Antagonism of the synaptic depressant actions of L-AP4 in the lateral perforant path by MAP4.


:A new mGluR antagonist, MAP4 (the alpha-methyl derivative of L-AP4), was found to antagonize the synaptic depressant actions of L-AP4 at the lateral perforant path synapse, in rat hippocampal slices.






Bushell TJ,Jane DE,Tse HW,Watkins JC,Davies CH,Garthwaite J,Collingridge GL




Has Abstract


1995-02-01 00:00:00














  • Repeated but not acute clomipramine decreases the effect of N-methyl-D-aspartate receptor activation on serotonergic transmission between the raphe nuclei and frontal cortex.

    abstract::The effect of acute or repeated treatment with the antidepressant clomipramine (CIM) on N-methyl-D-aspartate (NMDA) evoked changes in extracellular 5-hydroxytryptamine (5-HT) in the raphe nuclei and frontal cortex of the same rat has been studied using microdialysis. Acute injection of CIM (10 or 20 mg/kg) caused an i...


    pub_type: 杂志文章


    authors: Pallotta M,Segieth J,Sadideen F,Whitton PS

    更新日期:2001-09-01 00:00:00

  • T1-11 and JMF1907 ameliorate polyglutamine-expanded ataxin-3-induced neurodegeneration, transcriptional dysregulation and ataxic symptom in the SCA3 transgenic mouse.

    abstract::More studies are required to develop therapeutic agents for treating spinocerebellar ataxia type 3 (SCA3), which is caused by mutant polyglutamine-expanded ataxin-3 and is the most prevalent subtype of spinocerebellar ataxias. T1-11 [N6-(4-Hydroxybenzyl) adenosine], isolated from a Chinese medicinal herb Gastordia ela...


    pub_type: 杂志文章


    authors: Chou AH,Chen YL,Chiu CC,Yuan SJ,Weng YH,Yeh TH,Lin YL,Fang JM,Wang HL

    更新日期:2015-12-01 00:00:00

  • Localization and production of peptide endocannabinoids in the rodent CNS and adrenal medulla.

    abstract::The endocannabinoid system (ECS) comprises the cannabinoid receptors CB1 and CB2 and their endogenous arachidonic acid-derived agonists 2-arachidonoyl glycerol and anandamide, which play important neuromodulatory roles. Recently, a novel class of negative allosteric CB1 receptor peptide ligands, hemopressin-like pepti...


    pub_type: 杂志文章


    authors: Hofer SC,Ralvenius WT,Gachet MS,Fritschy JM,Zeilhofer HU,Gertsch J

    更新日期:2015-11-01 00:00:00

  • High doses of the histone deacetylase inhibitor sodium butyrate trigger a stress-like response.

    abstract::The hypothalamic-pituitary-adrenal (HPA) axis is activated by a wide range of stimuli, including drugs. Here we report that in male rats, a dose of sodium butyrate (NaBu) that is typically used to inhibit histone deacetylation (1200 mg/kg) increased the peripheral levels of HPA hormones and glucose. In a further exper...


    pub_type: 杂志文章


    authors: Gagliano H,Delgado-Morales R,Sanz-Garcia A,Armario A

    更新日期:2014-04-01 00:00:00

  • A mutation in the GABAA receptor alpha 1 subunit linked to human epilepsy affects channel gating properties.

    abstract::A genetic component is associated with the development of many forms of epilepsy. Recently, mutations in the GABAA receptor have been linked to several inherited epilepsies. One of these mutations is a non-conservative change of alanine to aspartate in the third transmembrane domain of the alpha1 subunit. To determine...


    pub_type: 杂志文章


    authors: Fisher JL

    更新日期:2004-04-01 00:00:00

  • The roles of nerve growth factor and cholecystokinin in the enhancement of morphine analgesia in a rodent model of central nervous system inflammation.

    abstract::Animal models of inflammatory pain are characterized by the release of inflammatory mediators such as cytokines and neurotrophic factors, and enhanced analgesic sensitivity to opioids. In this study, we examine the mechanisms underlying this effect, in particular the roles of cholecystokinin (CCK) and nerve growth fac...


    pub_type: 杂志文章


    authors: Xanthos DN,Kumar N,Theodorsson E,Coderre TJ

    更新日期:2009-03-01 00:00:00

  • Comparative study in the rat of the actions of different types of stress on the release of 5-HT in raphe nuclei and forebrain areas.

    abstract::The effects of several stress procedures on the release of 5-HT in the dorsal and median raphe nuclei (DRN and MRN, respectively) and in forebrain structures of the rat brain innervated by both nuclei have been studied using intracerebral microdialysis. Handling for 30 sec, a saline injection and forced swimming for 5...


    pub_type: 杂志文章


    authors: Adell A,Casanovas JM,Artigas F

    更新日期:1997-04-01 00:00:00

  • Dehydroevodiamine attenuates tau hyperphosphorylation and spatial memory deficit induced by activation of glycogen synthase kinase-3 in rats.

    abstract::Tau hyperphosphorylation and memory deficit are characteristic alterations of Alzheimer's disease (AD), and glycogen synthase kinase-3 (GSK-3) plays a crucial role in these AD-like changes. We have reported that activation of GSK-3 through ventricular injection of wortmannin and GF-109203X (WT/GFX, 100 microM each) in...


    pub_type: 杂志文章


    authors: Peng JH,Zhang CE,Wei W,Hong XP,Pan XP,Wang JZ

    更新日期:2007-06-01 00:00:00

  • PSD-95 deficiency alters GABAergic inhibition in the prefrontal cortex.

    abstract::Postsynaptic Density Protein-95 (PSD-95) is a major scaffolding protein in the excitatory synapses in the brain and a critical regulator of synaptic maturation for NMDA and AMPA receptors. PSD-95 deficiency has been linked to cognitive and learning deficits implicated in neurodevelopmental disorders such as autism and...


    pub_type: 杂志文章


    authors: McEachern EP,Coley AA,Yang SS,Gao WJ

    更新日期:2020-11-15 00:00:00

  • Synergistic effect of 5-HT1A and σ1 receptor activation on prefrontal dopaminergic transmission under circulating steroid deficiency.

    abstract::Serotonin (5-HT)1A and σ1 receptors have been implicated in psychiatric disorders. We previously found that combined 5-HT reuptake inhibition and σ1 receptor activation has a synergistic effect on prefrontal dopaminergic transmission in adrenalectomized/castrated mice lacking circulating steroid hormones. In the prese...


    pub_type: 杂志文章


    authors: Hiramatsu N,Ago Y,Hasebe S,Nishimura A,Mori K,Takuma K,Matsuda T

    更新日期:2013-12-01 00:00:00

  • Fluoxetine and vitamin C synergistically inhibits blood-spinal cord barrier disruption and improves functional recovery after spinal cord injury.

    abstract::Recently we reported that fluoxetine (10 mg/kg) improves functional recovery by attenuating blood spinal cord barrier (BSCB) disruption after spinal cord injury (SCI). Here we investigated whether a low-dose of fluoxetine (1 mg/kg) and vitamin C (100 mg/kg), separately not possessing any protective effect, prevents BS...


    pub_type: 杂志文章


    authors: Lee JY,Choi HY,Yune TY

    更新日期:2016-10-01 00:00:00

  • Spontaneous activity, singly bound states and the impact of alpha1Phe64 mutation on GABAAR gating in the novel kinetic model based on the single-channel recordings.

    abstract::GABAA receptor is the primary mediator of inhibition in the adult mammalian brain. Our recent studies revealed that a classic gating scheme for GABAAR needed to be updated with an intermediate step (flipping) and that the α1Phe64 mutation at the GABA binding site affects this transition. However, description of flippi...


    pub_type: 杂志文章


    authors: Kisiel M,Jatczak M,Brodzki M,Mozrzymas JW

    更新日期:2018-03-15 00:00:00

  • Favorable amphiphilicity of nimodipine facilitates its interactions with brain membranes.

    abstract::Nimodipine is a 1,4-dihydropyridine (DHP) calcium channel blocker which is used in the treatment of neurological deficits associated with subarachnoid hemorrhage. Small angle x-ray diffraction, differential scanning calorimetry, and equilibrium and kinetic binding techniques were used to study the interaction of nimod...


    pub_type: 杂志文章


    authors: Herbette LG,Mason PE,Sweeney KR,Trumbore MW,Mason RP

    更新日期:1994-02-01 00:00:00

  • Neonatal exposure to sevoflurane caused cognitive deficits by dysregulating SK2 channels and GluA2-lacking AMPA receptors in juvenile rat hippocampus.

    abstract::Anesthetics exposure to neonates leads to impairment of hippocampal synaptic plasticity and cognitive functions later in life. This phenomenon complies with the concept of metaplasticity: a priming stimulation can affect induction of synaptic plasticity mins or days later. We aimed to understand whether small conducta...


    pub_type: 杂志文章


    authors: Yu X,Zhang F,Shi J

    更新日期:2018-10-01 00:00:00

  • Opioid receptors: from binding sites to visible molecules in vivo.

    abstract::Opioid drugs such as heroin interact directly with opioid receptors whilst other addictive drugs, including marijuana, alcohol and nicotine indirectly activate endogenous opioid systems to contribute to their rewarding properties. The opioid system therefore plays a key role in addiction neurobiology and continues to ...


    pub_type: 杂志文章,评审


    authors: Kieffer BL,Evans CJ

    更新日期:2009-01-01 00:00:00

  • Moclobemide reduces intracellular pH and neuronal activity of CA3 neurones in guinea-pig hippocampal slices-implication for its neuroprotective properties.

    abstract::Mechanisms underlying the neuroprotective properties of the weak MAO-A inhibitor moclobemide are not understood. Increasing evidence suggests that a moderate increase in intracellular free protons may contribute to neuroprotective properties due to a proton-mediated decrease in neuronal activity. Therefore, we studied...


    pub_type: 杂志文章


    authors: Bonnet U,Leniger T,Wiemann M

    更新日期:2000-08-23 00:00:00

  • The kynurenine pathway and parasitic infections that affect CNS function.

    abstract::The kynurenine pathway of tryptophan metabolism has been implicated in brain function, immunoregulation, anti-microbial mechanisms and pregnancy. Some of these actions are due to depletion of tryptophan and others to the formation of biologically active metabolites. This review focuses on the roles of the kynurenine p...


    pub_type: 杂志文章,评审


    authors: Hunt NH,Too LK,Khaw LT,Guo J,Hee L,Mitchell AJ,Grau GE,Ball HJ

    更新日期:2017-01-01 00:00:00

  • Inactivation of the lateral orbitofrontal cortex increases drinking in ethanol-dependent but not non-dependent mice.

    abstract::Long-term consumption of ethanol affects cortical areas that are important for learning and memory, cognition, and decision-making. Deficits in cortical function may contribute to alcohol-abuse disorders by impeding an individual's ability to control drinking. Previous studies from this laboratory show that acute etha...


    pub_type: 杂志文章


    authors: den Hartog C,Zamudio-Bulcock P,Nimitvilai S,Gilstrap M,Eaton B,Fedarovich H,Motts A,Woodward JJ

    更新日期:2016-08-01 00:00:00

  • SB-699551-A (3-cyclopentyl-N-[2-(dimethylamino)ethyl]-N-[(4'-{[(2-phenylethyl)amino]methyl}-4-biphenylyl)methyl]propanamide dihydrochloride), a novel 5-ht5A receptor-selective antagonist, enhances 5-HT neuronal function: Evidence for an autoreceptor role

    abstract::This study utilised the selective 5-ht(5A) receptor antagonist, SB-699551-A (3-cyclopentyl-N-[2-(dimethylamino)ethyl]-N-[(4'-{[(2-phenylethyl)amino]methyl}-4-biphenylyl)methyl]propanamide dihydrochloride), to investigate 5-ht5A receptor function in guinea pig brain. SB-699551-A competitively antagonised 5-HT-stimulate...


    pub_type: 杂志文章


    authors: Thomas DR,Soffin EM,Roberts C,Kew JN,de la Flor RM,Dawson LA,Fry VA,Coggon SA,Faedo S,Hayes PD,Corbett DF,Davies CH,Hagan JJ

    更新日期:2006-09-01 00:00:00

  • Neurogenic hypertension after depletion of norepinephrine in anterior hypothalamus induced by 6-hydroxydopamine administration into the ventral pons: role of serotonin.

    abstract::Destruction of the ventral noradrenergic pathway elicited by administration of 6-hydroxydopamine (6-OHDA, 5 micrograms into each side of the ventral pons) reduced the content of norepinephrine (NE) in the anterior hypothalamus (-80%) and induced an increase in arterial blood pressure (ABP) and in heart rate. These hyp...


    pub_type: 杂志文章


    authors: Benarroch EE,Balda MS,Finkielman S,Nahmod VE

    更新日期:1983-01-01 00:00:00

  • Prior stimulation of the endocannabinoid system prevents methamphetamine-induced dopaminergic neurotoxicity in the striatum through activation of CB2 receptors.

    abstract::Methamphetamine toxicity is associated with cell death and loss of dopamine neuron terminals in the striatum similar to what is found in some neurodegenerative diseases. Conversely, the endocannabinoid system (ECS) has been suggested to be neuroprotective in the brain, and new pharmacological tools have been developed...


    pub_type: 杂志文章


    authors: Nader J,Rapino C,Gennequin B,Chavant F,Francheteau M,Makriyannis A,Duranti A,Maccarrone M,Solinas M,Thiriet N

    更新日期:2014-12-01 00:00:00

  • The cannabinoid system and pain.

    abstract::Chronic pain states are highly prevalent and yet poorly controlled by currently available analgesics, representing an enormous clinical, societal, and economic burden. Existing pain medications have significant limitations and adverse effects including tolerance, dependence, gastrointestinal dysfunction, cognitive imp...


    pub_type: 杂志文章,评审


    authors: Woodhams SG,Chapman V,Finn DP,Hohmann AG,Neugebauer V

    更新日期:2017-09-15 00:00:00

  • Protective efficacy of mitochondrial targeted antioxidant MitoQ against dichlorvos induced oxidative stress and cell death in rat brain.

    abstract::Dichlorvos is a synthetic insecticide that belongs to the family of chemically related organophosphate (OP) pesticides. It can be released into the environment as a major degradation product of other OPs, such as trichlorfon, naled, and metrifonate. Dichlorvos exerts its toxic effects in humans and animals by inhibiti...


    pub_type: 杂志文章


    authors: Wani WY,Gudup S,Sunkaria A,Bal A,Singh PP,Kandimalla RJ,Sharma DR,Gill KD

    更新日期:2011-12-01 00:00:00

  • Effects of cations on high-affinity binding of 3H-ADTN to dopaminergic sites in calf caudate tissue.

    abstract::Effects of cations on binding of 0.1-10 nM 3H-ADTN to calf caudate membranes included decreased apparent Bmax by [Na+] greater than or equal to 100 mM, little effect on Kd or on affinity of other dopamine (DA) agonists (DA and apomorphine), decreased slopes of inhibition curves produced by agonists, but increased affi...


    pub_type: 杂志文章


    authors: Lamont JS,Kula NS,Baldessarini RJ

    更新日期:1987-06-01 00:00:00

  • Effects of lobeline and dimethylphenylpiperazinium iodide (DMPP) on N-methyl-D-aspartate (NMDA)-evoked acetylcholine release in vitro: evidence for a lack of involvement of classical neuronal nicotinic acetylcholine receptors.

    abstract::Biochemical, behavioral and electrophysiological evidence suggests interactions between pathways containing neuronal nicotinic acetylcholine receptors (NAChRs) and excitatory amino acid receptors. Recently, protective effects of nicotine against N-methyl-D-aspartate (NMDA)-induced toxicity in primary cortical cultures...


    pub_type: 杂志文章


    authors: Rao TS,Correa LD,Lloyd GK

    更新日期:1997-01-01 00:00:00

  • Effects of the nootropic drug nefiracetam on the GABAA receptor-channel complex in dorsal root ganglion neurons.

    abstract::The effects of nefiracetam on GABA-induced chloride currents were studied with rat dorsal root ganglion neurons in primary culture using the whole-cell patch-clamp technique. The dose-response curve for GABA-induced currents was shifted by 16 microM to lower concentrations by 10 microM nefiracetam while the maximal re...


    pub_type: 杂志文章


    authors: Huang CS,Ma JY,Marszalec W,Narahashi T

    更新日期:1996-01-01 00:00:00

  • Ruthenium red, a novel enhancer of K+ currents at mouse motor nerve terminals.

    abstract::The effects of ruthenium red (RR) on transmitter release and pre-synaptic currents were studied in the mouse neuromuscular junction. The action of RR (10 microM) was shown not only in the complete suppression of nerve-evoked muscle contractions associated with the depression of endplate potential amplitude but also in...


    pub_type: 杂志文章


    authors: Lin MJ,Lin-Shiau SY

    更新日期:1996-05-01 00:00:00

  • Proconvulsant and anticonvulsant effects in mice of acute and chronic treatment with cocaine.

    abstract::The proconvulsant and anticonvulsant effects of acute and chronic exposure to cocaine were investigated in adult, male, CF-1 mice. The proconvulsant effects of cocaine in mice only manifested themselves after daily exposure to motor-stimulant doses. Although daily treatment decreased electroshock convulsion threshold,...


    pub_type: 杂志文章


    authors: Karler R,Petty C,Calder L,Turkanis SA

    更新日期:1989-07-01 00:00:00

  • A hydrophobic residue in position 15 of the rP2X3 receptor slows desensitization and reveals properties beneficial for pharmacological analysis and high-throughput screening.

    abstract::The homotrimeric P2X3 subtype, one of the seven members of the ATP-gated P2X receptor family, plays a role in sensory neurotransmission, including nociception. To overcome the bias resulting from fast desensitization of the P2X3 receptor in dose-response analyses, a non-desensitizing P2X2-X3 receptor chimera has been ...


    pub_type: 杂志文章


    authors: Hausmann R,Bahrenberg G,Kuhlmann D,Schumacher M,Braam U,Bieler D,Schlusche I,Schmalzing G

    更新日期:2014-04-01 00:00:00

  • Spinal superfusion of dopamine excites renal sympathetic nerve activity.

    abstract::Chloralose-anesthetized rats, spinalized at C1, were used to investigate the effects of spinal infusion of dopamine on renal sympathetic nerve activity (RSNA). A subarachnoid spinal superfusion technique was used to localize dopamine in the spinal cord while renal sympathetic nerve activity was recorded from the left ...


    pub_type: 杂志文章


    authors: Simon OR,Schramm LP

    更新日期:1983-03-01 00:00:00