Abstract:
:Several studies have shown that dietary lipid exerts an effect on carcinogenesis. We report here that progression to malignancy in vitro is associated with changes in the response to fatty acids (FAs). Tumorigenic (THKE) cells were more sensitive to the n-3 FAs eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) than immortalised (IHKE) cells. The growth of THKE cells was inhibited 25% more than the growth of IHKE cells at 80 microM EPA (P < 0.01) and 35% more at 40 microM DHA (P < 0.001). Furthermore, the results indicate that there is a wide cell type variation in the response to FAs. We found that the in vitro inhibition by FAs correlated with the reduction in the growth rate of the tumour in nude mice fed K85 (55% EPA and 30% DHA). A significant difference in tumour latency was observed for the A427 cell tumour groups (10 days, P < 0.05). Tumours in the animals fed n-3 FA exhibited significantly higher levels of EPA and DHA; the level of arachidonic acid (ARA) was significantly lower in THKE tumours and the level of linoleic acid (LA) was significantly lower in A427 tumours than in controls fed corn oil. The higher sensitivity of the A427 cell line was not explained by higher uptake of EPA/DHA.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Maehle L,Eilertsen E,Mollerup S,Schønberg S,Krokan HE,Haugen Adoi
10.1038/bjc.1995.136subject
Has Abstractpub_date
1995-04-01 00:00:00pages
691-6issue
4eissn
0007-0920issn
1532-1827journal_volume
71pub_type
杂志文章abstract::We determined the prevalence of type-specific hrHPV infections in the Netherlands on cervical scrapes of 45 362 women aged 18-65 years. The overall hrHPV prevalence peaked at the age of 22 with peak prevalence of 24%. Each of the 14 hrHPV types decreased significantly with age (P-values between 0.0009 and 0.03). The p...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6604162
更新日期:2008-02-12 00:00:00
abstract::Minisatellite DNA probes which can detect a large number of autosomal loci dispersed throughout the human genome were used to examine the constitutional and tumour DNA of 35 patients with a variety of cancers of which eight were of gastrointestinal origin. Somatic changes were seen in the tumour DNA in ten of the 35 c...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1987.71
更新日期:1987-04-01 00:00:00
abstract::The 5-year relative survival rates of women diagnosed with breast cancer between 1992 and 1994 were compared among the 99 Health Authorities (1999 boundaries) of England. Substantial variation, with evidence of geographical clustering was observed. Part of this variation was explained by differences in deprivation bet...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6601812
更新日期:2004-06-01 00:00:00
abstract:BACKGROUND:To report the long-term outcomes of a phase III trial designed to test two hypotheses: (1) elective nodal irradiation (ENI) is superior to conventional field irradiation (CFI), and (2) chemoradiotherapy plus erlotinib is superior to chemoradiotherapy in locally advanced oesophageal squamous cell cancer (ESCC...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-020-01054-6
更新日期:2020-11-01 00:00:00
abstract::Cancer survival rates decrease in the presence of disseminated disease. However, there are few therapies that are effective at eliminating the primary tumour while providing control of distant stage disease. Photodynamic therapy (PDT) is an FDA-approved modality that rapidly eliminates local tumours, resulting in cure...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6603792
更新日期:2007-06-18 00:00:00
abstract:BACKGROUND:Progression-free survival (PFS) is a surrogate endpoint widely used for overall survival (OS) in oncology. Validation of PFS as a surrogate must be done for each indication and each intervention. We aimed to identify all studies evaluating the validity of PFS as a surrogate for OS in oncology, and to describ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-020-0805-y
更新日期:2020-05-01 00:00:00
abstract::We investigated the effects of interleukin-2 (IL-2) exposure on T-cell signal transduction molecules and apoptosis markers in tumour-infiltrating lymphocytes (TIL) isolated from 20 melanoma and 16 colorectal carcinoma metastases and expanded in vitro for therapeutic reinfusion. Before IL-2 culture, TIL showed undetect...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6600679
更新日期:2003-01-27 00:00:00
abstract::We have examined the genetic aberrations in two near-diploid glioblastoma multiforme cell lines that appear to have arisen from different glial lineages. One cell line, Hu-O-2A/Gb1, expresses antigens and metabolic profiles characteristic of the oligodendrocyte-type-2 astrocyte (0-2A) lineage of the rat central nervou...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6690116
更新日期:1999-02-01 00:00:00
abstract:BACKGROUND:There remains uncertainty on the need for bone staging in men with intermediate-risk prostate cancer. Current guidelines do not use mpMRI-staging information and rely on historic pathology grading. METHODS:We investigated the ability of mpMRI and the new Grade Group system to better predict bone metastasis ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2016.353
更新日期:2016-11-22 00:00:00
abstract:BACKGROUND:Eukaryotic translation elongation factor 1A2 (eEF1A2) is a known proto-oncogene. We proposed that stimulation of the eEF1A2 expression in cancer tissues is caused by the loss of miRNA-mediated control. METHODS:Impact of miRNAs on eEF1A2 at the mRNA and protein levels was examined by qPCR and western blot, r...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2013.243
更新日期:2013-06-11 00:00:00
abstract::We screened 50 glioblastomas for P53 mutations. Five glioblastomas showed heterozygous mutations, while three were putatively heterozygous. Six of these eight glioblastomas showed elimination of wild-type P53 mRNA. These results strongly suggest that some sort of mechanism(s) favouring mutated over wild-type P53 mRNA ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6604258
更新日期:2008-04-22 00:00:00
abstract::Regionally administered vasopressors might increase tumour chemotherapy uptake by differentially constricting normal and tumour blood vessels, leading to a selective increase in blood flow to the tumour. In this study, we compared the effects of the vasopressors angiotensin II, vasopressin and endothelin I and the vas...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1997.534
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND:Aetiology of acute myeloid leukaemia (AML) is not well understood, perhaps because of its distinct subtypes. High-dose ionising radiation is a known risk factor, but less is known about risk from low-dose exposure such as from diagnostic radiography. METHODS:Subjects were 412 matched case-control pairs. Ten...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2011.114
更新日期:2011-04-26 00:00:00
abstract::One hundred and seven untreated patients with acute myelogenous leukaemia (AML) were admitted to St Bartholomew's Hospital between 10 October 1970 and 31 January 1973. Before receiving drugs to induce remission they were allocated alternatively into 2 groups to decide their remission treatment-a group to receive chemo...
journal_title:British journal of cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1038/bjc.1973.162
更新日期:1973-11-01 00:00:00
abstract:BACKGROUND:Antihypertensives may inhibit pancreatic carcinogenesis. We examined the association between use of these drugs and pancreatic cancer in patients with chronic pancreatitis. METHODS:We conducted a nationwide population-based cohort study of all chronic pancreatitis patients diagnosed in Denmark during 1996-2...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-019-0562-y
更新日期:2019-10-01 00:00:00
abstract::Between 1971 and 1988, 20 patients with previously undiagnosed non-Hodgkin's lymphoma (NHL), of intermediate or high grade histology presented with extradural spinal cord compression. All had decompressive surgery. The first treatment after surgery was chemotherapy in nine and radiotherapy in 11 patients. At presentat...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1991.25
更新日期:1991-01-01 00:00:00
abstract::To design hybrid tumour necrosis factor-alpha (TNF-alpha) applicable to systemic anti-tumour therapeutic use, we assessed the relationships among the molecular size of hybrid TNF-alpha, in vitro bioactivity and in vivo anti-tumour potency. Natural human TNF-alpha was covalently modified with polyethylene glycol (PEG) ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1996.495
更新日期:1996-10-01 00:00:00
abstract::Telomerase, an enzyme related with cellular immortality, has been extensively studied in many kinds of malignant tumours for clinical diagnostic or prognostic utilities. Telomerase activity is mainly regulated by the expression of hTERT (human telomerase reverse transcriptase), which is a catalytic component of human ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6602054
更新日期:2004-08-31 00:00:00
abstract::Eighteen patients with inoperable hepatocellular carcinoma (HCC) were treated with intrahepatic arterial yttrium-90 microspheres. All these patients showed a lung shunting below 15% and a tumour-to-normal ratio higher than 2 as determined by diagnostic technetium-99m macroaggregated albumin (Tc-MAA) gamma scintigraphy...
journal_title:British journal of cancer
pub_type: 临床试验,杂志文章
doi:10.1038/bjc.1994.436
更新日期:1994-11-01 00:00:00
abstract::A urinary gonadotrophin peptide (UGP) was isolated and purified from semi-purified human chorionic gonadotrophin (hCG), prepared from pregnancy urine. The peptide showed hCG-B subunit activity and no hCG-alpha subunit activity as demonstrated by binding studies with the relevant antibodies. It had a molecular weight s...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1988.204
更新日期:1988-09-01 00:00:00
abstract::Survivin is an apoptotic inhibitor that is expressed at high levels in a variety of malignancies. Survivin has four known alternative splice forms (Survivin, Survivin-2B, Survivin-deltaEx3, and Survivin-3B), and the recent literature suggests that these splice variants have unique functions and subcellular localisatio...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6602317
更新日期:2005-01-31 00:00:00
abstract:BACKGROUND:Venous thromboembolism (VTE) frequently complicates cancer. Data on tumour-specific VTE predictors are limited, but may inform strategies to prevent thrombosis. METHODS:We computed incidence rates (IRs) with 95% confidence intervals (CIs) for VTE hospitalisation in a cohort of cancer patients (n=57,591) and...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6605883
更新日期:2010-09-28 00:00:00
abstract::In rats a maximal tolerated dose of carboplatin (60 mg kg-1, i.v.) caused severe anaemia, leucopenia and thrombocytopenia. These indices of haematological toxicity were also observed with a maximal tolerated dose of cis-platin (6.5 mg kg-1, i.v.), but reductions in blood cell counts were less than those observed with ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1987.75
更新日期:1987-04-01 00:00:00
abstract::Histological sections of the primary tumour and of homolateral axillary lymph nodes from 500 women with operable invasive breast cancer have been examined. The tumours have been graded and the degree of round cell infiltration assessed. These features, together with clinical palpability and pathological involvement of...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1972.19
更新日期:1972-04-01 00:00:00
abstract::In a study involving 50 breast cancer tumours, we compared two oestrogen receptor (ER) detection methods developed by us--a microplate immunoenzymometric assay (EIA96) and an immunohistochemistry kit (HistoCIS-ER)--with the radioligand assay (RLA), the Abbott immunoenzymometric assay ER-EIA and the reverse transcripta...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1997.418
更新日期:1997-01-01 00:00:00
abstract::The prodrug N-[4-(daunorubicin-N-carbonyl-oxymethyl)phenyl] O-beta-glucuronyl carbamate (DNR-GA3) was synthesized for specific activation by human beta-glucuronidase, released in necrotic areas of tumour lesions. In vitro, DNR-GA3 was 18 times less toxic than daunorubicin (DNR) and the prodrug was completely activated...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1998.729
更新日期:1998-12-01 00:00:00
abstract::To identify tumour and tumour-associated antigens in patients with hepatocellular carcinoma (HCC) one may find potential diagnostic markers and immunotherapeutic targets. In the current study, 30 distinct antigens reactive with serum IgG from HCC patients were identified by serological analysis of cDNA expression libr...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6602460
更新日期:2005-03-14 00:00:00
abstract::Recepteur d'Origine Nantais (RON) is a distinct receptor tyrosine kinase in the c-met proto-oncogene family. We examined the mutational and expression patterns of RON in eight human uroepithelial cell lines. Biological effects of RON overexpression on cancer cells were investigated in vitro, and the prognostic signifi...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6602593
更新日期:2005-05-23 00:00:00
abstract:BACKGROUND:Stathmin mediates cell migration and invasion in vitro, and metastasis in vivo. To investigate stathmin's role on the metastatic process, we performed integrated mRNA-miRNA expression analysis to identify pathways regulated by stathmin. METHODS:MiRNA and gene arrays followed by miRNA-target-gene integration...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-019-0669-1
更新日期:2020-02-01 00:00:00
abstract::A brief review is presented of the evidence linking the development of certain types of neoplasms, and of the malignant lymphomas in particular, to chronic immunosuppression in animals and man and to the naturally occurring human immunologic deficiency states. The discussion then focuses on Hodgkin's disease and consi...
journal_title:British journal of cancer
pub_type: 杂志文章,评审
doi:10.1038/bjc.1971.78
更新日期:1971-12-01 00:00:00