Identification of paramyxovirus V protein residues essential for STAT protein degradation and promotion of virus replication.

abstract：:The VP6 protein of bluetongue virus possesses a number of activities, including nucleoside triphosphatase, RNA binding, and helicase activity (N. Stauber, J. Martinez-Costas, G. Sutton, K. Monastyrskaya, and P. Roy, J. Virol. 71:7220-7226, 1997). Although the enzymatic functions of the protein have been documented, a ...

journal_title：Journal of virology

authors： Kar AK,Roy P

更新日期：2003-11-01 00:00:00

abstract：:Whole-body bioimaging was used to study dissemination of vaccinia virus (VACV) in normal and in immune deficient (nu(-)/nu(-)) mice protected from lethality by postchallenge administration of ST-246. Total fluxes were recorded in the liver, spleen, lungs, and nasal cavities of live mice after intranasal infection with...

journal_title：Journal of virology

authors： Zaitseva M,Shotwell E,Scott J,Cruz S,King LR,Manischewitz J,Diaz CG,Jordan RA,Grosenbach DW,Golding H

更新日期：2013-05-01 00:00:00

abstract：:Adenovirus infection affects the nuclear distribution of host splicing factors. Late phase-infected cells contain discrete clusters of small nuclear ribonucleoproteins (snRNPs) that are separate from centers containing the viral 72-kilodalton DNA-binding protein (72K protein). In the present study, we demonstrate that...

journal_title：Journal of virology

authors： Bridge E,Xia DX,Carmo-Fonseca M,Cardinali B,Lamond AI,Pettersson U

更新日期：1995-01-01 00:00:00

abstract：:Some animal rotaviruses require the presence of sialic acid (SA) on the cell surface to infect the cell. We have isolated variants of rhesus rotavirus (RRV) whose infectivity no longer depends on SA. Both the SA-dependent and -independent interactions of these viruses with the cell are mediated by the virus spike prot...

journal_title：Journal of virology

authors： Zárate S,Espinosa R,Romero P,Méndez E,Arias CF,López S

更新日期：2000-01-01 00:00:00

abstract：UNLABELLED:Influenza virus hemagglutinin (HA) mediates virus entry by binding to cell surface receptors and fusing the viral and endosomal membranes following uptake by endocytosis. The acidic environment of endosomes triggers a large-scale conformational change in the transmembrane subunit of HA (HA2) involving a loop...

journal_title：Journal of virology

authors： Wang W,DeFeo CJ,Alvarado-Facundo E,Vassell R,Weiss CD

更新日期：2015-10-01 00:00:00

abstract：:During primary varicella-zoster virus (VZV) infection, it is presumed that virus is transmitted from mucosal sites to regional lymph nodes, where T cells become infected. The cell type responsible for VZV transport from the mucosa to the lymph nodes has not been defined. In this study, we assessed the susceptibility o...

journal_title：Journal of virology

authors： Abendroth A,Morrow G,Cunningham AL,Slobedman B

更新日期：2001-07-01 00:00:00

abstract：:Five human recombinant Fab fragments (Fabs) specific for measles virus (MV) proteins were isolated from three antibody phage display libraries generated from RNAs derived from bone marrow or splenic lymphocytes from three MV-immune individuals. All Fabs reacted in an enzyme-linked immunosorbent assay with MV antigens....

journal_title：Journal of virology

authors： de Carvalho Nicacio C,Williamson RA,Parren PW,Lundkvist A,Burton DR,Björling E

更新日期：2002-01-01 00:00:00

abstract：:A mouse model of high-risk human papillomavirus infection was developed in which human papillomavirus (HPV) type 16 DNA was inoculated into human foreskin grafted to the skin of severe combined immunodeficient (scid) mice. Grafted skin contained human epidermis and dermis and, like normal human skin, expressed involuc...

journal_title：Journal of virology

authors： Brandsma JL,Brownstein DG,Xiao W,Longley BJ

更新日期：1995-04-01 00:00:00

abstract：:Murine gammaherpesvirus 68 (MHV68 [also known as gammaHV-68]) is distinguished by its ability to replicate to high titers in cultured cells, making it an excellent candidate for studying gammaherpesvirus virion composition. Extracellular MHV68 virions were isolated, and abundant virion-associated proteins were identif...

journal_title：Journal of virology

authors： Bortz E,Whitelegge JP,Jia Q,Zhou ZH,Stewart JP,Wu TT,Sun R

更新日期：2003-12-01 00:00:00

abstract：:Encephalomyocarditis virus induced a rapid shutoff of host translation in mouse L cells shortly after infection and before viral proteins were made in detectable amounts. This kinetic pattern is similar to that seen in poliovirus-infected HeLa cells. However, the mechanisms of host shutoff are different in these two c...

journal_title：Journal of virology

authors： Jen G,Thach RE

更新日期：1982-07-01 00:00:00

abstract：:Reoviruses are a leading model for understanding cellular mechanisms of virus-induced apoptosis. Reoviruses induce apoptosis in multiple cell lines in vitro, and apoptosis plays a key role in virus-induced tissue injury of the heart and brain in vivo. The activation of transcription factors NF-kappaB and c-Jun are key...

journal_title：Journal of virology

authors： DeBiasi RL,Clarke P,Meintzer S,Jotte R,Kleinschmidt-Demasters BK,Johnson GL,Tyler KL

更新日期：2003-08-01 00:00:00

abstract：:Cyclosporine (CsA) and its derivatives potently suppress hepatitis C virus (HCV) replication. Recently, CsA-resistant HCV replicons have been identified in vitro. We examined the dependence of the wild-type and CsA-resistant replicons on various cyclophilins for replication. A strong correlation between CsA resistance...

journal_title：Journal of virology

authors： Yang F,Robotham JM,Nelson HB,Irsigler A,Kenworthy R,Tang H

更新日期：2008-06-01 00:00:00

abstract：:Viruses are considered to use vesicular trafficking in infected cells, but the details of assembly/release pathways of hepatitis B virus (HBV) are still unknown. To identify key regulators of HBV production, we performed short interfering RNA (siRNA) screening for Rab proteins, which are considered to act as molecular...

journal_title：Journal of virology

authors： Inoue J,Ninomiya M,Umetsu T,Nakamura T,Kogure T,Kakazu E,Iwata T,Takai S,Sano A,Fukuda M,Watashi K,Isogawa M,Tanaka Y,Shimosegawa T,McNiven MA,Masamune A

更新日期：2019-07-17 00:00:00

abstract：:We report the complete genome sequence of Pseudomonas aeruginosa siphophage MP1412, which displays synteny to those of P. aeruginosa phages M6 and YuA. However, the presence of two homing endonucleases of the GIY-YIG family is unique to MP1412, suggesting their unique role in the phage life cycle of the bacterial host...

journal_title：Journal of virology

authors： Bae HW,Chung IY,Sim N,Cho YH

更新日期：2012-09-01 00:00:00

abstract：:The herpes simplex virus type 1 (HSV-1) alkaline nuclease, encoded by the UL12 gene, plays an important role in HSV-1 replication, as a UL12 null mutant displays a severe growth defect. The HSV-1 alkaline exonuclease UL12 interacts with the viral single-stranded DNA binding protein ICP8 and promotes strand exchange in...

journal_title：Journal of virology

authors： Balasubramanian N,Bai P,Buchek G,Korza G,Weller SK

更新日期：2010-12-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) glycoprotein US2 increases the proteasome-mediated degradation of major histocompatibility complex (MHC) class I heavy chain (HC), class II DR-alpha and DM-alpha proteins, and HFE, a nonclassical MHC protein. US2-initiated degradation of MHC proteins apparently involves the recruitment of ...

journal_title：Journal of virology

authors： Chevalier MS,Johnson DC

更新日期：2003-04-01 00:00:00

abstract：:Accumulated evidence demonstrates that Japanese encephalitis virus (JEV) infection triggers endoplasmic reticulum (ER) stress and neuron apoptosis. ER stress sensor protein kinase R-like endoplasmic reticulum kinase (PERK) has been reported to induce apoptosis under acute or prolonged ER stress. However, the precise r...

journal_title：Journal of virology

authors： Wang Q,Xin X,Wang T,Wan J,Ou Y,Yang Z,Yu Q,Zhu L,Guo Y,Wu Y,Ding Z,Zhang Y,Pan Z,Tang Y,Li S,Kong L

更新日期：2019-08-13 00:00:00

abstract：:Immature retroviral particles are assembled by self-association of the structural polyprotein precursor Gag. During maturation the Gag polyprotein is proteolytically cleaved, yielding mature structural proteins, matrix (MA), capsid (CA), and nucleocapsid (NC), that reassemble into a mature viral particle. Proteolytic ...

journal_title：Journal of virology

authors： Hadravová R,de Marco A,Ulbrich P,Stokrová J,Dolezal M,Pichová I,Ruml T,Briggs JA,Rumlová M

更新日期：2012-02-01 00:00:00

abstract：:Three fish retroviruses infecting walleyes constitute the recently recognized genus called epsilonretrovirus. The founding member of this group, walleye dermal sarcoma virus (WDSV), induces benign skin tumors in the infected fish and replicates near 4 degrees C. While the viral genomic sequence is known, biochemical c...

journal_title：Journal of virology

authors： Fodor SK,Vogt VM

更新日期：2002-05-01 00:00:00

abstract：:The complete nucleotide sequences of the vesicular stomatitis virus mRNA's encoding the glycoprotein (G) and the matrix protein (M) have been determined from cDNA clones that contain the complete coding sequences from each mRNA. The G protein mRNA is 1,665 nucleotides long, excluding polyadenylic acid, and encodes a p...

journal_title：Journal of virology

authors： Rose JK,Gallione CJ

更新日期：1981-08-01 00:00:00

abstract：:Genetic variation of the more complex retroviruses in the human T-cell leukemia virus/bovine leukemia virus (HTLV/BLV) group is less than in some other retroviral genera. To test whether reverse transcription of HTLV/BLV group members is less error prone than that of members of other groups, we developed an assay for ...

journal_title：Journal of virology

authors： Mansky LM,Temin HM

更新日期：1994-01-01 00:00:00

abstract：:Parvovirus capsids are assembled from multiple forms of a single protein and are quite stable structurally. However, in order to infect cells, conformational plasticity of the capsid is required and this likely involves the exposure of structures that are buried within the structural models. The presence of functional...

journal_title：Journal of virology

authors： Nelson CD,Minkkinen E,Bergkvist M,Hoelzer K,Fisher M,Bothner B,Parrish CR

更新日期：2008-11-01 00:00:00

abstract：:Hydroxyurea, an inhibitor of ribonucleotide reductase, blocks replication of vaccinia virus. However, when medium containing hydroxyurea and dialyzed serum was supplemented with deoxyadenosine, the block to viral reproduction was circumvented, provided that an inhibitor of adenosine deaminase was also present. Deoxygu...

journal_title：Journal of virology

authors： Slabaugh MB,Howell ML,Wang Y,Mathews CK

更新日期：1991-05-01 00:00:00

abstract：:Cytomegalovirus (CMV) infection is the most common opportunistic infection in immunosuppressed individuals, such as transplant recipients or people living with HIV/AIDS, and congenital CMV is the leading viral cause of developmental disabilities in infants. Due to the highly species-specific nature of CMV, animal mode...

journal_title：Journal of virology

authors： Marsh AK,Willer DO,Ambagala AP,Dzamba M,Chan JK,Pilon R,Fournier J,Sandstrom P,Brudno M,MacDonald KS

更新日期：2011-12-01 00:00:00

abstract：:Glycoprotein D (gD) interacts with two alternative protein receptors, nectin1 and HveA, to mediate herpes simplex virus (HSV) entry into cells. Fusion of the envelope with the plasma membrane requires, in addition to gD, glycoproteins gB, gH, and gL. Coexpression of the four glycoproteins (gD, gB, gH, and gL) promotes...

journal_title：Journal of virology

authors： Zhou G,Avitabile E,Campadelli-Fiume G,Roizman B

更新日期：2003-03-01 00:00:00

abstract：UNLABELLED:Recent experiments suggest that some glycoprotein (GP)-specific monoclonal antibodies (MAbs) can protect experimental animals against the filovirus Ebola virus (EBOV). There is a need for isolation of MAbs capable of neutralizing multiple filoviruses. Antibody neutralization assays for filoviruses frequently...

journal_title：Journal of virology

authors： Ilinykh PA,Shen X,Flyak AI,Kuzmina N,Ksiazek TG,Crowe JE Jr,Bukreyev A

更新日期：2016-03-28 00:00:00

abstract：:Forty isolates of herpes simplex virus were compared by means of cross-neutralization curves. The 11 oral isolates were serotype 1, and all 29 genital/anal isolates were serotype 2. The cytopathic effects of the two serotypes were consistently different. Passage of strains of type 1 and type 2 in mice and in rabbits y...

journal_title：Journal of virology

authors： Plummer G,Waner JL,Phuangsab A,Goodheart CR

更新日期：1970-01-01 00:00:00

abstract：:Mumps is a highly contagious human disease, characterized by lateral or bilateral nonsuppurative swelling of the parotid glands and neurological complications that can result in aseptic meningitis or encephalitis. A mumps vaccination program implemented since the 1960s reduced mumps incidence by more than 99% and kept...

journal_title：Journal of virology

authors： Xu P,Chen Z,Phan S,Pickar A,He B

更新日期：2014-03-01 00:00:00

abstract：:The regressing and conventional strains of Friend virus were compared by neutralization assays, sodium dodecyl sulfate-polyacrylamide gel electrophoresis, and tryptic peptide mapping of the individual viral components. Neutralization rates of the two viruses differed in the presence of monospecific anti-gp70 antiserum...

journal_title：Journal of virology

authors： Furmanski P,Longley C,Bolles CS,Hines DL,Dietz M

更新日期：1980-03-01 00:00:00

abstract：:MxA is an abundant and ubiquitous cytoplasmic protein induced by alpha/beta interferon in human cells. Upon full induction, it can constitute 0.5 to 1% of cytosolic proteins. MxA can bind elements of the cytoskeleton, such as actin and tubulins, and several larger cellular proteins. However, these protein-protein inte...

journal_title：Journal of virology

authors： Horisberger MA

更新日期：1992-08-01 00:00:00