Uncompetitive NMDA receptor antagonists attenuate NMDA-induced impairment of passive avoidance learning and LTP.

abstract：:P2Y receptors are G-protein-coupled receptors (GPCRs) for extracellular nucleotides. There are eight mammalian P2Y receptor subtypes (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13, and P2Y14). P2Y receptors are widely expressed and play important roles in physiology and pathophysiology. One important example is the ADP-...

journal_title：Neuropharmacology

authors： von Kügelgen I,Hoffmann K

更新日期：2016-05-01 00:00:00

abstract：:The monosynaptic reflex (MSR), recorded in vitro from the neonatal rat spinal cord, was depressed by 5-hydroxytryptamine (5-HT) and 5-HT receptor agonists. The results, together with our previous findings, indicate an apparent rank order of potency: 5-carboxamidotryptamine (5-CT) > sumatriptan > methysergide > 5-HT > ...

journal_title：Neuropharmacology

authors： Crick H,Manuel NA,Wallis DI

更新日期：1994-07-01 00:00:00

abstract：:Increasingly in the realm of neurological disorders, particularly those involving neurodegeneration, mitochondrial dysfunction is emerging at the core of their pathogenic processes. Most of these diseases still lack effective treatment and are hampered by a shortfall in the development of novel medicines. Clearly new ...

journal_title：Neuropharmacology

authors： Chan F,Lax NZ,Davies CH,Turnbull DM,Cunningham MO

更新日期：2016-03-01 00:00:00

abstract：:The roles of recognition sites for central neurotransmitters in the mediation of the behavioural effects of the putative 5-hydroxytryptamine (5-HT1) receptor agonist, RU 24969 [5-methoxy-3(1,2,3,6-tetrahydropyridin-4-yl)1H indole] in the rat have been examined. The drug RU 24969 was found to have high affinity for 5-H...

journal_title：Neuropharmacology

authors： Tricklebank MD,Middlemiss DN,Neill J

更新日期：1986-08-01 00:00:00

abstract：:Diabetic neuropathic pain remains an unmet clinical problem and is poorly relieved by conventional analgesics. N-methyl-D-aspartate (NMDA) receptors play an important role in central sensitization in neuropathic pain. Although NMDA antagonists are highly effective in reducing neuropathic pain, these agents cause sever...

journal_title：Neuropharmacology

authors： Chen SR,Samoriski G,Pan HL

更新日期：2009-08-01 00:00:00

abstract：:Diazepam binding inhibitor (DBI) is a neuromodulatory peptide for gamma-aminobutyric acid (GABA) neurotransmission. Levels of DBI in cerebrospinal fluid (CSF) were found to be elevated in depressed patients, when compared to age- and sex-matched normal controls. Levels of the peptide, corticotropin-releasing hormone (...

journal_title：Neuropharmacology

authors： Roy A

更新日期：1991-12-01 00:00:00

abstract：BACKGROUND:Alcohol use disorder (AUD) develops after chronic and heavy use of alcohol. Insomnia, a hallmark of AUD, plays a crucial role in the development of AUD. However, the causal mechanisms are unknown. Since chronic alcohol reduces acetylated histones and disrupts the epigenome, we hypothesized that chronic alcoh...

journal_title：Neuropharmacology

authors： Sharma R,Sahota P,Thakkar MM

更新日期：2020-12-01 00:00:00

abstract：:Enhancement of GABAA receptor function with benzodiazepine (BZ) site agonists can disrupt memory formation and hippocampal synaptic plasticity. To investigate this further the effects of the agonist, flunitrazepam, were contrasted with that of the inverse agonist, methyl-6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxyl...

journal_title：Neuropharmacology

authors： Seabrook GR,Easter A,Dawson GR,Bowery BJ

更新日期：1997-06-01 00:00:00

abstract：:The effect of clonidine (0.1 mg/kg, i.p.), as a three-injection course, on behaviour in the forced swimming test was studied in rats injected intracerebroventricularly (i.c.v.) with 150 micrograms 5,7-dihydroxy-tryptamine (5,7-DHT) to destroy serotonin (5-HT) neurones or treated with 100 mg/kg (i.p.) (+/-)-sulpiride o...

journal_title：Neuropharmacology

authors： Cervo L,Rossi C,Samanin R

更新日期：1992-04-01 00:00:00

abstract：:Rabbits anesthetized with volatile anesthetics were given bolus doses of the n-methyl-D-aspartate (NMDA) receptor antagonist MK-801. Following observation and recording of the hemodynamic and electroencephalographic effects of MK-801, the animals were tested for requirements of volatile anesthetic to prevent movement ...

journal_title：Neuropharmacology

authors： Scheller MS,Zornow MH,Fleischer JE,Shearman GT,Greber TF

更新日期：1989-07-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Hyperdopaminergic signaling and an upregulated brain arachidonic acid (AA) cascade may contribute to bipolar disorder (BD). Lithium and carbamazepine, FDA-approved for the treatment of BD, attenuate brain dopaminergic D(2)-like (D(2), D(3), and D(4)) receptor signaling involving AA when given c...

journal_title：Neuropharmacology

authors： Ramadan E,Basselin M,Taha AY,Cheon Y,Chang L,Chen M,Rapoport SI

更新日期：2011-12-01 00:00:00

abstract：:The effects of (S)-4-amino-5-[(4,4-dimethylcyclohexyl)amino]-5-oxo-pentanoic acid ((S)CR 2249), a new chemical entity selected among a series of glutamic acid derivatives, were investigated on N-methyl-D-aspartate (NMDA)-evoked release of [3H]noradrenaline from rat hippocampal slices. (S)CR 2249 facilitated glycine-me...

journal_title：Neuropharmacology

authors： Lanza M,Bonnafous C,Colombo S,Revel L,Makovec F

更新日期：1997-08-01 00:00:00

abstract：:The ability of drugs of abuse to increase mesolimbic levels of dopamine is a characteristic associated with their rewarding effects. Exactly how these effects are produced by different substances is not as well characterised. Our previous work in rats has demonstrated that accumbal glycine receptors (GlyRs) are involv...

journal_title：Neuropharmacology

authors： Jonsson S,Adermark L,Ericson M,Söderpalm B

更新日期：2014-07-01 00:00:00

abstract：:Attentional impairments are found in a range of neurodegenerative and neuropsychiatric disorders. However, the development of procognitive enhancers to alleviate these impairments has been hindered by a lack of comprehensive hypotheses regarding the circuitry mediating the targeted attentional functions. Here we discu...

journal_title：Neuropharmacology

authors： Demeter E,Sarter M

更新日期：2013-01-01 00:00:00

abstract：:The inhibitory effects of 4-phenyl-1,2,3,4-tetrahydroisoquinoline (4-PTIQ) on methamphetamine-induced increases in dopamine and locomotion were investigated. Methamphetamine hydrochloride (10 micrograms) microinjected into the nucleus accumbens increased both locomotor activity and extracellular dopamine levels, measu...

journal_title：Neuropharmacology

authors： Tateyama M,Ohta S,Nagao T,Hirobe M,Ono H

更新日期：1993-08-01 00:00:00

abstract：:In PC12 cells, isosorbide dinitrate (ISDN) and S-nitrosol-acetyl-penicillamine (SNAP), both nitric oxide (NO) generators, attenuated K+ (56 mM)-stimulated release of dopamine. The attenuation was not observed with isosorbide, an ISDN analog lacking NO generating capacity. In this model, A23187 (Ca2+ ionophore), Bay K8...

journal_title：Neuropharmacology

authors： Sun P,Kanthasamy A,Yim GK,Isom GE

更新日期：1995-02-01 00:00:00

abstract：:This study analyzed and compared the effects of EGCG treatment on the expression of NTFs and NTF receptors expression in the sciatic nerve and the L3-L6 spinal cord segments at the early phase of regeneration following sciatic nerve crush injury. Analysis of BDNF, GDNF and NT3 neurotropic factors and Trk-B, Trk-C and ...

journal_title：Neuropharmacology

authors： Renno WM,Khan KM,Benov L

更新日期：2016-03-01 00:00:00

abstract：:The effects of the glycine derivative, CP 1552-S (2-N-pentylaminoacetamide hydrochloride) were evaluated for potential anticonvulsant activity in rats which were cortically- or amygdaloid-kindled. Large doses (300-600 mg/kg, i.p.) of CP 1552 given 30 min before stimulation resulted in significant reductions in duratio...

journal_title：Neuropharmacology

authors： Albertson TE,Stark LG,Joy RM

更新日期：1984-08-01 00:00:00

abstract：:Intensive computerized auditory training results in improved cognition for schizophrenia patients, but participants show variation in their cognitive gains and the biological factors that affect the response to training are unknown. Single nucleotide polymorphisms (SNPs) in the catechol-O-methyltransferase (COMT) gene...

journal_title：Neuropharmacology

authors： Panizzutti R,Hamilton SP,Vinogradov S

更新日期：2013-01-01 00:00:00

abstract：:Purines are ubiquitous endogenous metabolites, and their roles as signalling molecules, especially in the case of adenosine and ATP, are well documented. The release of purines is increased when cells are highly activated, stressed or damaged, and this is known to have profound effects on various organ systems. Recent...

journal_title：Neuropharmacology

authors： Chow SC,Kass GE,Orrenius S

更新日期：1997-09-01 00:00:00

abstract：:6-[(1S)-1-[1-[5-(2-hydroxyethoxy)-2-pyridyl]pyrazol-3-yl]ethyl]-3H-1,3-benzothiazol-2-one (LY3130481 or CERC-611) is a selective antagonist of AMPA receptors containing transmembrane AMPA receptor regulatory protein (TARP) γ-8. This molecule has been characterized as a potent and efficacious anticonvulsant in an array...

journal_title：Neuropharmacology

authors： Witkin JM,Li J,Gilmour G,Mitchell SN,Carter G,Gleason SD,Seidel WF,Eastwood BJ,McCarthy A,Porter WJ,Reel J,Gardinier KM,Kato AS,Wafford KA

更新日期：2017-11-01 00:00:00

abstract：:GABA(B) receptor antagonists have been shown to have antidepressant-like properties in animal models and thus, could represent a novel approach for the treatment of depression. The neurobiological mechanisms underlying these effects are currently unknown. Adult hippocampal neurogenesis (the birth of new neurons) is th...

journal_title：Neuropharmacology

authors： Felice D,O'Leary OF,Pizzo RC,Cryan JF

更新日期：2012-12-01 00:00:00

abstract：:A single oral administration of allylnitrile, crotononitrile or 2-pentenenitrile in rats induced behavioral abnormalities, such as head-twitching, head weaving, hindlimb abduction, backward pedaling and pivoting. The head-twitching, which was most consistently observed, was suppressed by serotonin (5-HT) antagonists, ...

journal_title：Neuropharmacology

authors： Tanii H,Hayashi M,Hashimoto K

更新日期：1991-08-01 00:00:00

abstract：:Dopamine (DA) is a classical neurotransmitter modulating various brain functions by acting on its specific receptors. In addition, DA is a reactive molecule that has been implicated in neurodegeneration, especially in Parkinson's disease. Here we show that DA inhibited cell growth of dopamine transporter transfected c...

journal_title：Neuropharmacology

authors： Woldman I,Reither H,Kattinger A,Hornykiewicz O,Pifl C

更新日期：2005-03-01 00:00:00

abstract：:The cannabinoid receptor CB2 plays a significant role in the regulation of immune function whereas neuronal expression remains a subject of contention. Multiple studies have described CB2 in retina and a recent study showed that CB2 deletion altered retinal visual processing. We revisited CB2 expression using immunohi...

journal_title：Neuropharmacology

authors： Borowska-Fielding J,Murataeva N,Smith B,Szczesniak AM,Leishman E,Daily L,Toguri JT,Hillard CJ,Romero J,Bradshaw H,Kelly MEM,Straiker A

更新日期：2018-10-01 00:00:00

abstract：:The risk of Alzheimer's disease (AD) is higher in patients with type 2 diabetes mellitus (T2DM). Previous studies in high-fat diet-induced AD animal models have shown that brain insulin resistance in these animals leads to the accumulation of amyloid beta (Aβ) and the reduction in GSK-3β phosphorylation, which promote...

journal_title：Neuropharmacology

authors： Kang S,Kim CH,Jung H,Kim E,Song HT,Lee JE

更新日期：2017-02-01 00:00:00

abstract：:Recent studies indicated that epigenetic modification, especially DNA methylation, play an important role in the persistence of addiction-related memory. 5-aza-2-deoxycytidine (5-aza), an inhibitor of DNA methyltransferases, was approved for clinical treatment. However, it is not clear whether 5-aza is involved in opi...

journal_title：Neuropharmacology

authors： Zhang JJ,Han J,Sui N

更新日期：2014-11-01 00:00:00

abstract：:Pyrantel is an anthelmintic which acts as an agonist of nicotinic receptors (AChRs) of nematodes and exerts its therapeutic effects by depolarizing their muscle membranes. Here we explore at the single-channel level the action of pyrantel at mammalian muscle AChR. AChR currents are elicited by pyrantel. However, openi...

journal_title：Neuropharmacology

authors： Rayes D,De Rosa MJ,Spitzmaul G,Bouzat C

更新日期：2001-08-01 00:00:00

abstract：:This study was undertaken to determine whether 1 alpha,25-dihydroxyvitamin D3 [1 alpha,25-(OH)(2)D(3)], an active metabolite of vitamin D, protects dopaminergic neurons against the neurotoxic effects of glutamate and dopaminergic toxins using rat mesecephalic culture. Brief glutamate exposure elicited cytotoxicity in ...

journal_title：Neuropharmacology

authors： Ibi M,Sawada H,Nakanishi M,Kume T,Katsuki H,Kaneko S,Shimohama S,Akaike A

更新日期：2001-05-01 00:00:00

abstract：:The effects of 3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole (YC-1), an activator of soluble guanylyl cyclase, on ionic currents have been assessed in rat pituitary GH(3) lactotrophs. In GH(3) cells bathed in normal Tyrode's solution, YC-1 (1 microM) reversibly suppressed the amplitude of the Ca(2+)-activated K(+) c...

journal_title：Neuropharmacology

authors： Wu SN,Hwang T,Teng CM,Li HF,Jan CR

更新日期：2000-07-24 00:00:00