA-induced currents was shifted by 16 microM to lower concentrations by 10 microM nefiracetam while the maximal re...

journal_title：Neuropharmacology

authors： Huang CS,Ma JY,Marszalec W,Narahashi T

更新日期：1996-01-01 00:00:00

abstract：:The effects of ruthenium red (RR) on transmitter release and pre-synaptic currents were studied in the mouse neuromuscular junction. The action of RR (10 microM) was shown not only in the complete suppression of nerve-evoked muscle contractions associated with the depression of endplate potential amplitude but also in...

journal_title：Neuropharmacology

authors： Lin MJ,Lin-Shiau SY

更新日期：1996-05-01 00:00:00

abstract：:The proconvulsant and anticonvulsant effects of acute and chronic exposure to cocaine were investigated in adult, male, CF-1 mice. The proconvulsant effects of cocaine in mice only manifested themselves after daily exposure to motor-stimulant doses. Although daily treatment decreased electroshock convulsion threshold,...

journal_title：Neuropharmacology

authors： Karler R,Petty C,Calder L,Turkanis SA

更新日期：1989-07-01 00:00:00

abstract：:The homotrimeric P2X3 subtype, one of the seven members of the ATP-gated P2X receptor family, plays a role in sensory neurotransmission, including nociception. To overcome the bias resulting from fast desensitization of the P2X3 receptor in dose-response analyses, a non-desensitizing P2X2-X3 receptor chimera has been ...

journal_title：Neuropharmacology

authors： Hausmann R,Bahrenberg G,Kuhlmann D,Schumacher M,Braam U,Bieler D,Schlusche I,Schmalzing G

更新日期：2014-04-01 00:00:00

abstract：:Chloralose-anesthetized rats, spinalized at C1, were used to investigate the effects of spinal infusion of dopamine on renal sympathetic nerve activity (RSNA). A subarachnoid spinal superfusion technique was used to localize dopamine in the spinal cord while renal sympathetic nerve activity was recorded from the left ...

journal_title：Neuropharmacology

authors： Simon OR,Schramm LP

更新日期：1983-03-01 00:00:00