Increased membrane cholesterol reduces the potentiation of GABA(A) currents by neurosteroids in dissociated hippocampal neurones.

abstract：:To assess a possible role for phospholipase D (PLD) in PC12 cell signal transduction and differentiation, we have investigated the expression of PLD in PC12 cells and found that the differentiation factor, nerve growth factor (NGF) increased PLD1 protein expression and phorbol 12-myristate 13 acetate (PMA)-induced PLD...

journal_title：Neuropharmacology

authors： Min DS,Ahn BH,Rhie DJ,Yoon SH,Hahn SJ,Kim MS,Jo YH

更新日期：2001-09-01 00:00:00

abstract：:Vesicular glutamate transporter 2 (VGLUT2)-which uptakes glutamate into presynaptic vesicles-is a fundamental component of the glutamate neurotransmitter system. Although several lines of evidence from genetically modified mice suggest a possible association of VGLUT2 with neuropathic pain, the specific role of VGLUT2...

journal_title：Neuropharmacology

authors： Zhang ZL,Yu G,Peng J,Wang HB,Li YL,Liang XN,Su RB,Gong ZH

更新日期：2020-03-01 00:00:00

abstract：:Recent experimental evidence indicates that in the neocortex, the manner in which each synapse releases neurotransmitter in response to trains of presynaptic action potentials is potentially unique. These unique transmission characteristics arise because of a large heterogeneity in various synaptic properties that det...

journal_title：Neuropharmacology

authors： Markram H,Pikus D,Gupta A,Tsodyks M

更新日期：1998-04-01 00:00:00

abstract：:Amphetamine-type stimulants (ATS) are the second most consumed illicit drug worldwide and lack good treatments for associated substance use disorders, lagging behind other addictive drugs. For this reason, a deeper understanding of the pharmacodynamics of ATS is required. The present study seeks to determine amphetami...

journal_title：Neuropharmacology

authors： Garton DR,Ross SG,Maldonado-Hernández R,Quick M,Lasalde-Dominicci JA,Lizardi-Ortiz JE

更新日期：2019-01-01 00:00:00

abstract：:Downregulation of the astroglial glutamate transporter GLT-1 is observed in the nucleus accumbens (NAc) following administration of multiple drugs of abuse. The decrease in GLT-1 protein expression following cocaine self-administration is dependent on both the amount of cocaine self-administered and the length of with...

journal_title：Neuropharmacology

authors： Kim R,Sepulveda-Orengo MT,Healey KL,Williams EA,Reissner KJ

更新日期：2018-01-01 00:00:00

abstract：:Central sensitization represents a key mechanism mediating chronic pain, a major clinical problem lacking effective treatment options. LIM-domain kinases (LIMKs) selectively regulate several substrates, e.g. cofilin and cAMP response element-binding protein (CREB), that profoundly affect neural activities, such as syn...

journal_title：Neuropharmacology

authors： Yang X,He G,Zhang X,Chen L,Kong Y,Xie W,Jia Z,Liu WT,Zhou Z

更新日期：2017-10-01 00:00:00

abstract：:Enhancement of GABAA receptor function with benzodiazepine (BZ) site agonists can disrupt memory formation and hippocampal synaptic plasticity. To investigate this further the effects of the agonist, flunitrazepam, were contrasted with that of the inverse agonist, methyl-6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxyl...

journal_title：Neuropharmacology

authors： Seabrook GR,Easter A,Dawson GR,Bowery BJ

更新日期：1997-06-01 00:00:00

abstract：:Differences in overall cocaine intake can directly affect neuroadaptations, and this relationship can make it difficult to interpret neurobiological changes seen in drug-choice studies, since drug intake varies between subjects. Herein, a choice procedure that controls for cocaine intake was utilized to explore if neu...

journal_title：Neuropharmacology

authors： Chow JJ,Hofford RS,Beckmann JS

更新日期：2021-02-15 00:00:00

abstract：:We investigated the role of nitric oxide (NO) in learning and memory formation in a radial maze test, by using the NO synthase (NOS) inhibitors, NG-nitro-L-arginine methyl ester (L-NAME) and 7-nitroindazole (7-NI), and an NO precursor, L-arginine. Rats were trained on a working and reference memory task in an eight ar...

journal_title：Neuropharmacology

authors： Zou LB,Yamada K,Tanaka T,Kameyama T,Nabeshima T

更新日期：1998-01-01 00:00:00

abstract：:Selective serotonin (5-HT) re-uptake inhibitors (SSRIs) are commonly used in the treatment of generalized anxiety disorder in Humans. However, because only few animal models display overt anxious-like behavior, detailed preclinical studies of the anxiolytic properties of antidepressants are still lacking. Here, we stu...

journal_title：Neuropharmacology

authors： Guilloux JP,David DJ,Xia L,Nguyen HT,Rainer Q,Guiard BP,Repérant C,Deltheil T,Toth M,Hen R,Gardier AM

更新日期：2011-09-01 00:00:00

abstract：:Behavioural studies can help to validate, modify and refine schemes for classifying receptors that are developed from electrophysiological and biochemical experiments. Drug discrimination constitutes one family of behavioural techniques that is being extensively used for studying subtypes of receptors, mainly because ...

journal_title：Neuropharmacology

authors： Stolerman IP,Stephenson JD,Rauch RJ

更新日期：1987-07-01 00:00:00

abstract：:Cholecystokinin octapeptide (CCK-8), caerulein and seven out of ten analogues of caerulein produced in mice, after subcutaneous administration, a dose-dependent drop in rectal temperature. For the hypothermic effect, i.e. a decrease in temperature by at least 1.5 degree C, ED50's were estimated with these peptides and...

journal_title：Neuropharmacology

authors： Zetler G

更新日期：1982-08-01 00:00:00

abstract：:The cannabinoid receptor CB2 plays a significant role in the regulation of immune function whereas neuronal expression remains a subject of contention. Multiple studies have described CB2 in retina and a recent study showed that CB2 deletion altered retinal visual processing. We revisited CB2 expression using immunohi...

journal_title：Neuropharmacology

authors： Borowska-Fielding J,Murataeva N,Smith B,Szczesniak AM,Leishman E,Daily L,Toguri JT,Hillard CJ,Romero J,Bradshaw H,Kelly MEM,Straiker A

更新日期：2018-10-01 00:00:00

abstract：:In vivo and in vitro studies suggest a crucial role for Sphingosine 1-phosphate (S1P) and its receptors in the development of the nervous system. Dihydrosphingosine 1-phosphate (dhS1P), a reduced form of S1P, is an agonist at S1P receptors, but the pharmacology and physiology of dhS1P has not been widely studied. The ...

journal_title：Neuropharmacology

authors： Callihan P,Zitomer NC,Stoeling MV,Kennedy PC,Lynch KR,Riley RT,Hooks SB

更新日期：2012-02-01 00:00:00

abstract：:Memory reactivation has been shown to open a time window for memory modulation. The majority of the methodological or pharmacological approaches target disruption of reconsolidation to weaken aversive memories. However, methods to improve appetitive memory persistence through reconsolidation or to reverse drug-induced...

journal_title：Neuropharmacology

authors： Wang SH

更新日期：2018-10-01 00:00:00

abstract：:The patch-clamp technique was used to study the effects of nystatin on a cloned delayed rectifier potassium channel (Kv1.3) expressed in Chinese hamster ovary (CHO) cells. Kv1.3 currents recorded in the whole-cell configuration, using an intracellular solution containing nystatin, were subjected to a time- and concent...

journal_title：Neuropharmacology

authors： Hahn SJ,Wang LY,Kaczmarek LK

更新日期：1996-01-01 00:00:00

abstract：:Parkinson's disease (PD) is a neurodegenerative disease characterized by the progressive loss of dopaminergic neurons in the substantia nigra, leading to motor symptoms. Despite the remarkable improvements in the management of PD in recent decades, many patients remain significantly disabled. Metformin is a primary me...

journal_title：Neuropharmacology

authors： Ryu YK,Go J,Park HY,Choi YK,Seo YJ,Choi JH,Rhee M,Lee TG,Lee CH,Kim KS

更新日期：2020-09-15 00:00:00

abstract：:Depolarizations provoked by acetylcholine (ACh) and three dicholines, succinylcholine (SCh), glutarylcholine (GCh) and azelainylcholine (AzCh) were measured in normal and 3-7 days denervated muscles of adult, and in normal muscles of 0-27 days old mice and rats. Soleus and flexor digitorum superficialis muscles were m...

journal_title：Neuropharmacology

authors： Lorković H

更新日期：1989-04-01 00:00:00

abstract：:The modulatory effects exerted by the glucocorticoid hydrocortisone (HC) on the nicotinic acetylcholine receptor (AChR) were studied in mutants of the alpha subunit M4 transmembrane region. Based on the photoaffinity labeling of alpha M4 412 with the steroid promegestone this position was mutated to different residues...

journal_title：Neuropharmacology

authors： Garbus I,Roccamo AM,Barrantes FJ

更新日期：2002-07-01 00:00:00

abstract：:Hypotheses are scaffoldings erected in front of a building and then dismantled when the building is finished. They are indispensable for the workman; but you mustn't mistake the scaffolding for the building. Johann Wolfgang von Goethe. The neurogenesis hypothesis of affective disorders - in its simplest form - postula...

journal_title：Neuropharmacology

authors： Petrik D,Lagace DC,Eisch AJ

更新日期：2012-01-01 00:00:00

abstract：:The central nucleus of the amygdala (CeA) is a component of the limbic fear-anxiety circuit, and has also been implicated in regulation of the hypothalamic-pituitary-adrenal (HPA) stress axis. The CeA receives dense noradrenergic innervation, and is rich in expression of alpha(1)-adrenergic receptors. We hypothesized ...

journal_title：Neuropharmacology

authors： Cecchi M,Khoshbouei H,Morilak DA

更新日期：2002-12-01 00:00:00

abstract：:The ventromedial nucleus of the hypothalamus (VMH) plays an important role in feeding and energy homeostasis. Electroconvulsive seizure (ECS) therapy is highly effective in the treatment of several psychiatric diseases, including depression, but may also have beneficial effects in other neurological diseases. Although...

journal_title：Neuropharmacology

authors： Segi-Nishida E,Sukeno M,Imoto Y,Kira T,Sakaida M,Tsuchiya S,Sugimoto Y,Okuno Y

更新日期：2013-08-01 00:00:00

abstract：:Dopaminergic innervation of the extended amygdala regulates anxiety-like behavior and stress responsivity. A portion of this dopamine input arises from dopamine neurons located in the ventral lateral periaqueductal gray (vlPAG) and rostral (RLi) and caudal linear nuclei of the raphe (CLi). These neurons receive substa...

journal_title：Neuropharmacology

authors： Williams MA,Li C,Kash TL,Matthews RT,Winder DG

更新日期：2014-11-01 00:00:00

abstract：:The demonstrated functional interaction of metabotropic glutamate 5 (mGlu₅) receptors with N-methyl-d-aspartate (NMDA) receptors has prompted speculation that their activation may offer a potential treatment for aspects of schizophrenia. Development of selective mGlu₅ agonists has been difficult, but several different...

journal_title：Neuropharmacology

authors： Gilmour G,Broad LM,Wafford KA,Britton T,Colvin EM,Fivush A,Gastambide F,Getman B,Heinz BA,McCarthy AP,Prieto L,Shanks E,Smith JW,Taboada L,Edgar DM,Tricklebank MD

更新日期：2013-01-01 00:00:00

abstract：:Heterogeneous binding interactions of cerebellar GABA(A) receptors were investigated with GABA agonists and neurosteroids. GABA(A) receptors of rat cerebellum were labelled with [(3)H]ethynylbicycloorthobenzoate (EBOB), a convulsant radioligand. Saturation analysis revealed a homogenous, nanomolar population of [(3)H]...

journal_title：Neuropharmacology

authors： Maksay G,Bíró T

更新日期：2005-09-01 00:00:00

abstract：:The effects of d-amphetamine (0.03-10.0 mg/kg), caffeine (0.3-100.0 mg/kg), nicotine (0.003-10.0 mg/kg) and cocaine (0.03-56.0 mg/kg) were compared on responding maintained under three different schedules of food presentation in mice. Cumulative doses of d-amphetamine, nicotine and cocaine only decreased responding ma...

journal_title：Neuropharmacology

authors： Glowa JR

更新日期：1986-10-01 00:00:00

abstract：:High performance liquid chromatography with electrochemical detection (HPLC-EC) was adapted for the analysis of metabolites of monoamines (MA) in the developing brain of the rat. 3-Methoxy-4-hydroxy-phenyl-ethylene glycol (MOPEG), dihydroxy phenylacetic acid (DOPAC), homovanillic acid (HVA) and 5-hydroxy-3-indoleaceti...

journal_title：Neuropharmacology

authors： Ribary U,Schlumpf M,Lichtensteiger W

更新日期：1986-09-01 00:00:00

abstract：:It has been reported that application of 1S,3R-1-aminocyclopentane 1,3-dicarboxylic acid (ACPD) in vitro triggers a slow-onset potentiation in the hippocampal CA1 region. This study examined the effect of ACPD in the CA1 of freely moving rats. No effect on fEPSP baseline recordings occurred at 40 and 400 microM/5 micr...

journal_title：Neuropharmacology

authors： Manahan-Vaughan D,Reymann KG

更新日期：1995-08-01 00:00:00

abstract：:Benzodiazepines (BZDs) are widely used in the treatment of a variety of neurological and psychiatric conditions including anxiety, insomnia and epilepsy. BZDs are thought to act predominantly by affecting the gating of GABAA receptor channels, resulting in enhanced GABA-mediated currents in neurons. However, mutations...

journal_title：Neuropharmacology

authors： Lévi S,Le Roux N,Eugène E,Poncer JC

更新日期：2015-01-01 00:00:00

abstract：:The aim of this study was to investigate the pharmacological characteristics of the 5-hydroxytryptamine-(5-HT)-induced electrical response in cultured neuroblastoma N1E-115 cells of the mouse. In these cells 5-HT induces a transient membrane depolarization, which is associated with a transient inward current, that has...

journal_title：Neuropharmacology

authors： Neijt HC,te Duits IJ,Vijverberg HP

更新日期：1988-03-01 00:00:00