The effects of chlorpromazine and phenobarbital on vasculogenesis in the cerebellar cortex.

abstract：:Two cases of Central neurocytoma arising in the lateral ventricles are presented. Both patients had well-circumscribed masses in the right lateral ventricle causing hydrocephalus. The tumors were composed of small round cells forming Homer Wright rosettes against a fine fibrillary background. In one patient surgical r...

journal_title：Acta neuropathologica

authors： Townsend JJ,Seaman JP

更新日期：1986-01-01 00:00:00

abstract：:Using a fluorescent antibody technique, sections of the brains of patients with senile dementia or Alzheimer's disease containing senile plaques were treated with rabbit antihuman immunoglobulins labelled with FITC (fluorescein isothiocyanate, BBL). The senile plaques and the cerebral amyloid angiopathy (drusige Entar...

journal_title：Acta neuropathologica

authors： Ishii T,Haga S

更新日期：1975-08-11 00:00:00

abstract：:A case history illustrating the potential clinical significance of subependymoma is presented. Fine structural studies indicate that the tumor is composed of cells having the cytoplasmic features of ependyma, astrocytes, and transitional cells. Its composition and structure are alike those in the adult mammalian subep...

journal_title：Acta neuropathologica

authors： Azzarelli B,Rekate HL,Roessmann U

更新日期：1977-11-28 00:00:00

abstract：:Mutations in the sarcomeric protein titin, encoded by TTN, are emerging as a common cause of myopathies. The diagnosis of a TTN-related myopathy is, however, often not straightforward due to clinico-pathological overlap with other myopathies and the prevalence of TTN variants in control populations. Here, we present a...

journal_title：Acta neuropathologica

authors： Rees M,Nikoopour R,Fukuzawa A,Kho AL,Fernandez-Garcia MA,Wraige E,Bodi I,Deshpande C,Özdemir Ö,Daimagüler HS,Pfuhl M,Holt M,Brandmeier B,Grover S,Fluss J,Longman C,Farrugia ME,Matthews E,Hanna M,Muntoni F,Sarkozy

更新日期：2021-01-15 00:00:00

abstract：:To investigate the pathogenetic role of human T lymphocyte virus type I (HTLV-I) in central nervous system disease, a rat model for HTLV-I-associated myelopathy/tropical spastic paraparesis, designated as HAM rat disease, has been established. Wistar-King-Aptekman-Hokudai strain rats with induced HTLV-I infection deve...

journal_title：Acta neuropathologica

authors： Kasai T,Ikeda H,Tomaru U,Yamashita I,Ohya O,Morita K,Wakisaka A,Matsuoka E,Moritoyo T,Hashimoto K,Higuchi I,Izumo S,Osame M,Yoshiki T

更新日期：1999-02-01 00:00:00

abstract：:Paediatric high grade glioma (pHGG) (World Health Organisation astrocytoma grades III and IV) remains poor prognosis tumours, with a median survival of only 15 months following diagnosis. Current investigation of anti-angiogenic strategies has focused on adult glioblastoma multiforme (GBM) with phase III trials target...

journal_title：Acta neuropathologica

authors： Smith SJ,Tilly H,Ward JH,Macarthur DC,Lowe J,Coyle B,Grundy RG

更新日期：2012-07-01 00:00:00

abstract：:Accumulation of mitochondrial DNA (mtDNA) deletions has been proposed to be responsible for the presence of respiratory-deficient neurons in several CNS diseases. Deletions are thought to originate from double-strand breaks due to attack of reactive oxygen species (ROS) of putative inflammatory origin. In epileptogene...

journal_title：Acta neuropathologica

authors： Volmering E,Niehusmann P,Peeva V,Grote A,Zsurka G,Altmüller J,Nürnberg P,Becker AJ,Schoch S,Elger CE,Kunz WS

更新日期：2016-08-01 00:00:00

abstract：:We recently examined the brain from an 8-month-old infant with Down's syndrome and found argyrophilic plaque-like deposits throughout the neocortex and cerebellum. To ascertain the specificity of this observation, we examined 27 additional brains from the pediatric autopsy service, including 1 from another patient wit...

journal_title：Acta neuropathologica

authors： Crain BJ,McPhatter L,Croom DW 2nd,Hulette CM

更新日期：1995-01-01 00:00:00

abstract：:Experimental brain tumors were produced in rats by stereotactical implantation of various neoplastic cell lines (RG 2, RG1 2.2, G 13/11, F 98, RN 6, B 104, and E 367). Using autoradiographic, bioluminescence, and fluoroscopic methods, the following regional hemodynamic and metabolic parameters were measured on intact ...

journal_title：Acta neuropathologica

authors： Hossmann KA,Mies G,Paschen W,Szabo L,Dolan E,Wechsler W

更新日期：1986-01-01 00:00:00

abstract：:Frontotemporal lobar degeneration is the term used to describe the non-Alzheimer clinical syndromes of frontotemporal dementia, semantic dementia and progressive non-fluent aphasia, regardless of the underlying neuropathological features. Considerable progress has been made in recent years in our understanding of the ...

journal_title：Acta neuropathologica

authors： Pickering-Brown SM

更新日期：2007-07-01 00:00:00

abstract：:Neurofibrillary tangles were induced in the motor neurons of the rabbit spinal cord by the intrathecal injection of colchicine, vinblastine, and vincristine. The tangles stained intensely by immunofluorescence and by the peroxidase-anti-peroxidase procedure using neurofilament antisera raised against chicken brain ant...

journal_title：Acta neuropathologica

authors： Dahl D,Bignami A,Bich NT,Chi NH

更新日期：1980-01-01 00:00:00

abstract：:Progressive supranuclear palsy (PSP) is a 4R-tauopathy predominated by subcortical pathology in neurons, astrocytes, and oligodendroglia associated with various clinical phenotypes. In the present international study, we addressed the question of whether or not sequential distribution patterns can be recognized for PS...

journal_title：Acta neuropathologica

authors： Kovacs GG,Lukic MJ,Irwin DJ,Arzberger T,Respondek G,Lee EB,Coughlin D,Giese A,Grossman M,Kurz C,McMillan CT,Gelpi E,Compta Y,van Swieten JC,Laat LD,Troakes C,Al-Sarraj S,Robinson JL,Roeber S,Xie SX,Lee VM,Trojan

更新日期：2020-08-01 00:00:00

abstract：:To assess whether amyloid plaque accumulation in the monkey brain can account for age-related cognitive impairment that begins at about 20 years of age, we measured plaque content in the brains of 14 rhesus monkeys aged 5-30 years. We used immunohistochemistry employing the monoclonal antibody 6E10, which is specific ...

journal_title：Acta neuropathologica

authors： Sloane JA,Pietropaolo MF,Rosene DL,Moss MB,Peters A,Kemper T,Abraham CR

更新日期：1997-11-01 00:00:00

abstract：:We examined the immunohistochemical localization of the proinflammatory cytokines tumor necrosis factor-alpha, lymphotoxin and interferon-gamma in 22 autopsy brains of patients with either cerebrovascular disease (CVD) or other neurological diseases as well as 2 non-neurological control brains. These cytokines were co...

journal_title：Acta neuropathologica

authors： Tomimoto H,Akiguchi I,Wakita H,Kinoshita A,Ikemoto A,Nakamura S,Kimura J

更新日期：1996-09-01 00:00:00

abstract：:Cerebellar torpedoes, unique fusiform swellings of Purkinje cell axons within the granular layer, have been known to occur sparsely associated with diffuse cerebellar changes. This report describes, in three human autopsy cases with focal necrotic lesions in the cerebellar white matter, torpedoes which were essentiall...

journal_title：Acta neuropathologica

authors： Takahashi N,Iwatsubo T,Nakano I,Machinami R

更新日期：1992-01-01 00:00:00

abstract：:New pericapillary inclusion bodies were found in 17 cases of sporadic amyotrophic lateral sclerosis (ALS). The inclusion bodies consisted of paracrystalline arrays with 5-7 nm electron-dense subunits, were discernible with the light microscope and had the staining properties of protein. They were surrounded by capilla...

journal_title：Acta neuropathologica

authors： Averback P

更新日期：1986-01-01 00:00:00

abstract：:The nature and distribution of vascular changes in acute Wernicke's encephalopathy (WE) were analyzed in three autopsy cases. Lesions of the lateral vestibular nucleus of the medulla oblongata (three cases) and lateral ventricular wall (one case) were examined by reconstruction of 200 serial sections, and the capillar...

journal_title：Acta neuropathologica

authors： Okeda R,Taki K,Ikari R,Funata N

更新日期：1995-01-01 00:00:00

abstract：:Bundles of paired helical filaments (PHF) accumulate in the pyramidal neurons that degenerate during Alzheimer's disease. This neurofibrillary degeneration is highly correlated with clinical signs of dementia. During the degenerating process, Tau proteins, which are the major antigenic components of PHF, are abnormall...

journal_title：Acta neuropathologica

authors： Delacourte A,Flament S,Dibe EM,Hublau P,Sablonnière B,Hémon B,Shérrer V,Défossez A

更新日期：1990-01-01 00:00:00

abstract：:The glial cytoplasmic inclusion (GCI) is a histological hallmark for multiple system atrophy (MSA): these inclusions are found in oligodendrocytes and consist of abnormal granule-coated fibrils of approximately 24- to 40-nm diameter. To clarify the significance of the presence of midkine (MK) in these GCIs, we carried...

journal_title：Acta neuropathologica

authors： Kato S,Shinozawa T,Takikawa M,Kato M,Hirano A,Awaya A,Ohama E

更新日期：2000-11-01 00:00:00

abstract：:We investigated clinicopathologically pyramidal signs, including hyperreflexia, Babinski sign, and spasticity, and the involvement of the primary motor cortex and pyramidal tract, in eight Japanese autopsy cases of amyotrophic lateral sclerosis (ALS) with dementia. Pyramidal signs were observed in seven (88%) of the e...

journal_title：Acta neuropathologica

authors： Tsuchiya K,Ikeda K,Mimura M,Takahashi M,Miyazaki H,Anno M,Shiotsu H,Akabane H,Niizato K,Uchihara T,Tominaga I,Nakano I

更新日期：2002-09-01 00:00:00

abstract：:Pediatric ependymomas are highly recurrent tumors resistant to conventional chemotherapy. Telomerase, a ribonucleoprotein critical in permitting limitless replication, has been found to be critically important for the maintenance of tumor-initiating cells (TICs). These TICs are chemoresistant, repopulate the tumor fro...

journal_title：Acta neuropathologica

authors： Barszczyk M,Buczkowicz P,Castelo-Branco P,Mack SC,Ramaswamy V,Mangerel J,Agnihotri S,Remke M,Golbourn B,Pajovic S,Elizabeth C,Yu M,Luu B,Morrison A,Adamski J,Nethery-Brokx K,Li XN,Van Meter T,Dirks PB,Rutka JT,Tay

更新日期：2014-12-01 00:00:00

abstract：:Round granulated body (RGB) and eosinophilic hyaline droplets (EHDs) have been described as cytoplasmic inclusions of certain astrocytic tumors. In the previous literature, however, these inclusions have been described using various terms or regarded as nosologically the same entity. Light microscopically, RGB appeare...

journal_title：Acta neuropathologica

authors： Hitotsumatsu T,Iwaki T,Fukui M,Tateishi J

更新日期：1994-01-01 00:00:00

abstract：:A total of 66 skin biopsies from persons with Alzheimer's disease (AD) or Down's syndrome (DS) and from persons without AD were used in this study. The age range was from 7 to 89 years. Positive immunoreactivity of skin biopsies to monoclonal antibody 4G8, which is reactive to amino acid residue 17-24 of synthetic amy...

journal_title：Acta neuropathologica

authors： Wen GY,Wisniewski HM,Blondal H,Benedikz E,Frey H,Pirttila T,Rudelli R,Kim KS

更新日期：1994-01-01 00:00:00

abstract：:This study reports the histological, ultrastructural, and immunocytochemical characteristics of intracytoplasmic eosinophilic inclusion bodies occurring in various types of neurons of the human central nervous system. By light microscopy, the inclusions were brightly eosinophilic, slightly birefringent, and sharply de...

journal_title：Acta neuropathologica

authors： Peña CE,Katoh A

更新日期：1989-01-01 00:00:00

abstract：:A 79-year-old woman had a 10-year history of dementia, initially presenting as non-fluent aphasia. Magnetic resonance imaging showed frontal atrophy (left greater than right) and hyperintense foci within white matter. Neuropathologically, there was severe frontal atrophy due to cortical neuronal loss with spongy chang...

journal_title：Acta neuropathologica

authors： Powers JM,Byrne NP,Ito M,Takao M,Yankopoulou D,Spillantini MG,Ghetti B

更新日期：2003-08-01 00:00:00

abstract：:Human adenovirus type 12 (Ad 12) was inoculated intraperitoneally, intrapleurally, intramuscularly or subcutaneously into newborn rodents. Tumors developed preferentially in the peritoneal cavities in 93.9% of the hamsters and 82.6% of the mice, but none in rats; in contrast to the high incidence of brain tumors in ra...

journal_title：Acta neuropathologica

authors： Ogawa K

更新日期：1989-01-01 00:00:00

abstract：:The thoracic sympathetic preganglionic outflow is important in the maintenance of postural normotension in man. Normative data on the intermediolateral column (ILC) neuron cell bodies is lacking. Counts and measurements on the right ILC cytons have been performed on the T6, T7 and T8 segments of 12 spinal cords of man...

journal_title：Acta neuropathologica

authors： Low PA,Okazaki H,Dyck PJ

更新日期：1977-09-26 00:00:00

abstract：:We estimated the total neurone number, glial number, and glial index (ratio glial cells/neurone) in the thalamic mediodorsal nucleus (MD) in seven patients suffering from Huntington's disease (HD; four males, three females, mean age 52.4 +/- 13.6 years) and age- and sex-matched controls (four males, three females, mea...

journal_title：Acta neuropathologica

authors： Heinsen H,Rüb U,Bauer M,Ulmar G,Bethke B,Schüler M,Böcker F,Eisenmenger W,Götz M,Korr H,Schmitz C

更新日期：1999-06-01 00:00:00

abstract：:Tenascins (TNs) are a family of extracellular matrix glycoproteins. The first member of this family to be recognized, tenascin-C (TN-C), is known to be expressed in various tumors including human astrocytomas. Tenascin-X (TN-X) is the latest member of the TN family to be reported, and its expression in tumor tissues h...

journal_title：Acta neuropathologica

authors： Hasegawa K,Yoshida T,Matsumoto K,Katsuta K,Waga S,Sakakura T

更新日期：1997-05-01 00:00:00

abstract：:A massive expansion of a GGGGCC repeat upstream of the C9orf72 coding region is the most common known cause of amyotrophic lateral sclerosis and frontotemporal dementia. Despite its intronic localization and lack of a canonical start codon, both strands are translated into aggregating dipeptide repeat (DPR) proteins: ...

journal_title：Acta neuropathologica

authors： Schludi MH,May S,Grässer FA,Rentzsch K,Kremmer E,Küpper C,Klopstock T,German Consortium for Frontotemporal Lobar Degeneration.,Bavarian Brain Banking Alliance.,Arzberger T,Edbauer D

更新日期：2015-10-01 00:00:00