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Decreased density of peripheral benzodiazepine binding sites on platelets of currently drinking, but not abstinent alcoholics.

Abstract：

:Using the isoquinoline carboxamide derivative, PK 11195 as selective ligand, the binding properties of peripheral benzodiazepine binding sites were compared on platelets of alcoholics and non-alcoholic, healthy controls. When compared to controls, alcoholics during prolonged ethanol consumption show a significant reduction in the density of platelet [3H]PK 11195 binding sites. However, following abstention from alcohol, the density of these sites is similar to controls. These data suggest that a reduction in the density of peripheral benzodiazepine binding sites on platelets may be a biochemical index of prolonged ethanol use and indicate a possible role for these sites in mediating the chronic effects of alcohol.

journal_name

Neuropharmacology

journal_title

Neuropharmacology

authors

Suranyi-Cadotte B,Lafaille F,Dongier M,Dumas M,Quirion R

doi

10.1016/0028-3908(88)90155-4

subject

Has Abstract

pub_date

1988-04-01 00:00:00

pages

443-5

issue

4

eissn

0028-3908

issn

1873-7064

journal_volume

27

pub_type

杂志文章

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