Antagonism of the synaptic depressant actions of L-AP4 in the lateral perforant path by MAP4.


:A new mGluR antagonist, MAP4 (the alpha-methyl derivative of L-AP4), was found to antagonize the synaptic depressant actions of L-AP4 at the lateral perforant path synapse, in rat hippocampal slices.






Bushell TJ,Jane DE,Tse HW,Watkins JC,Davies CH,Garthwaite J,Collingridge GL




Has Abstract


1995-02-01 00:00:00














  • Effects of fentanyl, injected into the hypothalamic supraoptic and paraventricular nuclei, in a water-loaded and ethanol-anesthetized rat.

    abstract::The analgesic fentanyl, having a predominantly mu-opioid agonist activity, when injected into the supraoptic or paraventricular nucleus of the hypothalamus in a water-loaded and ethanol-anesthetized rat, induced a potent antidiuretic effect in a time- and dose-dependent manner. The outflow of urine decreased to a mini...


    pub_type: 杂志文章


    authors: Tsushima H,Mori M,Matsuda T

    更新日期:1990-08-01 00:00:00

  • Potential for multiple mechanisms, phenomena and algorithms for synaptic plasticity at single synapses.

    abstract::Recent experimental evidence indicates that in the neocortex, the manner in which each synapse releases neurotransmitter in response to trains of presynaptic action potentials is potentially unique. These unique transmission characteristics arise because of a large heterogeneity in various synaptic properties that det...


    pub_type: 杂志文章


    authors: Markram H,Pikus D,Gupta A,Tsodyks M

    更新日期:1998-04-01 00:00:00

  • Proteomic analysis of the nucleus accumbens of rats with different vulnerability to cocaine addiction.

    abstract::Vulnerability to the addictive effects of drugs of abuse varies among individuals, but the biological basis of these differences are poorly known. This work tries to increase this knowledge by comparing the brain proteome of animals with different rate of extinction of cocaine-seeking behaviour. To achieve this goal, ...


    pub_type: 杂志文章


    authors: del Castillo C,Morales L,Alguacil LF,Salas E,Garrido E,Alonso E,Pérez-García C

    更新日期:2009-07-01 00:00:00

  • Morphine-induced analgesic tolerance, locomotor sensitization and physical dependence do not require modification of mu opioid receptor, cdk5 and adenylate cyclase activity.

    abstract::Acute morphine administration produces analgesia and reward, but prolonged use may lead to analgesic tolerance in patients chronically treated for pain and to compulsive intake in opioid addicts. Moreover, long-term exposure may induce physical dependence, manifested as somatic withdrawal symptoms in the absence of th...


    pub_type: 杂志文章


    authors: Contet C,Filliol D,Matifas A,Kieffer BL

    更新日期:2008-03-01 00:00:00

  • Pharmacological analysis of the behavioural and thermoregulatory effects of the putative 5-HT1 receptor agonist, RU 24969, in the rat.

    abstract::The roles of recognition sites for central neurotransmitters in the mediation of the behavioural effects of the putative 5-hydroxytryptamine (5-HT1) receptor agonist, RU 24969 [5-methoxy-3(1,2,3,6-tetrahydropyridin-4-yl)1H indole] in the rat have been examined. The drug RU 24969 was found to have high affinity for 5-H...


    pub_type: 杂志文章


    authors: Tricklebank MD,Middlemiss DN,Neill J

    更新日期:1986-08-01 00:00:00

  • Inhibitors of neuropeptide peptidases engaged in pain and drug dependence.

    abstract::Owing to a broad spectrum of functions performed by neuropeptides, this class of signaling molecules attracts an increasing interest. One of the key steps in the regulation of biological activity of neuropeptides is proteolytic conversion or degradation by proteinases that change or terminate biological activity of na...


    pub_type: 杂志文章,评审


    authors: Hartman K,Mielczarek P,Smoluch M,Silberring J

    更新日期:2020-09-15 00:00:00

  • A novel GLP-1/GIP dual receptor agonist protects from 6-OHDA lesion in a rat model of Parkinson's disease.

    abstract::The incretins glucagon-like peptide 1 (GLP-1) and glucose dependent insulinotropic polypeptide (GIP) are growth factors that have shown neuroprotective effects in animal models of Parkinson's and Alzheimer's disease. In addition, the GLP-1 mimetic exendin-4 has shown protective effects in a clinical trial in Parkinson...


    pub_type: 杂志文章


    authors: Jalewa J,Sharma MK,Gengler S,Hölscher C

    更新日期:2017-05-01 00:00:00

  • Ablation of μ opioid receptor-expressing GABA neurons in rostromedial tegmental nucleus increases ethanol consumption and regulates ethanol-related behaviors.

    abstract::There has been increasing interest in the rostromedial tegmental nucleus (RMTg), given its potential regulatory role in many aversion-related behaviors. The RMTg contains mostly GABAergic neurons, sends a dense inhibitory projection to dopamine neurons in the midbrain, and is rich with μ-opioid receptors (MOR). Like m...


    pub_type: 杂志文章


    authors: Fu R,Chen X,Zuo W,Li J,Kang S,Zhou LH,Siegel A,Bekker A,Ye JH

    更新日期:2016-08-01 00:00:00

  • Toll-like receptor signalling as a cannabinoid target in Multiple Sclerosis.

    abstract::Toll-like receptors (TLRs) are the sensors of pathogen-associated molecules that trigger tailored innate immune intracellular signalling responses to initiate innate immune reactions. Data from the experimental autoimmune encephalomyelitis (EAE) model indicates that TLR signalling machinery is a pivotal player in the ...


    pub_type: 杂志文章,评审


    authors: Fitzpatrick JK,Downer EJ

    更新日期:2017-02-01 00:00:00

  • Further characterization of the binding of the adenosine receptor agonist [3H]CGS 21680 to rat brain using autoradiography.

    abstract::2-[p-(2-carboxyethyl)-phenylethylamino]-5'-N-ethylcarboxamidoadeno sine (CGS 21680) is considered a selective ligand for adenosine A2A receptors, which are known to be enriched in striatum and olfactory tubercle. We have investigated the characteristics of [3H]CGS 21680 binding in several brain regions using quantitat...


    pub_type: 杂志文章


    authors: Johansson B,Fredholm BB

    更新日期:1995-04-01 00:00:00

  • Role of orexin/hypocretin and CRF in the formation of drug-dependent synaptic plasticity in the mesolimbic system.

    abstract::Dopamine neurons in the ventral tegmental area (VTA) play a very important role in a variety of physiological as well as addictive behaviors. However, a clear understanding of the cellular mechanisms underlying these behaviors is still missing. Within the VTA, recent studies have shown that forms of synaptic plasticit...


    pub_type: 杂志文章,评审


    authors: Bonci A,Borgland S

    更新日期:2009-01-01 00:00:00

  • Small molecule inhibitors of PSD95-nNOS protein-protein interactions as novel analgesics.

    abstract::Aberrant increases in NMDA receptor (NMDAR) signaling contributes to central nervous system sensitization and chronic pain by activating neuronal nitric oxide synthase (nNOS) and generating nitric oxide (NO). Because the scaffolding protein postsynaptic density 95kDA (PSD95) tethers nNOS to NMDARs, the PSD95-nNOS comp...


    pub_type: 杂志文章


    authors: Lee WH,Xu Z,Ashpole NM,Hudmon A,Kulkarni PM,Thakur GA,Lai YY,Hohmann AG

    更新日期:2015-10-01 00:00:00

  • Dopamine receptors mediate alterations in striato-nigral dynorphin and substance P pathways.

    abstract::Peptides derived from prodynorphin, dynorphin A and B, (Leu)-enkephalin and (Leu)enkephalyl-Arg, as well as substance P, were measured in substantia nigra, striatum and globus pallidus, after subacute (5 doses at 6 hr intervals) treatment of rats with a number of dopamine receptor agonists and antagonists. Drugs selec...


    pub_type: 杂志文章


    authors: Nylander I,Terenius LH

    更新日期:1987-09-01 00:00:00

  • Abstinence from U-50,488H, a kappa-opiate receptor agonist, decreases the binding of [3H]DPAT to 5-HT1A receptors in the hypothalamus of the rat.

    abstract::The effect of trans-(+/-)-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl) cyclohexyl]-benzene-acetamide methane sulfonate (U-50,488H), a kappa-opiate agonist-induced tolerance and abstinence on 5-HT1A receptors was determined in regions of the brain and spinal cord of the rat. The administration of U-50,488H (25 mg/kg, i....


    pub_type: 杂志文章


    authors: Reddy VP,Bhargava HN

    更新日期:1992-12-01 00:00:00

  • Influence of thyroid hormone on 5-HT(1A) and 5-HT(2A) receptor-mediated regulation of hippocampal BDNF mRNA expression.

    abstract::The aim of the present study was to determine the influence of thyroid hormone, T3, on the regulation of hippocampal BDNF expression by 5-HT receptor agonists. Chronic T3 administration prior to treatment with the 5-HT(1A) agonist, 8-OH-DPAT, significantly decreased BDNF mRNA in the dentate gyrus region of the hippoca...


    pub_type: 杂志文章


    authors: Vaidya VA,Castro ME,Pei Q,Sprakes ME,Grahame-Smith DG

    更新日期:2001-01-01 00:00:00

  • Use of an inverse agonist radioligand [3H]A-317920 reveals distinct pharmacological profiles of the rat histamine H3 receptor.

    abstract::Selective radioligands for histamine H(3) receptors have been used to characterize H(3) receptor pharmacology by radioligand binding assays and to determine H(3) receptor distribution by tissue autoradiography. Here we report the synthesis and receptor binding characterization of [(3)H]A-317920 (furan-2-carboxylic aci...


    pub_type: 杂志文章


    authors: Yao BB,Witte DG,Miller TR,Carr TL,Kang CH,Cassar S,Faghih R,Bennani YL,Surber BW,Hancock AA,Esbenshade TA

    更新日期:2006-03-01 00:00:00

  • Unliganded human mutant alpha 7 nicotinic receptors are modulated by Ca2+ and trace levels of Zn2+.

    abstract::A large body of evidence indicates that ligand-gated channels may open spontaneously, exhibiting a basal activity in the absence of the neurotransmitter. In the present work, we were interested in studying the Ca(2+)-induced modulation of the basal channel activity of unliganded human L248Talpha7 receptors expressed i...


    pub_type: 杂志文章


    authors: Tonini R,Renzi M,Eusebi F

    更新日期:2004-04-01 00:00:00

  • Cannabidiol induces rapid-acting antidepressant-like effects and enhances cortical 5-HT/glutamate neurotransmission: role of 5-HT1A receptors.

    abstract::Cannabidiol (CBD), the main non-psychotomimetic component of marihuana, exhibits anxiolytic-like properties in many behavioural tests, although its potential for treating major depression has been poorly explored. Moreover, the mechanism of action of CBD remains unclear. Herein, we have evaluated the effects of CBD fo...


    pub_type: 杂志文章


    authors: Linge R,Jiménez-Sánchez L,Campa L,Pilar-Cuéllar F,Vidal R,Pazos A,Adell A,Díaz Á

    更新日期:2016-04-01 00:00:00

  • Biochemical and electrophysiological studies on (S)-(+)-2-(3'-carboxybicyclo(1.1.1)pentyl)-glycine (CBPG), a novel mGlu5 receptor agonist endowed with mGlu1 receptor antagonist activity.

    abstract::The pharmacological profile of (S)-(+)-2-(3'-carboxybicyclo[1.1.1]pentyl)-glycine (CBPG) and of other group 1 metabotropic glutamate (mGlu) receptor agents were studied in BHK cells transfected with mGlu receptor subtypes or in native receptors in brain slices by measuring second messenger responses. The mGlu receptor...


    pub_type: 杂志文章


    authors: Mannaioni G,Attucci S,Missanelli A,Pellicciari R,Corradetti R,Moroni F

    更新日期:1999-07-01 00:00:00

  • CB1 cannabinoid receptor-mediated aggressive behavior.

    abstract::This study examined the role of cannabinoid CB1 receptors (CB1r) in aggressive behavior. Social encounters took place in grouped and isolated mice lacking CB1r (CB1KO) and in wild-type (WT) littermates. Cognitive impulsivity was evaluated in the delayed reinforcement task (DRT). Gene expression analyses of monoaminoox...


    pub_type: 杂志文章


    authors: Rodriguez-Arias M,Navarrete F,Daza-Losada M,Navarro D,Aguilar MA,Berbel P,Miñarro J,Manzanares J

    更新日期:2013-12-01 00:00:00

  • Revisiting cannabinoid receptor 2 expression and function in murine retina.

    abstract::The cannabinoid receptor CB2 plays a significant role in the regulation of immune function whereas neuronal expression remains a subject of contention. Multiple studies have described CB2 in retina and a recent study showed that CB2 deletion altered retinal visual processing. We revisited CB2 expression using immunohi...


    pub_type: 杂志文章


    authors: Borowska-Fielding J,Murataeva N,Smith B,Szczesniak AM,Leishman E,Daily L,Toguri JT,Hillard CJ,Romero J,Bradshaw H,Kelly MEM,Straiker A

    更新日期:2018-10-01 00:00:00

  • Comparative study in the rat of the actions of different types of stress on the release of 5-HT in raphe nuclei and forebrain areas.

    abstract::The effects of several stress procedures on the release of 5-HT in the dorsal and median raphe nuclei (DRN and MRN, respectively) and in forebrain structures of the rat brain innervated by both nuclei have been studied using intracerebral microdialysis. Handling for 30 sec, a saline injection and forced swimming for 5...


    pub_type: 杂志文章


    authors: Adell A,Casanovas JM,Artigas F

    更新日期:1997-04-01 00:00:00

  • Adaptive changes in the 5-HT2 binding site after chronic administration of agonists and antagonists.

    abstract::This study confirms and extends an earlier report that acute administration of the serotonin (5-HT) antagonist, mianserin, caused a marked decrease in the density of 5-HT2 binding sites in brain of the rat (Blackshear and Sanders-Bush, 1982). Using [3H]ketanserin, a selective ligand for the 5-HT2 site, the present stu...


    pub_type: 杂志文章


    authors: Blackshear MA,Martin LL,Sanders-Bush E

    更新日期:1986-11-01 00:00:00

  • Sodium phenobarbitone reverses the anxiogenic effects of compounds acting at three different central sites.

    abstract::Sodium phenobarbitone was tested for its ability to antagonise the anxiogenic effects of compounds acting at three different central sites. These compounds were: FG 7142, a beta-carboline which acts at the benzodiazepine binding site on the GABA-benzodiazepine receptor complex; pentylenetetrazole, which acts at the pi...


    pub_type: 杂志文章


    authors: Johnston AL,File SE

    更新日期:1989-01-01 00:00:00

  • Modulation of release of acetylcholine from the striatum by a proposed excitatory amino acid antagonist U-54494A: comparison with known antagonists, diazepam and phenytoin.

    abstract::The effect of (U-54494A) cis-3,4-dichloro-N-methyl-N-[2-(1-Pyrrolidinyl)- cyclohexyl] benzamide monohydrochloride, an excitatory amino acid antagonist, on N-methyl-D-aspartic acid (NMDA)- and K(+)-evoked release of [3H]acetylcholine [( 3H]ACh) from slices of striatum was investigated. For the purpose of comparison, MK...


    pub_type: 杂志文章


    authors: Sethy VH,Sage GP

    更新日期:1992-02-01 00:00:00

  • Overexpression of miRNA-137 in the brain suppresses seizure activity and neuronal excitability: A new potential therapeutic strategy for epilepsy.

    abstract::miRNA-137 is an extremely abundant miRNA in the central nervous system and is thought to be closely related to synaptic plasticity. Here, we report a previously unrecognized role of miRNA-137 in epilepsy. The expression of miRNA-137 was decreased both in patients with temporal lobe epilepsy (TLE) and in two different ...


    pub_type: 杂志文章


    authors: Wang W,Guo Y,He L,Chen C,Luo J,Ma Y,Li J,Yang Y,Yang Q,Du C,Zhang Y,Li Z,Xu X,Tian X,Wang X

    更新日期:2018-08-01 00:00:00

  • Effects of α7 positive allosteric modulators in murine inflammatory and chronic neuropathic pain models.

    abstract::Agonists and positive allosteric modulators (PAMs) of α7 nicotinic acetylcholine receptors (nAChRs) are currently being considered as novel therapeutic approaches for managing cognitive deficits in schizophrenia and Alzheimer's disease. Though α7 agonists were recently found to possess antinociceptive and anti-inflamm...


    pub_type: 杂志文章


    authors: Freitas K,Ghosh S,Ivy Carroll F,Lichtman AH,Imad Damaj M

    更新日期:2013-02-01 00:00:00

  • Biomarkers in translational research of Alzheimer's disease.

    abstract::The identification and characterization of amyloid-beta (Abeta) and tau as the main pathological substrates of Alzheimer's disease (AD) have driven many efforts in search for suitable biomarkers for AD. In the last decade, research in this area has focused on developing a better understanding of the principles that go...


    pub_type: 杂志文章,评审


    authors: Tarawneh R,Holtzman DM

    更新日期:2010-09-01 00:00:00

  • Central serotonin(2B) receptor blockade inhibits cocaine-induced hyperlocomotion independently of changes of subcortical dopamine outflow.

    abstract::The central serotonin2B receptor (5-HT2BR) is currently considered as an interesting pharmacological target for improved treatment of drug addiction. In the present study, we assessed the effect of two selective 5-HT2BR antagonists, RS 127445 and LY 266097, on cocaine-induced hyperlocomotion and dopamine (DA) outflow ...


    pub_type: 杂志文章


    authors: Devroye C,Cathala A,Di Marco B,Caraci F,Drago F,Piazza PV,Spampinato U

    更新日期:2015-10-01 00:00:00

  • Antinociceptive activity of chemical congeners of improgan: optimization of side chain length leads to the discovery of a new, potent, non-opioid analgesic.

    abstract::Improgan is a chemical congener of the H2 antagonist cimetidine which shows the profile of a highly effective analgesic when administered directly into the CNS. Although the improgan receptor is unknown, improgan activates analgesic pathways which are independent of opioids, but may utilize cannabinoid mechanisms. To ...


    pub_type: 杂志文章


    authors: Hough LB,de Esch IJ,Janssen E,Phillips J,Svokos K,Kern B,Trachler J,Abood ME,Leurs R,Nalwalk JW

    更新日期:2006-09-01 00:00:00