Abstract:
:The study investigated the interaction between phencyclidine (PCP) and morphine in affecting the levels of met-enkephalin, dopamine, DOPAC and HVA in mice. Morphine 5 mg/kg alone and PCP 10 mg/kg alone failed to change the levels of met-enkephalin in the midbrain and striatum. However, PCP in combination with morphine produced an increase in met-enkephalin levels and a decrease in HVA levels. In the midbrain, there was a direct relationship between the decrease in met-enkephalin levels and the increase in HVA levels. These results suggest that PCP may change the function in dopaminergic and enkephalinergic neuronal systems in the midbrain and/or striatum.
journal_name
Neuropharmacologyjournal_title
Neuropharmacologyauthors
Nabeshima T,Hiramatsu M,Furukawa H,Kameyama Tdoi
10.1016/0028-3908(85)90016-4subject
Has Abstractpub_date
1985-08-01 00:00:00pages
805-9issue
8eissn
0028-3908issn
1873-7064journal_volume
24pub_type
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journal_title:Neuropharmacology
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更新日期:2010-06-01 00:00:00
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更新日期:2017-02-01 00:00:00
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journal_title:Neuropharmacology
pub_type: 杂志文章,评审
doi:10.1016/j.neuropharm.2010.04.007
更新日期:2010-09-01 00:00:00
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更新日期:2016-02-01 00:00:00
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journal_title:Neuropharmacology
pub_type: 杂志文章
doi:10.1016/0028-3908(88)90161-x
更新日期:1988-02-01 00:00:00
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journal_title:Neuropharmacology
pub_type: 杂志文章
doi:10.1016/0028-3908(89)90116-0
更新日期:1989-10-01 00:00:00
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journal_title:Neuropharmacology
pub_type: 杂志文章
doi:10.1016/j.neuropharm.2007.04.016
更新日期:2007-07-01 00:00:00
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journal_title:Neuropharmacology
pub_type: 杂志文章
doi:10.1016/0028-3908(85)90089-9
更新日期:1985-01-01 00:00:00
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journal_title:Neuropharmacology
pub_type: 杂志文章,随机对照试验
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更新日期:2018-11-01 00:00:00
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journal_title:Neuropharmacology
pub_type: 杂志文章
doi:10.1016/0028-3908(88)90160-8
更新日期:1988-02-01 00:00:00
abstract::Cholecystokinin (CCK) is the most abundant neuropeptide in the central nervous system. In the hippocampal CA1 region, CCK is co-localized with GABA in a subset of interneurons that synapse on pyramidal cell somata and apical dendrites. CCK-containing interneurons also uniquely express a high level of the cannabinoid r...
journal_title:Neuropharmacology
pub_type: 杂志文章
doi:10.1016/j.neuropharm.2007.06.023
更新日期:2008-01-01 00:00:00
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journal_title:Neuropharmacology
pub_type: 杂志文章
doi:10.1016/0028-3908(92)90118-9
更新日期:1992-09-01 00:00:00
abstract::The effects of the anxiolytic benzodiazepine flurazepam and the anxiogenic beta-carboline N-methyl-beta-carboline-3-carboxylate (FG 7142) were measured in unanaesthetised rats. Changes in motor activity, using a Doppler-shift microwave device, and in the extracellular concentration of ascorbate in the striatum and nuc...
journal_title:Neuropharmacology
pub_type: 杂志文章
doi:10.1016/0028-3908(89)90087-7
更新日期:1989-05-01 00:00:00