In vivo effects of sumatriptan (GR 43175) on extracellular levels of 5-HT in the guinea pig.

abstract：:The effects of ruthenium red (RR) on transmitter release and pre-synaptic currents were studied in the mouse neuromuscular junction. The action of RR (10 microM) was shown not only in the complete suppression of nerve-evoked muscle contractions associated with the depression of endplate potential amplitude but also in...

journal_title：Neuropharmacology

authors： Lin MJ,Lin-Shiau SY

更新日期：1996-05-01 00:00:00

abstract：:Thyrotropin-releasing hormone (TRH) and TRH analogues have been reported to be neuroprotective in experimental models of spinal cord injury and head injury. We have previously shown that a diketopiperazine structurally related to the TRH metabolite cyclo-his-pro reduces neuronal cell death in vitro and in vivo. Here w...

journal_title：Neuropharmacology

authors： Faden AI,Movsesyan VA,Knoblach SM,Ahmed F,Cernak I

更新日期：2005-09-01 00:00:00

abstract：:Extracellular brain pH fluctuates in both physiological and disease conditions. The main postsynaptic proton receptor is the acid-sensing ion channels (ASICs). During the past decade, much progress has been made on protons, ASICs, and neurological disease. This review summarizes the recent progress on synaptic role of...

journal_title：Neuropharmacology

authors： Huang Y,Jiang N,Li J,Ji YH,Xiong ZG,Zha XM

更新日期：2015-07-01 00:00:00

abstract：:Spinal cord injury (SCI) is a debilitating condition which is characterized by an extended secondary injury due to the presence of inflammatory local milieu. Epigallocatechin gallate (EGCG) appears to possess strong neuroprotective properties. Here, we evaluated the beneficial effect of EGCG on recovery from SCI. Male...

journal_title：Neuropharmacology

authors： Machova Urdzikova L,Ruzicka J,Karova K,Kloudova A,Svobodova B,Amin A,Dubisova J,Schmidt M,Kubinova S,Jhanwar-Uniyal M,Jendelova P

更新日期：2017-11-01 00:00:00

abstract：:Attention-deficit hyperactivity disorder (ADHD) is a clinically and genetically heterogeneous syndrome which is comorbid with childhood conduct disorder, alcoholism, substance abuse, dis-social personality disorder, and affective disorders. A small but consistent overlap with autistic symptoms has also been establishe...

journal_title：Neuropharmacology

authors： Sharp SI,McQuillin A,Gurling HM

更新日期：2009-12-01 00:00:00

abstract：:We investigated the effect of 5-HT6 receptor subtype activation on glutamatergic transmission by means of whole-cell patch-clamp electrophysiological recordings from medium spiny neurons of the striatum and layer V pyramidal neurons of the prefrontal cortex. To this aim, we took advantage of a novel ligand, ST1936, sh...

journal_title：Neuropharmacology

authors： Tassone A,Madeo G,Schirinzi T,Vita D,Puglisi F,Ponterio G,Borsini F,Pisani A,Bonsi P

更新日期：2011-09-01 00:00:00

abstract：:Mechanisms underlying the neuroprotective properties of the weak MAO-A inhibitor moclobemide are not understood. Increasing evidence suggests that a moderate increase in intracellular free protons may contribute to neuroprotective properties due to a proton-mediated decrease in neuronal activity. Therefore, we studied...

journal_title：Neuropharmacology

authors： Bonnet U,Leniger T,Wiemann M

更新日期：2000-08-23 00:00:00

abstract：:The mGluR-mediated EPSP at parallel fibre-Purkinje cell synapses in the cerebellum was blocked concentration-dependently and reversibly by antagonists acting selectively on group-I mGluRs but not by an inhibitor of group-III receptors. The results provide pharmacological evidence that the receptor type responsible for...

journal_title：Neuropharmacology

authors： Batchelor AM,Knöpfel T,Gasparini F,Garthwaite J

更新日期：1997-03-01 00:00:00

abstract：:In previous studies, we have shown that agonists influence the ability of D2 dopamine receptors to couple to G proteins and here we extend this work. The human D2Short dopamine receptor and a natural polymorphism of this D(2Short)(Ser311Cys), have been studied by co-expressing the receptors in insect cells with Gbeta1...

journal_title：Neuropharmacology

authors： Nickolls SA,Strange PG

更新日期：2004-11-01 00:00:00

abstract：:Recent observations from synaptosome preparations have questioned the tetrodotoxin (TTX) insensitivity of nicotine-evoked release in the striatum, a characteristic previously considered diagnostic of presynaptically located nicotinic acetylcholine receptors (nAChRs). Therefore, we have undertaken a comparison of nicot...

journal_title：Neuropharmacology

authors： Marshall D,Soliakov L,Redfern P,Wonnacott S

更新日期：1996-01-01 00:00:00

abstract：:In the rat brain, gamma-hydroxybutyric-acid (GHB) increases the concentrations of 3alpha-hydroxy,5alpha-pregnan-20-one (allopregnanolone, 3alpha,5alpha-THP) and 3alpha,21-dihydroxy,5alpha-pregnan-20-one (allotetrahydrodeoxycorticosterone/3alpha,5alphaTHDOC), two neurosteroids acting as positive allosteric modulators o...

journal_title：Neuropharmacology

authors： Barbaccia ML,Carai MA,Colombo G,Lobina C,Purdy RH,Gessa GL

更新日期：2005-07-01 00:00:00

abstract：:The effects of the novel antidepressant tianeptine on behaviours induced by the serotonin (5-HT) precursor 5-hydroxytryptophan (5-HTP) and the 5-HT1A agonist 8-hydroxy-2-(di-n-propylamino)-tetralin (8-OH-DPAT) were investigated. Tianeptine (10 mg/kg, i.p.) significantly attenuated wet dog shakes (WDS) induced by 5-HTP...

journal_title：Neuropharmacology

authors： Datla KP,Curzon G

更新日期：1993-09-01 00:00:00

abstract：:The role of the stress-induced increase in the uptake of tryptophan in brain in opioid-induced analgesia was investigated by modifying the uptake of amino acid in brain with injections of competing amino acids. Blockade of analgesia by valine (200 mg/kg, i.p.) alone, and by valine and tyrosine (100 mg/kg, i.p.), but n...

journal_title：Neuropharmacology

authors： Kelly SJ,Franklin KB

更新日期：1985-11-01 00:00:00

abstract：:Psycho-genetic studies have revealed a role for the brain serotonin system in gambling proneness and poor decision-making. We assessed whether manipulation of brain serotonin levels in rats affected performance in operant-based tasks for decision-making and gambling proneness. Male Wistar rats were exposed to an l-try...

journal_title：Neuropharmacology

authors： Koot S,Zoratto F,Cassano T,Colangeli R,Laviola G,van den Bos R,Adriani W

更新日期：2012-03-01 00:00:00

abstract：:In rodents, insufficient adenosine produces behavioral and physiological symptoms consistent with several comorbidities of autism. In rodents and humans, stimuli postulated to increase adenosine can ameliorate these comorbidities. Because adenosine is a broad homeostatic regulator of cell function and nervous system a...

journal_title：Neuropharmacology

authors： Masino SA,Kawamura M Jr,Cote JL,Williams RB,Ruskin DN

更新日期：2013-05-01 00:00:00

abstract：:Stem cell research offers enormous potential for treating many diseases of the nervous system. At present, therapeutic strategies in stem cell research segregate into two approaches: cell transplantation or endogenous cell stimulation. Realistically, future cell therapies will most likely involve a combination of thes...

journal_title：Neuropharmacology

authors： Madhavan L,Collier TJ

更新日期：2010-05-01 00:00:00

abstract：:Calcium modulates the 5-HT3 receptor response by reducing peak current amplitude and increasing rates of activation, deactivation and desensitisation, but the binding site(s) and mechanism(s) of this modulation are unknown. Here we study residues that may be involved in calcium binding in two partially overlapping reg...

journal_title：Neuropharmacology

authors： Thompson AJ,Lummis SC

更新日期：2009-01-01 00:00:00

abstract：:The 15q25 gene cluster contains genes that code for the α5, α3, and β4 nicotinic acetylcholine receptor (nAChRs) subunits, and in human genetic studies, has shown the most robust association with smoking behavior and nicotine dependence to date. The limited available animal studies implicate a role for the α5 and β4 n...

journal_title：Neuropharmacology

authors： Jackson KJ,Sanjakdar SS,Muldoon PP,McIntosh JM,Damaj MI

更新日期：2013-07-01 00:00:00

abstract：:The ability of GABAA and GABAB receptors in the shell of the nucleus accumbens to modulate distinct types of turning behaviour was investigated in freely moving rats, using the unilateral injection technique. The GABAA receptor agonist muscimol and the GABAA receptor antagonist bicuculline did not produce turning beha...

journal_title：Neuropharmacology

authors： Akiyama G,Ikeda H,Matsuzaki S,Sato M,Moribe S,Koshikawa N,Cools AR

更新日期：2004-06-01 00:00:00

abstract：:Suicide is a major global problem, claiming more than 800,000 lives annually. The neurobiological changes that underlie suicidal ideation and behavior are not fully understood. Suicidal patients have been shown to display elevated levels of inflammation both in the central nervous system and the peripheral blood. A gr...

journal_title：Neuropharmacology

authors： Bryleva EY,Brundin L

更新日期：2017-01-01 00:00:00

abstract：:Enhancement of GABAA receptor function with benzodiazepine (BZ) site agonists can disrupt memory formation and hippocampal synaptic plasticity. To investigate this further the effects of the agonist, flunitrazepam, were contrasted with that of the inverse agonist, methyl-6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxyl...

journal_title：Neuropharmacology

authors： Seabrook GR,Easter A,Dawson GR,Bowery BJ

更新日期：1997-06-01 00:00:00

abstract：:Under conditions in which NG-nitro-L-arginine (NOArg) treatment prevents morphine tolerance, NOArg induces a slow progressive inhibition of nitric oxide synthase (NOS), starting at approx. 20% after a single treatment and increasing to approx. 65% after 10 days. Studies designed to examine potential changes in NOS lev...

journal_title：Neuropharmacology

authors： Babey AM,Kolesnikov Y,Cheng J,Inturrisi CE,Trifilletti RR,Pasternak GW

更新日期：1994-11-01 00:00:00

abstract：:Electrophysiological studies suggest that 5-HT autoreceptor desensitization may be responsible for the delayed clinical efficacy of some antidepressant drugs, such as selective 5-HT reuptake inhibitors (SSRI) and certain MAO inhibitors (MAOI). In the present study we have used in vivo microdialysis to test this hypoth...

journal_title：Neuropharmacology

authors： Hjorth S,Auerbach SB

更新日期：1994-03-01 00:00:00

abstract：:Inflammation plays a central role in the processes associated with neurodegeneration. The inflammatory response is mediated by activated microglia that release inflammatory mediators to the neuronal environment. Microglia-derived lysosomal cathepsins, including cathepsin X, are increasingly recognized as important med...

journal_title：Neuropharmacology

authors： Pišlar A,Božić B,Zidar N,Kos J

更新日期：2017-03-01 00:00:00

abstract：:We investigated the possibility that pituitary adenylate cyclase activating peptide (PACAP) has a role in the control of contractility in the mouse ileum. PACAP-(1-27) produced tetrodotoxin (TTX)-insensitive, concentration-dependent reduction of the amplitude of the spontaneous contractions of longitudinal muscle up t...

journal_title：Neuropharmacology

authors： Zizzo MG,Mulè F,Serio R

更新日期：2004-03-01 00:00:00

abstract：:Electrophysiological, biochemical, and behavioural studies have suggested that opiate withdrawal is mediated, at least in part, by a hyperactivity of locus coeruleus (LC) neurones. The aim of this study was to evaluate, using single-unit extracellular recordings, the role of NO in the opiate withdrawal-induced hyperac...

journal_title：Neuropharmacology

authors： Pineda J,Torrecilla M,Martín-Ruiz R,Ugedo L

更新日期：1998-06-01 00:00:00

abstract：:Mutations in LRRK2 (leucine-rich repeat kinase 2) are found associated with both sporadic and familial Parkinson's disease (PD). Pathogenic mutations are localized to the catalytic domains of LRRK2, including kinase and GTPase domains. Altered catalytic activity correlates with neurotoxicity, indicating that targeting...

journal_title：Neuropharmacology

authors： Gómez-Suaga P,Fdez E,Fernández B,Martínez-Salvador M,Blanca Ramírez M,Madero-Pérez J,Rivero-Ríos P,Fuentes JM,Hilfiker S

更新日期：2014-10-01 00:00:00

abstract：:Pain is among the most common symptoms in cancer and approximately 90% of patients experience end-stage cancer pain. The management of cancer pain is challenging due to the significant side effects associated with opioids, and novel therapeutic approaches are needed. MMG22 is a bivalent ligand containing MOR agonist a...

journal_title：Neuropharmacology

authors： Shueb SS,Erb SJ,Lunzer MM,Speltz R,Harding-Rose C,Akgün E,Simone DA,Portoghese PS

更新日期：2019-12-01 00:00:00

abstract：:Morphine alters affective states in humans and produces reinforcement in humans and animal subjects. Therefore, the present study was designed to determine whether morphine affected the functional activity in brain structures involved in emotion and motivation. Since opioid-induced analgesia largely reflects an influe...

journal_title：Neuropharmacology

authors： Cohen SR,Kimes AS,London ED

更新日期：1991-02-01 00:00:00

abstract：:Rat striatal slices, preincubated with [3H]dopamine (DA) and [14C]choline, were superfused continuously. Detection of radioactivity was used to monitor the release of the neurotransmitters DA and acetylcholine (ACh). 6-Cyano-7-nitroquinoxaline-2,3-dione (CNQX) and 2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(f)quinoxaline (...

journal_title：Neuropharmacology

authors： Jin S

更新日期：1997-11-01 00:00:00