COX-2 inhibitors and the heart: are all coxibs the same?

abstract：:A 77-year old woman with pituitary-driven Cushing's disease is described. The condition was completely controlled on long-term treatment with metyrapone. ...

journal_title：Postgraduate medical journal

authors： Donckier J,Burrin JM,Ramsay ID,Joplin GF

更新日期：1986-08-01 00:00:00

abstract：:There is evidence that acetylcholine antagonists at the neuromuscular junction and elsewhere can act by blocking the ionic channels opened by acetylcholine as well as by competing with acetylcholine for receptor sites. This type of uncompetitive antagonism can be distinguished from competitive antagonism in various wa...

journal_title：Postgraduate medical journal

authors： Rang HP

更新日期：1981-01-01 00:00:00

abstract：:Medullary carcinoma of the thyroid commonly spreads to the lymphatics and later on in the disease process, to distant sites such as lung, liver and bone. Spread to the breast is rare (only two previous reported cases) and presents a major diagnostic dilemma. We report a case of metastatic medullary carcinoma of the th...

journal_title：Postgraduate medical journal

authors： Kiely N,Williams N,Wilson G,Williams RJ

更新日期：1995-12-01 00:00:00

abstract：:Herniation of a thoracic disc in an acromegalic giant is reported. Degenerative changes in the spine in association with dorsal kyphosis, and the additional strain, resulted in the disc prolapse. ...

journal_title：Postgraduate medical journal

authors： Chhang WH,Sharma BS,Dash RJ,Kak VK

更新日期：1989-07-01 00:00:00

abstract：:We describe a patient with primary amyloidosis in whom multiple osteolytic lesions caused by amyloid bone tumours developed, and review the clinical features of the 18 cases with primary amyloidosis in whom destructive bone lesions have been reported. In contrast to amyloidosis associated with multiple myeloma, destru...

journal_title：Postgraduate medical journal

authors： Kramer MR,van Dijk JM,Hadas I,Hershko C

更新日期：1986-11-01 00:00:00

abstract：PURPOSE:To determine the association between professors' self-perception of mentoring skills and their academic performance. DESIGN:Two hundred and fifteen professors from Imperial College London, the first Academic Health Science Centre (AHSC) in the UK, were surveyed. The instrument adopted was the Mentorship Skills...

journal_title：Postgraduate medical journal

authors： Athanasiou T,Patel V,Garas G,Ashrafian H,Shetty K,Sevdalis N,Panzarasa P,Darzi A,Paroutis S

更新日期：2016-10-01 00:00:00

abstract：:Gastric cancer is a cause of significant morbidity and mortality. There are several risk factors, with occupation emerging as one of these. There is considerable evidence that occupations in coal and tin mining, metal processing, particularly steel and iron, and rubber manufacturing industries lead to an increased ris...

journal_title：Postgraduate medical journal

authors： Raj A,Mayberry JF,Podas T

更新日期：2003-05-01 00:00:00

abstract：:A patient is described who developed acute pericarditis during a severe first attack of Crohn's disease. The opportunity was taken to measure levels of circulating immune complexes, both during the acute phase of the illness and during convalescence; no significant change in these levels from normal values was found. ...

journal_title：Postgraduate medical journal

authors： Manomohan V,Subbuswamy SG,Willoughby CP

更新日期：1984-10-01 00:00:00

abstract：:Eight patients with steroid-sensitive nephrotic syndrome which frequently relapsed despite cyclophosphamide treatment were given cyclosporin A (7.5 mg/kg/day to 10 mg/kg/day) for 8 to 12 weeks. Six had minimal change glomerulonephritis and two had focal segmental glomerulonephritis. Cyclosporin A was given to 5 patien...

journal_title：Postgraduate medical journal

authors： Chan MK,Cheng IK

更新日期：1987-09-01 00:00:00

abstract：:Three women were admitted to the surgical wards with acute gastro-intestinal symptoms and despite good clinical (pigmentation, hypotension) and biochemical (hyponatraemia, acidosis) evidence of Addisonian crisis had unnecessary investigations with delay in the diagnosis and appropriate management of this medical emerg...

journal_title：Postgraduate medical journal

authors： Small M,MacCuish AC,Thomson JA

更新日期：1987-05-01 00:00:00

abstract：:Repeated pneumonia and hypogammaglobulinaemia was associated with long term low dose steroid therapy. Clinical improvement with restoration of antibody levels followed substitution of aerosol for oral therapy. ...

journal_title：Postgraduate medical journal

authors： Lee RJ,Fay AC

更新日期：1985-06-01 00:00:00

abstract：:Fibrosing colonopathy is a recently described complication of cystic fibrosis, of unknown aetiology but possibly related to treatment with high-dose pancreatic enzyme supplements. We have used a whole gut perfusion technique to study subclinical gut inflammation in cystic fibrosis patients; concentrations of haemoglob...

journal_title：Postgraduate medical journal

authors： Croft NM,Marshall TG,Ferguson A

更新日期：1996-03-01 00:00:00

abstract：:The Chancellor of the Exchequer's recent announcements to devolve decision making power from Whitehall to 30 English regions provide a challenge to use devolution to deliver more favourable health outcomes. However evaluation of devolved health models internationally is scarce, because it is rarely considered. Evidenc...

journal_title：Postgraduate medical journal

authors： Doyle Y,Johnstone P

更新日期：2016-05-01 00:00:00

abstract：:Liver transplantation is a useful treatment for end stage liver disease of all aetiologies but recurrent disease presents an ongoing challenge, particularly for hepatitis C virus (HCV) where recurrence is almost universal. Immunosuppression is needed for all patients after transplantation and should be tailored to the...

journal_title：Postgraduate medical journal

authors： Gee I,Alexander G

更新日期：2005-12-01 00:00:00

abstract：:Excess body weight, as defined by the body mass index (BMI), has been associated with several diseases and includes subjects who are overweight (BMI≥25-29.9 kg/m(2)) or obese (BMI≥30 kg/m(2)). Overweight and obesity constitute the fifth leading risk for overall mortality, accounting for at least 2.8 million adult deat...

journal_title：Postgraduate medical journal

authors： Bardou M,Barkun AN,Martel M

更新日期：2013-09-01 00:00:00

abstract：:The nature of rehabilitation medicine is outlined in terms of its objectives, its methods, the patient groups which it seeks to help and its relationships to other specialties. Some major advances of recent years are discussed, such as the development of the impairment/disability/handicap framework. With particular em...

journal_title：Postgraduate medical journal

authors： Cozens JA,Chamberlain MA

更新日期：1995-11-01 00:00:00

abstract：:A well documented sporadic case of multiple endocrine adenomatosis (MEA) type I, with the pituitary tumour presenting as a prolactinoma, is described in a 28-year-old female. Primary amenorrhoea, resulting from hyperprolactinaemia, was the first symptom of the polyglandular neoplasia. A gastrinoma was removed from the...

journal_title：Postgraduate medical journal

authors： Vandeweghe M,Braxel K,Schutyser J,Vermeulen A

更新日期：1978-09-01 00:00:00

abstract：:Participant modelling, a behaviourally-orientated treatment technique, is an effect method of treating phobias associated with minor medical procedures or apparatus such as needles or intravenous catheters. The steps in this technique are described and two cases of severe needle phobias successfully treated with parti...

journal_title：Postgraduate medical journal

authors： Taylor CB,Ferguson JM,Wermuth BM

更新日期：1977-01-01 00:00:00

abstract：:This review considers some of the more common problems in the interpretation of the results of biochemical tests and, where possible, highlights ways in which errors can be identified or avoided. ...

journal_title：Postgraduate medical journal

authors： Ayling RM

更新日期：2000-03-01 00:00:00

abstract：:Submucosal dissection of the oesophagus is a rare oesophageal disorder. We report a patient who had recurrent episodes of dissection and achalasia. Both recurrence and the association with achalasia are to our knowledge unique. ...

journal_title：Postgraduate medical journal

authors： Hooper TL,Gholkar J,Smith SR,Manns JJ,Moussalli H

更新日期：1986-10-01 00:00:00

abstract：:It was considered that the first dose reaction occurring with prazosin may have been due either to hypotension or to a specific reduction in cerebral blood flow. The development of a quantitative non-invasion nuclear medicine technique for cerebral flow has now made it possible to investigate the effects of prazosin o...

journal_title：Postgraduate medical journal

authors： Rutland MD,Lee TY,Nimmon CC,Granowska M,Britton KE

更新日期：1980-12-01 00:00:00

abstract：:Collapse of a lobe of a lung is an important indicator of a range of conditions, including malignancy. Clinical symptoms and signs may suggest a diagnosis of lobar collapse; however, it is often diagnosed, and always needs to be confirmed, with radiological examination. The radiological signs may be subtle, difficult ...

journal_title：Postgraduate medical journal

authors： Mullett R,Jain A,Kotugodella S,Curtis J

更新日期：2012-06-01 00:00:00

abstract：:Rectal (both digital and rigid sigmoidoscopic) examination is an important part of the clinical examination. The aim of this study was to find out the opinions of the patients to this routine examination at the time of referral by their general practitioner and during their first hospital interview. Assessment of the ...

journal_title：Postgraduate medical journal

authors： Ng DP,Mayberry JF,McIntyre AS,Long RG

更新日期：1991-10-01 00:00:00

abstract：:In the 1920s Moynihan described acute pancreatitis as "..the most terrible of all intra-abdominal calamities". He established a practice of immediate surgical intervention to remove the toxic products accumulating in the peritoneal cavity, and this treatment was endorsed by most centres, remaining the standard therapy...

journal_title：Postgraduate medical journal

authors： Skaife P,Kingsnorth AN

更新日期：1996-05-01 00:00:00

abstract：:Although there is good evidence that D-penicillamine can induce polymyositis, the exact pathogenic mechanism remains unclear. We report two patients with psoriatic arthritis and primary biliary cirrhosis respectively, who developed polymyositis while receiving D-penicillamine treatment for their primary diseases. Whet...

journal_title：Postgraduate medical journal

authors： Aydintug AO,Cervera R,D'Cruz D,Ramírez G,Asherson RA,Khamashta MA,Hughes GR

更新日期：1991-11-01 00:00:00

abstract：:The anticoagulant agents heparin and warfarin were introduced before the era of randomised clinical trials. As a result, the indications, dosages and monitoring techniques of these drugs have undergone re-evaluation in multiple clinical trials in the past years. Low molecular weight heparin has been developed, which h...

journal_title：Postgraduate medical journal

authors： Toh CH

更新日期：1997-05-01 00:00:00

abstract：:Reports of malignant melanoma involving the heart usually describe metastatic spread of pigmented (melanotic) forms of this tumour. We describe, and illustrate, a patient presenting with features related to cardiac tamponade and intracardiac obstruction. Transthoracic echocardiography initially showed a large mass wit...

journal_title：Postgraduate medical journal

authors： Dubrey S,Grocott-Mason R,Mittal T,Burke M

更新日期：2008-03-01 00:00:00

abstract：:The marked decline in coronary heart disease mortality in the United States since the late 1960s is most likely due in large part to successful efforts at primary prevention, attributable in turn to improved eating habits, better control of blood pressure and a reduction in smoking. Another part of the decline can pro...

journal_title：Postgraduate medical journal

authors： Epstein FH

更新日期：1984-01-01 00:00:00

abstract：:Splenic peliosis was identified at necropsy in a 62-year-old woman receiving continuous ambulatory peritoneal dialysis for end-stage renal failure, and erythropoietin therapy for uraemia and anaemia. The immediate cause of death was arrhythmia related to ischaemic heart disease, following an episode of intramuscular h...

journal_title：Postgraduate medical journal

authors： Lam KY,Chan AC,Chan TM

更新日期：1995-08-01 00:00:00

abstract：OBJECTIVES:Appropriate assessment of community-acquired pneumonia (CAP) allows accurate severity scoring and hence optimal management, leading to reduced morbidity and mortality. British Thoracic Society (BTS) guidelines provide an appropriate score. Adherence to BTS guidelines was assessed in our medical assessment un...

journal_title：Postgraduate medical journal

authors： Collini P,Beadsworth M,Anson J,Neal T,Burnham P,Deegan P,Beeching N,Miller A

更新日期：2007-08-01 00:00:00