The influence of G protein subtype on agonist action at D2 dopamine receptors.

abstract：:Neurotrophins jointly exert various functions in the nervous system, including neuronal differentiation, survival, and regulation of synaptic plasticity. However, the functional interactions of neurotrophins or mechanisms through which neurotrophins regulate each other are still not clear. In the present study, brain-...

journal_title：Neuropharmacology

authors： Xiong H,Futamura T,Jourdi H,Zhou H,Takei N,Diverse-Pierluissi M,Plevy S,Nawa H

更新日期：2002-06-01 00:00:00

abstract：:Rats were trained to recognize a discriminative stimulus (DS) elicited by the preferential dopamine D3 receptor agonists, PD128,907 (0.16 mg/kg, i.p.) and 7-OH-DPAT (0.16 mg/kg, i.p.). PD128,907 and 7-OH-DPAT showed "full" (> or = 80%) and mutual generalization. Chemically-diverse, preferential D3 versus D2 agonists, ...

journal_title：Neuropharmacology

authors： Millan MJ,Girardon S,Monneyron S,Dekeyne A

更新日期：2000-02-14 00:00:00

abstract：:U50488H is a benzeneacetamide κ-opioid receptor (κ-OR) agonist analgesic, widely used for investigating the pharmacology of G protein-coupled κ-ORs. However, U50488H is also known to directly block various voltage-gated ion channels in a G protein-independent manner. We investigated the direct actions of U50488H on va...

journal_title：Neuropharmacology

authors： Berecki G,Motin L,Adams DJ

更新日期：2016-10-01 00:00:00

abstract：:Stressful life events and chronic stressors have been associated with escalations in alcohol drinking. Stress exposure leads to the secretion of glucocorticoids (cortisol in the human; corticosterone (CORT) in the rodent). To model a period of heightened elevations in CORT, the present work assessed the effects of chr...

journal_title：Neuropharmacology

authors： Besheer J,Fisher KR,Lindsay TG,Cannady R

更新日期：2013-09-01 00:00:00

abstract：:The aim of this study was to investigate the pharmacological characteristics of the 5-hydroxytryptamine-(5-HT)-induced electrical response in cultured neuroblastoma N1E-115 cells of the mouse. In these cells 5-HT induces a transient membrane depolarization, which is associated with a transient inward current, that has...

journal_title：Neuropharmacology

authors： Neijt HC,te Duits IJ,Vijverberg HP

更新日期：1988-03-01 00:00:00

abstract：:Activation of the kappa opioid receptor (KOR) system mediates negative emotional states and considerable evidence suggests that KOR and their natural ligand, dynorphin, are involved in ethanol dependence and reward. The central amygdala (CeA) plays a major role in alcohol dependence and reinforcement. Dynorphin peptid...

journal_title：Neuropharmacology

authors： Gilpin NW,Roberto M,Koob GF,Schweitzer P

更新日期：2014-02-01 00:00:00

abstract：:Long-term L-DOPA treatment for Parkinson's disease (PD) is limited by motor complications, particularly L-DOPA-induced dyskinesia (LID). A therapy with the ability to ameliorate LID without reducing anti-parkinsonian benefit would be of great value. We assessed the ability of TC-8831, an agonist at nicotinic acetylcho...

journal_title：Neuropharmacology

authors： Johnston TH,Huot P,Fox SH,Koprich JB,Szeliga KT,James JW,Graef JD,Letchworth SR,Jordan KG,Hill MP,Brotchie JM

更新日期：2013-10-01 00:00:00

abstract：:Although the etiology of Alzheimer's disease (AD) is not fully understood, multiple lines of evidence suggests the importance of amyloid-beta (Abeta) in the initiation/progression of the disease. In this study, we investigated protective effects of erythropoietin (EPO) on Abeta(25-35)-induced cell death in cultured ra...

journal_title：Neuropharmacology

authors： Ma R,Xiong N,Huang C,Tang Q,Hu B,Xiang J,Li G

更新日期：2009-05-01 00:00:00

abstract：:The group II metabotropic glutamate (mGlu) receptors comprised of the mGlu2 and mGlu3 receptor subtypes have gained recognition in recent years as potential targets for psychiatric disorders, including anxiety and schizophrenia. In addition to studies already indicating which subtype mediates the anxiolytic and anti-p...

journal_title：Neuropharmacology

authors： Sanger H,Hanna L,Colvin EM,Grubisha O,Ursu D,Heinz BA,Findlay JD,Vivier RG,Sher E,Lodge D,Monn JA,Broad LM

更新日期：2013-03-01 00:00:00

abstract：:For a number of years it has been known that the CNS convulsant picrotoxin inhibits the GABA(A) receptor, an anion-selective member of the ligand-gated ion channel (LGIC) superfamily. PTX also inhibits other anion-selective LGIC members, such as GABA(C), glycine and glutamate-gated Cl(-) channels. In the present repor...

journal_title：Neuropharmacology

authors： Das P,Bell-Horner CL,Machu TK,Dillon GH

更新日期：2003-03-01 00:00:00

abstract：:Intracerebroventricular (i.c.v.) administration of histamine in chloral anaesthetized rats exposed to an ambient temperature of 22 C elicited a rise in their colonic temperature associated with a shivering. This effect was shared by the H2 receptor agonists dimaprit and impromidine. Impromidine is, in this respect, a ...

journal_title：Neuropharmacology

authors： Colboc O,Protais P,Costentin J

更新日期：1982-01-01 00:00:00

abstract：:The N-methyl-d-aspartate (NMDA) receptor is a key target of ethanol action in the central nervous system. Alcohol inhibition of NMDA receptor function involves small clusters of residues in the third and fourth membrane-associated (M) domains. Previous results from this laboratory have shown that two adjacent position...

journal_title：Neuropharmacology

authors： Ren H,Zhao Y,Wu M,Dwyer DS,Peoples RW

更新日期：2017-03-01 00:00:00

abstract：:Dopamine (DA) is a major catecholamine neurotransmitter in the mammalian brain that controls neural circuits involved in the cognitive, emotional, and motor aspects of goal-directed behavior. Accordingly, perturbations in DA neurotransmission play a central role in several neuropsychiatric disorders. Somewhat surprisi...

journal_title：Neuropharmacology

authors： Covey DP,Mateo Y,Sulzer D,Cheer JF,Lovinger DM

更新日期：2017-09-15 00:00:00

abstract：:Multiple administrations of methamphetamine to rats produced elevated concentrations of substance P-like immunoreactivity within the substantia nigra, an effect which is believed to be mediated by increases in dopaminergic activity induced by methamphetamine. The results reported here demonstrate that the effect of me...

journal_title：Neuropharmacology

authors： Sonsalla PK,Gibb JW,Hanson GR

更新日期：1986-11-01 00:00:00

abstract：:Neonatal administration of monosodium glutamate (MSG) destroyed perikarya in the arcuate nucleus and median eminence, including those that contain met-enkephalin and beta-endorphin and it increased the density of opiate receptors in the midbrain. Treatment with glutamate decreased the analgesic response on the jump te...

journal_title：Neuropharmacology

authors： Badillo-Martinez D,Kirchgessner AL,Butler PD,Bodnar RJ

更新日期：1984-10-01 00:00:00

abstract：:Nitric oxide modulates pain development. However, there is no evidence on the effect of nitroxyl (HNO/NO⁻) in nociception. Therefore, we addressed whether nitroxyl inhibits inflammatory hyperalgesia and its mechanism using the nitroxyl donor Angeli's salt (AS; Na₂N₂O₃). Mechanical hyperalgesia was evaluated using a mo...

journal_title：Neuropharmacology

authors： Zarpelon AC,Souza GR,Cunha TM,Schivo IR,Marchesi M,Casagrande R,Pinge-Filho P,Cunha FQ,Ferreira SH,Miranda KM,Verri WA Jr

更新日期：2013-08-01 00:00:00

abstract：:2-[p-(2-carboxyethyl)-phenylethylamino]-5'-N-ethylcarboxamidoadeno sine (CGS 21680) is considered a selective ligand for adenosine A2A receptors, which are known to be enriched in striatum and olfactory tubercle. We have investigated the characteristics of [3H]CGS 21680 binding in several brain regions using quantitat...

journal_title：Neuropharmacology

authors： Johansson B,Fredholm BB

更新日期：1995-04-01 00:00:00

abstract：:Previously, we have found that activation of mGlu receptors using a group I-specific mGlu receptor agonist, (RS)-3,5-DHPG, can induce long-term depression (LTD) in the CA1 region of the hippocampus and that, once established, this synaptic depression can be reversed by application of the mGlu receptor antagonist, (S)-...

journal_title：Neuropharmacology

authors： Schnabel R,Kilpatrick IC,Collingridge GL

更新日期：1999-10-01 00:00:00

abstract：:It is estimated that up to 30% of epilepsy patients are poorly treated with available anti-epileptic drugs (AEDs). Thus, there is a medical need for new AEDs with novel mechanisms of action to serve as alternate or adjunct therapy for the treatment of drug-resistant or refractory epilepsy. One potential anti-epileptic...

journal_title：Neuropharmacology

authors： Wickenden AD

更新日期：2002-12-01 00:00:00

abstract：:The effects of N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ), an alkylating agent producing irreversible blockade of various membrane bound receptors in brain, were investigated on four different types of serotonin receptors, 5-HT1A, 5-HT1B, 5-HT2A and 5-HT3, in various brain regions in the rat. In addition, t...

journal_title：Neuropharmacology

authors： Gozlan H,Laporte AM,Thibault S,Schechter LE,Bolaños F,Hamon M

更新日期：1994-03-01 00:00:00

abstract：:Oxytocin (100 ng) injected unilaterally into the ventral subiculum of the hippocampus induces penile erection episodes, which started 30 min after treatment and were abolished by the prior injection of d(CH(2))(5)Tyr(Me)(2)-Orn(8)-vasotocin (2 μg), an oxytocin receptor antagonist, into the ventral subiculum. Oxytocin-...

journal_title：Neuropharmacology

authors： Succu S,Sanna F,Argiolas A,Melis MR

更新日期：2011-07-01 00:00:00

abstract：:In this study, we investigated whether resveratrol could protect against ischemic injury by improving brain energy metabolism and alleviating oxidative stress. Male rats were divided into three groups: sham operation, ischemia treatment, and ischemia combined with resveratrol treatment (resveratrol-treated group, 30 m...

journal_title：Neuropharmacology

authors： Li H,Yan Z,Zhu J,Yang J,He J

更新日期：2011-02-01 00:00:00

abstract：:In the cerebellum of juvenile mice or rats, endocannabinoids are shown to mediate depolarization-induced suppression of excitation (DSE) and retrograde suppression induced by activation of type 1 metabotropic glutamate receptor (mGluR1) at parallel fiber (PF) to Purkinje cell (PC) synapses. However, recent studies sho...

journal_title：Neuropharmacology

authors： Tanimura A,Kawata S,Hashimoto K,Kano M

更新日期：2009-08-01 00:00:00

abstract：:Neuronal nicotinic acetylcholine receptors (nAChRs) are widely distributed in the nervous system and are implicated in many normal and pathological processes. The structural determinants of allostery in nAChRs are not well understood. One class of nAChR allosteric modulators, including the small molecule morantel (Mor...

journal_title：Neuropharmacology

authors： Short CA,Cao AT,Wingfield MA,Doers ME,Jobe EM,Wang N,Levandoski MM

更新日期：2015-04-01 00:00:00

abstract：:The effect of (U-54494A) cis-3,4-dichloro-N-methyl-N-[2-(1-Pyrrolidinyl)- cyclohexyl] benzamide monohydrochloride, an excitatory amino acid antagonist, on N-methyl-D-aspartic acid (NMDA)- and K(+)-evoked release of [3H]acetylcholine [( 3H]ACh) from slices of striatum was investigated. For the purpose of comparison, MK...

journal_title：Neuropharmacology

authors： Sethy VH,Sage GP

更新日期：1992-02-01 00:00:00

abstract：:Inhibition of 5-HT(6) receptors has been shown to improve memory consolidation, thus we tested whether a novel tryptamine analog with high affinity for 5-HT(6) receptors, BGC20-761 (5-methoxy-2-phenyl-N,N-dimethyltryptamine, PMDT), can enhance long-term memory. BGC20-761 (10 mg/kg i.p.) alone had no effect on social r...

journal_title：Neuropharmacology

authors： Mitchell ES,Hoplight BJ,Lear SP,Neumaier JF

更新日期：2006-03-01 00:00:00

abstract：:Stem cell research offers enormous potential for treating many diseases of the nervous system. At present, therapeutic strategies in stem cell research segregate into two approaches: cell transplantation or endogenous cell stimulation. Realistically, future cell therapies will most likely involve a combination of thes...

journal_title：Neuropharmacology

authors： Madhavan L,Collier TJ

更新日期：2010-05-01 00:00:00

abstract：:We used rats with a sciatic nerve chronic constrictive injury (CCI) and combined behavioural, molecular and morphological approaches to assess the involvement of mGlu5 receptors in neuropathic pain-associated hyperalgesia and spinal cord neuron apoptosis. Mechanical and thermal hyperalgesia developed 2-3 days after su...

journal_title：Neuropharmacology

authors： de Novellis V,Siniscalco D,Galderisi U,Fuccio C,Nolano M,Santoro L,Cascino A,Roth KA,Rossi F,Maione S

更新日期：2004-03-01 00:00:00

abstract：:The preparation of an isolated hemisected spinal cord preparation, maintained in vitro, from mature (180-300 g body weight) rats is described. Sacral and coccygeal segments (S2-Co1) gave consistent ventral root reflexes (DR-VRP) from electrical stimulation of dorsal roots. The mean latency and amplitude of the fastest...

journal_title：Neuropharmacology

authors： Long SK,Evans RH,Cull L,Krijzer F,Bevan P

更新日期：1988-05-01 00:00:00

abstract：:Chronic administration of desipramine resulted in a significant decrease in the degree of stimulation of production of cyclic AMP by noradrenaline, isoproterenol and forskolin in slices of the cerebral cortex of the rat. In preparations of membranes from similarly treated animals, GppNHp- and forskolin-stimulated aden...

journal_title：Neuropharmacology

authors： Newman ME,Lipot M,Lerer B

更新日期：1987-08-01 00:00:00