The effect of the scorpion venom, tityustoxin, on high-affinity choline uptake in rat brain cortical slices.

abstract：:We have used a focal stimulation method to study neurotransmission at synapses onto hippocampal pyramidal neurons in cultures derived from neonatal rats. Single functional boutons were visualized by activity-dependent preloading with the fluorescent dye FM1-43, then focally stimulated by localized application of eleva...

journal_title：Neuropharmacology

authors： Liu G,Tsien RW

更新日期：1995-11-01 00:00:00

abstract：:A number of pre-clinical studies have shown that brain-generated acetaldehyde, the first metabolite of ethanol, exerts reinforcing effects that promote the acquisition of ethanol intake, while chronic intake maintenance appears to be mediated by alcohol-induced brain neuroinflammation/oxidative stress. Recently, it wa...

journal_title：Neuropharmacology

authors： Rivera-Meza M,Vásquez D,Quintanilla ME,Lagos D,Rojas B,Herrera-Marschitz M,Israel Y

更新日期：2019-03-01 00:00:00

abstract：:Anesthetics exposure to neonates leads to impairment of hippocampal synaptic plasticity and cognitive functions later in life. This phenomenon complies with the concept of metaplasticity: a priming stimulation can affect induction of synaptic plasticity mins or days later. We aimed to understand whether small conducta...

journal_title：Neuropharmacology

authors： Yu X,Zhang F,Shi J

更新日期：2018-10-01 00:00:00

abstract：:Mice were found to exhibit a marked suppression of motor activity when placed into the same experimental chamber in which they had previously received electrical shocks. This suppression was found to be a stable response when mice, 6-8 weeks of age, received shocks of frequencies of 1/10 or 1/30 Hz, and their motility...

journal_title：Neuropharmacology

authors： Kameyama T,Nagasaka M

更新日期：1982-12-01 00:00:00

abstract：:Activation of the kappa opioid receptor (KOR) system mediates negative emotional states and considerable evidence suggests that KOR and their natural ligand, dynorphin, are involved in ethanol dependence and reward. The central amygdala (CeA) plays a major role in alcohol dependence and reinforcement. Dynorphin peptid...

journal_title：Neuropharmacology

authors： Gilpin NW,Roberto M,Koob GF,Schweitzer P

更新日期：2014-02-01 00:00:00

abstract：:The effects of chronic administration of the nonselective monoamine oxidase (MAO) inhibitor, phenelzine, and two selective inhibitors, clorgyline, and pargyline on adrenergic receptor binding and MAO activity were studied in the rat brain. Chronic but not acute administration of both phenelzine and the MAO-A inhibitor...

journal_title：Neuropharmacology

authors： Cohen RM,Campbell IC,Dauphin M,Tallman JF,Murphy DL

更新日期：1982-04-01 00:00:00

abstract：:Chronic nicotine administration in animals, and smoking in humans, causes up-regulation of α4β2* neuronal nicotinic receptors (nAChRs), which has been hypothesized to contribute to the addictive actions of nicotine. We used a rat model to test whether such up-regulatory effects differ in adolescents versus adults, and...

journal_title：Neuropharmacology

authors： Hoegberg BG,Lomazzo E,Lee NH,Perry DC

更新日期：2015-12-01 00:00:00

abstract：:In isolation-reared mice, social encounter stimulation induces locomotor hyperactivity and activation of the dorsal raphe nucleus (DRN), suggesting that dysregulation of dorsal raphe function may be involved in abnormal behaviors. In this study, we examined the involvement of dorsal raphe GABAergic dysregulation in th...

journal_title：Neuropharmacology

authors： Araki R,Hiraki Y,Nishida S,Kuramoto N,Matsumoto K,Yabe T

更新日期：2016-02-01 00:00:00

abstract：:GABAA and glycine receptors are close relatives in the "gene superfamily" of ligand-gated ion channels, but have distinctly different pharmacology. For example, barbiturates have two effects on GABAA receptors (GABAA-R): at low micromolar concentrations (2-5 microM), the anesthetic barbiturate methohexital potentiates...

journal_title：Neuropharmacology

authors： Koltchine VV,Ye Q,Finn SE,Harrison NL

更新日期：1996-01-01 00:00:00

abstract：:Schizophrenia is associated with increased oxidative stress, although the source of this redox disequilibrium requires further study. Altered tryptophan metabolism has been described in schizophrenia, possibly linked to inflammation and glutamate-directed excitotoxicity. Social isolation rearing (SIR) in rats induces ...

journal_title：Neuropharmacology

authors： Möller M,Du Preez JL,Emsley R,Harvey BH

更新日期：2012-06-01 00:00:00

abstract：:The inhibitory effects of 4-phenyl-1,2,3,4-tetrahydroisoquinoline (4-PTIQ) on methamphetamine-induced increases in dopamine and locomotion were investigated. Methamphetamine hydrochloride (10 micrograms) microinjected into the nucleus accumbens increased both locomotor activity and extracellular dopamine levels, measu...

journal_title：Neuropharmacology

authors： Tateyama M,Ohta S,Nagao T,Hirobe M,Ono H

更新日期：1993-08-01 00:00:00

abstract：:24S-hydroxycholesterol (24S-HC) is a brain-derived product of lipid metabolism present in the systemic circulation, where its level can change significantly in response to physiological and pathophysiological conditions. Here, using electrophysiological and optical approaches, we have found a high sensitivity to 24S-H...

journal_title：Neuropharmacology

authors： Kasimov MR,Fatkhrakhmanova MR,Mukhutdinova KA,Petrov AM

更新日期：2017-05-01 00:00:00

abstract：:Tobacco addiction is a chronic disorder that is characterized by craving for tobacco products, withdrawal upon smoking cessation, and relapse after periods of abstinence. Previous studies demonstrated that systemic administration of α2-adrenergic receptor agonists attenuates stress-induced reinstatement of drug seekin...

journal_title：Neuropharmacology

authors： Yamada H,Bruijnzeel AW

更新日期：2011-02-01 00:00:00

abstract：:The effect of the inhibition of aminopeptidase and enkephalinase A on the pain threshold of mice and rats was investigated, using bestatin and thiorphan as selective peptidase inhibitors. The results indicate that both enzymes are relevant to the catabolism of enkephalins in vivo; however, their simultaneous activatio...

journal_title：Neuropharmacology

authors： Carenzi A,Frigeni V,Reggiani A,Della Bella D

更新日期：1983-11-01 00:00:00

abstract：:We have examined the regulation of neuronal nitric oxide synthase (NOS) by phosphorylation with cyclic-GMP (PKG) and cyclic-AMP-dependent (PKA) protein kinases. In vitro phosphorylation studies indicate that both PKG and PKA phosphorylate NOS on a single site. Phosphoamino-acid analysis and peptide mapping demonstrate...

journal_title：Neuropharmacology

authors： Dinerman JL,Steiner JP,Dawson TM,Dawson V,Snyder SH

更新日期：1994-11-01 00:00:00

abstract：:The autoradiographic distribution of binding sites for [3H]AMPA, [3H]kainate, [3H]MK-801 and [3H]L-glutamate and the in situ hybridization of GluR-A, GluR-B, GluR-C and GluR-D in rat spinal cord sections were determined. All of the radioligands had similar localisations with the dorsal horn being the most intensely la...

journal_title：Neuropharmacology

authors： Henley JM,Jenkins R,Hunt SP

更新日期：1993-01-01 00:00:00

abstract：:Conantokin-G (con-G), conantokin-T (con-T), a truncated conantokin-R (con-R[1-17]), that functions the same as wild-type con-R, and variant sequences of con-T, were chemically synthesized and employed to investigate their selectivities as antagonists of glutamate/glycine-evoked ion currents in human embryonic kidney-2...

journal_title：Neuropharmacology

authors： Sheng Z,Dai Q,Prorok M,Castellino FJ

更新日期：2007-07-01 00:00:00

abstract：:The information processing at central synapses is mediated not only by homosynaptic transmission with direct synaptic connections but also by heterosynaptic interactions between distinct synaptic inputs. Using rat brain slices and whole-cell recordings this study aimed to examine the roles of GABA(B) receptors in syna...

journal_title：Neuropharmacology

authors： Yamada J,Saitow F,Satake S,Kiyohara T,Konishi S

更新日期：1999-11-01 00:00:00

abstract：:In vivo and in vitro studies suggest a crucial role for Sphingosine 1-phosphate (S1P) and its receptors in the development of the nervous system. Dihydrosphingosine 1-phosphate (dhS1P), a reduced form of S1P, is an agonist at S1P receptors, but the pharmacology and physiology of dhS1P has not been widely studied. The ...

journal_title：Neuropharmacology

authors： Callihan P,Zitomer NC,Stoeling MV,Kennedy PC,Lynch KR,Riley RT,Hooks SB

更新日期：2012-02-01 00:00:00

abstract：:Desensitization of the nicotinic acetylcholine receptor (nAChR) containing the β2 subunit is a potentially critical mechanism underlying the body weight (BW) reducing effects of nicotine. The purpose of this study was a) to determine the α subunit(s) that partners with the β2 subunit to form the nAChR subtype that end...

journal_title：Neuropharmacology

authors： Dezfuli G,Olson TT,Martin LM,Keum Y,Siegars BA,Desai A,Uitz M,Sahibzada N,Gillis RA,Kellar KJ

更新日期：2020-04-01 00:00:00

abstract：:The effect of an acute intraperitoneal (i.p.) injection of acetaldehyde, 20 mg/kg or 100 mg/kg, on the microdialysate content of both amino acids and monoamines was studies in the nucleus accumbens (NA) by a microdialysis technique. Acetaldehyde, ACH, which was detectable at levels of 50-130 mumol/g brain tissue 10 mi...

journal_title：Neuropharmacology

authors： Ward RJ,Colantuoni C,Dahchour A,Quertemont E,De Witte P

更新日期：1997-02-01 00:00:00

abstract：:The effects of 5-hydroxytryptamine (5-HT) on neuronal excitability, evaluated as depolarization-induced firing rate, and on amino acid release, measured as electrically-evoked [(3)H]GABA and [(3)H]d-aspartate efflux, were investigated in rat primary cortical neuronal cultures. 5-HT displayed a concentration-dependent,...

journal_title：Neuropharmacology

authors： Bianchi C,Marani L,Marino S,Barbieri M,Nazzaro C,Beani L,Siniscalchi A

更新日期：2007-03-01 00:00:00

abstract：:To study individual differences in nicotine preference and intake, male and female rats were given free access to a choice of oral nicotine (10 or 20 mg/L) or water for 24 h/day for periods of at least six weeks, starting at adolescence or adulthood. A total of 341 rats, were used in four different experiments; weight...

journal_title：Neuropharmacology

authors： Nesil T,Kanit L,Collins AC,Pogun S

更新日期：2011-07-01 00:00:00

abstract：:In this study we investigate the presence, modulation and biological function of P2 receptors and extracellular ATP in cultured cerebellar granule neurons. As we demonstrate by RT-PCR and western blotting, both P2X and P2Y receptor subtypes are expressed and furthermore regulated as a function of neuronal maturation. ...

journal_title：Neuropharmacology

authors： Amadio S,D'Ambrosi N,Cavaliere F,Murra B,Sancesario G,Bernardi G,Burnstock G,Volonté C

更新日期：2002-03-01 00:00:00

abstract：:C57BL/6J mice were introduced to a nine arm radial maze without prior habituation and trained in the acquisition of a working memory task in 16 sessions, one session per day. In this maze mice need to climb onto an upward inclined bridge in order to reach and cross onto an arm. They received in each session an i.p. in...

journal_title：Neuropharmacology

authors： Ennaceur A,Michalikova S,van Rensburg R,Chazot PL

更新日期：2011-10-01 00:00:00

abstract：:We examined the effects of two protein tyrosine phosphatase inhibitors on the induction of synaptic plasticity in CA1 slices of rat hippocampus. Field potential recordings were made in stratum radiatum in response to stimulation of the Schaffer collateral afferents. Bath application of the tyrosine phosphatase inhibit...

journal_title：Neuropharmacology

authors： Coussens CM,Williams JM,Ireland DR,Abraham WC

更新日期：2000-09-01 00:00:00

abstract：:The contribution of metabotropic glutamate receptors (mGluRs) to the modulation of nociception by the periaqueductal gray (PAG) matter was investigated in mice. Intra-PAG microinjection of (IS,3R)-ACPD, an agonist of groups I and II mGluRs, as well as (S)-3,5-DHPG, a selective agonist of group I mGluRs, increased the ...

journal_title：Neuropharmacology

authors： Maione S,Marabese I,Leyva J,Palazzo E,de Novellis V,Rossi F

更新日期：1998-12-01 00:00:00

abstract：:In three experiments, rats were injected once daily with 5.0 mg/kg apomorphine or vehicle and tested for locomotor activity for 10-14 days. In each experiment, apomorphine produced behavioral sensitization, characterized by a progressively greater increase in locomotor activity with each succeeding injection. On day 1...

journal_title：Neuropharmacology

authors： Rowlett JK,Mattingly BA,Bardo MT

更新日期：1991-02-01 00:00:00

abstract：:Diazepam binding inhibitor (DBI) acts in brain by binding to GABAA/benzodiazepine receptors (GBR) and to mitochondrial benzodiazepine receptors (MBR). Because DBI acting at MBR, has been shown to be an effector of ACTH-induced steroidogenesis and stress is known to change the level of GBR and MBR, the model of acute n...

journal_title：Neuropharmacology

authors： Ferrarese C,Mennini T,Pecora N,Pierpaoli C,Frigo M,Marzorati C,Gobbi M,Bizzi A,Codegoni A,Garattini S

更新日期：1991-12-01 00:00:00

abstract：:Histamine H3 receptor (H3R) antagonists are currently being investigated for the possible therapeutic use in various cognitive deficits such as those in schizophrenia, attention deficit hyperactivity disorder and Alzheimer's disease. Our previous studies suggest a role for H3Rs in ethanol-related behaviors in rat and ...

journal_title：Neuropharmacology

authors： Nuutinen S,Vanhanen J,Pigni MC,Panula P

更新日期：2011-06-01 00:00:00