Antagonism of the synaptic depressant actions of L-AP4 in the lateral perforant path by MAP4.

abstract：:The analgesic fentanyl, having a predominantly mu-opioid agonist activity, when injected into the supraoptic or paraventricular nucleus of the hypothalamus in a water-loaded and ethanol-anesthetized rat, induced a potent antidiuretic effect in a time- and dose-dependent manner. The outflow of urine decreased to a mini...

journal_title：Neuropharmacology

authors： Tsushima H,Mori M,Matsuda T

更新日期：1990-08-01 00:00:00

abstract：:Recent experimental evidence indicates that in the neocortex, the manner in which each synapse releases neurotransmitter in response to trains of presynaptic action potentials is potentially unique. These unique transmission characteristics arise because of a large heterogeneity in various synaptic properties that det...

journal_title：Neuropharmacology

authors： Markram H,Pikus D,Gupta A,Tsodyks M

更新日期：1998-04-01 00:00:00

abstract：:Vulnerability to the addictive effects of drugs of abuse varies among individuals, but the biological basis of these differences are poorly known. This work tries to increase this knowledge by comparing the brain proteome of animals with different rate of extinction of cocaine-seeking behaviour. To achieve this goal, ...

journal_title：Neuropharmacology

authors： del Castillo C,Morales L,Alguacil LF,Salas E,Garrido E,Alonso E,Pérez-García C

更新日期：2009-07-01 00:00:00

abstract：:Acute morphine administration produces analgesia and reward, but prolonged use may lead to analgesic tolerance in patients chronically treated for pain and to compulsive intake in opioid addicts. Moreover, long-term exposure may induce physical dependence, manifested as somatic withdrawal symptoms in the absence of th...

journal_title：Neuropharmacology

authors： Contet C,Filliol D,Matifas A,Kieffer BL

更新日期：2008-03-01 00:00:00

abstract：:The roles of recognition sites for central neurotransmitters in the mediation of the behavioural effects of the putative 5-hydroxytryptamine (5-HT1) receptor agonist, RU 24969 [5-methoxy-3(1,2,3,6-tetrahydropyridin-4-yl)1H indole] in the rat have been examined. The drug RU 24969 was found to have high affinity for 5-H...

journal_title：Neuropharmacology

authors： Tricklebank MD,Middlemiss DN,Neill J

更新日期：1986-08-01 00:00:00

abstract：:Owing to a broad spectrum of functions performed by neuropeptides, this class of signaling molecules attracts an increasing interest. One of the key steps in the regulation of biological activity of neuropeptides is proteolytic conversion or degradation by proteinases that change or terminate biological activity of na...

journal_title：Neuropharmacology

authors： Hartman K,Mielczarek P,Smoluch M,Silberring J

更新日期：2020-09-15 00:00:00

abstract：:The incretins glucagon-like peptide 1 (GLP-1) and glucose dependent insulinotropic polypeptide (GIP) are growth factors that have shown neuroprotective effects in animal models of Parkinson's and Alzheimer's disease. In addition, the GLP-1 mimetic exendin-4 has shown protective effects in a clinical trial in Parkinson...

journal_title：Neuropharmacology

authors： Jalewa J,Sharma MK,Gengler S,Hölscher C

更新日期：2017-05-01 00:00:00

abstract：:There has been increasing interest in the rostromedial tegmental nucleus (RMTg), given its potential regulatory role in many aversion-related behaviors. The RMTg contains mostly GABAergic neurons, sends a dense inhibitory projection to dopamine neurons in the midbrain, and is rich with μ-opioid receptors (MOR). Like m...

journal_title：Neuropharmacology

authors： Fu R,Chen X,Zuo W,Li J,Kang S,Zhou LH,Siegel A,Bekker A,Ye JH

更新日期：2016-08-01 00:00:00

abstract：:Toll-like receptors (TLRs) are the sensors of pathogen-associated molecules that trigger tailored innate immune intracellular signalling responses to initiate innate immune reactions. Data from the experimental autoimmune encephalomyelitis (EAE) model indicates that TLR signalling machinery is a pivotal player in the ...

journal_title：Neuropharmacology

authors： Fitzpatrick JK,Downer EJ

更新日期：2017-02-01 00:00:00

abstract：:2-[p-(2-carboxyethyl)-phenylethylamino]-5'-N-ethylcarboxamidoadeno sine (CGS 21680) is considered a selective ligand for adenosine A2A receptors, which are known to be enriched in striatum and olfactory tubercle. We have investigated the characteristics of [3H]CGS 21680 binding in several brain regions using quantitat...

journal_title：Neuropharmacology

authors： Johansson B,Fredholm BB

更新日期：1995-04-01 00:00:00

abstract：:Dopamine neurons in the ventral tegmental area (VTA) play a very important role in a variety of physiological as well as addictive behaviors. However, a clear understanding of the cellular mechanisms underlying these behaviors is still missing. Within the VTA, recent studies have shown that forms of synaptic plasticit...

journal_title：Neuropharmacology

authors： Bonci A,Borgland S

更新日期：2009-01-01 00:00:00

abstract：:Aberrant increases in NMDA receptor (NMDAR) signaling contributes to central nervous system sensitization and chronic pain by activating neuronal nitric oxide synthase (nNOS) and generating nitric oxide (NO). Because the scaffolding protein postsynaptic density 95kDA (PSD95) tethers nNOS to NMDARs, the PSD95-nNOS comp...

journal_title：Neuropharmacology

authors： Lee WH,Xu Z,Ashpole NM,Hudmon A,Kulkarni PM,Thakur GA,Lai YY,Hohmann AG

更新日期：2015-10-01 00:00:00

abstract：:Peptides derived from prodynorphin, dynorphin A and B, (Leu)-enkephalin and (Leu)enkephalyl-Arg, as well as substance P, were measured in substantia nigra, striatum and globus pallidus, after subacute (5 doses at 6 hr intervals) treatment of rats with a number of dopamine receptor agonists and antagonists. Drugs selec...

journal_title：Neuropharmacology

authors： Nylander I,Terenius LH

更新日期：1987-09-01 00:00:00

abstract：:The effect of trans-(+/-)-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl) cyclohexyl]-benzene-acetamide methane sulfonate (U-50,488H), a kappa-opiate agonist-induced tolerance and abstinence on 5-HT1A receptors was determined in regions of the brain and spinal cord of the rat. The administration of U-50,488H (25 mg/kg, i....

journal_title：Neuropharmacology

authors： Reddy VP,Bhargava HN

更新日期：1992-12-01 00:00:00

abstract：:The aim of the present study was to determine the influence of thyroid hormone, T3, on the regulation of hippocampal BDNF expression by 5-HT receptor agonists. Chronic T3 administration prior to treatment with the 5-HT(1A) agonist, 8-OH-DPAT, significantly decreased BDNF mRNA in the dentate gyrus region of the hippoca...

journal_title：Neuropharmacology

authors： Vaidya VA,Castro ME,Pei Q,Sprakes ME,Grahame-Smith DG

更新日期：2001-01-01 00:00:00

abstract：:Selective radioligands for histamine H(3) receptors have been used to characterize H(3) receptor pharmacology by radioligand binding assays and to determine H(3) receptor distribution by tissue autoradiography. Here we report the synthesis and receptor binding characterization of [(3)H]A-317920 (furan-2-carboxylic aci...

journal_title：Neuropharmacology

authors： Yao BB,Witte DG,Miller TR,Carr TL,Kang CH,Cassar S,Faghih R,Bennani YL,Surber BW,Hancock AA,Esbenshade TA

更新日期：2006-03-01 00:00:00

abstract：:A large body of evidence indicates that ligand-gated channels may open spontaneously, exhibiting a basal activity in the absence of the neurotransmitter. In the present work, we were interested in studying the Ca(2+)-induced modulation of the basal channel activity of unliganded human L248Talpha7 receptors expressed i...

journal_title：Neuropharmacology

authors： Tonini R,Renzi M,Eusebi F

更新日期：2004-04-01 00:00:00

abstract：:Cannabidiol (CBD), the main non-psychotomimetic component of marihuana, exhibits anxiolytic-like properties in many behavioural tests, although its potential for treating major depression has been poorly explored. Moreover, the mechanism of action of CBD remains unclear. Herein, we have evaluated the effects of CBD fo...

journal_title：Neuropharmacology

authors： Linge R,Jiménez-Sánchez L,Campa L,Pilar-Cuéllar F,Vidal R,Pazos A,Adell A,Díaz Á

更新日期：2016-04-01 00:00:00

abstract：:The pharmacological profile of (S)-(+)-2-(3'-carboxybicyclo[1.1.1]pentyl)-glycine (CBPG) and of other group 1 metabotropic glutamate (mGlu) receptor agents were studied in BHK cells transfected with mGlu receptor subtypes or in native receptors in brain slices by measuring second messenger responses. The mGlu receptor...

journal_title：Neuropharmacology

authors： Mannaioni G,Attucci S,Missanelli A,Pellicciari R,Corradetti R,Moroni F

更新日期：1999-07-01 00:00:00

abstract：:This study examined the role of cannabinoid CB1 receptors (CB1r) in aggressive behavior. Social encounters took place in grouped and isolated mice lacking CB1r (CB1KO) and in wild-type (WT) littermates. Cognitive impulsivity was evaluated in the delayed reinforcement task (DRT). Gene expression analyses of monoaminoox...

journal_title：Neuropharmacology

authors： Rodriguez-Arias M,Navarrete F,Daza-Losada M,Navarro D,Aguilar MA,Berbel P,Miñarro J,Manzanares J

更新日期：2013-12-01 00:00:00

abstract：:The cannabinoid receptor CB2 plays a significant role in the regulation of immune function whereas neuronal expression remains a subject of contention. Multiple studies have described CB2 in retina and a recent study showed that CB2 deletion altered retinal visual processing. We revisited CB2 expression using immunohi...

journal_title：Neuropharmacology

authors： Borowska-Fielding J,Murataeva N,Smith B,Szczesniak AM,Leishman E,Daily L,Toguri JT,Hillard CJ,Romero J,Bradshaw H,Kelly MEM,Straiker A

更新日期：2018-10-01 00:00:00

abstract：:The effects of several stress procedures on the release of 5-HT in the dorsal and median raphe nuclei (DRN and MRN, respectively) and in forebrain structures of the rat brain innervated by both nuclei have been studied using intracerebral microdialysis. Handling for 30 sec, a saline injection and forced swimming for 5...

journal_title：Neuropharmacology

authors： Adell A,Casanovas JM,Artigas F

更新日期：1997-04-01 00:00:00

abstract：:This study confirms and extends an earlier report that acute administration of the serotonin (5-HT) antagonist, mianserin, caused a marked decrease in the density of 5-HT2 binding sites in brain of the rat (Blackshear and Sanders-Bush, 1982). Using [3H]ketanserin, a selective ligand for the 5-HT2 site, the present stu...

journal_title：Neuropharmacology

authors： Blackshear MA,Martin LL,Sanders-Bush E

更新日期：1986-11-01 00:00:00

abstract：:Sodium phenobarbitone was tested for its ability to antagonise the anxiogenic effects of compounds acting at three different central sites. These compounds were: FG 7142, a beta-carboline which acts at the benzodiazepine binding site on the GABA-benzodiazepine receptor complex; pentylenetetrazole, which acts at the pi...

journal_title：Neuropharmacology

authors： Johnston AL,File SE

更新日期：1989-01-01 00:00:00

abstract：:The effect of (U-54494A) cis-3,4-dichloro-N-methyl-N-[2-(1-Pyrrolidinyl)- cyclohexyl] benzamide monohydrochloride, an excitatory amino acid antagonist, on N-methyl-D-aspartic acid (NMDA)- and K(+)-evoked release of [3H]acetylcholine [( 3H]ACh) from slices of striatum was investigated. For the purpose of comparison, MK...

journal_title：Neuropharmacology

authors： Sethy VH,Sage GP

更新日期：1992-02-01 00:00:00

abstract：:miRNA-137 is an extremely abundant miRNA in the central nervous system and is thought to be closely related to synaptic plasticity. Here, we report a previously unrecognized role of miRNA-137 in epilepsy. The expression of miRNA-137 was decreased both in patients with temporal lobe epilepsy (TLE) and in two different ...

journal_title：Neuropharmacology

authors： Wang W,Guo Y,He L,Chen C,Luo J,Ma Y,Li J,Yang Y,Yang Q,Du C,Zhang Y,Li Z,Xu X,Tian X,Wang X

更新日期：2018-08-01 00:00:00

abstract：:Agonists and positive allosteric modulators (PAMs) of α7 nicotinic acetylcholine receptors (nAChRs) are currently being considered as novel therapeutic approaches for managing cognitive deficits in schizophrenia and Alzheimer's disease. Though α7 agonists were recently found to possess antinociceptive and anti-inflamm...

journal_title：Neuropharmacology

authors： Freitas K,Ghosh S,Ivy Carroll F,Lichtman AH,Imad Damaj M

更新日期：2013-02-01 00:00:00

abstract：:The identification and characterization of amyloid-beta (Abeta) and tau as the main pathological substrates of Alzheimer's disease (AD) have driven many efforts in search for suitable biomarkers for AD. In the last decade, research in this area has focused on developing a better understanding of the principles that go...

journal_title：Neuropharmacology

authors： Tarawneh R,Holtzman DM

更新日期：2010-09-01 00:00:00

abstract：:The central serotonin2B receptor (5-HT2BR) is currently considered as an interesting pharmacological target for improved treatment of drug addiction. In the present study, we assessed the effect of two selective 5-HT2BR antagonists, RS 127445 and LY 266097, on cocaine-induced hyperlocomotion and dopamine (DA) outflow ...

journal_title：Neuropharmacology

authors： Devroye C,Cathala A,Di Marco B,Caraci F,Drago F,Piazza PV,Spampinato U

更新日期：2015-10-01 00:00:00

abstract：:Improgan is a chemical congener of the H2 antagonist cimetidine which shows the profile of a highly effective analgesic when administered directly into the CNS. Although the improgan receptor is unknown, improgan activates analgesic pathways which are independent of opioids, but may utilize cannabinoid mechanisms. To ...

journal_title：Neuropharmacology

authors： Hough LB,de Esch IJ,Janssen E,Phillips J,Svokos K,Kern B,Trachler J,Abood ME,Leurs R,Nalwalk JW

更新日期：2006-09-01 00:00:00