Vascular changes in acute Wernicke's encephalopathy.

abstract：:Astrocytic alpha-synuclein-immunoreactive inclusions have recently been noted to develop in sporadic Parkinson's disease (PD). Here, the presence of immunoreactive astrocytes is reported in 14 autopsy cases with clinically diagnosed PD and a neuropathological stage of 4 or higher. The labeled astrocytes occur preferen...

journal_title：Acta neuropathologica

authors： Braak H,Sastre M,Del Tredici K

更新日期：2007-09-01 00:00:00

abstract：:Electron microscopy and computerized morphometric techniques were employed to examine pericyte ultrastructure and to assess quantitatively their relationship to endothelial cells in five cases of cerebellar capillary hemangioblastoma. A total of 97 cross-sectioned capillary profiles were studied. Pericyte coverage of ...

journal_title：Acta neuropathologica

authors： Ho KL

更新日期：1985-01-01 00:00:00

abstract：:Motor dysfunction is frequently noted in human immunodeficiency virus type 1 (HIV-1)-infected patients. Until recently, neuropathological changes found in the basal ganglia were advanced as pathogenetic mechanisms. In the present study, further brain structures involved in motor control were analyzed morphometrically....

journal_title：Acta neuropathologica

authors： Abe H,Mehraein P,Weis S

更新日期：1996-08-01 00:00:00

abstract：:In this study we evaluated the relationship between polyglucosan bodies and peripheral nerve lesions. The biopsied sural nerve from a patient with late-onset chronic sensori-motor neuropathy showed many intra-axonal polyglucosan bodies and segmental demyelination/remyelination. The formation of Schwann cell hyperplasi...

journal_title：Acta neuropathologica

authors： Matsumuro K,Izumo S,Minauchi Y,Inose M,Higuchi I,Osame M

更新日期：1993-01-01 00:00:00

abstract：:Using a photochemical method silver was demonstrated in the brains of 1-, 14-, and 45-day-old rats which had been exposed to silver on gestational days 18 and 19. In the brain tissue of new-born rats, silver was found in the lysosomes of neurons and astroglia. Minor changes in the anatomic distribution of silver were ...

journal_title：Acta neuropathologica

authors： Rungby J,Danscher G

更新日期：1983-01-01 00:00:00

abstract：:DICER1 syndrome is a rare tumor predisposition syndrome with manifestations that predominantly affect children and young adults. The syndrome is typically caused by heterozygous germline loss-of-function DICER1 alterations accompanied on the other allele by somatic missense mutations occurring at one of a few mutation...

journal_title：Acta neuropathologica

authors： de Kock L,Priest JR,Foulkes WD,Alexandrescu S

更新日期：2020-04-01 00:00:00

abstract：:Histochemical and electron microscopic studies were performed in an attempt to clarify the muscle pathology in an 18-year-old man with Fabry disease, showing proximal limb muscle atrophy, and his 52-year-old mother, who is a Fabry carrier with hypertrophic cardiomyopathy. Despite the relatively mild myopathic changes ...

journal_title：Acta neuropathologica

authors： Uchino M,Uyama E,Kawano H,Hokamaki J,Kugiyama K,Murakami Y,Yasue H,Ando M

更新日期：1995-01-01 00:00:00

abstract：:A woman of 22 years developed heavy pain in the neck and arms with weakness and paresthesia. She died two days after a myelography which was normal. At autopsy an enterogenous extra- and intra-medullary cyst of the cervical cord (C3, C4) was found. In addition the cervical cord apart from the cyst and the uppermost th...

journal_title：Acta neuropathologica

authors： Pilz P,Fischbach R,Brenneis M

更新日期：1977-11-28 00:00:00

abstract：:The endothelial cells of three cases of cerebellar capillary hemangioblastoma were studied by means of electron microscopy. Crystalloid bodies, not previously described in the vessels of the central nervous system (CNS), were found in 5%-10% of the endothelial cells, more often in the capillaries with small irregular ...

journal_title：Acta neuropathologica

authors： Ho KL

更新日期：1985-01-01 00:00:00

abstract：:Severe hypoxic-ischemic cerebral damage was produced in 8-day-old rats following permanent bilateral carotid artery occlusion and 15 min of ischemia. Cellular damage consisted of early necrosis and appearance of cells with apoptotic-like morphology (karyorrhectic cells) and cells with granular chromatin degeneration i...

journal_title：Acta neuropathologica

authors： Ferrer I,Pozas E,López E,Ballabriga J

更新日期：1997-12-01 00:00:00

abstract：:In spite of several cases reported in the literature, the exact pathogenetic mechanism of neuropathic changes in porphyric neuropathy remains uncertain. Various authors have ascribed the neuropathologic findings to either a dying-back axonal degeneration or segmental demyelination. In recent years, the hypothesis of a...

journal_title：Acta neuropathologica

authors： Di Trapani G,Casali C,Tonali P,Topi GC

更新日期：1984-01-01 00:00:00

abstract：:This report illustrates a case of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) masquerading as neurofibromatosis due to multifocal enlargements of spinal nerve roots. The patient initially complained of intermittent numbness of the hands and leg weakness at age 62. Nerve conduction velocities were ...

journal_title：Acta neuropathologica

authors： Pytel P,Rezania K,Soliven B,Frank J,Wollmann R

更新日期：2003-02-01 00:00:00

abstract：:The mechanisms underlying neurodegenerative diseases are the outcome of pathological alterations of evolutionary conserved molecular and cellular cascades. For this reason, Drosophila and C. elegans serve as useful model systems to study various aspects of neurodegenerative diseases. Here, we introduce the advantageou...

journal_title：Acta neuropathologica

authors： Shemesh OA,Spira ME

更新日期：2010-08-01 00:00:00

abstract：:A system is presented for the classification of chronic herniations of the cerebellar tonsils in the absence of space-occupying intracranial lesions, based on a survey of the literature and 13 own cases. The Arnold-Chiari malformation in adults typically involves herniation of the cerebellar tonsils instead of herniat...

journal_title：Acta neuropathologica

authors： Friede RL,Roessmann U

更新日期：1976-03-30 00:00:00

abstract：:Twenty necropsy cases of the association of fetal encephalitis with porencephaly, hydranencephaly or polymicrogyria were reviewed including 5 from the authors' material. The latter include a basket brain, a porencephalic necrosis of recent date and a polymicrogyria in the formative state. The supratentorial lesions ar...

journal_title：Acta neuropathologica

authors： Friede RL,Mikolasek J

更新日期：1978-08-07 00:00:00

abstract：:Considering the possibility of a paracellular route for edema resolution we studied the microvasculature of the subependymal and subcortical white matter in hydrocephalic rats. Normal adult rats were used as controls. After injection of kaolin suspension into the cisterna magna, the animals were killed at intervals of...

journal_title：Acta neuropathologica

authors： Nakagawa Y,Cervós-Navarro J,Artigas J

更新日期：1984-01-01 00:00:00

abstract：:Charcot-Marie-Tooth disease type 1 B (CMT1B) is a demyelinating neuropathy caused by mutations in the myelin protein zero (P0) gene (MPZ). A few cases of CMT1B were recently found to be characterized by focally folded myelin sheaths in nerve biopsy specimens; the significance of this association is unknown. Here, we d...

journal_title：Acta neuropathologica

authors： Fabrizi GM,Taioli F,Cavallaro T,Rigatelli F,Simonati A,Mariani G,Perrone P,Rizzuto N

更新日期：2000-09-01 00:00:00

abstract：:Structural proteins of cultured neurofibromatosis (NF) tumor and skin cells were studied with reference to control skin fibroblasts. In polyacrylamide gel electrophoresis (PAGE)/fluorography the banding patterns of the cell lysates were markedly similar. NF tumor cells, however, produced a 60 kD band with a stronger a...

journal_title：Acta neuropathologica

authors： Peltonen J,Näntö-Salonen K,Aho HJ,Kouri T,Virtanen I,Penttinen R

更新日期：1984-01-01 00:00:00

abstract：:A 77-year-old man suffered intermittent hemiconvulsions of unknown etiology on the left side for a period of about 5 weeks. At the autopsy, there was marked neuronal loss, severe proliferation of astrocytes and spongiform changes in the right cerebral cortex. The cerebral white matter showed loosening with astroglial ...

journal_title：Acta neuropathologica

authors： Yamanouchi H,Matsui R,Tomonaga M,Sakurai H,Yoshimura M,Shimada H

更新日期：1988-01-01 00:00:00

abstract：:We describe three cases of early- (cases 1-3, 28-39 years) and one of late-onset (case 4, 76 years) Alzheimer's disease (AD) with 'cotton wool' plaques (CWPs) but without a family history indicating autosomal dominant inheritance. The early-onset cases, but not the late-onset case, showed remarkable aggression, disinh...

journal_title：Acta neuropathologica

authors： Yokota O,Terada S,Ishizu H,Ujike H,Ishihara T,Namba M,Hayashi Y,Nishinaka T,Namba R,Nakashima H,Uéda K,Checler F,Kuroda S

更新日期：2003-10-01 00:00:00

abstract：:Seizures commonly occur in glioma patients, but their pathogenesis is poorly understood, in part due to a lack of valid and versatile experimental models. We have established a new model that enables comprehensive neuropathological and neurophysiological analysis on identical tissue preparations. Rat C6 glioma cells s...

journal_title：Acta neuropathologica

authors： Senner V,Köhling R,Püttmann-Cyrus S,Straub H,Paulus W,Speckmann EJ

更新日期：2004-01-01 00:00:00

abstract：:We studied the microscopic features of 137 cases of human cerebral infarct. In each case, the age of the lesion was determined by measuring the time elapsed between initial clinical presentation and date of surgery or death. Multiple microscopic variables were analyzed on hematoxylin and eosin-stained sections. There ...

journal_title：Acta neuropathologica

authors： Mena H,Cadavid D,Rushing EJ

更新日期：2004-12-01 00:00:00

abstract：:A murine model of Tay-Sachs disease, the prototype of the GM2 gangliosidoses, was produced through the targeted disruption of the Hexa gene encoding the subunit of alpha-hexosaminidase A. The mice were completely devoid of beta-hexosaminidase A activity and accumulated GM2 ganglioside in the CNS in an age-dependent ma...

journal_title：Acta neuropathologica

authors： Taniike M,Yamanaka S,Proia RL,Langaman C,Bone-Turrentine T,Suzuki K

更新日期：1995-01-01 00:00:00

abstract：:Inappropriate apoptosis has been implicated in the mechanism of neuronal death in Huntington's disease (HD). In this study, we report the expression of apoptotic markers in HD caudate nucleus (grades 1-4) and compare this with controls without neurological disease. Terminal transferase-mediated biotinylated-UTP nick e...

journal_title：Acta neuropathologica

authors： Vis JC,Schipper E,de Boer-van Huizen RT,Verbeek MM,de Waal RM,Wesseling P,ten Donkelaar HJ,Kremer B

更新日期：2005-03-01 00:00:00

abstract：:The neuropathological staging model of Alzheimer's disease proposed by Braak and Braak [Acta Neuropathol (1991) 82:259] requires that the evolution of neurofibrillary pathology follows a predictable pattern that can be ordered in a regular regional hierarchy. We have operationalized the neuropathological staging syste...

journal_title：Acta neuropathologica

authors： Gertz HJ,Xuereb J,Huppert F,Brayne C,McGee MA,Paykel E,Harrington C,Mukaetova-Ladinska E,Arendt T,Wischik CM

更新日期：1998-02-01 00:00:00

abstract：:Inflammatory processes have been implicated in the formation of senile plaques in the cerebral cortex of patients with dementia of the Alzheimer type (DAT), since several inflammation-induced proteins are present within these plaques. The relation between inflammatory components and other amyloid beta protein (A beta)...

journal_title：Acta neuropathologica

authors： Verbeek MM,Otte-Höller I,Wesseling P,Ruiter DJ,de Waal RM

更新日期：1996-01-01 00:00:00

abstract：:The long-term survival of oligodendrocytes in the absence of axons in adult animals was studied following Wallerian degeneration of the optic nerves of adult rats for periods up to 22 months. In contrast to the findings in development and in young animals, large numbers of oligodendrocytes survived during this time pe...

journal_title：Acta neuropathologica

authors： Ludwin SK

更新日期：1990-01-01 00:00:00

abstract：:Focal cerebral ischemia was induced by occlusion of the right middle cerebral artery in hypoglycemic, normoglycemic, as well as in acute and chronic diabetic rats. The brain damage was studied after 4 days. The volume of infarction was decreased in hypoglycemia (29 +/- 19 mm3 (mean +/- SD) versus 58 +/- 35 mm3, P less...

journal_title：Acta neuropathologica

authors： Nedergaard M,Diemer NH

更新日期：1987-01-01 00:00:00

abstract：:We report the case of an elderly woman with a history of headache, vomiting and dizziness while walking. On CT scans a mass was identified in the right cerebellar hemisphere exhibiting radiological characteristics of lipomatous tissue. Surgery revealed a compact lesion consisting of whitish-yellow tissue with a fatty ...

journal_title：Acta neuropathologica

authors： Walter A,Dingemans KP,Weinstein HC,Troost D

更新日期：1994-01-01 00:00:00

abstract：:This ultrastructural study deals with the synapses of primary dendrites of the anterior horn neurons in the lower lumbar spinal cords of seven patients with amyotrophic lateral sclerosis (ALS) who had mild neuronal depletion. Specimens from seven age-matched, neurologically normal individuals served as controls. In ea...

journal_title：Acta neuropathologica

authors： Sasaki S,Iwata M

更新日期：1996-01-01 00:00:00