Effects of phencyclidine in combination with morphine on the levels of met-enkephalin, dopamine, DOPAC and HVA in discrete brain areas of mice.

Abstract:

:The study investigated the interaction between phencyclidine (PCP) and morphine in affecting the levels of met-enkephalin, dopamine, DOPAC and HVA in mice. Morphine 5 mg/kg alone and PCP 10 mg/kg alone failed to change the levels of met-enkephalin in the midbrain and striatum. However, PCP in combination with morphine produced an increase in met-enkephalin levels and a decrease in HVA levels. In the midbrain, there was a direct relationship between the decrease in met-enkephalin levels and the increase in HVA levels. These results suggest that PCP may change the function in dopaminergic and enkephalinergic neuronal systems in the midbrain and/or striatum.

journal_name

Neuropharmacology

journal_title

Neuropharmacology

authors

Nabeshima T,Hiramatsu M,Furukawa H,Kameyama T

doi

10.1016/0028-3908(85)90016-4

subject

Has Abstract

pub_date

1985-08-01 00:00:00

pages

805-9

issue

8

eissn

0028-3908

issn

1873-7064

journal_volume

24

pub_type

杂志文章
  • Use of the radioligand [(125)I]-SB-217644 in the characterisation and solubilisation of the novel binding site for the anticonvulsant SB-204269 in rat brain membranes and cell lines.

    abstract::SB-204269 (trans-(+)-6-acetyl-4S-(4-fluorobenzoylamino)-3, 4-dihydro-2,2-dimethyl-2H-benzo[b]pyran-3R-ol) shows anticonvulsant activity in a range of animal seizure models, with a high therapeutic index and a lack of side-effects. We have previously reported the characterisation of a novel binding site for [(3)H]-SB-2...

    journal_title:Neuropharmacology

    pub_type: 杂志文章

    doi:10.1016/s0028-3908(00)00071-x

    authors: Herdon HJ,Godfrey FM,Chan WN

    更新日期:2000-09-01 00:00:00

  • Olvanil: a non-pungent TRPV1 activator has anti-emetic properties in the ferret.

    abstract::Anti-emetic drugs such as the tachykinin NK(1) receptor antagonists are useful to control emesis induced by diverse challenges. Evidence suggests pungent capsaicin-like TRPV1 activators also have broad inhibitory anti-emetic activity. However, pungent compounds are associated with undesirable effects including adverse...

    journal_title:Neuropharmacology

    pub_type: 杂志文章

    doi:10.1016/j.neuropharm.2009.10.002

    authors: Chu KM,Ngan MP,Wai MK,Yeung CK,Andrews PL,Percie du Sert N,Rudd JA

    更新日期:2010-02-01 00:00:00

  • Glycine transporters type 1 inhibitor promotes brain preconditioning against NMDA-induced excitotoxicity.

    abstract::Brain preconditioning is a protective mechanism, which can be activated by sub-lethal stimulation of the NMDA receptors (NMDAR) and be used to achieve neuroprotection against stroke and neurodegenerative diseases models. Inhibitors of glycine transporters type 1 modulate glutamatergic neurotransmission through NMDAR, ...

    journal_title:Neuropharmacology

    pub_type: 杂志文章

    doi:10.1016/j.neuropharm.2014.10.003

    authors: Pinto MC,Lima IV,da Costa FL,Rosa DV,Mendes-Goulart VA,Resende RR,Romano-Silva MA,de Oliveira AC,Gomez MV,Gomez RS

    更新日期:2015-02-01 00:00:00

  • Involvement of the nucleus accumbens shell dopaminergic system in prelimbic NMDA-induced anxiolytic-like behaviors.

    abstract:BACKGROUND:Nucleus accumbens (NAc) and prefrontal cortex (PFC) dopaminergic and glutamatergic systems are involved in fear/anxiety-related behaviors; meanwhile NAc dopaminergic system activity is mediated by PFC via NAc glutamatergic projections. This study has investigated the involvement of NAc shell dopaminergic sys...

    journal_title:Neuropharmacology

    pub_type: 杂志文章

    doi:10.1016/j.neuropharm.2013.03.017

    authors: Ahmadi H,Nasehi M,Rostami P,Zarrindast MR

    更新日期:2013-08-01 00:00:00

  • Antagonist discrimination of two muscarinic responses elicited by applied agonists and orthodromic stimuli in superior cervical ganglion of rabbit.

    abstract::Pirenzepine and gallamine selectively and differentially antagonized two muscarinic responses, in the superior cervical ganglion of the rabbit, whether elicited by the muscarinic agonist methacholine or by orthodromic stimulation. Methacholine elicited a biphasic ganglionic response, consisting of hyperpolarizing and ...

    journal_title:Neuropharmacology

    pub_type: 杂志文章

    doi:10.1016/0028-3908(87)90001-3

    authors: Yarosh CA,Ashe JH

    更新日期:1987-11-01 00:00:00

  • Reduced anxiety-like behaviour induced by genetic and pharmacological inhibition of the endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) is mediated by CB1 receptors.

    abstract::Anandamide and 2-arachidonoyl glycerol, referred to as endocannabinoids (eCBs), are the endogenous agonists for the cannabinoid receptor type 1 (CB1). Several pieces of evidence support a role for eCBs in the attenuation of anxiety-related behaviours, although the precise mechanism has remained uncertain. The fatty ac...

    journal_title:Neuropharmacology

    pub_type: 杂志文章

    doi:10.1016/j.neuropharm.2007.07.005

    authors: Moreira FA,Kaiser N,Monory K,Lutz B

    更新日期:2008-01-01 00:00:00

  • Adrenergic receptors in rat spinal cord.

    abstract::Radioligand binding assays were used to demonstrate the presence of alpha 1, alpha 2 and beta receptors in rat spinal cord. Specific and saturable binding was exhibited for [3H]-WB 4101 (alpha 1), [3H]-aminoclonidine (alpha 2) and [3H]-dihydroalprenolol (beta). Binding was of high affinity and the total number of bind...

    journal_title:Neuropharmacology

    pub_type: 杂志文章

    doi:10.1016/0028-3908(82)90162-9

    authors: Jones DJ,Kendall DE,Enna SJ

    更新日期:1982-02-01 00:00:00

  • Inhibitory effect of 4-phenyltetrahydroisoquinoline on locomotion and dopamine release induced by micro-injection of methamphetamine into the nucleus accumbens of the rat.

    abstract::The inhibitory effects of 4-phenyl-1,2,3,4-tetrahydroisoquinoline (4-PTIQ) on methamphetamine-induced increases in dopamine and locomotion were investigated. Methamphetamine hydrochloride (10 micrograms) microinjected into the nucleus accumbens increased both locomotor activity and extracellular dopamine levels, measu...

    journal_title:Neuropharmacology

    pub_type: 杂志文章

    doi:10.1016/0028-3908(93)90184-5

    authors: Tateyama M,Ohta S,Nagao T,Hirobe M,Ono H

    更新日期:1993-08-01 00:00:00

  • Chronic valproate treatment blocks D2-like receptor-mediated brain signaling via arachidonic acid in rats.

    abstract:BACKGROUND AND OBJECTIVE:Hyperdopaminergic signaling and an upregulated brain arachidonic acid (AA) cascade may contribute to bipolar disorder (BD). Lithium and carbamazepine, FDA-approved for the treatment of BD, attenuate brain dopaminergic D(2)-like (D(2), D(3), and D(4)) receptor signaling involving AA when given c...

    journal_title:Neuropharmacology

    pub_type: 杂志文章

    doi:10.1016/j.neuropharm.2011.07.025

    authors: Ramadan E,Basselin M,Taha AY,Cheon Y,Chang L,Chen M,Rapoport SI

    更新日期:2011-12-01 00:00:00

  • Evidence that physical dependence on morphine is mediated by the ventral midbrain.

    abstract::Rats were given daily injections of increasing doses of morphine sulfate (40-100 mg/kg, s.c.), for 4 days. Twenty hours after the last injection of morphine, the animals received bilateral injections of naloxone (1-10 micrograms) into the substantia nigra, ventral tegmental area or sites 2 mm rostral, caudal or dorsal...

    journal_title:Neuropharmacology

    pub_type: 杂志文章

    doi:10.1016/0028-3908(89)90204-9

    authors: Baumeister AA,Anticich TG,Hebert G,Hawkins MF,Nagy M

    更新日期:1989-11-01 00:00:00

  • A mutant thyroid hormone receptor alpha1 alters hippocampal circuitry and reduces seizure susceptibility in mice.

    abstract::Thyroid hormone deficiency during early developmental stages causes a multitude of functional and morphological deficits in the brain. In the present study we investigate the effects of a mutated thyroid hormone receptor TR alpha 1 and the resulting receptor-mediated hypothyroidism on the development of GABAergic neur...

    journal_title:Neuropharmacology

    pub_type: 杂志文章

    doi:10.1016/j.neuropharm.2010.02.005

    authors: Hadjab-Lallemend S,Wallis K,van Hogerlinden M,Dudazy S,Nordström K,Vennström B,Fisahn A

    更新日期:2010-06-01 00:00:00

  • Neuronal oscillations: A physiological correlate for targeting mitochondrial dysfunction in neurodegenerative diseases?

    abstract::Increasingly in the realm of neurological disorders, particularly those involving neurodegeneration, mitochondrial dysfunction is emerging at the core of their pathogenic processes. Most of these diseases still lack effective treatment and are hampered by a shortfall in the development of novel medicines. Clearly new ...

    journal_title:Neuropharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuropharm.2015.10.033

    authors: Chan F,Lax NZ,Davies CH,Turnbull DM,Cunningham MO

    更新日期:2016-03-01 00:00:00

  • Furosemide modulation of GABA(A) receptors in dopaminergic neurones of the rat substantia nigra.

    abstract::Furosemide is a diuretic which has been shown to decrease recombinant GABA(A) receptor (GABA(A)R)-mediated currents and also to block epileptiform discharges. Here, we show that furosemide actions on GABA(A)Rs of rat substantia nigra dopaminergic neurones depend on both furosemide and GABA(A)R agonist concentrations. ...

    journal_title:Neuropharmacology

    pub_type: 杂志文章

    doi:10.1016/s0028-3908(02)00178-8

    authors: Guyon A,Cathala L,Paupardin-Tritsch D,Eugène D

    更新日期:2002-09-01 00:00:00

  • The new antiepileptic drugs lamotrigine and felbamate are effective in phenytoin-resistant kindled rats.

    abstract::We evaluated the anticonvulsant efficacy of the antiepileptic drugs (AEDs) lamotrigine (LTG) and felbamate (FBM) in amygdala kindled rats that had been preselected with respect to their response to phenytoin. Anticonvulsant response was tested by determining the afterdischarge threshold (ADT), i.e., a sensitive measur...

    journal_title:Neuropharmacology

    pub_type: 杂志文章

    doi:10.1016/s0028-3908(00)00039-3

    authors: Ebert U,Reissmüller E,Löscher W

    更新日期:2000-07-24 00:00:00

  • Divergent cAMP signaling differentially regulates serotonin-induced spinal motor plasticity.

    abstract::Spinal metabotropic serotonin receptors encode transient experiences into long-lasting changes in motor behavior (i.e. motor plasticity). While interactions between serotonin receptor subtypes are known to regulate plasticity, the significance of molecular divergence in downstream G protein coupled receptor signaling ...

    journal_title:Neuropharmacology

    pub_type: 杂志文章

    doi:10.1016/j.neuropharm.2016.09.018

    authors: Fields DP,Mitchell GS

    更新日期:2017-02-01 00:00:00

  • Multiphoton in vivo imaging of amyloid in animal models of Alzheimer's disease.

    abstract::Amyloid-beta (Abeta) deposition is a defining feature of Alzheimer's disease (AD). The toxicity of Abeta aggregation is thought to contribute to clinical deficits including progressive memory loss and cognitive dysfunction. Therefore, Abeta peptide has become the focus of many therapeutic approaches for the treatment ...

    journal_title:Neuropharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuropharm.2010.04.007

    authors: Dong J,Revilla-Sanchez R,Moss S,Haydon PG

    更新日期:2010-09-01 00:00:00

  • Responses of hippocampal pyramidal cells to putative serotonin 5-HT1A and 5-HT1B agonists: a comparative study with dorsal raphe neurons.

    abstract::In low cerveau isolé transected rats, the effects of microiontophoretic application of putative serotonin 5-HT1A and 5-HT1B agonists on the spontaneous firing rate of CA1 pyramidal cells were compared to those of 5-HT. In contrast to the large current-dependent suppression of unit activity observed with 5-HT, the 5-HT...

    journal_title:Neuropharmacology

    pub_type: 杂志文章

    doi:10.1016/0028-3908(88)90079-2

    authors: Sprouse JS,Aghajanian GK

    更新日期:1988-07-01 00:00:00

  • Prokineticin system modulation as a new target to counteract the amyloid beta toxicity induced by glutamatergic alterations in an in vitro model of Alzheimer's disease.

    abstract::The accumulation of β-amyloid (Aβ) is one of the hallmarks of Alzheimer disease (AD). Beyond the inflammatory reactions promoted by Aβ, it has been demonstrated that the prokineticin (PK) system, composed of the chemokine prokineticin 2 (PK2) and its receptors, is involved in Aβ toxicity. In this study we have analyze...

    journal_title:Neuropharmacology

    pub_type: 杂志文章

    doi:10.1016/j.neuropharm.2016.12.012

    authors: Caioli S,Severini C,Ciotti T,Florenzano F,Pimpinella D,Petrocchi Passeri P,Balboni G,Polisca P,Lattanzi R,Nisticò R,Negri L,Zona C

    更新日期:2017-04-01 00:00:00

  • In vitro binding affinities of a series of flavonoids for μ-opioid receptors. Antinociceptive effect of the synthetic flavonoid 3,3-dibromoflavanone in mice.

    abstract::The pharmacotherapy for the treatment of pain is an active area of investigation. There are effective drugs to treat this problem, but there is also a need to find alternative treatments free of undesirable side effects. In the present work the capacity of a series of flavonoids to bind to the μ opioid receptor was ev...

    journal_title:Neuropharmacology

    pub_type: 杂志文章

    doi:10.1016/j.neuropharm.2013.04.020

    authors: Higgs J,Wasowski C,Loscalzo LM,Marder M

    更新日期:2013-09-01 00:00:00

  • Jingzhaotoxin-IX, a novel gating modifier of both sodium and potassium channels from Chinese tarantula Chilobrachys jingzhao.

    abstract::Tarantula Chilobrachys jingzhao is one of the most venomous species distributed in China. In this study, we have isolated and characterized a novel neurotoxin named Jingzhaotoxin-IX (JZTX-IX) from the venom of the tarantula. JZTX-IX is a C-terminally amidated peptide composed of 35 amino acid residues. The toxin shows...

    journal_title:Neuropharmacology

    pub_type: 杂志文章

    doi:10.1016/j.neuropharm.2009.04.009

    authors: Deng M,Kuang F,Sun Z,Tao H,Cai T,Zhong L,Chen Z,Xiao Y,Liang S

    更新日期:2009-08-01 00:00:00

  • Blockade of T-type calcium channels prevents tonic-clonic seizures in a maximal electroshock seizure model.

    abstract::T-type (Cav3) calcium channels play important roles in neuronal excitability, both in normal and pathological activities of the brain. In particular, they contribute to hyper-excitability disorders such as epilepsy. Here we have characterized the anticonvulsant properties of TTA-A2, a selective T-type channel blocker,...

    journal_title:Neuropharmacology

    pub_type: 杂志文章

    doi:10.1016/j.neuropharm.2015.09.032

    authors: Sakkaki S,Gangarossa G,Lerat B,Françon D,Forichon L,Chemin J,Valjent E,Lerner-Natoli M,Lory P

    更新日期:2016-02-01 00:00:00

  • Involvement of ventral noradrenergic bundle in corticosterone secretion following neural stimuli.

    abstract::In view of the involvement of noradrenaline (NA) in the regulation of adrenocortical secretion, its role in the rise of plasma corticosterone following neural stimuli was evaluated in rats. The injection of the catecholamine neurotoxin 6-hydroxydopamine (6-OHDA) into the ventral noradrenergic bundle in the brain stem,...

    journal_title:Neuropharmacology

    pub_type: 杂志文章

    doi:10.1016/0028-3908(88)90161-x

    authors: Feldman S,Conforti N,Melamed E

    更新日期:1988-02-01 00:00:00

  • A local serotonergic component involved in the spinal antinociceptive action of morphine.

    abstract::Participation of opiate, serotonergic and noradrenergic components in the antinociceptive action of intrathecally administered morphine was evaluated by measuring the ability of subcutaneously administered doses of naloxone, methysergide and phentolamine to alter analgesia. Morphine produced a dose-dependent elevation...

    journal_title:Neuropharmacology

    pub_type: 杂志文章

    doi:10.1016/0028-3908(89)90116-0

    authors: Crisp T,Smith DJ

    更新日期:1989-10-01 00:00:00

  • Subtype-selective antagonism of N-methyl-D-aspartate receptor ion channels by synthetic conantokin peptides.

    abstract::Conantokin-G (con-G), conantokin-T (con-T), a truncated conantokin-R (con-R[1-17]), that functions the same as wild-type con-R, and variant sequences of con-T, were chemically synthesized and employed to investigate their selectivities as antagonists of glutamate/glycine-evoked ion currents in human embryonic kidney-2...

    journal_title:Neuropharmacology

    pub_type: 杂志文章

    doi:10.1016/j.neuropharm.2007.04.016

    authors: Sheng Z,Dai Q,Prorok M,Castellino FJ

    更新日期:2007-07-01 00:00:00

  • Monovalent cation dependency for the inhibition of outward transport of [3H]norepinephrine.

    abstract::Rat hearts were labelled with [3H]norepinephrine in vivo. Slices of ventricles were prepared, preincubated in Krebs-HCO3 medium (KRB), and then incubated in a Na+-deficient, choline+-Krebs HCO3 (Ch+-Ca2+). The choline+-Krebs HCO3 medium induced a delayed neurosecretion which could be inhibited by either one of the blo...

    journal_title:Neuropharmacology

    pub_type: 杂志文章

    doi:10.1016/0028-3908(85)90089-9

    authors: Bogdanski DF

    更新日期:1985-01-01 00:00:00

  • A sub-set of psychoactive effects may be critical to the behavioral impact of ketamine on cocaine use disorder: Results from a randomized, controlled laboratory study.

    abstract::Efforts to translate sub-anesthetic ketamine infusions into widespread clinical use have centered around developing medications with comparable neurobiological activity, but with attenuated psychoactive effects so as to minimize the risk of behavioral toxicity and abuse liability. Converging lines of research, however...

    journal_title:Neuropharmacology

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.neuropharm.2018.01.005

    authors: Dakwar E,Nunes EV,Hart CL,Hu MC,Foltin RW,Levin FR

    更新日期:2018-11-01 00:00:00

  • Anti-serotonin action in combination with noradrenaline-stimulating action is important for inhibiting muricide in midbrain raphe-lesioned rats.

    abstract::The present study was designed to examine the possible involvement of both an anti-serotonin action and a catecholamine-stimulating action in the mechanism of the inhibition of the muricide in rats with lesions of the midbrain raphe. Serotonin antagonists, such as cyproheptadine (10 mg/kg), cinanserin (10 mg/kg) and p...

    journal_title:Neuropharmacology

    pub_type: 杂志文章

    doi:10.1016/0028-3908(88)90160-8

    authors: Yamamoto T,Ohno M,Takao K,Ueki S

    更新日期:1988-02-01 00:00:00

  • Cholecystokinin inhibits endocannabinoid-sensitive hippocampal IPSPs and stimulates others.

    abstract::Cholecystokinin (CCK) is the most abundant neuropeptide in the central nervous system. In the hippocampal CA1 region, CCK is co-localized with GABA in a subset of interneurons that synapse on pyramidal cell somata and apical dendrites. CCK-containing interneurons also uniquely express a high level of the cannabinoid r...

    journal_title:Neuropharmacology

    pub_type: 杂志文章

    doi:10.1016/j.neuropharm.2007.06.023

    authors: Karson MA,Whittington KC,Alger BE

    更新日期:2008-01-01 00:00:00

  • Effects of intracerebroventricularly administered mu-, delta- and kappa-opioid agonists on locomotor activity of the guinea pig and the pharmacology of the locomotor response to U50,488H.

    abstract::The effects of intracerebroventricular administration of morphine, the selective mu-agonist DAMGO, the delta-agonist DPDPE, the kappa-preferring peptide dynorphin A(1-13) and the kappa-agonist U50,488H on locomotor behaviour in the guinea pig were investigated. Morphine (total dose = 0.01, 0.1, 1, 10, 200 nmol), DAMGO...

    journal_title:Neuropharmacology

    pub_type: 杂志文章

    doi:10.1016/0028-3908(92)90118-9

    authors: Bot G,Chahl LA,Brent PJ,Johnston PA

    更新日期:1992-09-01 00:00:00

  • The effects of anxiolytic and anxiogenic benzodiazepine receptor ligands on motor activity and levels of ascorbic acid in the nucleus accumbens and striatum of the rat.

    abstract::The effects of the anxiolytic benzodiazepine flurazepam and the anxiogenic beta-carboline N-methyl-beta-carboline-3-carboxylate (FG 7142) were measured in unanaesthetised rats. Changes in motor activity, using a Doppler-shift microwave device, and in the extracellular concentration of ascorbate in the striatum and nuc...

    journal_title:Neuropharmacology

    pub_type: 杂志文章

    doi:10.1016/0028-3908(89)90087-7

    authors: Brose N,O'Neill RD,Boutelle MG,Fillenz M

    更新日期:1989-05-01 00:00:00