Neurotransmitter-blocking agents influence antinociceptive effects of carbamazepine, baclofen, pentazocine and morphine on bradykinin-induced trigeminal pain.

abstract：:The effect of varying the ratio of extraction volume to tissue weight (EVR) on the apparent concentration of histamine (HA) in the hypothalamus of the rat was examined. Increasing the weight of tissue (by pooling 1, 2 or 3 hypothalami), in a constant extraction volume, resulted in progressive decreases in apparent con...

journal_title：Neuropharmacology

authors： Lewis SJ,Verberne AJ,Fennessy MR,Jarrott B

更新日期：1987-08-01 00:00:00

abstract：:Agomelatine (S 20098) is a novel antidepressant drug with melatonin receptor agonist and 5-HT(2C) receptor antagonist properties, but actual mechanisms underlying its antidepressant action are unknown. Because functional desensitization of 5-HT(1A) autoreceptors in the dorsal raphe nucleus (DRN) occurs after chronic a...

journal_title：Neuropharmacology

authors： Hanoun N,Mocaër E,Boyer PA,Hamon M,Lanfumey L

更新日期：2004-09-01 00:00:00

abstract：:In the present study, we investigated the effects of N(G)-nitro-L-arginine (L-NAME), an inhibitor of nitric oxide synthase, on repeated cerebral ischemia-induced impairment of spatial memory of the 8-arm radial maze in rats. Repeated ischemia (10 min ischemia x 2 times with 1 h interval) impaired the spatial memory in...

journal_title：Neuropharmacology

authors： Mishima K,Pu F,Kaneko T,Egashira N,Iwasaki K,Fujiwara M

更新日期：2003-03-01 00:00:00

abstract：:In the present study we examined the effect of MPEP [2-methyl-6-(phenylethynyl)-pyridine] a potent, selective and systemically active metabotropic glutamate receptor (mGluR) type I (subtype mGluR5) antagonist on conditioned morphine reward in mice. In an unbiased version of conditioned place preference (CPP) paradigm,...

journal_title：Neuropharmacology

authors： Popik P,Wróbel M

更新日期：2002-12-01 00:00:00

abstract：:An elevated plus-maze, used to identify anxiolytic effects of drugs (Pellow et al., 1985), reflected as increased open-arm exploration, was employed in cycling and ovariectomised rats, to determine the effect of diazepam on the cycle and, after ovariectomy, to investigate possible influences of treatment with oestradi...

journal_title：Neuropharmacology

authors： Nomikos GG,Spyraki C

更新日期：1988-07-01 00:00:00

abstract：:Previous research shows Ouabain (OUA) to bind Na, K-ATPase, thereby triggering a number of signaling pathways, including the transcription factors NFᴋB and CREB. These transcription factors play a key role in the regulation of BDNF and WNT-β-catenin signaling cascades, which are involved in neuroprotection and memory ...

journal_title：Neuropharmacology

authors： Orellana AM,Leite JA,Kinoshita PF,Vasconcelos AR,Andreotti DZ,de Sá Lima L,Xavier GF,Kawamoto EM,Scavone C

更新日期：2018-09-15 00:00:00

abstract：:Hippocampal damage produces spatial memory impairment and hyperactivity in animals, while reductions in hippocampal size have been associated with memory deficits in humans. There are no known treatments for the behavioral changes specifically related to reduced hippocampal size. The purpose of this study was to deter...

journal_title：Neuropharmacology

authors： Bardgett ME,Baum KT,O'Connell SM,Lee NM,Hon JC

更新日期：2006-12-01 00:00:00

abstract：:Trazodone is one of the most commonly prescribed medicines for treating depression and insomnia. However, the pharmacological mechanism of action underlying trazodone's unique effects is unclear. Despite its nanomolar affinity for 5HT(2A) receptors, histamine(1) receptors and alpha(1) adrenoceptors the drug is given a...

journal_title：Neuropharmacology

authors： Kraus RL,Li Y,Jovanovska A,Renger JJ

更新日期：2007-08-01 00:00:00

abstract：:The GABA(B) receptor has been shown to consist of a heterodimer of two related 7-transmembrane receptors GABAB-R1 and GABA(B)-R2. These receptors share close homology to the Ca2+-sensing receptor and also to the metabotropic glutamate receptors, which have also been shown to respond to extracellular calcium. We show h...

journal_title：Neuropharmacology

authors： Wise A,Green A,Main MJ,Wilson R,Fraser N,Marshall FH

更新日期：1999-11-01 00:00:00

abstract：:Schizophrenic patients have been shown to exhibit abnormal cortical gamma band oscillation (GBO), which is thought to be related to the symptoms of schizophrenia, including cognitive impairment. Recently, non-competitive NMDA receptor (NMDAr) antagonists such as MK-801 and ketamine have been reported to increase the b...

journal_title：Neuropharmacology

authors： Hiyoshi T,Kambe D,Karasawa J,Chaki S

更新日期：2014-10-01 00:00:00

abstract：:Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by memory deficits and cognitive decline. Amyloid-β (Aβ) deposition and cholinergic defect are widely thought to be the underlying mechanism of learning and memory impairment. Geniposide, which is the main active component of the tradit...

journal_title：Neuropharmacology

authors： Zhao C,Zhang H,Li H,Lv C,Liu X,Li Z,Xin W,Wang Y,Zhang W

更新日期：2017-04-01 00:00:00

abstract：:Consistent experimental evidence supports an important role of the glutamatergic system in the etiopathogenesis of schizophrenia. Numerous studies propose that blockade of the NMDA receptor by its antagonist ketamine impairs cognition and can mimic certain aspects of positive and negative symptoms of schizophrenia in ...

journal_title：Neuropharmacology

authors： Zoupa E,Gravanis A,Pitsikas N

更新日期：2019-06-01 00:00:00

abstract：:Neural sensorimotor gating mechanisms prevent the interruption of ongoing information processing routines by ensuing stimuli to permit mental integration and adaptive behavior. Prepulse inhibition (PPI), an operational measure of sensorimotor gating, is now being investigated using murine models to exploit transgenic ...

journal_title：Neuropharmacology

authors： Dulawa SC,Geyer MA

更新日期：2000-08-23 00:00:00

abstract：:Downregulation of the astroglial glutamate transporter GLT-1 is observed in the nucleus accumbens (NAc) following administration of multiple drugs of abuse. The decrease in GLT-1 protein expression following cocaine self-administration is dependent on both the amount of cocaine self-administered and the length of with...

journal_title：Neuropharmacology

authors： Kim R,Sepulveda-Orengo MT,Healey KL,Williams EA,Reissner KJ

更新日期：2018-01-01 00:00:00

abstract：:There is poor experimental evidence concerning the effects of anesthetic doses of the non-competitive NMDA receptor antagonist ketamine on rodents' memory abilities. The present study was designed to investigate a) the long-term consequences of anesthetic ketamine on rats' non-spatial and spatial recognition memory; b...

journal_title：Neuropharmacology

authors： Pitsikas N,Boultadakis A

更新日期：2009-07-01 00:00:00

abstract：:Groups of hypophysectomised rats were given either an electroconvulsive shock (ECS; 125V, 1 sec) once daily for 10 days or a sham-shock. Twenty-four hours after the final treatment both groups were tested for their responses to the dopamine agonist, apomorphine, the 5-hydroxytryptamine agonist, quipazine, and the alph...

journal_title：Neuropharmacology

authors： Nutt DJ,Smith SL,Heal DJ

更新日期：1982-09-01 00:00:00

abstract：:Neurosteroids are synthesized in the brain and have been demonstrated to modulate various cerebral functions. Allopregnanolone (3alpha-hydroxy-5alpha-pregnan-20-one), a naturally occurring neurosteroid, and ganaxolone (3alpha-hydroxy-3beta-methyl-5alpha-pregnan-20-one), a synthetic derivative, are two neurosteroids ac...

journal_title：Neuropharmacology

authors： Citraro R,Russo E,Di Paola ED,Ibbadu GF,Gratteri S,Marra R,De Sarro G

更新日期：2006-06-01 00:00:00

abstract：:miR-132 and miR-212 are structurally-related microRNAs that are expressed from the same non-coding transcript. Accumulating evidence has shown that the dysregulation of these microRNAs contributes to aberrant neuronal plasticity and gene expression in the mammalian brain. Consistent with this, altered expression of mi...

journal_title：Neuropharmacology

authors： Aten S,Page CE,Kalidindi A,Wheaton K,Niraula A,Godbout JP,Hoyt KR,Obrietan K

更新日期：2019-01-01 00:00:00

abstract：:Cyclic nucleotide-gated (CNG) channels, which are directly activated by cAMP and cGMP, have long been known to play a key role in retinal and olfactory signal transduction. Emerging evidence indicates that CNG channels are also involved in signaling pathways important for pain processing. Here, we found that the expre...

journal_title：Neuropharmacology

authors： Kallenborn-Gerhardt W,Metzner K,Lu R,Petersen J,Kuth MS,Heine S,Drees O,Paul M,Becirovic E,Kennel L,Flauaus C,Gross T,Wack G,Hohmann SW,Nemirovski D,Del Turco D,Biel M,Geisslinger G,Michalakis S,Schmidtko A

更新日期：2020-07-01 00:00:00

abstract：:How does an agonist activate a receptor? In this article I consider the activation process in muscle nicotinic acetylcholine receptors (AChRs), a prototype for understanding the energetics of binding and gating in other ligand-gated ion channels. Just as movements that generate gating currents activate voltage-gated i...

journal_title：Neuropharmacology

authors： Auerbach A

更新日期：2015-09-01 00:00:00

abstract：:A functional balance between excitatory and inhibitory control over dopamine (DA)-dependent behavioral and neurochemical effects of cocaine is afforded by the serotonin(2C) receptor (5-HT(2C)R) located within the ventral tegmental area and the nucleus accumbens (NAc). The 5-HT(2C)R located in the medial prefrontal cor...

journal_title：Neuropharmacology

authors： Leggio GM,Cathala A,Moison D,Cunningham KA,Piazza PV,Spampinato U

更新日期：2009-02-01 00:00:00

abstract：:C57BL/6J mice were introduced to a nine arm radial maze without prior habituation and trained in the acquisition of a working memory task in 16 sessions, one session per day. In this maze mice need to climb onto an upward inclined bridge in order to reach and cross onto an arm. They received in each session an i.p. in...

journal_title：Neuropharmacology

authors： Ennaceur A,Michalikova S,van Rensburg R,Chazot PL

更新日期：2011-10-01 00:00:00

abstract：:The effects of high-K, glutamate and glutamate receptor agonists on the efflux of Ca2+ were studied in cultured primary astrocytes, prepared from the brains of newborn rats. An increase in efflux of 45Ca2+ of produced by a large extracellular concentration of K+ was effectively inhibited by verapamil, a blocker of vol...

journal_title：Neuropharmacology

authors： Holopainen I,Akerman KE

更新日期：1990-08-01 00:00:00

abstract：:This study investigated the structure-activity relationships and kinetic properties of a library of kynurenate analogues as inhibitors of 3H-L-glutamate transport into rat forebrain synaptic vesicles. The lack of inhibitory activity observed with the majority of the monocyclic pyridine derivatives suggested that the s...

journal_title：Neuropharmacology

authors： Bartlett RD,Esslinger CS,Thompson CM,Bridges RJ

更新日期：1998-07-01 00:00:00

abstract：:Both psychostimulants and antidepressants target monoamine transporters and, as a consequence, augment monoamine transmission. These two groups of drugs also increase motor activity in preclinical behavioural screens for antidepressants. Substance P-preferring receptor (NK1R) antagonists similarly increase both motor ...

journal_title：Neuropharmacology

authors： Stanford SC

更新日期：2014-12-01 00:00:00

abstract：:We describe a touchscreen method that satisfies a proposed 'wish-list' of desirables for a cognitive testing method for assessing rodent models of schizophrenia. A number of tests relevant to schizophrenia research are described which are currently being developed and validated using this method. These tests can be us...

journal_title：Neuropharmacology

authors： Bussey TJ,Holmes A,Lyon L,Mar AC,McAllister KA,Nithianantharajah J,Oomen CA,Saksida LM

更新日期：2012-03-01 00:00:00

abstract：:A once daily injection to rats of triiodothyronine (T3; 100 micrograms/kg s.c.) for 10 days enhanced the locomotor responses of rats pretreated with tranylcypromine (5 mg/kg) to an injection into the nucleus accumbens of dopamine (5 micrograms bilaterally), when tested 24 hr after the last T3 administration. This trea...

journal_title：Neuropharmacology

authors： Heal DJ,Atterwill CK

更新日期：1982-02-01 00:00:00

abstract：:Traumatic injuries to peripheral nerves are frequent, however, specific pharmacological treatments are currently lacking. Curcumin has antioxidant, anti-inflammatory and neuroprotective properties but high oral doses are required for therapeutic use, particularly due to its low bioavailability. The aim of the present ...

journal_title：Neuropharmacology

authors： Caillaud M,Chantemargue B,Richard L,Vignaud L,Favreau F,Faye PA,Vignoles P,Sturtz F,Trouillas P,Vallat JM,Desmoulière A,Billet F

更新日期：2018-09-01 00:00:00

abstract：:Despite evidence of local glycinergic circuits in the mature cerebellar nuclei the result of their activation remains unknown. Here, using whole cell recordings in rat cerebellar slices we demonstrated that after postnatal day 17 (>P17) glycinergic IPSCs can be readily evoked in large deep cerebellar nuclear neurons (...

journal_title：Neuropharmacology

authors： Pedroarena CM,Kamphausen S

更新日期：2008-04-01 00:00:00

abstract：:The anticonvulsant action and the long-term effects on learning, memory and behavior of the new generation antiepileptic drug gabapentin (GBP) were investigated in immature animals. Kainic acid (KA) was administered to rats on postnatal day (P) 35. Animals were treated with GBP or saline from P36 to P75 and spontaneou...

journal_title：Neuropharmacology

authors： Cilio MR,Bolanos AR,Liu Z,Schmid R,Yang Y,Stafstrom CE,Mikati MA,Holmes GL

更新日期：2001-01-01 00:00:00