当前位置： SCI文献检索 > BRITISH JOURNAL OF CANCER期刊下所有文献 > Treatment and survival of lymphoid malignancy in the north-west of England: a population-based study.

Treatment and survival of lymphoid malignancy in the north-west of England: a population-based study.

Abstract：

:Classification of lymphoid malignancy has changed markedly in recent years and advances have been made in therapy. This study investigated the variations in treatment and survival of 1622 patients in a population-based registry. A total of 1009 cases of malignant lymphoma (ML) were classified according to the Kiel classification. Pathology review resulted in major diagnostic changes for 24% of cases. Of the ML cases, 39% had not had full staging procedures. Younger patients were more likely to have been treated with multiagent chemotherapy regimens, as were patients with B symptoms. Median survival for ML patients was 12 months for high-grade patients and more than 60 months for low-grade patients. Significant factors affecting the survival of ML patients were performance status, whether treatment had followed a recognised protocol, whether treatment had been carried out at a specialist oncology centre (SOC), grade of disease, stage, gender and age. The same factors had a significant effect on survival of the leukaemia patients, except for treatment at an SOC, which had a significant favourable effect on survival of acute lymphoblastic leukaemia (ALL) patients only. Median survival for patients with chronic lymphocytic leukaemia was 43 months and 7 months for ALL patients.

journal_name

Br J Cancer

journal_title

British journal of cancer

authors

Youngson JH,Jones JM,Chang JG,Harris M,Banergee SS

doi

10.1038/bjc.1995.406

subject

Has Abstract

pub_date

1995-09-01 00:00:00

pages

757-65

issue

3

eissn

0007-0920

issn

1532-1827

journal_volume

72

pub_type

杂志文章

相关文献

BRITISH JOURNAL OF CANCER文献大全
  • Luminal membrane expression of mesothelin is a prominent poor prognostic factor for gastric cancer.

    abstract：BACKGROUND:Mesothelin is expressed in various types of malignant tumour, and we recently reported that expression of mesothelin was related to an unfavourable patient outcome in pancreatic ductal adenocarcinoma. In this study, we examined the clinicopathological significance of the mesothelin expression in gastric canc...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2012.235

    authors： Einama T,Homma S,Kamachi H,Kawamata F,Takahashi K,Takahashi N,Taniguchi M,Kamiyama T,Furukawa H,Matsuno Y,Tanaka S,Nishihara H,Taketomi A,Todo S

    更新日期：2012-06-26 00:00:00

  • The impact of psychiatric utilisation prior to cancer diagnosis on survival of solid organ malignancies.

    abstract：BACKGROUND:Among patients with cancer, prior research suggests that patients with mental illness may have reduced survival. The objective was to assess the impact of psychiatric utilisation (PU) prior to cancer diagnosis on survival outcomes. METHODS:All residents of Ontario diagnosed with one of the top 10 malignanci...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/s41416-019-0390-0

    authors： Klaassen Z,Wallis CJD,Goldberg H,Chandrasekar T,Sayyid RK,Williams SB,Moses KA,Terris MK,Nam RK,Urbach D,Austin PC,Kurdyak P,Kulkarni GS

    更新日期：2019-04-01 00:00:00

  • Risk factors for oral and pharyngeal cancer in women: a study from Italy and Switzerland.

    abstract：:We analysed two case-control studies of women from Italy and Switzerland, including 195 cases of oral and pharyngeal cancers and 1113 controls. The multivariate odds ratio was 4.6 for heavy smokers and 2.7 for high alcohol intake. Vegetables, fruit, beta-carotene and wholegrain foods were inversely, butter and retinol...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1054/bjoc.1999.0900

    authors： Bosetti C,Negri E,Franceschi S,Conti E,Levi F,Tomei F,La Vecchia C

    更新日期：2000-01-01 00:00:00

  • p53 polymorphisms associated with mutations in and loss of heterozygosity of the p53 gene in male oral squamous cell carcinomas in Taiwan.

    abstract：:The present study was designed to examine whether different p53 haplotypes of exon 4-intron 3-intron 6 affect the frequency of mutations and loss of heterozygosity (LOH) of the p53 gene in male oral squamous cell carcinomas (OSCCs) in Taiwan. We found that individuals without two Pro-W-G alleles had significantly high...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6602271

    authors： Hsieh LL,Huang TH,Chen IH,Liao CT,Wang HM,Lai CH,Liou SH,Chang JT,Cheng AJ

    更新日期：2005-01-17 00:00:00

  • Evaluation of dimethylhydrazine induced tumours in mice as a model system for colorectal cancer.

    abstract：:The evolution and structure of adenomatous polyps and adenocarcinomata of the colon in NMRI mice induced by dimethylhydrazine are described. Severe toxic reactions in the liver and other organs are produced by dimethylhydrazine (DMH), but tumours are induced only in the colon and around the anus. The 100% incidence an...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1973.183

    authors： Haase P,Cowen DM,Knowles JC,Cooper EH

    更新日期：1973-12-01 00:00:00

  • Tumour vasculature--a potential therapeutic target.

    abstract：:The tumour vasculature is vital for the establishment, growth and metastasis of solid tumours. Its physiological properties limit the effectiveness of conventional anti-cancer strategies. Therapeutic approaches directed at the tumour vasculature are reviewed, suggesting the potential of anti-angiogenesis and the targe...

    journal_title：British journal of cancer

    pub_type： 杂志文章,评审

    doi：10.1038/bjc.1995.323

    authors： Baillie CT,Winslet MC,Bradley NJ

    更新日期：1995-08-01 00:00:00

  • Mapping loss of heterozygosity in normal human breast cells from BRCA1/2 carriers.

    abstract：:We have studied loss of heterozygosity at the BRCA1 and BRCA2 loci in 992 normal cell clones derived from topographically defined areas of normal tissue in four samples from BRCA1/BRCA2 mutation carriers. The frequency of loss of heterozygosity in the clones was low (1.01%), but it was found in all four samples, wheth...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6603298

    authors： Clarke CL,Sandle J,Jones AA,Sofronis A,Patani NR,Lakhani SR

    更新日期：2006-08-21 00:00:00

  • Expression of laminin 5-γ2 chain in cutaneous squamous cell carcinoma and its role in tumour invasion.

    abstract：BACKGROUND:Laminin-5 (Ln5), a heterotrimer composed of three chains (α3, β3, and γ2), is a major component of the basement membrane in most adult tissues. One of the chains, Ln5-γ2, is a marker of invasive tumours because it is frequently expressed as a monomer in malignant tumours. Recent studies from our laboratories...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2011.283

    authors： Hamasaki H,Koga K,Aoki M,Hamasaki M,Koshikawa N,Seiki M,Iwasaki H,Nakayama J,Nabeshima K

    更新日期：2011-09-06 00:00:00

  • Loss of acetoacetate coenzyme A transferase activity in tumours of peripheral tissues.

    abstract：:The presence of succinyl-coenzyme A: acetoacetate CoA--transferase (3-oxo acid-CoA transferase), an initiator of ketone body utilization in non-hepatic tissue was examined in a number of animal and human tumours of peripheral tissues. While enzyme levels in heart, kidney, lymphocytes and bladder were high, the tumours...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1983.38

    authors： Tisdale MJ,Brennan RA

    更新日期：1983-02-01 00:00:00

  • What are the information priorities for cancer patients involved in treatment decisions? An experienced surrogate study in Hodgkin's disease.

    abstract：:A total of 165 adult patients with Hodgkin's disease (HD) were questioned following treatment to examine their perceptions of actual and desired involvement and provision of information in the treatment decision-making process. Irrespective of the degree to which patients felt they had been involved in the decision-ma...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1996.39

    authors： Turner S,Maher EJ,Young T,Young J,Vaughan Hudson G

    更新日期：1996-01-01 00:00:00

  • The oncogenic potential of a combination of hyperthermia and chemotherapy agents.

    abstract：:The modulating effect of 43 degrees C hyperthermia on the induction of oncogenic transformation by the antineoplastic agents, actinomycin D, mitomycin C, and 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) was examined using the C3H 10T1/2 cell line. For any given level of cytotoxicity, cells exposed to the three chemothe...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1988.9

    authors： Komatsu K,Miller RC,Hall EJ

    更新日期：1988-01-01 00:00:00

  • Detection and characterisation of multi-drug resistance protein 1 (MRP-1) in human mitochondria.

    abstract：BACKGROUND:Overexpression of plasma membrane multi-drug resistance protein 1 (MRP-1) can lead to multidrug resistance. In this study, we describe for the first time the expression of mitochondrial MRP-1 in untreated human normal and cancer cells and tissues. METHODS:MRP-1 expression and subcellular localisation in nor...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2012.40

    authors： Roundhill EA,Burchill SA

    更新日期：2012-03-13 00:00:00

  • Lowering of innate resistance of the lungs to the growth of blood-borne cancer cells in states of topical and systemic stress.

    abstract：:The survival and clonogenic growth (measured in terms of colony forming efficiency (CFE) of intravenously injected (i.v.) Walker (W256) tumour cells in the lungs of rats was greatly enhanced by states of topical and systemic stress induced by the intraperitoneal (i.p.) injection of rats with a single dose of 10(-5)-10...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1976.7

    authors： Van Den Brenk HA,Stone MG,Kelly H,Sharpington C

    更新日期：1976-01-01 00:00:00

  • Importance of P450 reductase activity in determining sensitivity of breast tumour cells to the bioreductive drug, tirapazamine (SR 4233).

    abstract：:P450 reductase (NADPH:cytochrome P450 reductase, EC 1.6.2.4) is known to be important in the reductive activation of the benzotriazene-di-N-oxide tirapazamine (SR 4233). Using a panel of six human breast adenocarcinoma cell lines we have examined the relationship between P450 reductase activity and sensitivity to tira...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1995.478

    authors： Patterson AV,Barham HM,Chinje EC,Adams GE,Harris AL,Stratford IJ

    更新日期：1995-11-01 00:00:00

  • External validity of a prediction rule for residual mass histology in testicular cancer: an evaluation for good prognosis patients.

    abstract：:We assessed the external validity of a prediction rule for nonseminomatous testicular cancer patients. The rule was developed to predict the probability of retroperitoneal metastases being benign (only necrosis/fibrosis) after chemotherapy treatment. Patients with a high probability of benign residual masses might be ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6600759

    authors： Vergouwe Y,Steyerberg EW,de Wit R,Roberts JT,Keizer HJ,Collette L,Stenning SP,Habbema JD

    更新日期：2003-03-24 00:00:00

  • Sex hormones in women in rural China and in Britain.

    abstract：:Plasma concentrations of certain hormones linked to breast cancer risk were measured in age-pooled samples from 3,250 rural Chinese women in 65 counties, and 300 British women, all aged 35-64. In age-groups 35-44, 45-54 and 55-64 respectively, mean oestradiol concentrations were 36% (P = 0.043), 90% (P less than 0.001...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1990.344

    authors： Key TJ,Chen J,Wang DY,Pike MC,Boreham J

    更新日期：1990-10-01 00:00:00

  • Incidence and possible pathogenesis of sentinel node micrometastases in ductal carcinoma in situ of the breast detected using molecular whole lymph node assay.

    abstract：BACKGROUND:The pathogenesis of lymph node metastases in preinvasive breast cancer – ductal carcinoma in situ (DCIS) – remains controversial. The one-step nucleic acid amplification (OSNA) assay is a novel molecular method that can assess a whole node and detect clinically relevant metastases. In this retrospective coho...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2012.168

    authors： Osako T,Iwase T,Kimura K,Masumura K,Horii R,Akiyama F

    更新日期：2012-05-08 00:00:00

  • Molecular alterations associated with liver metastases development in colorectal cancer patients.

    abstract：BACKGROUND:Understanding the molecular biology of colorectal cancer (CRC) provides opportunities for effective personalised patient management. We evaluated whether chromosomal aberrations, mutations in the PI(3)K signalling pathway and the CpG-island methylator phenotype (CIMP) in primary colorectal tumours can predic...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2011.184

    authors： Bruin SC,He Y,Mikolajewska-Hanclich I,Liefers GJ,Klijn C,Vincent A,Verwaal VJ,de Groot KA,Morreau H,van Velthuysen ML,Tollenaar RA,van 't Veer LJ

    更新日期：2011-07-12 00:00:00

  • Radiosensitivity in breast cancer assessed by the Comet and micronucleus assays.

    abstract：:Spontaneous and radiation-induced genetic instability of peripheral blood mononuclear cells derived from unselected breast cancer (BC) patients (n=50) was examined using the single-cell gel electrophoresis (Comet) assay and a modified G2 micronucleus (MN) test. Cells from apparently healthy donors (n=16) and from canc...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6603005

    authors： Djuzenova CS,Mühl B,Fehn M,Oppitz U,Müller B,Flentje M

    更新日期：2006-04-24 00:00:00

  • The anti-proliferative effect of lithium chloride on melanoma cells and its reversion by myo-inositol.

    abstract：:The effect of LiCl on melanoma cell growth and differentiation was studied in mouse and human melanoma cell lines. LiCl markedly inhibited B16 and HT-144 melanoma cell growth in vitro. Clonogenicity in soft agar of the melanoma cells was also markedly inhibited by LiCl. Pretreatment of B16 mouse melanoma cells with Li...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1987.9

    authors： Nordenberg J,Panet C,Wasserman L,Malik Z,Fuchs A,Stenzel KH,Novogrodsky A

    更新日期：1987-01-01 00:00:00

  • Prognostic role of clinical, pathological and biological characteristics in patients with locally advanced breast cancer.

    abstract：:Forty-two patients with clinical stage IIIA or IIIB breast cancer were treated with neoadjuvant chemotherapy followed by mastectomy and radiotherapy. The median follow-up was 32 months (range 10-72 months) and the median time to progression was 17 months (range 10-30 months). A multivariate analysis showed that a long...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1998.99

    authors： Honkoop AH,van Diest PJ,de Jong JS,Linn SC,Giaccone G,Hoekman K,Wagstaff J,Pinedo HM

    更新日期：1998-02-01 00:00:00

  • Detection and prognostic role of heterogeneous populations of melanoma circulating tumour cells.

    abstract：BACKGROUND:Circulating tumour cells (CTCs) can be assessed through a minimally invasive blood sample with potential utility as a predictive, prognostic and pharmacodynamic biomarker. The large heterogeneity of melanoma CTCs has hindered their detection and clinical application. METHODS:Here we compared two microfluidi...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/s41416-020-0750-9

    authors： Aya-Bonilla CA,Morici M,Hong X,McEvoy AC,Sullivan RJ,Freeman J,Calapre L,Khattak MA,Meniawy T,Millward M,Ziman M,Gray ES

    更新日期：2020-03-01 00:00:00

  • DNA methylation analysis at distal and proximal promoter regions of the oestrogen receptor gene in breast cancers.

    abstract：:Oestrogen receptor alpha (ER-alpha) gene has two specific promoters, distal (P0) and proximal (P1), which induce almost identical transcripts in size due to different splicing. We examined the methylation at both promoter regions of the ER-alpha gene using HpaII, a methylation-sensitive restriction enzyme, prior to po...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6690631

    authors： Iwase H,Omoto Y,Iwata H,Toyama T,Hara Y,Ando Y,Ito Y,Fujii Y,Kobayashi S

    更新日期：1999-08-01 00:00:00

  • Sentinel node biopsy in early vulvar cancer.

    abstract：:Lymph node pathologic status is the most important prognostic factor in vulvar cancer; however, complete inguinofemoral node dissection is associated with significant morbidity. Lymphoscintigraphy associated with gamma-probe guided surgery reliably detects sentinel nodes in melanoma and breast cancer patients. This st...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1054/bjoc.1999.0918

    authors： De Cicco C,Sideri M,Bartolomei M,Grana C,Cremonesi M,Fiorenza M,Maggioni A,Bocciolone L,Mangioni C,Colombo N,Paganelli G

    更新日期：2000-01-01 00:00:00

  • Activity of the multikinase inhibitor dasatinib against ovarian cancer cells.

    abstract：BACKGROUND:Here, we explore the therapeutic potential of dasatinib, a small-molecule inhibitor that targets multiple cytosolic and membrane-bound tyrosine kinases, including members of the Src kinase family, EphA2, and focal adhesion kinase for the treatment of ovarian cancer. METHODS:We examined the effects of dasati...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6605381

    authors： Konecny GE,Glas R,Dering J,Manivong K,Qi J,Finn RS,Yang GR,Hong KL,Ginther C,Winterhoff B,Gao G,Brugge J,Slamon DJ

    更新日期：2009-11-17 00:00:00

  • Prognostic relevance of Tiam1 protein expression in prostate carcinomas.

    abstract：:The Rac-specific guanine nucleotide exchange factor, Tiam1, plays a major role in oncogenicity, tumour invasion and metastasis but its usefulness as a prognostic marker in human cancer has not been tested yet. In the present study, Tiam1 expression was analysed in benign secretory epithelium, pre-neoplastic high-grade...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6603385

    authors： Engers R,Mueller M,Walter A,Collard JG,Willers R,Gabbert HE

    更新日期：2006-10-23 00:00:00

  • Prevention of murine sarcoma virus oncogenesis in offspring of immunized female mice.

    abstract：:BALB/c mice born to and nursed by females immunized against MSV-M showed a reduced tumour incidence and a high tumour regression rate following MSV-M injection at 7-14 days of age. Females immunized long before mating could also confer protection to their offspring whereas females immunized after parturition could not...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1973.143

    authors： Chieco-Bianchi L,Collavo D,Biasi G,Colombatti A

    更新日期：1973-09-01 00:00:00

  • Cancer-associated tumour markers CA 19-9 and CA-50 in patients with pancreatic cancer with special reference to the Lewis blood cell status.

    abstract：:Monoclonal antibodies 19-9 and C-50 were used to assay the cancer associated tumour antigens CA 19-9 and CA-50 in plasma from patients with confirmed pancreatic cancer, and related to the blood group and Lewis blood cell status. The plasma expressions of CA 19-9 or CA-50 were similar, including cases where the patient...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1990.241

    authors： Masson P,Pålsson B,Andrén-Sandberg A

    更新日期：1990-07-01 00:00:00

  • Expression of survivin and its splice variants survivin-2B and survivin-DeltaEx3 in breast cancer.

    abstract：:Alternative splicing of survivin mRNA gives rise to multiple isoforms, that is, survivin and 3 splice variants, survivin-2B, survivin-3B and survivin-DeltaEx3. The aim of this study was to compare the expression of survivin, survivin-2B and survivin-DeltaEx3 in normal breast tissue, fibroadenomas, primary breast cance...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6602314

    authors： Ryan B,O'Donovan N,Browne B,O'Shea C,Crown J,Hill AD,McDermott E,O'Higgins N,Duffy MJ

    更新日期：2005-01-17 00:00:00

  • Risk factors cannot explain the higher prevalence rates of precancerous colorectal lesions in men.

    abstract：BACKGROUND:Prevalence of (pre)cancerous colorectal lesions are higher in men than in women, although transition rates from advanced lesions to cancer is similar in both sexes. Our aim was to investigate whether the sex-specific difference in incidence of premalignant colorectal lesions might be explained by the impact ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2016.324

    authors： Waldmann E,Heinze G,Ferlitsch A,GessI I,Sallinger D,Jeschek P,Britto-Arias M,Salzl P,Fasching E,Jilma B,Kundi M,Trauner M,Ferlitsch M

    更新日期：2016-11-22 00:00:00