当前位置： SCI文献检索 > NEUROPHARMACOLOGY期刊下所有文献 > Rapamycin ameliorates cadmium-induced activation of MAPK pathway and neuronal apoptosis by preventing mitochondrial ROS inactivation of PP2A.

Rapamycin ameliorates cadmium-induced activation of MAPK pathway and neuronal apoptosis by preventing mitochondrial ROS inactivation of PP2A.

Abstract：

:Cadmium (Cd) is a highly toxic metal that affects the central nervous system. Recently we have demonstrated that inhibition of mTOR by rapamycin rescues neuronal cells from Cd-poisoning. Here we show that rapamycin inhibited Cd-induced mitochondrial ROS-dependent neuronal apoptosis. Intriguingly, rapamycin remarkably blocked phosphorylation of JNK, Erk1/2 and p38 in neuronal cells induced by Cd, which was strengthened by co-treatment with Mito-TEMPO. Inhibition of JNK and Erk1/2 by SP600125 and U0126, respectively, potentiated rapamycin's prevention from Cd-induced apoptosis. Consistently, over-expression of dominant negative c-Jun or MKK1 also potently improved the inhibitory effect of rapamycin on Cd neurotoxicity. Furthermore, pretreatment with SP600125 or U0126, or expression of dominant negative c-Jun or MKK1 enhanced the inhibitory effects of rapamycin or Mito-TEMPO on Cd-induced ROS. Further investigation found that co-treatment with Mito-TEMPO/rapamycin more effectively rescued cells by preventing Cd inactivation of PP2A than treatment with rapamycin or Mito-TEMPO alone. Over-expression of wild-type PP2A reinforced rapamycin or Mito-TEMPO suppression of activated JNK and Erk1/2 pathways, as well as ROS production and apoptosis in neuronal cells in response to Cd. The findings indicate that rapamycin ameliorates Cd-evoked neuronal apoptosis by preventing mitochondrial ROS inactivation of PP2A, thereby suppressing activation of JNK and Erk1/2 pathways. Our results underline that rapamycin may have a potential in preventing Cd-induced oxidative stress and neurodegenerative diseases.

journal_name

Neuropharmacology

journal_title

Neuropharmacology

authors

Xu C,Wang X,Zhu Y,Dong X,Liu C,Zhang H,Liu L,Huang S,Chen L

doi

10.1016/j.neuropharm.2016.01.030

subject

Has Abstract

pub_date

2016-06-01 00:00:00

pages

270-284

eissn

0028-3908

issn

1873-7064

pii

S0028-3908(16)30029-6

journal_volume

105

pub_type

杂志文章

相关文献

NEUROPHARMACOLOGY文献大全
  • Modulation of expression of fear by oxytocin signaling in the central amygdala: From reduction of fear to regulation of defensive behavior style.

    abstract：:Many studies in preclinical animal models have described fear-reducing effects of the neuropeptide oxytocin in the central nucleus of the amygdala. However, recent studies have refined the role of oxytocin in the central amygdala, which may extend to the selection of an active defensive coping style in the face of imm...

    journal_title：Neuropharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuropharm.2020.108130

    authors： van den Burg EH,Hegoburu C

    更新日期：2020-08-15 00:00:00

  • General anesthetic exposure in adolescent rats causes persistent maladaptations in cognitive and affective behaviors and neuroplasticity.

    abstract：:Accumulating evidence indicates that exposure to general anesthetics during infancy and childhood can cause persistent cognitive impairment, alterations in synaptic plasticity, and, to a lesser extent, increased incidence of behavioral disorders. Unfortunately, the developmental parameters of susceptibility to general...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2019.03.022

    authors： Landin JD,Palac M,Carter JM,Dzumaga Y,Santerre-Anderson JL,Fernandez GM,Savage LM,Varlinskaya EI,Spear LP,Moore SD,Swartzwelder HS,Fleming RL,Werner DF

    更新日期：2019-05-15 00:00:00

  • Block of calcium channels in rat neurons by synthetic omega-Aga-IVA.

    abstract：:We investigated block of voltage-dependent Ca channels in freshly dissociated rat central and peripheral neurons by the synthetic peptide omega-Aga-IVA. Synthetic omega-Aga-IVA blocked approximately 90% of the high-threshold Ca current in cerebellar Purkinje neurons with an estimated Kd of approximately 1.5 nM, slight...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/0028-3908(93)90010-z

    authors： Mintz IM,Bean BP

    更新日期：1993-11-01 00:00:00

  • Translational neurophysiological markers for activity of the metabotropic glutamate receptor (mGluR2) modulator JNJ-40411813: Sleep EEG correlates in rodents and healthy men.

    abstract：:Alterations in rapid eye movement sleep (REM) have been suggested as valid translational efficacy markers: activation of the metabotropic glutamate receptor 2 (mGluR2) was shown to increase REM latency and to decrease REM duration. The present paper addresses the effects on vigilance states of the mGluR2 positive allo...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2015.11.031

    authors： Ahnaou A,de Boer P,Lavreysen H,Huysmans H,Sinha V,Raeymaekers L,Van De Casteele T,Cid JM,Van Nueten L,Macdonald GJ,Kemp JA,Drinkenburg WH

    更新日期：2016-04-01 00:00:00

  • Differential effects of adolescent and adult-initiated voluntary exercise on context and cued fear conditioning.

    abstract：:Adolescence is a critical period for postnatal brain maturation and a time during which there is increased susceptibility to developing emotional and cognitive-related disorders. Exercise during adulthood has been shown to increase hippocampal plasticity and enhance cognition. However, the impact of exercise initiated...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2018.05.007

    authors： O'Leary JD,Hoban AE,Cryan JF,O'Leary OF,Nolan YM

    更新日期：2019-02-01 00:00:00

  • Chronic alcohol exposure reduces acetylated histones in the sleep-wake regulatory brain regions to cause insomnia during withdrawal.

    abstract：BACKGROUND:Alcohol use disorder (AUD) develops after chronic and heavy use of alcohol. Insomnia, a hallmark of AUD, plays a crucial role in the development of AUD. However, the causal mechanisms are unknown. Since chronic alcohol reduces acetylated histones and disrupts the epigenome, we hypothesized that chronic alcoh...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2020.108332

    authors： Sharma R,Sahota P,Thakkar MM

    更新日期：2020-12-01 00:00:00

  • Cross-sensitization to the excitatory effect of morphine in post-dependent rats.

    abstract：:Time-effects of morphine, methadone, meperidine and pentazocine upon locomotor activity were investigated in naive and in post-dependent rats. Dependence was induced by daily injection of 20 mg/kg (i.p.) of morphine for 30 days. Tests were run starting from 1 month after withdrawal from morphine. Morphine produced a g...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/0028-3908(85)90041-3

    authors： Bartoletti M,Gaiardi M,Gubellini C,Bacchi A,Babbini M

    更新日期：1985-09-01 00:00:00

  • Melanocortin 4 receptor stimulation improves social deficits in mice through oxytocin pathway.

    abstract：:Several studies on humans and mice support oxytocin's role in improving social behaviour, but its use in pharmacotherapy presents some important limiting factors. To date, it is emerging a pharmacological potential for melanocortin 4 receptor (MC4R) agonism in social deficits treatment. Recently, we demonstrated that ...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2018.02.007

    authors： Mastinu A,Premoli M,Maccarinelli G,Grilli M,Memo M,Bonini SA

    更新日期：2018-05-01 00:00:00

  • Differential modulatory actions of the volatile convulsant flurothyl and its anesthetic isomer at inhibitory ligand-gated ion channels.

    abstract：:A challenge for theories of general anesthesia is the existence of compounds predicted to be anesthetics but which, instead, do not produce anesthesia and often elicit other behavioral effects such as convulsions. This study focused on flurothyl (bis[2,2, 2-trifluoroethyl] ether), a potent volatile convulsant, and its...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/s0028-3908(99)00221-x

    authors： Krasowski MD

    更新日期：2000-04-27 00:00:00

  • A novel biscoumarin compound ameliorates cerebral ischemia reperfusion-induced mitochondrial oxidative injury via Nrf2/Keap1/ARE signaling.

    abstract：:Some phytochemical-derived synthetic compounds have been shown to improve neurological disorders, especially in ischemic stroke. In this study, we identified a novel biscoumarin compound, known as COM 3, which had substantial antioxidant effects in neurons. Next, we found that COM 3 occupies a critical binding site be...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2019.107918

    authors： Wang J,Zhang W,Lv C,Wang Y,Ma B,Zhang H,Fan Z,Li M,Li X

    更新日期：2020-05-01 00:00:00

  • Safinamide inhibits in vivo glutamate release in a rat model of Parkinson's disease.

    abstract：:To investigate whether the reversible MAO-B inhibitor and sodium channel blocker safinamide impairs glutamate release under parkinsonian conditions in vivo, and this effect is dependent on MAO-B inhibition, safinamide (and rasagiline as a comparator) were administered to 6-hydroxydopamine hemilesioned rats, a model of...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2020.108006

    authors： Pisanò CA,Brugnoli A,Novello S,Caccia C,Keywood C,Melloni E,Vailati S,Padoani G,Morari M

    更新日期：2020-05-01 00:00:00

  • THC and gabapentin interactions in a mouse neuropathic pain model.

    abstract：:Clinical studies have shown that the major psychoactive ingredient of Cannabis sativa Δ9-tetrahydrocannabinol (THC) has some analgesic efficacy in neuropathic pain states. However, THC has a significant side effect profile. We examined whether the profile of THC could be improved by co-administering it with the first-...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2018.10.006

    authors： Atwal N,Casey SL,Mitchell VA,Vaughan CW

    更新日期：2019-01-01 00:00:00

  • The effect of estradiol on the alterations in monoamine-mediated behavioural responses induced by administration of electroconvulsive shocks or imipramine to female rats.

    abstract：:Female rats were treated daily with electroconvulsive shocks (ECS) or imipramine (10 mg/kg) for 10 days. Both types of treatment enhanced behavioural responses mediated by 5-hydroxytryptamine (5-HT) and noradrenaline (NA). A behavioural response mediated by dopamine (DA) was enhanced by electroconvulsive shock-treatme...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/0028-3908(83)90099-0

    authors： Bhavsar VH,Dhumal VR,Kelkar VV

    更新日期：1983-06-01 00:00:00

  • Potential for multiple mechanisms, phenomena and algorithms for synaptic plasticity at single synapses.

    abstract：:Recent experimental evidence indicates that in the neocortex, the manner in which each synapse releases neurotransmitter in response to trains of presynaptic action potentials is potentially unique. These unique transmission characteristics arise because of a large heterogeneity in various synaptic properties that det...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/s0028-3908(98)00049-5

    authors： Markram H,Pikus D,Gupta A,Tsodyks M

    更新日期：1998-04-01 00:00:00

  • Stimulation of α2-adrenergic receptors in the central nucleus of the amygdala attenuates stress-induced reinstatement of nicotine seeking in rats.

    abstract：:Tobacco addiction is a chronic disorder that is characterized by craving for tobacco products, withdrawal upon smoking cessation, and relapse after periods of abstinence. Previous studies demonstrated that systemic administration of α2-adrenergic receptor agonists attenuates stress-induced reinstatement of drug seekin...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2010.09.013

    authors： Yamada H,Bruijnzeel AW

    更新日期：2011-02-01 00:00:00

  • Repeated but not acute clomipramine decreases the effect of N-methyl-D-aspartate receptor activation on serotonergic transmission between the raphe nuclei and frontal cortex.

    abstract：:The effect of acute or repeated treatment with the antidepressant clomipramine (CIM) on N-methyl-D-aspartate (NMDA) evoked changes in extracellular 5-hydroxytryptamine (5-HT) in the raphe nuclei and frontal cortex of the same rat has been studied using microdialysis. Acute injection of CIM (10 or 20 mg/kg) caused an i...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/s0028-3908(01)00078-8

    authors： Pallotta M,Segieth J,Sadideen F,Whitton PS

    更新日期：2001-09-01 00:00:00

  • The GABAergic Gudden's dorsal tegmental nucleus: A new relay for serotonergic regulation of sleep-wake behavior in the mouse.

    abstract：:Serotonin (5-HT) neurons are involved in wake promotion and exert a strong inhibitory influence on rapid eye movement (REM) sleep. Such effects have been ascribed, at least in part to the action of 5-HT at post-synaptic 5-HT1A receptors (5-HT1AR) in the brainstem, a major wake/REM sleep regulatory center. However, the...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2018.06.014

    authors： Chazalon M,Dumas S,Bernard JF,Sahly I,Tronche F,de Kerchove d'Exaerde A,Hamon M,Adrien J,Fabre V,Bonnavion P

    更新日期：2018-08-01 00:00:00

  • A green tea polyphenol epigallocatechin-3-gallate enhances neuroregeneration after spinal cord injury by altering levels of inflammatory cytokines.

    abstract：:Spinal cord injury (SCI) is a debilitating condition which is characterized by an extended secondary injury due to the presence of inflammatory local milieu. Epigallocatechin gallate (EGCG) appears to possess strong neuroprotective properties. Here, we evaluated the beneficial effect of EGCG on recovery from SCI. Male...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2017.09.006

    authors： Machova Urdzikova L,Ruzicka J,Karova K,Kloudova A,Svobodova B,Amin A,Dubisova J,Schmidt M,Kubinova S,Jhanwar-Uniyal M,Jendelova P

    更新日期：2017-11-01 00:00:00

  • Reversal of morphine-induced catalepsy in the rat by narcotic antagonists and their quaternary derivatives.

    abstract：:The effects of the pure narcotic antagonists, naloxone and naltrexone, and their quaternary derivatives, methylnaloxone and methylnaltrexone, were examined in reversing the catalepsy induced by morphine in rats. Morphine, 20 mg/kg, induced rigid catalepsy which attained a peak effect (as manifested by duration of cata...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/0028-3908(83)90246-0

    authors： Brown DR,Robertson MJ,Goldberg LI

    更新日期：1983-03-01 00:00:00

  • Inhibitory effects of clonidine and tizanidine on release of substance P from slices of rat spinal cord and antagonism by alpha-adrenergic receptor antagonists.

    abstract：:Effects of clonidine and tizanidine, which have antinociceptive and alpha 2-agonistic actions, were studied on the release of substance P from slices of spinal cord from the rat. Veratridine-evoked depolarization induced a 2-3-fold increase in the release of substance P from the slices of spinal cord. Exposure of the ...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/0028-3908(91)90077-o

    authors： Ono H,Mishima A,Ono S,Fukuda H,Vasko MR

    更新日期：1991-06-01 00:00:00

  • Nigrostriatal dopamine actions on the D2 receptors mediate methamphetamine effects on the striatonigral substance P system.

    abstract：:Multiple administrations of methamphetamine to rats produced elevated concentrations of substance P-like immunoreactivity within the substantia nigra, an effect which is believed to be mediated by increases in dopaminergic activity induced by methamphetamine. The results reported here demonstrate that the effect of me...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/0028-3908(86)90139-5

    authors： Sonsalla PK,Gibb JW,Hanson GR

    更新日期：1986-11-01 00:00:00

  • A local serotonergic component involved in the spinal antinociceptive action of morphine.

    abstract：:Participation of opiate, serotonergic and noradrenergic components in the antinociceptive action of intrathecally administered morphine was evaluated by measuring the ability of subcutaneously administered doses of naloxone, methysergide and phentolamine to alter analgesia. Morphine produced a dose-dependent elevation...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/0028-3908(89)90116-0

    authors： Crisp T,Smith DJ

    更新日期：1989-10-01 00:00:00

  • Proconvulsant and anticonvulsant effects in mice of acute and chronic treatment with cocaine.

    abstract：:The proconvulsant and anticonvulsant effects of acute and chronic exposure to cocaine were investigated in adult, male, CF-1 mice. The proconvulsant effects of cocaine in mice only manifested themselves after daily exposure to motor-stimulant doses. Although daily treatment decreased electroshock convulsion threshold,...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/0028-3908(89)90155-x

    authors： Karler R,Petty C,Calder L,Turkanis SA

    更新日期：1989-07-01 00:00:00

  • Differential effects of the novel antidepressant agomelatine (S 20098) versus fluoxetine on 5-HT1A receptors in the rat brain.

    abstract：:Agomelatine (S 20098) is a novel antidepressant drug with melatonin receptor agonist and 5-HT(2C) receptor antagonist properties, but actual mechanisms underlying its antidepressant action are unknown. Because functional desensitization of 5-HT(1A) autoreceptors in the dorsal raphe nucleus (DRN) occurs after chronic a...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2004.06.003

    authors： Hanoun N,Mocaër E,Boyer PA,Hamon M,Lanfumey L

    更新日期：2004-09-01 00:00:00

  • Inhibition of cathepsin X reduces the strength of microglial-mediated neuroinflammation.

    abstract：:Inflammation plays a central role in the processes associated with neurodegeneration. The inflammatory response is mediated by activated microglia that release inflammatory mediators to the neuronal environment. Microglia-derived lysosomal cathepsins, including cathepsin X, are increasingly recognized as important med...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2016.11.019

    authors： Pišlar A,Božić B,Zidar N,Kos J

    更新日期：2017-03-01 00:00:00

  • Antagonism of alpha-adrenoceptor agonist-induced antinociception in the rat.

    abstract：:The present study investigated the effects of WB4101, a selective alpha 1-adrenoceptor blocking agent, and idazoxan, a selective alpha 2-adrenoceptor blocking agent, on antinociception and sedation in the rat mediated by adrenoceptors. Selective alpha 1-adrenoceptor agonists, e.g. ST587 and methoxamine induced antinoc...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/0028-3908(86)90234-0

    authors： Hayes AG,Skingle M,Tyers MB

    更新日期：1986-04-01 00:00:00

  • Long-term potentiation persists in an occult state following mGluR-dependent depotentiation.

    abstract：:Depotentiation, the reversal of long-term potentiation (LTP), can be induced by activation of metabotropic glutamate receptors (mGluRs) or NMDA receptors (NMDARs). Although NMDAR-dependent depotentiation is due to a protein phosphatase-dependent erasure of LTP, the notion that mGluR-dependent depotentiation also invol...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2005.01.008

    authors： Delgado JY,O'dell TJ

    更新日期：2005-06-01 00:00:00

  • The interaction between P2X7Rs and T-type calcium ion channels in penicillin-induced epileptiform activity.

    abstract：:Limited information exists on the link between purinergic class P2X7 receptors (P2X7Rs) and calcium ion channels in epilepsy; no data has been reported regarding the interaction between P2X7Rs and T-type calcium ion channels in epilepsy. Thus, this study is an evaluation of the role that T-type calcium ion channels pl...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/j.neuropharm.2019.01.027

    authors： Arslan G,Avci B,Kocacan SE,Rzayev E,Ayyildiz M,Agar E

    更新日期：2019-05-01 00:00:00

  • Sexually differentiated actions of 3-PPP enantiomers on prolactin secretion.

    abstract：:The ability of the enantiomers of the atypical dopamine receptor agonist 3-(3-hydroxyphenyl)-N-n-propylpiperidine (3-PPP) to counteract gamma-butyrolactone-induced hyperprolactinemia was compared in male and female rats. Following gamma-butyrolactone (GBL) pretreatment serum prolactin concentrations were higher in fem...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/0028-3908(86)90028-6

    authors： Carlsson M,Eriksson E,Nilsson C,Carlsson A

    更新日期：1986-08-01 00:00:00

  • Effect of organochlorine insecticides on nicotinic acetylcholine receptor-rich membranes.

    abstract：:The so-called generalized polarization (GP) of the fluorescent probe Laurdan and the steady-state fluorescence anisotropy of the probe diphenylhexatriene (DPH) and its phenylpropionic derivative (PA-DPH) were used to study the effects of several organochlorine insecticides of the chlorophenylethane, chlorinated cycloh...

    journal_title：Neuropharmacology

    pub_type： 杂志文章

    doi：10.1016/s0028-3908(99)00194-x

    authors： Massol RH,Antollini SS,Barrantes FJ

    更新日期：2000-04-03 00:00:00